TCEB1 Antibody (1076415) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: IHC, ICC/IF
• Clone: 1076415
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

TCEB1 Antibody (1076415) [Alexa Fluor® 488] Summary

• Immunogen: Spodoptera frugiperda, Sf 21 (baculovirus)-derived human VHL/ELOB/ELOC/CUL2/RBX1 Complex
  Accession # Q15369
• Specificity: Detects hElongin B/Elongin C/VHL/CUL2/RBX1 Complex in Direct ELISA
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TCEB1 Antibody (1076415) [Alexa Fluor® 488]

• ELOC
• elongin 15 kDa subunit
• elongin-C
• RNA polymerase II transcription factor SIII subuni
• RNA polymerase II transcription factor SIII subunit C
• SIII p15
• SIII
• TCEB1
• transcription elongation factor B (SIII), polypept
• transcription elongation factor B (SIII), polypeptide 1 (15kD, elongin C)
• transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
• transcription elongation factor B polypeptide 1
• transcription elongation factor B subunit 1
• transcription elongation factor B, polypeptide 1

Background

Elongin C is a 12kDa, 112aa general transcription elongation factor.  Elongin C, along with Elongin B, Cul2 and Rbx1 to forms a complex with VHL, and Elongin C is required for the function of VHL.  Mutations in Elongin C are responsible for 0.5% to 5% of clear cell renal cell carcinomas.  Tumorigenic mutations frequently occur in a 35-residume domain of VHL responsible for Elongin C binding.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.