Recombinant Mouse TGF-beta 1 Protein, CF

Recombinant mouse TGF-beta 1 (7666-MB/CF) inhibits IL-4-dependent proliferation in the HT-2 mouse T cell line. The ED50 for this effect is 0.04-0.2 ng/mL.

• Reactivity: Mu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Mouse TGF-beta 1 Protein, CF Summary

• Details of Functionality: Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7:389. The ED₅₀ for this effect is 0.04-0.2 ng/mL.
• Source: Chinese Hamster Ovary cell line, CHO-derived mouse TGF-beta 1 protein
  Ala279-Ser390
• Accession #: P04202
• N-terminal Sequence: Ala279
• Structure / Form: Disulfide-linked homodimer
• Protein/Peptide Type: Recombinant Proteins
• Gene: Tgfb1
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Endotoxin Note: <0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 12.8 kDa (monomer).
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 10.5 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in HCl.
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Reconstitution Instructions: Reconstitute at 50 μg/mL in 4 mM HCl.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse TGF-beta 1 Protein, CF

• CEDLAP
• DPD1
• latency-associated peptide
• TGF beta
• TGF beta1
• TGFB
• TGFB1
• TGF-beta 1 protein
• TGFbeta 1
• TGF-beta 1
• TGFbeta
• TGF-beta-1
• transforming growth factor beta-1
• transforming growth factor, beta 1

Background

TGF-beta 1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF‑ beta superfamily that share a characteristic cystine knot structure (1‑7). TGF‑ beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial‑mesenchymal transition (1‑4). Each TGF‑ beta isoform has some non‑redundant functions; for TGF‑ beta 1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation, and die of overwhelming inflammation (2). Human or mouse TGF‑ beta 1 cDNA encodes a 390 amino acid (aa) precursor that contains a 29 aa signal peptide and a 361 aa proprotein (8). A furin‑like convertase processes the proprotein to generate an N‑terminal 249 aa latency‑associated peptide (LAP) and a C‑terminal 112 aa mature TGF‑ beta 1 (8, 9). Disulfide‑linked homodimers of LAP and TGF‑ beta 1 remain non‑covalently associated after secretion, forming the small latent TGF‑ beta 1 complex (8‑10). Covalent linkage of LAP to one of three latent TGF‑ beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix (9, 10). TGF‑ beta is activated from latency by pathways that include actions of the protease plasmin, matrix metalloproteases, thrombospondin 1 and a subset of integrins (10). Mature mouse TGF‑ beta 1 shares 99‑100% aa sequence identity with human, rat, equine, porcine, canine and bovine TGF‑ beta 1. It demonstrates cross‑species activity (1). TGF‑ beta 1 signaling begins with high‑affinity binding to a type II ser/thr kinase receptor termed TGF‑ beta  RII. This receptor then phosphorylates and activates a second ser/thr kinase receptor, TGF‑ beta  RI (also called activin receptor‑like kinase (ALK) ‑5), or alternatively, ALK‑1. This complex phosphorylates and activates Smad proteins that regulate transcription (3, 11, 12). Contributions of the accessory receptors betaglycan (also known as TGF‑ beta  RIII) and endoglin, or use of Smad‑independent signaling pathways, allow for disparate actions observed in response to TGF‑ beta in different contexts (11).

1. Derynck, R. and K. Miyazono (2008) Cold Spring Harbor Laboratory Press, 29.
2. Dunker, N. and K. Krieglstein (2000) Eur. J. Biochem. 267:6982.
3. Wahl, S.M. (2006) Immunol. Rev. 213:213.
4. Chang, H. et al. (2002) Endocr. Rev. 23:787.
5. Lin, J.S. et al. (2006) Reproduction 132:179.
6. Hinck, A.P. et al. (1996) Biochemistry 35:8517.
7. Mittl, P.R.E. et al. (1996) Protein Sci. 5:1261.
8. Derynck, R. et al. (1985) Nature 316:701.
9. Miyazono, K. et al. (1988) J. Biol. Chem. 263:6407.
10. Oklu, R. and R. Hesketh (2000) Biochem. J. 352:601.
11. de Caestecker, M. et al. (2004) Cytokine Growth Factor Rev. 15:1.
12. Zuniga, J.E. et al. (2005) J. Mol. Biol. 354:1052.

Publications for TGF-beta 1 (7666-MB/CF)(323)

Publications using 7666-MB/CF

• Cruz, LC;Habibovic, A;Dempsey, B;Massafera, MP;Janssen-Heininger, YMW;Lin, MJ;Hoffman, ET;Weiss, DJ;Huang, SK;van der Vliet, A;Meotti, FC; Identification of tyrosine brominated extracellular matrix proteins in normal and fibrotic lung tissues Redox biology 2024-05-01 [PMID: 38430684] (Bioassay, Mouse)
• L�tge, M;De Martin, A;Gil-Cruz, C;Perez-Shibayama, C;Stanossek, Y;Onder, L;Cheng, HW;Kurz, L;Cadosch, N;Soneson, C;Robinson, MD;Stoeckli, SJ;Ludewig, B;Pikor, NB; Conserved stromal-immune cell circuits secure B cell homeostasis and function Nature immunology 2023-05-18 [PMID: 37202489] (Bioassay, Mouse)
• D Irala, S Wang, K Sakers, L Nagendren, FP Ulloa-Seve, DS Bindu, C Eroglu Astrocyte-Secreted Neurocan Controls Inhibitory Synapse Formation and Function bioRxiv : the preprint server for biology, 2023-04-03;0(0):. 2023-04-03 [PMID: 37066164] (Bioassay, Mouse)
