Serpin G1/C1 Inhibitor Antibody (350507) [Alexa Fluor® 532]

• Reactivity: Hu
• Applications: WB, IP
• Clone: 350507
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 532

Serpin G1/C1 Inhibitor Antibody (350507) [Alexa Fluor® 532] Summary

• Immunogen: Human plasma-derived Serpin G1/C1 Inhibitor
• Specificity: Detects human Serpin G1/C1 Inhibitor in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human Serpin A1, A3, A4, A5, C1, D1, E2, or F1 is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 degreesC as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Serpin G1/C1 Inhibitor Antibody (350507) [Alexa Fluor® 532]

• C1 Inhibitor
• C1IN
• C1INH
• C1NH
• HAE1
• HAE2
• Serpin G1
• SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1

Background

As a member of the serpin superfamily of serine protease inhibitors, Serpin G1/C1 inhibitor is the physiological inhibitor of activated C1r and C1s, two serine proteases involved in the classical complement pathway. In addition, it inhibits plasma kallikrein and coagulation factor XIIa, two serine proteases involved in the processing of kininogen to release bradykinin. Therefore, it plays an important role in regulating activation of both the complement and contact systems (1). Serpin G1 deficiency results in hereditary angioedema, which is characterized by recurrent episodes of localized angioedema of the skin, gastrointestinal mucosa or upper respiratory mucosa (2). The deduced amino acid sequence of human Serpin G1 precursor consists of 500 residues with a signal peptide. The mature protein of 478 amino acid residues is heavily glycosylated (1).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.