Human Serpin A4/Kallistatin DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Serpin A4/Kallistatin DuoSet ELISA, 15 Plate Summary

• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: SERPINA4

Applications/Dilutions

• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Serpin A4/Kallistatin DuoSet ELISA, 15 Plate

• antitrypsin), member 4
• KAL
• Kallistatin
• KLST
• KSTKallikrein inhibitor
• member 4
• PI-4
• PI4Peptidase inhibitor 4
• protease inhibitor 4 (kallistatin)
• serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase
• Serpin A4
• serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)

Background

The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

Publications for Serpin A4/Kallistatin (DY1669)(4)

Publications using DY1669

• Yiu W, Wong D, Wu H, Li R, Yam I, Chan L, Leung J, Lan H, Lai K, Tang S Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress. Kidney Int, 2015;0(0):. 2015 [PMID: 26536000] (Human)
• Tuo J, Wang Y, Cheng R, Li Y, Chen M, Qiu F, Qian H, Shen D, Penalva R, Xu H, Ma J, Chan C Wnt signaling in age-related macular degeneration: human macular tissue and mouse model. J Transl Med, 2015;13(0):330. 2015 [PMID: 26476672] (Human)
• McBride J, Jenkins A, Liu X, Zhang B, Lee K, Berry W, Janknecht R, Griffin C, Aston C, Lyons T, Tomasek J, Ma J Elevated circulation levels of an antiangiogenic SERPIN in patients with diabetic microvascular complications impair wound healing through suppression of Wnt signaling. J Invest Dermatol, 2014;134(6):1725-34. 2014 [PMID: 24463424] (Human)
• Liu, Xiaochen, Zhang, Bin, McBride, Jeffrey, Zhou, Kevin, Lee, Kyungwon, Zhou, Yueping, Liu, Zuguo, Ma, Jian-xin Antiangiogenic and antineuroinflammatory effects of kallistatin through interactions with the canonical Wnt pathway. Diabetes, 2013;62(12):4228-38. 2013 [PMID: 23884893] (Human)

FAQs for Serpin A4/Kallistatin (DY1669). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: SERPINA4