Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Species: Hu, Fe, Pm, Po, Pm, Pm-Or, RM
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
WB, ELISA, PA, AP
Accumulating evidence has demonstrated that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling) (1-3). To date, there are eight members of SOCS family that have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally, the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that has been called the SOCS box (4). The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism (5). Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS 3 is an important regulator of fetal liver hematopoiesis. It is also involved in a broad spectrum of cytokines, e.g. IL-2, IL-3, IL-4, IL-6, Epo, Prolactin, and GH (6-8).
Research Areas for SOCS-3
Find related products by research area and learn more about each of the different research areas below.Signal Transduction
Bioinformatics Tool for SOCS-3
Discover related pathways, diseases and genes to SOCS-3. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.