Siglec-H Products

Description

Siglec-H, or sialic acid binding immunoglobulin-like lectin H, is a CD33 related protein expressed specifically by plasmacytoid dendritic cells or pDCs. Antigen-mediated delivery by Siglec-H in pDCs inhibits Th cell proliferation and further antibody responses. This leads to lessened expansion and Th1/Th17 polarization. Constant and low density antigen presentation by Siglec-H is thought to lead to an exhaustive type lessening of the response in CD4+ cells but not tolerance. A number of pathways have been proposed for the Siglec-H induced T cell hyporesponsiveness. Ever decreasing activation cycles in the presence of low level but continuous antigen delivery, as that observed with Siglec-H, have also been demonstrated to impart FoxP3+ Tregs immunosuppressive tolerogen-like effects. Ability to identify and control Siglec-H antigen mediated delivery activities with specific antibody provides a focal point for potential development of inflammation controls.

Bioinformatics

Product By Gene ID	233274
Alternate Names	6430529G09Rik Siglech sialic acid binding Ig-like lectin H SiglecH Siglec-H