Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF
Host: Mouse Monoclonal
Species: Hu, Ca
Applications: WB, ELISA, IHC
Host: Goat Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Rabbit Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
AS160, also known as TBC1D4, is a 160 kDa Akt substrate that plays a critical role in regulating insulin-stimulated exocytosis of glucose transporter GLUT4. AS-160 contains a Rab GTPase-activating protein domain (GAP), suggesting its potential role in membrane trafficking. Insulin-stimulated phosphorylation of AS160 on threonine 642 is critical for mediating GLUT4 translocation in fat and muscle cells, via inactivation of Rab GAP function. Phosphorylation of Thr642 is also important in mediating TBC1D4 redistribution from low density microsomes to the cytosol in adipocytes.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
9882 |
| Alternate Names |
- Akt substrate of 160 kDa
- AS160Acrg embryonic lethality minimal region ortholog
- DKFZp779C0666
- KIAA0603TBC (Tre-2, BUB2, CDC16) domain-containing protein
- TBC1 domain family member 4
- TBC1 domain family, member 4
|
![Western Blot TBC1D4 [p Thr642] Antibody (JE60-97)](http://images.novusbio.com/fullsize/nbp3-32749_rabbit-tbc1d4-p-thr642-mab-je60-97-278202415212425.jpg)
![Immunocytochemistry/ Immunofluorescence TBC1D4 [p Thr642] Antibody (JE60-97)](http://images.novusbio.com/fullsize/nbp3-32749_rabbit-tbc1d4-p-thr642-mab-je60-97-29202410484887.jpg)
