IL-26/AK155 Antibody


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Product Details

Reactivity HuSpecies Glossary
Applications WB

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IL-26/AK155 Antibody Summary

E. coli-derived recombinant human IL-26 (R&D Systems, Catalog # 1375-IL)
Accession # Q9NPH9
Detects human IL-26 in direct ELISAs and Western blots. In these formats, less than 5% cross‑reactivity with recombinant human IL-10 is observed.
Immunogen affinity purified
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 0.1 ug/mL
Read Publications using
AF1375 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
No Preservative
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-26/AK155 Antibody

  • AK155
  • AK155IL-26interleukin-26
  • IL26
  • IL-26
  • interleukin 26
  • Protein AK155


IL-26 was originally cloned from herpesvirus saimiri (HVS)-transformed T cells and named AK155 (1). It is a member of the IL-10 family of class II cytokines that signal via heterodimeric receptor complexes composed of two type I transmembrane receptor subunits (2). The human IL-26 gene has been mapped to chromosome 12q15. It encodes a 171 amino acid polypeptide with a 21 amino acid signal peptide. In addition to HVS-transformed T cells, IL-26 is also expressed in other virus transformed T cell lines, fresh peripheral mononuclear cells, activated NK cells and T cells. A mouse homologue of human IL-26 has not been identified. IL-26 binds with high-affinity to the heterodimeric complex consisting of the ligand-binding IL-20 R alpha and non ligand-binding IL-10 R beta (3). Activation of the receptor complex results in rapid phosphorylation of STAT1 and STAT3. Although the IL-26 receptor complex is highly specific for IL-26 and is not activated by other class II cytokines, the individual subunits of the IL-26 receptor complex are components in receptor complexes for other class II cytokines (1). IL-20 R alpha can form dimers with IL-20 R beta to function as signaling receptors for IL-19, IL-20, and IL-24. IL-10 R beta  can complex with IL-10 R alpha , IL-22 R, and IL-28 R alpha  to transduce signals for IL-10, IL-22, and the three novel IFNs (IL-28A, IL-28B and IL-29), respectively. The physiological functions of IL-26 remain to be determined. IL-26 was reported to be a homodimer in solution (1).

  1. Knappe. A. et al. (2000) J. Virology 74:3881.
  2. Renauld, J.-C. (2003) Nature Reviews Immunology 3:667.
  3. Sheikh, F. et al. (2004) J. Immunol. 172(4):2006.
  4. Unpublished data (2003) R&D Systems, Inc.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IL-26/AK155 Antibody (AF1375)(5)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: ELISA Development, ICC, Neutralization, Western Blot.

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ELISA Development
Western Blot
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Showing Publications 1 - 5 of 5.
Publications using AF1375 Applications Species
T Itoh, R Hatano, Y Horimoto, T Yamada, D Song, H Otsuka, Y Shirakawa, S Mastuoka, N Iwao, TM Aune, NH Dang, Y Kaneko, K Okumura, C Morimoto, K Ohnuma IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells Cell Death & Disease, 2021;12(6):520. 2021 [PMID: 34021125] (ICC, Human) ICC Human
Ohnuma K, Hatano R, Aune T, Otsuka H, Iwata S, Dang N, Yamada T, Morimoto C Regulation of pulmonary graft-versus-host disease by IL-26+CD26+CD4 T lymphocytes. J Immunol, 2015;194(8):3697-712. 2015 [PMID: 25786689] (Neutralization, Mouse) Neutralization Mouse
Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, Hoppe E, Barre B, Audran M, Bouvard B, Saint-Andre J, Jeannin P IL-26 Is Overexpressed in Rheumatoid Arthritis and Induces Proinflammatory Cytokine Production and Th17 Cell Generation. PLoS Biol, 2012;10(9):e1001395. 2012 [PMID: 23055831] (ELISA Development, Human) ELISA Development Human
Dambacher J, Beigel F, Zitzmann K, De Toni EN, Goke B, Diepolder HM, Auernhammer CJ, Brand S The role of the novel Th17 cytokine IL-26 in intestinal inflammation. Gut, 2009;58(9):1207-17. 2009 [PMID: 18483078] (ELISA Development, Human) ELISA Development Human
Sheikh F, Baurin VV, Lewis-Antes A, Shah NK, Smirnov SV, Anantha S, Dickensheets H, Dumoutier L, Renauld JC, Zdanov A, Donnelly RP, Kotenko SV Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. J. Immunol., 2004;172(4):2006-10. 2004 [PMID: 14764663] (Western Blot, Human) Western Blot Human

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Gene Symbol IL26