Sortilin Antibody (1B3)

Western Blot: Sortilin Antibody (1B3) [H00006272-M01] - SORT1 monoclonal antibody (M01), clone 1B3. Analysis of SORT1 expression in human placenta.

Western Blot: Sortilin Antibody (1B3) [H00006272-M01] - SORT1 monoclonal antibody (M01), clone 1B3. Western Blot analysis of SORT1 expression in human spleen.

Western Blot: Sortilin Antibody (1B3) [H00006272-M01] - SORT1 monoclonal antibody (M01), clone 1B3. Analysis of SORT1 expression in rat brain.

ELISA: Sortilin Antibody (1B3) [H00006272-M01] - Detection limit for recombinant GST tagged SORT1 is 0.1 ng/ml as a capture antibody.

Product Discontinued

Sortilin Antibody (1B3) Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: SORT1 (NP_002950, 203 a.a. ~ 299 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. FAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALELWRTSDLGKSFKTI
• Specificity: SORT1 - sortilin 1
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: SORT1
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot
• Application Notes: Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: In 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Sortilin Antibody (1B3)

• 100 kDa NT receptor
• Glycoprotein 95
• Gp95
• Gp95LDLCQ6
• Neurotensin receptor 3
• NT3NTR3
• Ntr3
• SORT1
• sortilin 1
• Sortilin

Background

This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SORT1
• Entrez:
  • 6272(Human)
• OMIM:
  • 602458(Human)
• Uniprot:
  • NP_002950(Human)