SETDB1 Antibody [Alexa Fluor™ Plus 555]

• Reactivity: Hu
• Applications: WB, IP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Alexa Fluor Plus 555

SETDB1 Antibody [Alexa Fluor™ Plus 555] Summary

• Immunogen: The immunogen recognized by this antibody maps to a region between residues 1125 and 1175 of human SET Domain, Bifurcated 1 using the numbering given in entry NP_036564.2 (GeneID 9869).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SETDB1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for SETDB1 Antibody [Alexa Fluor™ Plus 555]

• ERG-associated protein with SET domain
• ESETEC 2.1.1.43
• H3-K9-HMTase 4
• Histone H3-K9 methyltransferase 4
• histone-lysine N-methyltransferase SETDB1
• histone-lysine N-methyltransferase, H3lysine-9 specific 4
• KG1T
• KIAA0067H3-K9-HMTase4
• KMT1EERG-associated protein with a SET domain, ESET
• Lysine N-methyltransferase 1E
• SET domain bifurcated 1
• SET domain, bifurcated 1

Background

The SET domain is a highly conserved, approximately 150-amino acid motif implicated in the modulation of chromatin structure. It was originally identified as part of a larger conserved region present in the Drosophila Trithorax protein and was subsequently identified in the Drosophila Su(var)3-9 and 039;Enhancer of zeste 039 proteins, from which the acronym SET is derived. Studies have suggested that the SET domain may be a signature of proteins that modulate transcriptionally active or repressed chromatin states through chromatin remodeling activities. [supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SETDB1