• Y Liao, L Sun, M Nie, J Li, X Huang, S Heng, W Zhang, T Xia, Z Guo, Q Zhao, LJ Zhang Modulation of Skin Inflammatory Responses by Aluminum Adjuvant Pharmaceutics, 2023-02-08;15(2):. 2023-02-08 [PMID: 36839900] (Bioassay, Mouse)
• C Yi, J Liu, W Deng, C Luo, J Qi, M Chen, H Xu Old age promotes retinal fibrosis in choroidal neovascularization through circulating fibrocytes and profibrotic macrophages Journal of Neuroinflammation, 2023-02-23;20(1):45. 2023-02-23 [PMID: 36823538] (Bioassay, Mouse)
• S De Scheppe, JZ Ge, G Crowley, LSS Ferreira, D Garceau, CE Toomey, D Sokolova, J Rueda-Carr, SH Shin, JS Kim, T Childs, T Lashley, JJ Burden, M Sasner, C Sala Frige, S Jung, S Hong Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer&#039;s disease Nature Neuroscience, 2023-02-06;0(0):. 2023-02-06 [PMID: 36747024] (Bioassay, Mouse)
• RK Gurram, D Wei, Q Yu, MJ Butcher, X Chen, K Cui, G Hu, M Zheng, X Zhu, J Oh, B Sun, JF Urban, K Zhao, WJ Leonard, J Zhu Crosstalk between ILC2s and Th2 cells varies among mouse models Cell Reports, 2023-02-02;42(2):112073. 2023-02-02 [PMID: 36735533] (Bioassay, Mouse)
• T Kasuya, S Tanaka, J Tamura, K Etori, J Shoda, K Hattori, Y Endo, M Kitajima, T Kageyama, T Iwamoto, M Yokota, A Iwata, A Suto, K Suzuki, H Suzuki, SF Ziegler, H Nakajima Epithelial cell-derived cytokine TSLP activates regulatory T cells by enhancing fatty acid uptake Scientific Reports, 2023-01-30;13(1):1653. 2023-01-30 [PMID: 36717741] (Cell Culture, Mouse)
• TT Li, XW Su, LL Chen, WN Zhang, JP Zhang, Y Wang, WH Xu Roxarsone inhibits hepatic stellate cell activation and ameliorates liver fibrosis by blocking TGF-beta1/Smad signaling pathway International immunopharmacology, 2022-12-19;114(0):109527. 2022-12-19 [PMID: 36700762] (Cell Culture, Human)
• L Tang, M Zhu, X Che, X Yang, Y Xu, Q Ma, M Zhang, Z Ni, X Shao, S Mou Astragaloside IV Targets Macrophages to Alleviate Renal Ischemia-Reperfusion Injury via the Crosstalk between Hif-1alpha and NF-kappaB (p65)/Smad7 Pathways Journal of personalized medicine, 2022-12-27;13(1):. 2022-12-27 [PMID: 36675720] (Bioassay, Mouse)
• T Blanco, R Bir Singh, H Nakagawa, Y Taketani, TH Dohlman, Y Chen, SK Chauhan, J Yin, R Danan Conventional Type I Migratory CD103+ Dendritic Cells are Required for Corneal Allograft Survival Mucosal Immunology, 2023-01-13;0(0):. 2023-01-13 [PMID: 36642378] (Bioassay, Mouse)
• J Li, Z Yao, X Liu, R Duan, X Yi, A Ayoub, JO Sanders, A Mesfin, L Xing, BF Boyce TGFbeta1+CCR5+ neutrophil subset increases in bone marrow and causes age-related osteoporosis in male mice Nature Communications, 2023-01-11;14(1):159. 2023-01-11 [PMID: 36631487] (Bioassay, Mouse)
• D Shore, N Griggs, V Graffeo, ARMR Amin, XM Zha, Y Xu, JP McAleer GPR68 limits the severity of chemical-induced oral epithelial dysplasia Scientific Reports, 2023-01-07;13(1):353. 2023-01-07 [PMID: 36611126] (Cell Culture, Mouse)
• B Wang, Y Tan, Y Zhang, S Zhang, X Duan, Y Jiang, T Li, Q Zhou, X Liu, Z Zhan Loss of KDM5B ameliorates pathological cardiac fibrosis and dysfunction by epigenetically enhancing ATF3 expression Experimental & Molecular Medicine, 2022-12-08;0(0):. 2022-12-08 [PMID: 36481938] (Mouse)
• M Scherlinge, W Pan, R Hisada, A Boulougour, N Yoshida, M Vukelic, M Umeda, S Krishfield, MG Tsokos, GC Tsokos Phosphofructokinase P fine-tunes T regulatory cell metabolism, function, and stability in systemic autoimmunity Science Advances, 2022-11-30;8(48):eadc9657. 2022-11-30 [PMID: 36449620] (Bioassay, Transgenic Mouse)
• Y Geng, L Li, J Yan, K Liu, A Yang, L Zhang, Y Shen, H Gao, X Wu, I Noth, Y Huang, J Liu, X Fan PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis Nature Communications, 2022-11-19;13(1):7114. 2022-11-19 [PMID: 36402779] (Bioassay, Mouse)
• M Schmitt, F Ceteci, J Gupta, M Pesic, TW Böttger, AM Nicolas, KB Kennel, E Engel, M Schewe, A Callak Kir, V Petrocelli, Y Dabiri, J Varga, M Ramakrishn, M Karimova, A Ablasser, T Sato, MC Arkan, FJ de Sauvage, FR Greten Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation Nature, 2022-11-16;0(0):. 2022-11-16 [PMID: 36385525] (Bioassay, Mouse)
• S Munakarmi, Y Gurau, J Shrestha, P Risal, HS Park, HB Shin, YJ Jeong Hepatoprotective Effects of a Natural Flavanol 3,3&#039;-Diindolylmethane against CCl4-Induced Chronic Liver Injury in Mice and TGFbeta1-Induced EMT in Mouse Hepatocytes via Activation of Nrf2 Cascade International Journal of Molecular Sciences, 2022-09-27;23(19):. 2022-09-27 [PMID: 36232707] (Cell Culture, Mouse)
• WE Jiao, S Xu, YL Qiao, YG Kong, L Sun, YQ Deng, R Yang, ZZ Tao, QQ Hua, SM Chen Notch2-dependent GATA3+ Treg cells alleviate allergic rhinitis by suppressing the Th2 cell response International immunopharmacology, 2022-09-22;112(0):109261. 2022-09-22 [PMID: 36155282] (Bioassay, Mouse)
• BA Dos Santos, AC Anauate, E Maquigussa, MA Boim, A da Silva N Determination of reference genes as a quantitative standard for gene expression analysis in mouse mesangial cells stimulated with TGF-beta Scientific Reports, 2022-09-17;12(1):15626. 2022-09-17 [PMID: 36115882] (Cell Culture, Mouse)
