TM4SF1/L6 Antibody - BSA Free

Western Blot: TM4SF1/L6 Antibody [NBP1-76549] - Human lung tissue lysate with TM4SF1 antibody at (A) 0.5 and (B) 1 ug/mL.

Immunohistochemistry-Paraffin: TM4SF1/L6 Antibody [NBP1-76549] - Mouse lung tissue with TM4SF1 antibody at 2 ug/mL.

Immunohistochemistry-Paraffin: TM4SF1/L6 Antibody [NBP1-76549] - Human lung tissue with TM4SF1 antibody at 5 ug/mL.

Immunohistochemistry: TM4SF1/L6 Antibody - BSA Free [NBP1-76549] - Immunohistochemistry of TM4SF1/L6 in mouse lung tissue with TM4SF1/L6 antibody at 5 ug/mL.

Immunocytochemistry/ Immunofluorescence: TM4SF1/L6 Antibody - BSA Free [NBP1-76549] - Immunofluorescence of TM4SF1/L6 in human lung tissue with TM4SF1/L6 antibody at 20 ug/mL.

Immunocytochemistry/ Immunofluorescence: TM4SF1/L6 Antibody - BSA Free [NBP1-76549] - Immunofluorescence of TM4SF1/L6 in mouse lung tissue with TM4SF1/L6 antibody at 20 ug/mL.Red: TM4SF1/L6 Antibody Blue: DAPI staining

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

TM4SF1/L6 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit TM4SF1/L6 Antibody - BSA Free (NBP1-76549) is a polyclonal antibody validated for use in IHC, WB, ELISA and ICC/IF. Anti-TM4SF1/L6 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human TM4SF1. The immunogen is located within the first 50 amino acids of TM4SF1. Amino Acid Squence: LYFPNGETKYASENHLSR
• Specificity: At least three isoforms of TM4SF1 are known to exist; this antibody will recognize only the two largest isoforms. TM4SF1 antibody is predicted to not cross-react with other tetraspanin proteins.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TM4SF1
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/ml
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Paraffin
  • Western Blot 0.5-1 ug/ml
• Control Peptide:

  TM4SF1/L6 Peptide (NBP1-76549PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for TM4SF1/L6 Antibody - BSA Free

• L6
• M3s1
• M3S1Tumor-associated antigen L6
• Membrane component chromosome 3 surface marker 1
• membrane component, chromosome 3, surface marker 1
• TAAL6
• TAAL6H-L6
• TM4SF1
• transmembrane 4 L six family member 1
• transmembrane 4 L6 family member 1
• transmembrane 4 superfamily member 1

Background

TM4SF1 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains and mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TM4SF1 is a cell surface antigen and is highly expressed in the vascular endothelium of several human cancers. Knockdown experiments of TM4SF1 prevented filopodia formation, inhibited cell mobility, blocked cytokinesis, and inhibited maturation of VEGF-A-induced angiogenesis, suggesting that TM4SF1 may be an attractive target for anti-angiogenesis therapy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TM4SF1/L6 Antibody (NBP1-76549)(1)

Publication using NBP1-76549

• Hou S, Hao X, Li J et al. TM4SF1 promotes esophageal squamous cell carcinoma metastasis by interacting with integrin alpha 6 Cell death & disease 2022-07-14 [PMID: 35835740] (IHC-P, Human)

Bioinformatics

• Gene Symbol: TM4SF1
• Entrez:
  • 4071(Human)
  • 17112(Mouse)
• Uniprot:
  • P30408()