Sulfatase-2/SULF2 Antibody (2B4) [DyLight 405]


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Product Details

Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, IHC, IHC-P, IP
Please see the vial label for concentration. If unlisted please contact technical services.

Sulfatase-2/SULF2 Antibody (2B4) [DyLight 405] Summary

Partial recombinant human Sulfatase 2 isoform b [Accession# NP_940998].
Endoplasmic reticulum
Does not recognize human or mouse Sulfatase 1 or other family members.
Protein G purified
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Packaging, Storage & Formulations

Store at 4C in the dark.
DyLight 405
DyLight 405 (A=400, E=420)
50mM Sodium Borate
0.05% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
Protein G purified


Application Notes
This Sulfatase 2 (2B4) antibody is useful for Western Blot, Immunoprecipitation, Immunohistochemistry on paraffin-embedded sections and ELISA. For WB a band can be seen at 50 kDa. Other bands may be seen at 135 kDa (unprocessed protein) and 37 kDa (fragment of 50 kDa subunit). For ELISA, use this antibody at 1-10 ug/ml for capture and 1-5 ug/ml for detection. It has been reported that NBP1-36727 picks up a 130 kDa band that is not Sulfatase 2 in human plasma. Because of this we do not recommend NBP1-36727 for capture of the human protein.

Reactivity Notes

Human and mouse.

Alternate Names for Sulfatase-2/SULF2 Antibody (2B4) [DyLight 405]

  • DKFZp313E091
  • EC 3.1.6
  • EC 3.1.6.-
  • EC
  • extracellular sulfatase Sulf-2
  • FLJ44488
  • FLJ90554
  • hSulf-2
  • KIAA1247HSULF-2
  • MGC126411
  • SULF2
  • SULF-2
  • sulfatase 2
  • Sulfatase2


Sulfatase 2 (SULF2) is a member of sulfatase family and catalyzes the removal of 6-O-sulfate groups from the heparan sulfate (HS) disaccharide units of heparan sulfate proteoglycans (HSPGs). HSPGs are present on the cell surface as well as in the extracellular matrix and act either as sequestration sites for growth factor/cytokine ligands or as coreceptors in multiple signal transduction pathways. SULF2 mediated desulfation of HSPGs is proposed to decrease the affinity of HSPGs for a variety of signaling ligands, releasing them from sequestration sites and making them available for triggering signaling stimuli. SULF2 is localized in endoplasmic reticulum, Golgi apparatus and also on the cell surface, and is expressed at highest levels in tissues such as ovary, skeletal muscle, stomach, brain, uterus, heart, kidney and placenta. In its post-translational modification, the conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. SULF2 enzyme regulates the activities of a number of signal transduction pathways which are up-regulated in many tissues during development and disease.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies


Isotype Controls

Other Available Formats

Biotin Labeled NBP1-36727B
DyLight 488 Labeled NBP1-36727G
DyLight 550 Labeled NBP1-36727R
DyLight 650 Labeled NBP1-36727C
FITC Labeled NBP1-36727F
HRP Labeled NBP1-36727H

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Contact Information

Product PDFs


Gene Symbol SULF2

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