• M Bobowski-G, C Boulet, FP Zummo, J Dubois-Che, C Gheeraert, M Bou Saleh, JM Strub, A Farce, M Ploton, L Guille, J Vandel, A Bongiovann, N Very, E Woitrain, A Deprince, F Lalloyer, E Bauge, L Ferri, LC Ntandja-Wa, AK Cotte, C Grangette, E Vallez, S Cianférani, V Raverdy, R Caiazzo, V Gnemmi, E Leteurtre, B Pourcet, R Paumelle, K Ravnskjaer, G Lassailly, JT Haas, P Mathurin, F Pattou, L Dubuquoy, B Staels, P Lefebvre, J Eeckhoute Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis Nature Communications, 2022-09-10;13(1):5324. 2022-09-10 [PMID: 36088459] (Bioassay, Mouse)
• EC Freckmann, E Sandilands, E Cumming, M Neilson, A Román-Fern, K Nikolatou, M Nacke, TRM Lannagan, A Hedley, D Strachan, M Salji, JP Morton, L McGarry, HY Leung, OJ Sansom, CJ Miller, DM Bryant Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging Nature Communications, 2022-09-09;13(1):5317. 2022-09-09 [PMID: 36085324] (Bioassay, Mouse)
• L Rani, A Kumar, J Karhade, G Pandey, A Guha, GC Mishra, MR Wani IL-3 regulates the differentiation of pathogenic Th17 cells European Journal of Immunology, 2022-09-26;0(0):. 2022-09-26 [PMID: 36074916] (Bioassay, Mouse)
• N Nishiyama, C Nakahashi-, A Shibuya Interferon-beta promotes the survival and function of induced regulatory T cells Cytokine, 2022-08-29;158(0):156009. 2022-08-29 [PMID: 36049243] (Bioassay, Transgenic Mouse)
• SI Tsukumo, PG Subramani, N Seija, M Tabata, Y Maekawa, Y Mori, C Ishifune, Y Itoh, M Ota, K Fujio, JM Di Noia, K Yasutomo AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination Science Advances, 2022-08-24;8(34):eabq0008. 2022-08-24 [PMID: 36001653] (Cell Culture, Mouse)
• JN Chi, JY Yang, CH Hsueh, CY Tsai, HC Chuang, TH Tan MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKbeta and inducing IKKbeta-mediated FoxO1 nuclear export and Foxp3 downregulation Theranostics, 2022-07-18;12(13):5744-5760. 2022-07-18 [PMID: 35966593] (Cell Culture, Mouse)
• Z Li, J Wang, C Chen, Q He, X Xu, Z Da, B Wang, M Wang, X Gao, G Zhang, Q Gao, X Si, Y Luo, X Ma Intratumoral IL-28B Gene Delivery Elicits Antitumor Effects by Remodeling of the Tumor Microenvironment in H22-Bearing Mice Journal of Immunology Research, 2022-07-28;2022(0):1345971. 2022-07-28 [PMID: 35935577] (Cell Culture, Mouse)
• EG Vasquez, N Nasreddin, GN Valbuena, EJ Mulholland, HL Belnoue-Da, HR Eggington, RO Schenck, VM Wouters, P Wirapati, K Gilroy, TRM Lannagan, DJ Flanagan, AK Najumudeen, S Omwenga, AMB McCorry, A Easton, VH Koelzer, JE East, D Morton, L Trusolino, T Maughan, AD Campbell, MB Loughrey, PD Dunne, P Tsantoulis, DJ Huels, S Tejpar, OJ Sansom, SJ Leedham Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia Cell Stem Cell, 2022-08-04;29(8):1213-1228.e8. 2022-08-04 [PMID: 35931031] (Bioassay, Mouse)
• K Nishida-Ta, A Kimura, T Tsubata, S Takahashi, H Suzuki Antioxidative enzyme NAD(P)H quinone oxidoreductase 1 (NQO1) modulates the differentiation of Th17 cells by regulating ROS levels PLoS ONE, 2022-07-29;17(7):e0272090. 2022-07-29 [PMID: 35905076] (Bioassay, Mouse)
• T Ahmed, PC Flores, CC Pan, HR Ortiz, YS Lee, PR Langlais, K Mythreye, NY Lee EPDR1 is a Non-canonical Effector of Insulin-mediated Angiogenesis Regulated by an Endothelial-specific TGF-beta Receptor Complex The Journal of Biological Chemistry, 2022-07-21;0(0):102297. 2022-07-21 [PMID: 35872017] (Bioassay, Mouse, Transgenic Mouse)
• Y Su, X Sun, X Liu, Q Qu, L Yang, Q Chen, F Liu, Y Li, Q Wang, B Huang, XJ Huang, XH Zhang hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype Journal of hematology & oncology, 2022-07-21;15(1):99. 2022-07-21 [PMID: 35864538] (Bioassay, Mouse)
• E Ledoult, M Jendoubi, A Collet, T Guerrier, A Largy, S Speca, S Vivier, F Bray, M Figeac, E Hachulla, M Labalette, F Leprêtre, S Sebda, S Sanges, C Rolando, V Sobanski, S Dubucquoi, D Launay Simple gene signature to assess murine fibroblast polarization Scientific Reports, 2022-07-11;12(1):11748. 2022-07-11 [PMID: 35817787] (Bioassay, Mouse)
• P Kim, J Park, DJ Lee, S Mizuno, M Shinohara, CP Hong, Y Jeong, R Yun, H Park, S Park, KM Yang, MJ Lee, SP Jang, HY Kim, SJ Lee, SU Song, KS Park, M Tanaka, H Ohshima, JW Cho, F Sugiyama, S Takahashi, HS Jung, SJ Kim Mast4 determines the cell fate of MSCs for bone and cartilage development Nature Communications, 2022-07-08;13(1):3960. 2022-07-08 [PMID: 35803931] (Bioassay, Mouse)
• Y Xia, K Inoue, Y Du, SJ Baker, E Premkumar, MB Greenblatt, B Zhao TGFbeta reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis Nature Communications, 2022-07-07;13(1):3920. 2022-07-07 [PMID: 35798734] (Bioassay, Mouse)
• P Lu, J Li, C Liu, J Yang, H Peng, Z Xue, Z Liu Salvianolic acid B dry powder inhaler for the treatment of idiopathic pulmonary fibrosis Asian journal of pharmaceutical sciences, 2022-04-30;17(3):447-461. 2022-04-30 [PMID: 35782322] (Bioassay, Mouse)
• LM Fan, YQ Zhang, YP Chen, LL Chen, WH Xu, LH Nan, W Xu, B Lu, Y Wang, KD Chu, JP Zhang Cryptotanshinone ameliorates dextran sulfate sodium-induced murine acute and chronic ulcerative colitis via suppressing STAT3 activation and Th17 cell differentiation Oncogene, 2022-05-31;108(0):108894. 2022-05-31 [PMID: 35729830] (Bioassay, Mouse)
