Sortilin Products

Description

Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.

Bioinformatics

Entrez	20661 Mouse 6272 Human 83576 Rat
Uniprot	NP_002950 Human O54861 Rat Q99523 Human
Product By Gene ID	6272
Alternate Names	100 kDa NT receptor Glycoprotein 95 Gp95LDLCQ6 Neurotensin receptor 3 NT3NTR3 sortilin 1 sortilin

Research Areas for Sortilin

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Golgi Apparatus Markers