SOCS-3 Antibody

Images

 
Western Blot: SOCS-3 Antibody [NBP2-27210] - Analysis of SOCS3. Jurkat lysate in the 1) absence and 2) presence of immunizing peptide probed with 4 ug/ml of SOCS3 antibody. I goat anti-rabbit Ig HRP secondary antibody ...read more
Immunohistochemistry-Paraffin: SOCS-3 Antibody [NBP2-27210] - Human kidney probed with SOCS3 antibody at 5 ug/ml.

Product Details

Summary
Reactivity Hu, Fe, PmSpecies Glossary
Applications WB, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

SOCS-3 Antibody Summary

Immunogen
This antibody was raised against SOCS3
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SOCS3
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1-5ug/ml
  • Immunohistochemistry-Paraffin 5ug/ml~

Reactivity Notes

The amino acid sequence used as immunogen for this antibody is 100% homologous in human, rhesus monkey, orangutan, european pole-cat, and chimpanzee, 94% in new world monkey, and pig, 89% in panda, dog, chinese hamster, and horse, 83% in cow, african bush elephant, mouse, sheep, and rat, and 61% homologous in guinea pig.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.2 ml PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for SOCS-3 Antibody

  • ATOD4
  • CIS3
  • CIS3CIS-3
  • Cish3
  • cytokine-induced SH2 protein 3
  • Cytokine-inducible SH2 protein 3
  • SOCS3
  • SOCS-3
  • SOCS-3STAT-induced STAT inhibitor 3
  • SSI-3
  • SSI-3ATOD4
  • SSI3MGC71791
  • suppressor of cytokine signaling 3

Background

SOCS3 is a member of the suppressor of cytokine signaling family with a molecular weight of ~ 25 kDa. It is also an SSI or stat-induced stat inhibitor protein. IL-6, for example, induces SOCS3 expression and in turn SOCS3 negatively regulates IL-6 induced immune signaling and inflammatory pathways. SOCS3 is also induced by IL-10 and IFNgamma (1-3). SOCS3 plays an important role in the initial stages of B-cell development and differentiation (1). IL-6, IL-10, and IFNgamma feedback loops and likely involvement of SOCS3 may also be critical in controlling and fine-tuning the inflammatory responses of activated macrophages through TLR ligands, a direct involvement therefore of SOCS3 in innate immune signaling pathways (4, 5). SOCS3 antibody provides an opportunity to identify and clarify the SOCS3 feedback control mechanism in host defense, innate immunity and autoimmune inflammatory cascades.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SOCS3
Entrez