TM4SF1/L6 Antibody

Images

 
Western Blot: TM4SF1/L6 Antibody [NBP1-76549] - Human lung tissue lysate with TM4SF1 antibody at (A) 0.5 and (B) 1 ug/mL.
Immunocytochemistry/ Immunofluorescence: TM4SF1/L6 Antibody [NBP1-76549] - Immunofluorescence of TM4SF1 in human lung tissue with TM4SF1 antibody at 20 ug/mL.
Immunohistochemistry: TM4SF1/L6 Antibody [NBP1-76549] - Staining of TM4SF1 in mouse lung tissue with TM4SF1 antibody at 5 ug/mL.
Immunohistochemistry: TM4SF1/L6 Antibody [NBP1-76549] - Immunohistochemistry of TM4SF1 in human lung tissue with TM4SF1 antibody at 5 ug/mL.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

TM4SF1/L6 Antibody Summary

Immunogen
Antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human TM4SF1. The immunogen is located within the first 50 amino acids of TM4SF1.
Specificity
At least three isoforms of TM4SF1 are known to exist; this antibody will recognize only the two largest isoforms. TM4SF1 antibody is predicted to not cross-react with other tetraspanin proteins.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TM4SF1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 0.5-1 ug/ml
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/ml
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Paraffin
Positive Control
TM4SF1/L6 Lysate (NBP2-65314)
Control Peptide
TM4SF1/L6 Peptide (NBP1-76549PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for TM4SF1/L6 Antibody

  • L6
  • M3s1
  • M3S1Tumor-associated antigen L6
  • Membrane component chromosome 3 surface marker 1
  • membrane component, chromosome 3, surface marker 1
  • TAAL6
  • TAAL6H-L6
  • TM4SF1
  • transmembrane 4 L six family member 1
  • transmembrane 4 L6 family member 1
  • transmembrane 4 superfamily member 1

Background

TM4SF1 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains and mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TM4SF1 is a cell surface antigen and is highly expressed in the vascular endothelium of several human cancers. Knockdown experiments of TM4SF1 prevented filopodia formation, inhibited cell mobility, blocked cytokinesis, and inhibited maturation of VEGF-A-induced angiogenesis, suggesting that TM4SF1 may be an attractive target for anti-angiogenesis therapy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol TM4SF1
Entrez
Uniprot