SLC7A8 Antibody - BSA Free

Immunohistochemistry-Paraffin: SLC7A8 Antibody [NBP2-49026] - Staining of human liver shows no positivity in hepatocytes as expected.

Immunohistochemistry-Paraffin: SLC7A8 Antibody [NBP2-49026] - Staining of human liver shows low expression as expected.

Immunohistochemistry-Paraffin: SLC7A8 Antibody [NBP2-49026] - Staining of human parathyroid gland shows high expression.

Immunohistochemistry-Paraffin: SLC7A8 Antibody [NBP2-49026] - Staining in human parathyroid gland and liver tissues using anti-SLC7A8 antibody. Corresponding SLC7A8 RNA-seq data are presented for the same tissues.

Immunohistochemistry-Paraffin: SLC7A8 Antibody [NBP2-49026] - Analysis in human parathyroid gland and liver tissues. Corresponding SLC7A8 RNA-seq data are presented for the same tissues.

Immunohistochemistry-Paraffin: SLC7A8 Antibody [NBP2-49026] - Staining of human kidney shows moderate to strong cytoplasmic positivity in cells in tubules.

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

SLC7A8 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit SLC7A8 Antibody - BSA Free (NBP2-49026) is a polyclonal antibody validated for use in IHC. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was developed against a recombinant protein corresponding to amino acids: MEEGARHRNNTEKKHPGGGESDASPEAGSGGGGVALKKEI
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SLC7A8
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:500 - 1:1000
  • Immunohistochemistry-Paraffin 1:500 - 1:1000
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.
• Control Peptide:

  SLC7A8 Recombinant Protein Antigen (NBP2-49026PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for SLC7A8 Antibody - BSA Free

• hLAT2
• integral membrane protein E16H
• large neutral amino acids transporter small subunit 2
• LAT2L-type amino acid transporter 2
• LPI-PC1
• solute carrier family 7 (amino acid transporter, L-type), member 8
• Solute carrier family 7 member 8
• y+ system), member 8

Background

Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SLC7A8