SPTLC1 Antibody - BSA Free

Immunohistochemistry-Paraffin: SPTLC1 Antibody [NBP1-81737] - Staining of human breast shows moderate cytoplasmic positivity in glandular cells.

Analysis using NBP1-81737 (A) shows similar pattern to independent antibody NBP2-56477 (B).

• Reactivity: Hu
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

SPTLC1 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit SPTLC1 Antibody - BSA Free (NBP1-81737) is a polyclonal antibody validated for use in IHC and WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: KTYKLQERSDLTVKEKEELIEEWQPEPLVPPVPKDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPR
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SPTLC1
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
  • Western Blot 0.04-0.4 ug/ml
• Application Notes: HIER pH6 retrieval is recommended.
• Control Peptide:

  SPTLC1 Protein (NBP1-81737PEP)

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (88%), Rat (89%)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for SPTLC1 Antibody - BSA Free

• EC 2.3.1.50
• hereditary sensory neuropathy, type 1
• HSAN1
• LBC1
• LCB 1
• LCB1
• LCB1HSAN
• Long chain base biosynthesis protein 1
• MGC14645
• serine C-palmitoyltransferase
• serine palmitoyltransferase 1
• serine palmitoyltransferase, long chain base subunit 1
• Serine-palmitoyl-CoA transferase 1
• SPT 1
• SPT1
• SPT1HSN1
• SPTI
• SPTLC1

Background

Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SPTLC1