TBC1D4 Antibody - BSA Free

Immunohistochemistry: TBC1D4 Antibody - BSA Free [NBP2-81935] - Immunohistochemistry of TBC1D4 in human prostate tissue with TBC1D4 antibody at 10 ug/mL.

• Reactivity: Hu
• Applications: ELISA, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

TBC1D4 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit TBC1D4 Antibody - BSA Free (NBP2-81935) is a polyclonal antibody validated for use in IHC and ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: TBC1D4 antibody was raised against an 19 amino acid peptide near the carboxy terminus of human TBC1D4 . The immunogen is located within amino acids 1190 - 1240 of TBC1D4. Amino Acid Squence: ETLEKLERANSQLKRQNMD
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TBC1D4
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry 10 ug/ml
  • Immunohistochemistry-Paraffin
• Theoretical MW: 140 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse: (89%)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for TBC1D4 Antibody - BSA Free

• Akt substrate of 160 kDa
• AS160Acrg embryonic lethality minimal region ortholog
• DKFZp779C0666
• KIAA0603TBC (Tre-2, BUB2, CDC16) domain-containing protein
• TBC1 domain family member 4
• TBC1 domain family, member 4

Background

AS160, also known as TBC1D4, is a 160 kDa Akt substrate that plays a critical role in regulating insulin-stimulated exocytosis of glucose transporter GLUT4. AS-160 contains a Rab GTPase-activating protein domain (GAP), suggesting its potential role in membrane trafficking. Insulin-stimulated phosphorylation of AS160 on threonine 642 is critical for mediating GLUT4 translocation in fat and muscle cells, via inactivation of Rab GAP function. Phosphorylation of Thr642 is also important in mediating TBC1D4 redistribution from low density microsomes to the cytosol in adipocytes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TBC1D4