SIRT6 Antibody


Western Blot: SIRT6 Antibody [NB100-2524] - Detection of SIRT6 in HeLa whole cell lysate.
Immunocytochemistry/ Immunofluorescence: SIRT6 Antibody [NB100-2524] - SIRT6 antibody was tested in Hela cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 more

Product Details

Reactivity HuSpecies Glossary
Applications WB, ICC/IF
1.05 mg/ml

SIRT6 Antibody Summary

A synthetic peptide made to a C-terminal region of the human SIRT6 protein (within residues 300-355). [Swiss-Prot Q8N6T7]
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C. Do not freeze.
Tris-citrate/phosphate, pH 7-8
0.1% Sodium Azide
1.05 mg/ml
Immunogen affinity purified


Application Notes
This SIRT6 antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot analysis, where a band is seen at ~39 kDa. A higher MW band ~59 kDa may be seen with lower dilutions (ie: 2 ug/ml). In ICC/IF nuclear staining was observed.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
39 kDa
Control Peptide
SIRT6 Peptide (NB100-2524PEP)
Read Publication using
NB100-2524 in the following applications:

  • WB
    1 publication

Reactivity Notes

Human. Immunogen sequence has 72% homology to rat.

Alternate Names for SIRT6 Antibody

  • EC 3.5.1.-
  • NAD-dependent deacetylase sirtuin-6
  • SIR2L6sir2-related protein type 6
  • SIR2-like protein 6
  • sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
  • sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6
  • sirtuin 6
  • sirtuin type 6


SIRT6 (SIR2-like protein 6) is a member of the yeast silent information regulator 2 (SIR2) family and possesses both strong ADP-ribosyltransferase activity as well as protein deacetylase activity which is dependent on NAD(+). SIRT6 exerts deacetylase activity towards histone H3K9Ac and H3K56Ac, and alters histone H3 acetylation in telomeric chromatin during cell cycle's S-phase. It deacetylates histone H3K9Ac at NFkB target promoters and downregulates a subset of NFkB target genes. Upon DNA damage, SIRT6 promotes DNA end resection via deacetylation of RBBP8. SIRT6 also serves as a corepressor of the transcription factor HIF1 alpha for regulating the expression of multiple glycolytic genes to control glucose homeostasis, and is required for normal IGF1 serum levels. SIRT6 play critical roles in maintaining telomere integrity, fine-tuning aging-associated gene expression programs, preventing genomic instability, and maintaining metabolic homeostasis, thus impacting on several pathways relevant for cancer, metabolism, aging, cellular senescence and apoptosis.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SIRT6 Antibody (NB100-2524)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

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Product General Protocols

View specific protocols for SIRT6 Antibody (NB100-2524): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor (R) 405 Labeled NB100-2524AF405
Alexa Fluor (R) 488 Labeled NB100-2524AF488
Alexa Fluor (R) 647 Labeled NB100-2524AF647
Alexa Fluor (R) 700 Labeled NB100-2524AF700
Biotin Labeled NB100-2524B
DyLight 405 Labeled NB100-2524V
DyLight 488 Labeled NB100-2524G
DyLight 550 Labeled NB100-2524R
DyLight 650 Labeled NB100-2524C
FITC Labeled NB100-2524F
HRP Labeled NB100-2524H

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Contact Information

Product PDFs


Gene Symbol SIRT6

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