• SPS Pandi, MJ Shattock, BM Hendry, CC Sharpe Stimulated phosphorylation of ERK in mouse kidney mesangial cells is dependent upon expression of Cav3.1 Oncogene, 2022-06-16;23(1):211. 2022-06-16 [PMID: 35710406] (Bioassay, Mouse)
• I Nanda, C Steinlein, T Haaf, EM Buhl, DG Grimm, SL Friedman, SK Meurer, SK Schröder, R Weiskirche Genetic Characterization of Rat Hepatic Stellate Cell Line HSC-T6 for In Vitro Cell Line Authentication Cells, 2022-05-29;11(11):. 2022-05-29 [PMID: 35681478] (Bioassay, Rat)
• S Urbanczyk, OR Baris, J Hofmann, RV Taudte, N Guegen, F Golombek, K Castiglion, X Meng, A Bozec, J Thomas, L Weckwerth, D Mougiakako, SR Schulz, W Schuh, U Schlötzer-, TD Steinmetz, S Brodesser, RJ Wiesner, D Mielenz Mitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling the flux of the TCA cycle Cell Reports, 2022-06-07;39(10):110912. 2022-06-07 [PMID: 35675769] (Bioassay, Mouse)
• F Wang, F Stappenbec, LY Tang, YE Zhang, ST Hui, AJ Lusis, F Parhami Oxy210, a Semi-Synthetic Oxysterol, Exerts Anti-Inflammatory Effects in Macrophages via Inhibition of Toll-like Receptor (TLR) 4 and TLR2 Signaling and Modulation of Macrophage Polarization International Journal of Molecular Sciences, 2022-05-13;23(10):. 2022-05-13 [PMID: 35628290] (Bioassay, Mouse)
• DL Marvin, L You, L Bornes, M van Dinthe, N Peters, H Dang, SK Hakuno, M Hornsveld, O Kranenburg, J van Rheene, JHT Rohling, MP Chien, P Ten Dijke, L Ritsma Dynamic Visualization of TGF-beta/SMAD3 Transcriptional Responses in Single Living Cells Cancers, 2022-05-19;14(10):. 2022-05-19 [PMID: 35626109] (Bioassay, Mouse)
• YS Zhang, DE Xin, Z Wang, W Peng, Y Zeng, J Liang, M Xu, N Chen, J Zhang, J Yue, M Cao, C Zhang, Y Wang, Z Chang, XM Lu, L Chang, YE Chinn Acetylation licenses Th1 cell polarization to constrain Listeria monocytogenes infection Cell Death and Differentiation, 2022-05-25;0(0):. 2022-05-25 [PMID: 35614130] (Bioassay, Mouse)
• AP Leinroth, AJ Mirando, D Rouse, Y Kobayahsi, PR Tata, HE Rueckert, Y Liao, JT Long, JV Chakkalaka, MJ Hilton Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations Cell Reports, 2022-05-10;39(6):110785. 2022-05-10 [PMID: 35545045] (Bioassay, Mouse)
• Y Yoshimatsu, T Sujino, K Miyamoto, Y Harada, S Tanemoto, K Ono, S Umeda, K Yoshida, T Teratani, T Suzuki, Y Mikami, N Nakamoto, N Sasaki, K Takabayash, N Hosoe, H Ogata, K Sawada, T Imamura, A Yoshimura, T Kanai Aryl hydrocarbon receptor signals in epithelial cells govern the recruitment and location of Helios+ Tregs in the gut Cell Reports, 2022-05-10;39(6):110773. 2022-05-10 [PMID: 35545035] (Bioassay, Mouse)
• S Balasubram, M Andreani, JG Andrade, T Saha, D Sundaravin, J Garzón, W Zhang, O Popp, SI Hiraga, A Rahjouei, DB Rosen, P Mertins, BT Chait, AD Donaldson, M Di Virgili Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region Elife, 2022-04-13;11(0):. 2022-04-13 [PMID: 35416772] (Stimulation, Mouse)
• C Yi, J Liu, W Deng, C Luo, J Qi, M Chen, H Xu Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis Journal of Neuroinflammation, 2022-04-05;19(1):78. 2022-04-05 [PMID: 35382832] (Bioassay, Mouse)
• C Ge, J Tan, D Lou, L Zhu, Z Zhong, X Dai, Y Sun, Q Kuang, J Zhao, L Wang, J Liu, B Wang, M Xu Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling Redox Biology, 2022-02-24;51(0):102274. 2022-02-24 [PMID: 35240537] (Bioassay, Human)
• H Kubota, H Yamada, T Sugimoto, N Wada, S Motoyama, M Saburi, D Miyawaki, N Wakana, D Kami, T Ogata, M Ibi, S Matoba Repeated Social Defeat Enhances CaCl2-Induced Abdominal Aortic Aneurysm Expansion by Inhibiting the Early Fibrotic Response via the MAPK-MKP-1 Pathway Cells, 2022-02-19;11(4):. 2022-02-19 [PMID: 35203381] (Bioassay, Mouse)
• GS Whitehead, SY Thomas, K Nakano, DJ Royer, CG Burke, H Nakano, DN Cook A neutrophil/TGF-beta axis limits the pathogenicity of allergen-specific CD4+ T cells JCI Insight, 2022-02-22;7(4):. 2022-02-22 [PMID: 35191395] (In Vivo, Mouse)
• H Ni, C Liu, Y Chen, Y Lu, Y Ji, M Xiang, Y Xie MGP Regulates Perivascular Adipose-Derived Stem Cells Differentiation Toward Smooth Muscle Cells Via BMP2/SMAD Pathway Enhancing Neointimal Formation Cell Transplantation, 2022-01-01;31(0):9636897221075. 2022-01-01 [PMID: 35168405] (Bioassay, Mouse)
• A Bartolomé, N Suda, J Yu, C Zhu, J Son, H Ding, A Califano, D Accili, UB Pajvani Notch-mediated Ephrin signaling disrupts islet architecture and beta cell function JCI Insight, 2022-03-22;0(0):. 2022-03-22 [PMID: 35167496] (Bioassay, Mouse)
• H Qin, Y Tang, Y Mao, X Zhou, T Xu, W Liu, X Su C-MYC induces idiopathic pulmonary fibrosis via modulation of miR-9-5p-mediated TBPL1 Cellular Signalling, 2022-02-03;0(0):110274. 2022-02-03 [PMID: 35122989] (Bioassay, Mouse)
• D Yang, P Xu, H Su, W Zhong, J Xu, Z Su, X Liu The histone methyltransferase DOT1L is a new epigenetic regulator of pulmonary fibrosis Cell Death & Disease, 2022-01-17;13(1):60. 2022-01-17 [PMID: 35039472] (Bioassay, Mouse)
