Siglec-H Antibody (23M15C8)

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Immunohistochemistry-Paraffin: Siglec-H Antibody (23M15C8) [NBP2-27062] - Analysis of Siglec-H in mouse spleen tissue using Siglec-H antibody

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP2-27062
    • Availability
      Product Discontinued

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Siglec-H Antibody (23M15C8) Summary

Immunogen
A portion of amino acids 50-100 of mouse Siglec-H was used as the immunogen for this antibody.
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Rat
Gene
Siglech
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5ug/ml
Publications
Read Publications using
NBP2-27062 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for Siglec-H Antibody (23M15C8)

  • 6430529G09Rik
  • Siglech sialic acid binding Ig-like lectin H
  • SiglecH
  • Siglec-H

Background

Siglec-H, or sialic acid binding immunoglobulin-like lectin H, is a CD33 related protein expressed specifically by plasmacytoid dendritic cells or pDCs (1, 2). Antigen-mediated delivery by Siglec-H in pDCs inhibits Th cell proliferation and further antibody responsesThis leads to lessened expansion and Th1/Th17 polarization (3). Constant and low density antigen presentation by Siglec-H is thought to lead to an exhaustive type lessening of the response in CD4+ cells but not tolerance. A number of pathways have been proposed for the Siglec-H induced T cell hyporesponsiveness. Ever decreasing activation cycles in the presence of low level but continuous antigen delivery, as that observed with Siglec-H, have also been demonstrated to impart FoxP3+ Tregs immunosuppressive tolerogen-like effects (4, 5). Ability to identify and control Siglec-H antigen mediated delivery activities with specific antibody provides a focal point for potential development of inflammation controls.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Siglec-H Antibody (NBP2-27062)(2)

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol Siglech
Uniprot