SOCS-3 Products

SOCS-3 Antibody (516919) [Unc ...
SOCS-3 Antibody (516919) [Unconjug...
Species: Hu, Mu
Applications: WB
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
Recombinant Human SOCS-3 Prot ...
Recombinant Human SOCS-3 Protein, CF
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Human SOCS-3 GST ...
Recombinant Human SOCS-3 GST (N-Te...
Species: Hu
Applications: WB, ELISA, PA, AP
Recombinant Human SOCS-3 His ...
Recombinant Human SOCS-3 His Protein
Species: Hu
Applications: PAGE


Accumulating evidence has demonstrated that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling) (1-3). To date, there are eight members of SOCS family that have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally, the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that has been called the SOCS box (4). The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism (5). Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS 3 is an important regulator of fetal liver hematopoiesis. It is also involved in a broad spectrum of cytokines, e.g. IL-2, IL-3, IL-4, IL-6, Epo, Prolactin, and GH (6-8).


Entrez Human
Uniprot Human
Product By Gene ID 9021
Alternate Names
  • cytokine-induced SH2 protein 3
  • Cish3
  • SSI3MGC71791
  • SSI-3ATOD4
  • SOCS-3STAT-induced STAT inhibitor 3
  • CIS3CIS-3
  • Cytokine-inducible SH2 protein 3
  • suppressor of cytokine signaling 3

Research Areas for SOCS-3

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Signal Transduction

Bioinformatics Tool for SOCS-3

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