• A Jorapur, LA Marshall, S Jacobson, M Xu, S Marubayash, M Zibinsky, DX Hu, O Robles, JJ Jackson, V Baloche, P Busson, D Wustrow, DG Brockstedt, O Talay, PD Kassner, G Cutler EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22 PloS Pathogens, 2022-01-13;18(1):e1010200. 2022-01-13 [PMID: 35025968] (Bioassay, Mouse)
• BY Nam, JH Jhee, J Park, S Kim, G Kim, JT Park, TH Yoo, SW Kang, JW Yu, SH Han PGC-1alpha inhibits the NLRP3 inflammasome via preserving mitochondrial viability to protect kidney fibrosis Cell Death & Disease, 2022-01-10;13(1):31. 2022-01-10 [PMID: 35013155] (Bioassay, Mouse)
• Y Liu, W Zhong, J Zhang, W Chen, Y Lu, Y Qiao, Z Zeng, H Huang, S Cai, H Dong Tetrandrine Modulates Rheb-mTOR Signaling-Mediated Selective Autophagy and Protects Pulmonary Fibrosis Frontiers in Pharmacology, 2021-11-22;12(0):739220. 2021-11-22 [PMID: 34880752] (Bioassay, Mouse)
• J Chatterjee, S Sanapala, O Cobb, A Bewley, AK Goldstein, E Cordell, X Ge, JR Garbow, MJ Holtzman, DH Gutmann Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia Nature Communications, 2021-12-08;12(1):7122. 2021-12-08 [PMID: 34880260] (Bioassay, Mouse)
• KM Deng, XS Yang, Q Luo, YX She, QY Yu, XX Tang Deleterious Role of Th9 Cells in Pulmonary Fibrosis Cells, 2021-11-17;10(11):. 2021-11-17 [PMID: 34831433] (Bioassay, Mouse)
• P Chauhan, WS Sheng, S Hu, S Prasad, JR Lokensgard Differential Cytokine-Induced Responses of Polarized Microglia Brain sciences, 2021-11-10;11(11):. 2021-11-10 [PMID: 34827481] (Bioassay, Mouse)
• M Rogier, J Moritz, I Robert, C Lescale, V Heyer, A Abello, O Martin, K Capitani, M Thomas, AS Thomas-Cla, B Laffleur, F Jouan, E Pinaud, K Tarte, M Cogné, SG Conticello, E Soutoglou, L Deriano, B Reina-San- Fam72a enforces error-prone DNA repair during antibody diversification Nature, 2021-11-24;0(0):. 2021-11-24 [PMID: 34819671] (Bioassay, Mouse)
• Y Feng, C Li, JA Stewart, P Barbulescu, NS Desivo, A Álvarez-Qu, RC Pezo, MLW Perera, K Chan, AHY Tong, R Mohamad-Ra, M Berru, D Nakib, G Li, GA Kardar, JR Carlyle, J Moffat, D Durocher, JM Di Noia, AS Bhagwat, A Martin FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation Nature, 2021-11-24;0(0):. 2021-11-24 [PMID: 34819670] (Bioassay, Mouse)
• Y Shi, S Li, H Zhang, J Zhu, T Che, B Yan, J Li, C Liu The effect of macrophage polarization on the expression of the oxytocin signalling system in enteric neurons Journal of Neuroinflammation, 2021-11-08;18(1):261. 2021-11-08 [PMID: 34749758] (Bioassay, Mouse)
• HM Shih, SY Pan, CJ Wu, YH Chou, CY Chen, FC Chang, YT Chen, WC Chiang, HC Tsai, YM Chen, SL Lin Transforming growth factor-beta1 decreases erythropoietin production through repressing hypoxia-inducible factor 2alpha in erythropoietin-producing cells Journal of Biomedical Science, 2021-11-02;28(1):73. 2021-11-02 [PMID: 34724959] (Bioassay, Mouse)
• W Chen, J Zhang, W Zhong, Y Liu, Y Lu, Z Zeng, H Huang, X Wan, X Meng, F Zou, S Cai, H Dong Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis Frontiers in Pharmacology, 2021-09-16;12(0):744826. 2021-09-16 [PMID: 34603058] (Bioassay, Mouse)
• S Yamada, K Tsushima, M Kinoshita, H Sakashita, T Kajikawa, C Fujihara, H Yuan, S Suzuki, T Morisaki, S Murakami Mouse Model of Loeys-Dietz Syndrome Shows Elevated Susceptibility to Periodontitis via Alterations in Transforming Growth Factor-Beta Signaling Frontiers in Physiology, 2021-08-11;12(0):715687. 2021-08-11 [PMID: 34456753] (Bioassay, Mouse)
• A Agasing, JL Quinn, G Kumar, RC Axtell Interferon-beta Intensifies Interleukin-23-Driven Pathogenicity of T Helper Cells in Neuroinflammatory Disease Cells, 2021-08-20;10(8):. 2021-08-20 [PMID: 34440908] (Bioassay, Mouse)
• Y Choi, S Sim, DH Lee, HR Lee, GY Ban, YS Shin, YK Kim, HS Park Effect of TGF-beta1 on eosinophils to induce cysteinyl leukotriene E4 production in aspirin-exacerbated respiratory disease PLoS ONE, 2021-08-26;16(8):e0256237. 2021-08-26 [PMID: 34437574] (Bioassay, Mouse)
• SM Kim, WH Hur, BY Kang, SW Lee, PR Roh, DJ Park, PS Sung, SK Yoon Death-Associated Protein 6 (Daxx) Alleviates Liver Fibrosis by Modulating Smad2 Acetylation Cells, 2021-07-09;10(7):. 2021-07-09 [PMID: 34359912] (Bioassay, Mouse)
• Y Yokozeki, A Kawakubo, M Miyagi, A Kuroda, H Sekiguchi, G Inoue, M Takaso, K Uchida Reduced TGF-beta Expression and CD206-Positive Resident Macrophages in the Intervertebral Discs of Aged Mice BioMed Research International, 2021-07-12;2021(0):7988320. 2021-07-12 [PMID: 34337052] (Bioassay, Mouse)
• J Basu, BS Reis, S Peri, J Zha, X Hua, L Ge, K Ferchen, E Nicolas, P Czyzewicz, KQ Cai, Y Tan, JI Fuxman Bas, AJM Walhout, HL Grimes, SI Grivenniko, D Mucida, DJ Kappes Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4+ T cell identity and function Nature Immunology, 2021-07-26;22(8):969-982. 2021-07-26 [PMID: 34312548] (Bioassay, Mouse)
• Y Yokozeki, K Uchida, A Kawakubo, M Nakawaki, T Okubo, M Miyagi, G Inoue, M Itakura, H Sekiguchi, M Takaso TGF-beta regulates nerve growth factor expression in a mouse intervertebral disc injury model Bmc Musculoskeletal Disorders, 2021-07-23;22(1):634. 2021-07-23 [PMID: 34301215] (Bioassay, Mouse)
