RFXANK Products

Description

Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity. [provided by RefSeq]

Bioinformatics

Product By Gene ID	8625
Alternate Names	ANKRA1Regulatory factor X subunit B ankyrin repeat-containing regulatory factor X-associated protein BLS DNA-binding protein RFXANK F14150_1 MGC138628 regulatory factor X-associated ankyrin-containing proteinAnkyrin repeat family A protein 1 RFXB RFX-BRFX-Bdelta4

Research Areas for RFXANK

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Immunology