SIGIRR Antibody Summary
This antibody was developed against synthetic peptides corresponding to aa 300-350 and 370-420 of human SIGIRR.
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Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Whole antisera with 0.2 ml PBS and 0.1 mg/ml BSA
0.02% Sodium Azide
- Western Blot 1:500-1:1000
Alternate Names for SIGIRR Antibody
- single Ig IL-1-related receptor
- Single Ig IL-1R-related molecule
- single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
- single immunoglobulin domain IL1R1 related
- Single immunoglobulin domain-containing IL1R-related protein
- Toll/interleukin-1 receptor 8
SIGIRR (single Ig IL-1R-related molecule) is a novel member of the interleukin 1 receptor (IL-1R) superfamily (1). Although it shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. A chimera, in which the SIGIRR intracellular domain was fused to the IL-1R extracellular domain, did not activate NFkappaB unlike similar fusion proteins of other IL-1R related molecules. Phylogenetic data that suggest that the plasma membrane protein SIGIRR is a close functional relative of MyD88 in mammals (2).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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