SREBP1 Antibody [Janelia Fluor® 549]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bv, Ha, Pl, ChHaSpecies Glossary
Applications ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Janelia Fluor 549

SREBP1 Antibody [Janelia Fluor® 549] Summary

Immunogen
A synthetic peptide made to a portion of the human SREBP1 protein sequence (between residues 300-400). [Uniprot: P36956]
Localization
Membranes of ER, Golgi and Cytoplasmic Vesicles. Processed SREBP1 (1-490 a.a.) translocates to the nucleus.
Predicted Species
Chinese Hamster (92%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SREBF1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Bovine reactivity reported in scientific literature (PMID: 25558823). Plant reactivity reported in scientific literature (PMID: 24649190). Hamster reactivity reported in scientific literature (PMID: 28987370).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Unprocessed SREBP1 is an ~122 kDa integral membrane protein that moves from ER to golgi for processing. The first cleavage is performed by S2P at residue 490, and the resulting active portion is then translocated out of the golgi. This is the ~65 kDa mature form that is detected by NB100-2215. The second cleavage is performed by S1P at residue 530, and the resulting C-term portion (from residues 530-1147) remains in the golgi where it is detected as a ~65 kDa protein by NB100-60545.

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for SREBP1 Antibody [Janelia Fluor® 549]

  • BHLHD1
  • Class D basic helix-loop-helix protein 1
  • SREBP 1c
  • SREBP-1
  • SREBP1bHLHd1SREBP-1c
  • sterol regulatory element binding protein-1
  • sterol regulatory element binding transcription factor 1
  • sterol regulatory element-binding protein 1
  • Sterol regulatory element-binding transcription factor 1

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

FAQs for SREBP1 Antibody (NB100-2215JF549) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NB100-2215AF350
Alexa Fluor 405 NB100-2215AF405
Alexa Fluor 488 NB100-2215AF488
Alexa Fluor 532 NB100-2215AF532
Alexa Fluor 594 NB100-2215AF594
Alexa Fluor 647 NB100-2215AF647
Alexa Fluor 700 NB100-2215AF700
Alexa Fluor 750 NB100-2215AF750
Biotin NB100-2215B
DyLight 350 NB100-2215UV
DyLight 405 NB100-2215V
DyLight 488 NB100-2215G
DyLight 550 NB100-2215R
DyLight 594 NB100-2215DL594
DyLight 650 NB100-2215C
DyLight 680 NB100-2215FR
DyLight 755 NB100-2215IR
FITC NB100-2215F
HRP NB100-2215H
Janelia Fluor 549 NB100-2215JF549
Janelia Fluor 646 NB100-2215JF646

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Bioinformatics Tool for SREBP1 Antibody (NB100-2215JF549)

Discover related pathways, diseases and genes to SREBP1 Antibody (NB100-2215JF549). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Research Areas for SREBP1 Antibody (NB100-2215JF549)

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Blogs on SREBP1.

SREBP2 - regulating cholesterol homeostasis and lipid metabolism
Sterol regulatory element-binding proteins (SREBP) are important transcription factors regulating the synthesis and uptake of lipids including cholesterol. This essential role in lipid metabolism makes investigations into the functions SREBPs im...  Read full blog post.

SREBP: Gatekeeper of Cholesterol Homeostasis
SREBP1 (sterol-regulatory-element-binding protein 2) is a basic-helix-loop-helix-leucine zipper (bHLH-ZIP) transcription factor. It regulates sterol and cholesterol homeostasis by controlling enzymes involved in cholesterol synthesis and uptake, e.g....  Read full blog post.

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Bioinformatics

Gene Symbol SREBF1