• J Fu, L Li, D Huo, R Yang, B Yang, B Xu, X Yang, M Dai, C Tan, H Chen, X Wang Meningitic Escherichia coli alpha-hemolysin aggravates blood-brain barrier disruption via targeting TGFbeta1-triggered hedgehog signaling Molecular Brain, 2021-07-19;14(1):116. 2021-07-19 [PMID: 34281571] (In Vivo, Mouse)
• J He, X Shangguan, W Zhou, Y Cao, Q Zheng, J Tu, G Hu, Z Liang, C Jiang, L Deng, S Wang, W Yang, Y Zuo, J Ma, R Cai, Y Chen, Q Fan, B Dong, W Xue, H Tan, Y Qi, J Gu, B Su, Y Eugene Chi, G Chen, Q Wang, T Wang, J Cheng Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development Nature Communications, 2021-07-16;12(1):4371. 2021-07-16 [PMID: 34272364] (Bioassay, Mouse)
• B Ng, AA Widjaja, S Viswanatha, J Dong, SP Chothani, S Lim, SG Shekeran, J Tan, NE McGregor, EC Walker, NA Sims, S Schafer, SA Cook Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis Scientific Reports, 2021-07-08;11(1):14088. 2021-07-08 [PMID: 34239012] (Bioassay, Mouse)
• J Zhou, X Zhang, J Hu, R Qu, Z Yu, H Xu, H Chen, L Yan, C Ding, Q Zou, Y Ye, Z Wang, RA Flavell, HB Li m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity Science Advances, 2021-06-16;7(25):. 2021-06-16 [PMID: 34134995] (Bioassay, Mouse)
• G Vasiukov, A Menshikh, P Owens, T Novitskaya, P Hurley, T Blackwell, I Feoktistov, SV Novitskiy Adenosine/TGF&amp;beta axis in regulation of mammary fibroblast functions PLoS ONE, 2021-06-08;16(6):e0252424. 2021-06-08 [PMID: 34101732] (Bioassay, Mouse)
• A Singh, M Dashynam, B Chim, TM Escobar, X Liu, X Hu, S Patnaik, X Xu, N Southall, J Marugan, A Jadhav, V Lazarevic, SA Muljo, M Ferrer Identification of Small Molecule Inhibitors of a Mir155 Transcriptional Reporter in Th17 Cells Scientific Reports, 2021-06-01;11(1):11498. 2021-06-01 [PMID: 34075120] (Bioassay, Mouse)
• E Pontemezzo, E Foglio, E Vernucci, A Magenta, M D'Agostino, S Sileno, E Astanina, F Bussolino, L Pellegrini, A Germani, MA Russo, F Limana miR-200c-3p Regulates Epitelial-to-Mesenchymal Transition in Epicardial Mesothelial Cells by Targeting Epicardial Follistatin-Related Protein 1 International Journal of Molecular Sciences, 2021-05-07;22(9):. 2021-05-07 [PMID: 34067060] (Bioassay, Mouse)
• C Guan, HF Zhang, YJ Wang, ZT Chen, BQ Deng, Q Qiu, SX Chen, MX Wu, YX Chen, JF Wang The Downregulation of ADAM17 Exerts Protective Effects against Cardiac Fibrosis by Regulating Endoplasmic Reticulum Stress and Mitophagy Oxidative Medicine and Cellular Longevity, 2021-05-06;2021(0):5572088. 2021-05-06 [PMID: 34035876] (Cell Culture, Mouse)
• J Zhou, N Zhang, W Zhang, C Lu, F Xu The YAP/HIF-1&amp;alpha/miR-182/EGR2 axis is implicated in asthma severity through the control of Th17 cell differentiation Cell & bioscience, 2021-05-12;11(1):84. 2021-05-12 [PMID: 33980319] (Bioassay, Mouse)
• MN Wosczyna, EE Perez Carb, MW Wagner, S Paredes, CT Konishi, L Liu, TT Wang, RA Walsh, Q Gan, CS Morrissey, TA Rando Targeting microRNA-mediated gene repression limits adipogenic conversion of skeletal muscle mesenchymal stromal cells Cell Stem Cell, 2021-05-03;0(0):. 2021-05-03 [PMID: 33945794] (Bioassay, Mouse)
• Y Zhang, Y Bian, Y Wang, Y Wang, X Duan, Y Han, L Zhang, F Wang, Z Gu, Z Qin HIF-1&amp;alpha is necessary for activation and tumour-promotion effect of cancer-associated fibroblasts in lung cancer Journal of Cellular and Molecular Medicine, 2021-05-04;0(0):. 2021-05-04 [PMID: 33943003] (Bioassay, Mouse)
• D Guan, Z Wang, J Huo, S Xu, KP Lam Bruton&#039;s tyrosine kinase regulates gut immune homeostasis through attenuating Th1 response Cell Death & Disease, 2021-04-30;12(5):431. 2021-04-30 [PMID: 33931590] (Bioassay, Mouse)
• JA Manning, SS Shah, A Nikolic, TL Henshall, Y Khew-Gooda, S Kumar The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease Cell Death & Disease, 2021-04-14;12(4):398. 2021-04-14 [PMID: 33854040] (Bioassay, Mouse)
• X Zhu, Y Du, D Li, J Xu, Q Wu, W He, K Zhang, J Zhu, L Guo, M Qi, A Liu, J Qi, G Wang, J Meng, Z Yang, K Zhang, Y Lu Aberrant TGF-&amp;beta1 signaling activation by MAF underlies pathological lens growth in high myopia Nature Communications, 2021-04-08;12(1):2102. 2021-04-08 [PMID: 33833231] (Cell Culture, Mouse)
• F Girardi, A Taleb, M Ebrahimi, A Datye, DG Gamage, C Peccate, L Giordani, DP Millay, PM Gilbert, B Cadot, F Le Grand TGF&amp;beta signaling curbs cell fusion and muscle regeneration Nature Communications, 2021-02-02;12(1):750. 2021-02-02 [PMID: 33531466] (Bioassay, Mouse)
• I Paredes, JR Vieira, B Shah, CF Ramunno, J Dyckow, H Adler, M Richter, G Schermann, E Giannakour, L Schirmer, HG Augustin, C Ruiz de Al Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor-endothelial cell crosstalk Nature Neuroscience, 2021-01-28;0(0):. 2021-01-28 [PMID: 33510480] (Bioassay, Mouse)
• SS Son, S Hwang, JH Park, Y Ko, SI Yun, JH Lee, B Son, TR Kim, HO Park, EY Lee In vivo silencing of amphiregulin by a novel effective Self-Assembled-Micelle inhibitory RNA ameliorates renal fibrosis via inhibition of EGFR signals Scientific Reports, 2021-01-26;11(1):2191. 2021-01-26 [PMID: 33500443] (Bioassay, Mouse)
