SOCS-3 Products

Antibodies
SOCS-3 Antibody
SOCS-3 Antibody
NBP2-27210
Species: Hu, Fe, Pm
Applications: WB, IHC-P
Host: Rabbit Polyclonal
SOCS-3 Antibody
SOCS-3 Antibody
NBP2-20451
Species: Hu, Mu, Bovine, Porcine, Rat, Monkey
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
SOCS-3 Antibody (3D3)
SOCS-3 Antibody (3D3)
NBP2-00817
Species: Hu
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Lysates
SOCS-3 Overexpression Lysate ...
SOCS-3 Overexpression Lysate (Native)
NBL1-16327
Applications: WB
SOCS-3 Overexpression Lysate ...
SOCS-3 Overexpression Lysate (Dena...
H00009021-T02
Applications: WB
Proteins
SOCS-3 Recombinant Protein
SOCS-3 Recombinant Protein
NBP2-51603
Species: Hu
Applications: PAGE
SOCS-3 Recombinant Protein
SOCS-3 Recombinant Protein
H00009021-P01
Species: Hu
Applications: WB, ELISA, PA
RNAi
SOCS-3 RNAi
SOCS-3 RNAi
H00009021-R01
Species: Hu

Description

Accumulating evidence has demonstrated that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling) (1-3). To date, there are eight members of SOCS family that have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally, the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that has been called the SOCS box (4). The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism (5). Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS 3 is an important regulator of fetal liver hematopoiesis. It is also involved in a broad spectrum of cytokines, e.g. IL-2, IL-3, IL-4, IL-6, Epo, Prolactin, and GH (6-8).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Mouse
Product By Gene ID 9021
Alternate Names
  • cytokine-induced SH2 protein 3
  • Cish3
  • SSI3MGC71791
  • SSI-3ATOD4
  • SOCS-3STAT-induced STAT inhibitor 3
  • CIS3CIS-3
  • Cytokine-inducible SH2 protein 3
  • suppressor of cytokine signaling 3

Research Areas for SOCS-3

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction

Bioinformatics Tool for SOCS-3

Discover related pathways, diseases and genes to SOCS-3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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