SOCS-5 Antibody

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Western Blot: SOCS-5 Antibody [NB100-56639] - Analysis for SOCS5 using NB100-56639 at 1:500 dilution against 15 ug/lane of mouse spleen (lane A) and human spleen (lane B) lysates.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

SOCS-5 Antibody Summary

Immunogen
This polyclonal antibody was raised against a synthetic peptide containing amino acid residues of human SOCS5 protein. Human or mouse spleen lysate can be used as a positive control.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SOCS5
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500
Positive Control
Spleen Lysate (NB820-59259)
Spleen Lysate (NB820-59670)
Publications
Read Publication using NB100-56639.

Reactivity Notes

Cross reacts with Mouse and Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS containing 0.1 mg/ml BSA.
Preservative
0.02% Sodium Azide
Purity
Protein G purified

Alternate Names for SOCS-5 Antibody

  • CIS6
  • CIS6Cytokine-inducible SH2 protein 6
  • CISH5
  • CISH6
  • CISH6CIS-6
  • KIAA0671Cytokine-inducible SH2-containing protein 5
  • SOCS5
  • SOCS-5
  • SOCS-5CISH5
  • suppressor of cytokine signaling 5

Background

The suppressor of cytokine signaling (SOCS) family of proteins (SOCS1-SOCS7 and CIS) inhibit cytokine production by a classical negative feedback mechanism. These proteins are upregulated in response to cytokine stimulation followed by inhibition of cytokine-inducing signal pathway. Role of each member of the family has been determined by gene knockout experiments (1). SOCS5 protein is preferentially expressed in committed T-helper (Th1) cells. The action of SOCS5 is probably mediated by its interaction with the cytoplasmic domain of IL-4 receptor. During Th1 differentiation, there is a reduction in the association of Janus kinase 1 with the IL-4 receptor (IL-4R), which is correlated with the expression of SOCS5 pressor of cytokine signaling-5 (SOCS5). It has been also shown that in the overexpression of SOCS5 in transgenic mice leads to impaired Th2 development, suggesting that SOCS5 may plan an important role in the Th1 differentiation by regulating a balance between Th1 and Th2 (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SOCS-5 Antibody (NB100-56639)(1)

We have publications tested in 1 confirmed species: Rat.


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Video Protocols

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol SOCS5
Entrez
Uniprot