Siglec-H Antibody (23M15C8)

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Immunohistochemistry-Paraffin: Siglec-H Antibody (23M15C8) [NBP2-27062] - Analysis of Siglec-H in mouse spleen tissue using Siglec-H antibody at 5 ug/ml.

Product Details

Summary
Reactivity MuSpecies Glossary
Applications IHC-P
Clone
23M15C8
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Siglec-H Antibody (23M15C8) Summary

Immunogen
A portion of amino acids 50-100 of mouse Siglec-H was used as the immunogen for this antibody.
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Rat
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 5ug/ml
Publications
Read Publication using
NBP2-27062 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Siglec-H antibody at 0.5 mg/ml in PBS containing 0.05% BSA.
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for Siglec-H Antibody (23M15C8)

  • 6430529G09Rik
  • Siglech sialic acid binding Ig-like lectin H
  • SiglecH
  • Siglec-H

Background

Siglec-H, or sialic acid binding immunoglobulin-like lectin H, is a CD33 related protein expressed specifically by plasmacytoid dendritic cells or pDCs (1, 2). Antigen-mediated delivery by Siglec-H in pDCs inhibits Th cell proliferation and further antibody responsesThis leads to lessened expansion and Th1/Th17 polarization (3). Constant and low density antigen presentation by Siglec-H is thought to lead to an exhaustive type lessening of the response in CD4+ cells but not tolerance. A number of pathways have been proposed for the Siglec-H induced T cell hyporesponsiveness. Ever decreasing activation cycles in the presence of low level but continuous antigen delivery, as that observed with Siglec-H, have also been demonstrated to impart FoxP3+ Tregs immunosuppressive tolerogen-like effects (4, 5). Ability to identify and control Siglec-H antigen mediated delivery activities with specific antibody provides a focal point for potential development of inflammation controls.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Siglec-H Antibody (NBP2-27062)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IHC-P.


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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NBP2-27062AF405
Alexa Fluor 488 Labeled NBP2-27062AF488
Alexa Fluor 647 Labeled NBP2-27062AF647
Alexa Fluor 700 Labeled NBP2-27062AF700
Biotin Labeled NBP2-27062B
DyLight 350 Labeled NBP2-27062UV
DyLight 405 Labeled NBP2-27062V
DyLight 488 Labeled NBP2-27062G
DyLight 550 Labeled NBP2-27062R
DyLight 650 Labeled NBP2-27062C
DyLight 680 Labeled NBP2-27062FR
DyLight 755 Labeled NBP2-27062IR
HRP Labeled NBP2-27062H

Additional Array Products

Array NBP2-27062

Diseases for Siglec-H Antibody (NBP2-27062)

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Pathways for Siglec-H Antibody (NBP2-27062)

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