RFXANK Antibody

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-196
    • Availability
      Product Discontinued

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RFXANK Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 200 and the C-terminus (residue 260) of human Regulatory Factor X-associated Ankyrin-containing protein using the numbering given in entry NP_003712.1 (GeneID 8625).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
RFXANK
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:5000
  • Immunoprecipitation 1:10-1:500

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.1% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for RFXANK Antibody

  • ANKRA1Regulatory factor X subunit B
  • ankyrin repeat-containing regulatory factor X-associated protein
  • BLS
  • DNA-binding protein RFXANK
  • F14150_1
  • MGC138628
  • regulatory factor X-associated ankyrin-containing proteinAnkyrin repeat family A protein 1
  • RFXB
  • RFX-BRFX-Bdelta4

Background

MHC class II deficiency is an autosomal recessive immunodeficiency syndrome resulting from defects in transacting factors essential for transcription of MHC class II genes. There are 4 genetic complementation groups (A, B, C, and D), reflecting the existence of 4 MHC class II regulators. Group B is characterized by a defect in RFX binding, and although it accounts for the majority of patients, the factor defective in group B remained unknown until Masternak et al. (1998) isolated RFX by a novel single-step DNA-affinity purification approach and identified RFXANK, the gene encoding the third subunit of RFX. The gene was symbolized RFXANK because the protein contains 3 ankyrin repeats.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol RFXANK