Recombinant Rat IL-22 Protein


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Reactivity RtSpecies Glossary
Applications Bioactivity

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Recombinant Rat IL-22 Protein Summary

Details of Functionality
Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells. Nagalakshmi, M.L. et al. (2004) International Immunopharmacology 4:679. The ED50 for this effect is 150-750 pg/mL.
E. coli-derived rat IL-22 protein
Leu27-Val172, with an N-terminal Met
Accession #
N-terminal Sequence
Protein/Peptide Type
Recombinant Proteins
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.1 EU per 1 μg of the protein by the LAL method.


Theoretical MW
16.7 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Read Publications using
1316-RL in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 10 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Rat IL-22 Protein

  • Cytokine Zcyto18
  • IL-10-related T-cell-derived inducible factor
  • IL-21
  • IL22
  • IL-22
  • IL-22IL21
  • IL-D110
  • IL-TIF
  • ILTIFIL-10-related T-cell-derived-inducible factor
  • IL-TIFMGC79382
  • interleukin 21
  • interleukin 22
  • interleukin-22
  • MGC79384
  • TIFa
  • TIFIL-23
  • zcyto18


Interleukin-22 (IL-22), also known as IL-10-related T cell-derived inducible factor (IL-TIF), was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. It belongs to the IL-10-related cytokine family that consists of six members (IL-10, IL-19, IL-20, IL-22, IL-24/MDA-7, and IL-26/AK155). These proteins share structural homology and some degree of amino acid sequence homology to IL-10. Receptors for these proteins are members of the class II cytokine receptor family (1). The rat IL-22 coding region corresponding to amino acids 48 - 179 was deduced from a rat genomic clone (Genbank accession numaber AC111483). The N-terminal portion was cloned from rat adipocyte first strands using degenerate forward primers based on the human and mouse IL-22 amino acid sequences in two independent PCR reactions (2). Rat IL-22 cDNA predicts a 179 amino acid (aa) residue precursor protein with a putative 33 aa signal peptide that is cleaved to generate a 147 aa mature protein, which shares approximately 92% and 79% aa sequence identity with mouse and human IL-22, respectively. IL-22 signals through a heterodimeric receptor complex composed of the IL-22R (CRF2-9) subunit and the ( chain of IL-10R (CRF2-4). In addition, IL-22 also binds to a secreted member of the class II cytokine receptor family called IL-22BP that acts as a natural IL-22 antagonist. IL-22 upregulates acute-phase reactants in the liver and hepatoma cells. In a rat hepatoma cell line, IL-22 has been shown to activate the Jak/STAT and MAPK signaling pathways (3).

  1. Kotenko, S.V. (2002) Cytokine and Growth Factor Reviews 13:223.
  2. Kettlewell, J. (2002) R&D Systems, unpublished results.
  3. Lejeune, D. et al. (2002) J. Biol. Chem. 277:33673.

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Publications for IL-22 (1316-RL)(2)

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 2 applications: Cell Culture, In Vivo.

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Gene Symbol Il22