SOCS-3 Products

Description

Accumulating evidence has demonstrated that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling) (1-3). To date, there are eight members of SOCS family that have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally, the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that has been called the SOCS box (4). The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism (5). Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS 3 is an important regulator of fetal liver hematopoiesis. It is also involved in a broad spectrum of cytokines, e.g. IL-2, IL-3, IL-4, IL-6, Epo, Prolactin, and GH (6-8).

Bioinformatics

Entrez	12702 Mouse 89829 Rat 9021 Human
Uniprot	AAH60858 Human AAH60858.1 Human NM_003955 Human NP_003946. Human NP_003946.3 Human O14543 Human O35718 Mouse
Product By Gene ID	9021
Alternate Names	CIS3CIS-3 Cish3 cytokine-induced SH2 protein 3 Cytokine-inducible SH2 protein 3 SOCS-3STAT-induced STAT inhibitor 3 SSI-3ATOD4 SSI3MGC71791 suppressor of cytokine signaling 3

Research Areas for SOCS-3

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Signal Transduction