SOCS-3 Antibody

Images

 
Western Blot: SOCS-3 Antibody [NBP2-27210] - Analysis of SOCS3. Jurkat lysate in the 1) absence and 2) presence of immunizing peptide probed with 4 ug/ml of SOCS3 antibody. Goat anti-rabbit Ig HRP secondary antibody and ...read more
Immunohistochemistry-Paraffin: SOCS-3 Antibody [NBP2-27210] - Human kidney probed with SOCS3 antibody at 5 ug/ml.

Product Details

Summary
Reactivity Hu, Fe, Pm, Po, Pm, Pm-Or, RMSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

SOCS-3 Antibody Summary

Immunogen
A portion of amino acids 110-160 from human SOCS3 was used as the immunogen for this antibody.
Predicted Species
Porcine (94%), Chimpanzee (100%), Orangutan (100%), Rhesus Macaque (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SOCS3
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-5ug/ml
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5ug/ml~

Reactivity Notes

The amino acid sequence used as immunogen for this antibody is 100% homologous in human, rhesus monkey, orangutan, european pole-cat, and chimpanzee; 94% in new world monkey and pig; 89% in panda, dog, chinese hamster, and horse; 83% in cow, african bush elephant, mouse, sheep, and rat; and 61% homologous in guinea pig.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.2 ml PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for SOCS-3 Antibody

  • ATOD4
  • CIS3
  • CIS3CIS-3
  • Cish3
  • cytokine-induced SH2 protein 3
  • Cytokine-inducible SH2 protein 3
  • SOCS3
  • SOCS-3
  • SOCS-3STAT-induced STAT inhibitor 3
  • SSI-3
  • SSI-3ATOD4
  • SSI3MGC71791
  • suppressor of cytokine signaling 3

Background

SOCS3 is a member of the suppressor of cytokine signaling family with a molecular weight of ~ 25 kDa. It is also an SSI or stat-induced stat inhibitor protein. IL-6, for example, induces SOCS3 expression and in turn SOCS3 negatively regulates IL-6 induced immune signaling and inflammatory pathways. SOCS3 is also induced by IL-10 and IFNgamma (1-3). SOCS3 plays an important role in the initial stages of B-cell development and differentiation (1). IL-6, IL-10, and IFNgamma feedback loops and likely involvement of SOCS3 may also be critical in controlling and fine-tuning the inflammatory responses of activated macrophages through TLR ligands, a direct involvement therefore of SOCS3 in innate immune signaling pathways (4, 5). SOCS3 antibody provides an opportunity to identify and clarify the SOCS3 feedback control mechanism in host defense, innate immunity and autoimmune inflammatory cascades.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-27210AF350
Alexa Fluor 405 NBP2-27210AF405
Alexa Fluor 488 NBP2-27210AF488
Alexa Fluor 532 NBP2-27210AF532
Alexa Fluor 594 NBP2-27210AF594
Alexa Fluor 647 NBP2-27210AF647
Alexa Fluor 700 NBP2-27210AF700
Alexa Fluor 750 NBP2-27210AF750
Biotin NBP2-27210B
DyLight 350 NBP2-27210UV
DyLight 405 NBP2-27210V
DyLight 488 NBP2-27210G
DyLight 550 NBP2-27210R
DyLight 594 NBP2-27210DL594
DyLight 650 NBP2-27210C
DyLight 680 NBP2-27210FR
DyLight 755 NBP2-27210IR
FITC NBP2-27210F
HRP NBP2-27210H
Janelia Fluor 549 NBP2-27210JF549
Janelia Fluor 646 NBP2-27210JF646

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Bioinformatics

Gene Symbol SOCS3