RFXANK Antibody

Product Discontinued

RFXANK Antibody Summary

• Immunogen: The immunogen recognized by this antibody maps to a region between residue 200 and the C-terminus (residue 260) of human Regulatory Factor X-associated Ankyrin-containing protein using the numbering given in entry NP_003712.1 (GeneID 8625).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: RFXANK
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 1:10-1:500
  • Western Blot 1:500-1:5000

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Tris-Citrate/Phosphate (pH 7.0 - 8.0)
• Preservative: 0.1% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for RFXANK Antibody

• ANKRA1Regulatory factor X subunit B
• ankyrin repeat-containing regulatory factor X-associated protein
• BLS
• DNA-binding protein RFXANK
• F14150_1
• MGC138628
• regulatory factor X-associated ankyrin-containing proteinAnkyrin repeat family A protein 1
• RFXB
• RFX-BRFX-Bdelta4

Background

MHC class II deficiency is an autosomal recessive immunodeficiency syndrome resulting from defects in transacting factors essential for transcription of MHC class II genes. There are 4 genetic complementation groups (A, B, C, and D), reflecting the existence of 4 MHC class II regulators. Group B is characterized by a defect in RFX binding, and although it accounts for the majority of patients, the factor defective in group B remained unknown until Masternak et al. (1998) isolated RFX by a novel single-step DNA-affinity purification approach and identified RFXANK, the gene encoding the third subunit of RFX. The gene was symbolized RFXANK because the protein contains 3 ankyrin repeats.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RFXANK