Serpin A3/alpha 1-Antichymotrypsin Antibody (CL10697) - Azide and BSA Free

Analysis in human liver and skeletal muscle tissues using NBP3-44021 antibody. Corresponding Serpin A3/alpha 1-Antichymotrypsin RNA-seq data are presented for the same tissues.

Staining of human cerebral cortex shows cytoplasmic and nuclear positivity in a subset of glial cells.

Staining of human skeletal muscle shows no positivity in myocytes as expected.

Staining of human liver shows strong cytoplasmic positivity in hepatocytes.

Staining of human uterine cervix shows moderate cytoplasmic positivity in squamous epithelial cells.

• Reactivity: Hu
• Applications: IHC
• Clone: CL10697
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free
• Concentration: LYOPH

Serpin A3/alpha 1-Antichymotrypsin Antibody (CL10697) - Azide and BSA Free Summary

• Description: Novus Biologicals Mouse Serpin A3/alpha 1-Antichymotrypsin Antibody (CL10697) - Azide and BSA Free (NBP3-07987) is a monoclonal antibody validated for use in IHC. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was generated using a recombinant protein sequence of P01011, with the exact immunogen sequence remaining proprietary.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: SERPINA3
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry-Paraffin 1:2500 - 1:5000
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from a 0.2 um filtered solution in PBS with Trehalose
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein A purified
• Reconstitution Instructions: Centrifuge the vial of lyophilized antibody at 12,000 x g for 20 seconds. Reconstitute by adding sterile, distilled water to achieve a final antibody concentration of 1mg/ml.

Alternate Names for Serpin A3/alpha 1-Antichymotrypsin Antibody (CL10697) - Azide and BSA Free

• AACTMGC88254
• ACTGIG25
• alpha 1-Antichymotrypsin
• alpha-1-antichymotrypsin
• antitrypsin), member 3
• Cell growth-inhibiting gene 24/25 protein
• growth-inhibiting protein 24
• growth-inhibiting protein 25
• member 3
• serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase
• serine (or cysteine) proteinase inhibitor, clade A, member 3
• Serpin A3
• serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)

Background

Alpha 1 Antichymotrypsin is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variation in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SERPINA3