STING/TMEM173 Antibody [Alexa Fluor® 532]

• Reactivity: Hu
• Applications: WB, KO
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 532

STING/TMEM173 Antibody [Alexa Fluor® 532] Summary

• Immunogen: E. coli-derived recombinant human STING/TMEM173
  Ala215-Ser379
  Accession # Q86WV6
• Specificity: Detects human STING/TMEM173 in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: STING1
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Knockout Validated
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for STING/TMEM173 Antibody [Alexa Fluor® 532]

• endoplasmic reticulum IFN stimulator
• Endoplasmic reticulum interferon stimulator
• ERIS
• FLJ38577
• hMITA
• hSTING
• Mediator of IRF3 activation
• MITA
• mitochondrial mediator of IRF3 activation
• MPYS
• NET23
• N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner
• SAVI
• Stimulator of interferon genes protein
• stimulator of interferon protein
• STING
• STING-beta
• TMEM173
• transmembrane protein 173

Background

STING (Stimulator of interferon genes; also ERIS, MPYS, MITA and TMEM173) is a 40-42 kDa 4-transmembrane protein that mediates both antiviral and MHC-II antigen recognition responses. STING is found in the ER, mitochondrial outer membrane and plasma membrane. It acts as an adaptor protein for intracellular viral detection molecules, participating in the induction of type I interferon. It also may play a role in the initiation of apoptosis following MHC-II engagement. Cells known to express STING include B cells, dendritic cells, macrophages, and monocytes. Human STING is 379 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-20), four transmembrane segments (aa 21-173), and a C-terminal cytoplasmic domain (aa 174-379). Ubiquitination occurs at Lys150, and phosphorylation occurs at Ser358. STING forms 80 kDa homodimers. There are two potential splice forms, one that shows a 25 aa substitution for aa 1-173, and another that possesses an alternative start site at Met215, coupled to a premature truncation following Arg334. Over aa 215-379, human STING shares 76% aa identity with mouse STING.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: STING1