Complement Component C1r Antibody [Unconjugated]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

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Complement Component C1r Antibody [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Complement Component C1r
Ser18-Asp705
Accession # NP_001724
Specificity
Detects human Complement Component C1r in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human Complement Component C1s is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
C1R
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Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
  • Immunoprecipitation 25 ug/mL
Reviewed Applications
Read 1 Review rated 4
using
AF1807 in the following applications:

Publications
Read Publications using
AF1807 in the following applications:

  • 1 publication
  • WB
    1 publication

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Complement Component C1r Antibody [Unconjugated]

  • C1r
  • complement C1r subcomponent
  • Complement component 1 subcomponent r
  • complement component 1, r subcomponent
  • Complement Component C1r
  • EC 3.4.21
  • EC 3.4.21.41

Background

The classical complement pathway plays a major role in innate immunity against infection. This pathway is triggered by C1, a multimolecular complex composed of the recognition protein C1q and two serine proteases, C1r and C1s. Following the C1q recognition, C1r is autoactivated, and in turn activates C1s, which cleaves C4 and C2, the C1 substrates (1). Both C1r and C1s activation involve cleavage of a specific Arg-Ile bond, converting single-chain proenzymes into active proteases of disulfide bond-linked chains (A and B) (2). The A chains contain multiple domains in the order of CUB1-EGF-CUB2-CCP1-CCP2-Activation Peptide. The B chains contain the serine protease catalytic domain. The full-length (amino acid residues 1‑705) of human C1r was expressed, which had the Leu152 natural variant (3). The purified protein corresponded to the processed active form, with A and B chains starting at residue Ser18 and Ile464, respectively.

  1. Arlaud, G.J. et al. (2002) Biochem. Soc. Trans. 30:1001.
  2. Lacroix, M. et al. (2001) J. Biol. Chem. 276:36233.
  3. Journet A. and M. Tosi (1986) Biochem. J. 240:783.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Complement Component C1r Antibody (AF1807)(2)

Review for Complement Component C1r Antibody (AF1807) (1) 41

Average Rating: 4
(Based on 1 review)
We have 1 review tested in 1 species: Human.

Reviews using AF1807:
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WB
(1)
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Human
(1)
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Images Ratings Applications Species Date Details
 
reviewed by:
Anonymous
WB Human 01/05/2015
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Summary

ApplicationWestern Blot
Sample TestedSee PMID 21584940
SpeciesHuman

Blocking

Blocking DetailsSee PMID 21584940

Details

Detection NotesSee PMID 21584940

Comments

CommentsGave a very good westernSee PMID 21584940

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Recent Reviews

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1
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Anonymous
01/05/2015
Application: WB
Species: Human

Bioinformatics

Gene Symbol C1R
Entrez
Uniprot