• J Fu, L Li, D Huo, S Zhi, R Yang, B Yang, B Xu, T Zhang, M Dai, C Tan, H Chen, X Wang Astrocyte-Derived TGF&amp;beta1 Facilitates Blood-Brain Barrier Function via Non-Canonical Hedgehog Signaling in Brain Microvascular Endothelial Cells Brain sciences, 2021-01-08;11(1):. 2021-01-08 [PMID: 33430164] (Bioassay, Mouse)
• R Contreras-, R Elizondo-V, N Luque-Camp, MJ Torres, C Pradenas, G Tejedor, MJ Paredes-Ma, AM Vega-Lette, M Campos-Mor, Y Rigual-Gon, K Oyarce, M Salgado, C Jorgensen, M Khoury, MLÁ Garcia-Rob, C Altamirano, F Djouad, P Luz-Crawfo The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potential Theranostics, 2021-01-01;11(1):445-460. 2021-01-01 [PMID: 33391485] (Bioassay, Mouse)
• VK Rangasami, S Samanta, VS Parihar, K Asawa, K Zhu, OP Varghese, Y Teramura, B Nilsson, J Hilborn, RA Harris, OP Oommen Harnessing hyaluronic acid-based nanoparticles for combination therapy: A novel approach for suppressing systemic inflammation and to promote antitumor macrophage polarization Carbohydrate polymers, 2020-10-27;254(0):117291. 2020-10-27 [PMID: 33357860] (Bioassay, Mouse)
• R Kato, K Haratani, H Hayashi, K Sakai, H Sakai, H Kawakami, K Tanaka, M Takeda, K Yonesaka, K Nishio, K Nakagawa Nintedanib promotes antitumour immunity and shows antitumour activity in combination with PD-1 blockade in mice: potential role of cancer-associated fibroblasts British Journal of Cancer, 2020-12-10;0(0):. 2020-12-10 [PMID: 33299131] (Bioassay, Mouse)
• SW Clayton, GI Ban, C Liu, R Serra Canonical and noncanonical TGF-&amp;beta signaling regulate fibrous tissue differentiation in the axial skeleton Scientific Reports, 2020-12-07;10(1):21364. 2020-12-07 [PMID: 33288795] (Cell Culture, Mouse)
• A Nilchian, N Giotopoulo, W Sun, J Fuxe Different Regulation of Glut1 Expression and Glucose Uptake during the Induction and Chronic Stages of TGF&amp;beta1-Induced EMT in Breast Cancer Cells Biomolecules, 2020-12-01;10(12):. 2020-12-01 [PMID: 33271824] (Bioassay, Cell Culture, Mouse)
• H Yang, Y He, P Zou, Y Hu, X Li, L Tang, Z Zhu, S Tai, T Tu, Y Xiao, M Chen, C Wu, S Zhou Legumain is a predictor of all-cause mortality and potential therapeutic target in acute myocardial infarction Cell Death Dis, 2020-11-26;11(11):1014. 2020-11-26 [PMID: 33243972] (Cell Culture, Mouse)
• K Little, M Llorián-Sa, M Tang, X Du, S Marry, M Chen, H Xu Macrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degeneration J Neuroinflammation, 2020-11-25;17(1):355. 2020-11-25 [PMID: 33239022] (Cell Culture, Mouse)
• M Wang, H Xu, Y Li, C Cao, H Zhu, Y Wang, Z Zhao, G Pei, F Zhu, Q Yang, X Deng, C Zhou, Y Guo, J Wu, W Liao, J Yang, Y Yao, R Zeng Exogenous bone marrow derived-putative endothelial progenitor cells attenuate ischemia reperfusion-induced vascular injury and renal fibrosis in mice dependent on pericytes Theranostics, 2020-10-25;10(26):12144-12157. 2020-10-25 [PMID: 33204334] (In Vivo, Mouse)
• SH Shin, HY Kim, HS Yoon, WJ Park, DR Adams, NJ Pyne, S Pyne, JW Park A Novel Selective Sphingosine Kinase 2 Inhibitor, HWG-35D, Ameliorates the Severity of Imiquimod-Induced Psoriasis Model by Blocking Th17 Differentiation of Na�ve CD4 T Lymphocytes Int J Mol Sci, 2020-11-08;21(21):. 2020-11-08 [PMID: 33171607] (Bioassay, Mouse)
• D Ponikwicka, M Chrusciel, K Pulawska, P Bernaczyk, M Sztachelsk, P Guo, X Li, J Toppari, IT Huhtaniemi, S Wo?czy?ski, NA Rahman Mifepristone Treatment Promotes Testicular Leydig Cell Tumor Progression in Transgenic Mice Cancers (Basel), 2020-11-04;12(11):. 2020-11-04 [PMID: 33158280] (Bioassay, Mouse)
• K Masada, S Miyagawa, Y Sakai, A Harada, T Kanaya, Y Sawa Synthetic Prostacyclin Agonist Attenuates Pressure-Overloaded Cardiac Fibrosis by Inhibiting FMT Mol Ther Methods Clin Dev, 2020-09-16;19(0):210-219. 2020-09-16 [PMID: 33102614] (Bioassay, Mouse)
• X Zheng, Q Wang, X Yuan, Y Zhou, H Chu, G Wang, X Li, Y Wang, L Wei, L Wang, X Li B7-H4 Inhibits the Development of Primary Sj�gren&#039;s Syndrome by Regulating Treg Differentiation in NOD/Ltj Mice J Immunol Res, 2020-09-27;2020(0):4896727. 2020-09-27 [PMID: 33062721] (Bioassay, Mouse)
• Y Tashima, H He, JZ Cui, AJ Pedroza, K Nakamura, N Yokoyama, C Iosef, G Burdon, T Koyano, A Yamaguchi, MP Fischbein Androgens Accentuate TGF-&amp;beta Dependent Erk/Smad Activation During Thoracic Aortic Aneurysm Formation in Marfan Syndrome Male Mice J Am Heart Assoc, 2020-10-16;9(20):e015773. 2020-10-16 [PMID: 33059492] (Bioassay, Mouse)
• CH Pai, SR Lin, CH Liu, SY Pan, H Hsu, YT Chen, CT Yen, IS Yu, HL Wu, SL Lin, SW Lin Targeting fibroblast CD248 attenuates CCL17-expressing macrophages and tissue fibrosis Sci Rep, 2020-10-08;10(1):16772. 2020-10-08 [PMID: 33033277] (Bioassay, Mouse)
• W Pan, A Sharabi, AP Ferretti, Y Zhang, C Burbano, N Yoshida, MG Tsokos, GC Tsokos PPP2R2D suppresses interleukin-2 production and regulatory T cell function JCI Insight, 2020-10-02;5(19):. 2020-10-02 [PMID: 32897879] (Bioassay, Mouse)
