SLC7A8 Products

Description

Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney

Bioinformatics

Entrez	23428 Human 494 Human
Uniprot	NP_036376 Human NP_036376.2 Human NP_877392 Human
Product By Gene ID	23428
Alternate Names	hLAT2 integral membrane protein E16H large neutral amino acids transporter small subunit 2 LAT2L-type amino acid transporter 2 LPI-PC1 solute carrier family 7 (amino acid transporter, L-type), member 8 Solute carrier family 7 member 8 y+ system), member 8