• P Francica, M Mutlu, VA Blomen, C Oliveira, Z Nowicka, A Trenner, NM Gerhards, P Bouwman, E Stickel, ML Hekkelman, L Lingg, I Klebic, M van de Ven, R de Korte-G, D Howald, J Jonkers, AA Sartori, W Fendler, JR Chapman, T Brummelkam, S Rottenberg Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining Cell Rep, 2020-08-25;32(8):108068. 2020-08-25 [PMID: 32846126] (Bioassay, Mouse)
• C Cho, R Mukherjee, AR Peck, Y Sun, N McBrearty, KV Katlinski, J Gui, PK Govindaraj, E Puré, H Rui, SY Fuchs Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intratumoral stromagenesis Oncogene, 2020-08-17;0(0):. 2020-08-17 [PMID: 32807917] (Bioassay, Mouse)
• SK Meurer, O Tezcan, T Lammers, R Weiskirche Differential regulation of Lipocalin 2 (LCN2) in doxorubicin-resistant 4T1 triple negative breast cancer cells Cell. Signal., 2020-08-03;74(0):109731. 2020-08-03 [PMID: 32758668] (Bioassay, Mouse)
• YH Chou, SY Pan, YH Shao, HM Shih, SY Wei, CF Lai, WC Chiang, C Schrimpf, KC Yang, LC Lai, YM Chen, TS Chu, SL Lin Methylation in pericytes after acute injury promotes chronic kidney disease J. Clin. Invest., 2020-09-01;0(0):. 2020-09-01 [PMID: 32749240] (Bioassay, Cell Culture, Mouse)
• P Thapa, Y Gu, YS Kil, SC Baek, KH Kim, AR Han, EK Seo, H Choi, JH Chang, JW Nam N-Acetyldopamine derivatives from Periostracum Cicadae and their regulatory activities on Th1 and Th17 cell differentiation Bioorg. Chem., 2020-07-14;102(0):104095. 2020-07-14 [PMID: 32721777] (Bioassay, Mouse)
• RA Contreras-, R Elizondo-V, MJ Torres, AM Vega-Lette, N Luque-Camp, MJ Paredes-Ma, C Pradenas, G Tejedor, K Oyarce, M Salgado, C Jorgensen, M Khoury, G Kronke, MA Garcia-Rob, C Altamirano, P Luz-Crawfo, F Djouad PPAR&amp;beta/&amp;delta-dependent MSC metabolism determines their immunoregulatory properties Sci Rep, 2020-07-10;10(1):11423. 2020-07-10 [PMID: 32651456] (Bioassay, Mouse)
• Y Liu, R Bockermann, M Hadi, I Safari, B Carrion, M Kveiborg, S Issazadeh- ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation Cell. Mol. Immunol., 2020-06-22;0(0):. 2020-06-22 [PMID: 32572163] (Bioassay, Mouse)
• N Al-Azzam, LR Teegala, S Pokhrel, S Ghebreigzi, T Chachkovsk, S Thodeti, I Gavilanes, K Covington, CK Thodeti, S Paruchuri Transient Receptor Potential Vanilloid channel regulates fibroblast differentiation and airway remodeling by modulating redox signals through NADPH Oxidase 4 Sci Rep, 2020-06-17;10(1):9827. 2020-06-17 [PMID: 32555397] (Bioassay, Mouse)
• T Schmit, S Ghosh, RK Mathur, T Barnhardt, G Ambigapath, M Wu, C Combs, MN Khan IL-6 Deficiency Exacerbates Allergic Asthma and Abrogates the Protective Effect of Allergic Inflammation against Streptococcus pneumoniae Pathogenesis J. Immunol., 2020-06-15;0(0):. 2020-06-15 [PMID: 32540994] (Bioassay, Mouse)
• A Kim, L Han, K Yu Immunoglobulin Class Switch Recombination is initiated by rare cytosine deamination events at switch regions Mol. Cell. Biol., 2020-07-29;0(0):. 2020-07-29 [PMID: 32513818] (Bioassay, Mouse)
• A Adhyatmika, L Beljaars, KSS Putri, H Habibie, CE Boorsma, C Reker-Smit, T Luangmonko, B Guney, A Haak, KA Mangnus, E Post, K Poelstra, K Ravnskjaer, P Olinga, BN Melgert Osteoprotegerin is More than a Possible Serum Marker in Liver Fibrosis: A Study into its Function in Human and Murine Liver Pharmaceutics, 2020-05-21;12(5):. 2020-05-21 [PMID: 32455750] (Tissue Culture, Mouse)
• J Duerr, DHW Leitz, M Szczygiel, D Dvornikov, SG Fraumann, C Kreutz, PK Zadora, A Seyhan Agi, P Konietzke, TA Engelmann, J Hegermann, S Mulugeta, H Kawabe, L Knudsen, M Ochs, D Rotin, T Muley, M Kreuter, FJF Herth, MO Wielpütz, MF Beers, U Klingmülle, MA Mall Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice Nat Commun, 2020-04-24;11(1):2012. 2020-04-24 [PMID: 32332792] (Bioassay, Mouse)
• A Kurata, Y Tachibana, T Takahashi, N Horiba Novel AXL-specific inhibitor ameliorates kidney dysfunction through the inhibition of epithelial-to-mesenchymal transition of renal tubular cells PLoS ONE, 2020-04-23;15(4):e0232055. 2020-04-23 [PMID: 32324796] (Cell Culture, Rat)
• G Vasiukov, T Novitskaya, A Zijlstra, P Owens, F Ye, Z Zhao, HL Moses, T Blackwell, I Feoktistov, SV Novitskiy Myeloid cell-derived TGF-beta signaling regulates ECM deposition in mammary carcinoma via adenosine-dependent mechanisms Cancer Res., 2020-04-20;0(0):. 2020-04-20 [PMID: 32312837] (Bioassay, Mouse)
• AS Nelson, M Maddaloni, JR Abbott, C Hoffman, A Akgul, C Ohland, RZ Gharaibeh, C Jobin, TM Brusko, DW Pascual Oral therapy with colonization factor antigen I prevents development of type 1 diabetes in Non-obese Diabetic mice Sci Rep, 2020-04-09;10(1):6156. 2020-04-09 [PMID: 32273533] (ELISA Standard, Mouse)
• AJ Gunderson, T Yamazaki, K McCarty, N Fox, M Phillips, A Alice, T Blair, M Whiteford, D O'Brien, R Ahmad, MX Kiely, A Hayman, T Crocenzi, MJ Gough, MR Crittenden, KH Young TGF&amp;beta suppresses CD8+ T cell expression of CXCR3 and tumor trafficking Nat Commun, 2020-04-09;11(1):1749. 2020-04-09 [PMID: 32273499] (Bioassay, Mouse)
• H Gan, T Shen, DP Chupp, JR Taylor, HN Sanchez, X Li, Z Xu, H Zan, P Casali B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response Sci Adv, 2020-04-01;6(14):eaay2793. 2020-04-01 [PMID: 32270032] (Cell Culture, Mouse)
• JS Dolina, J Lee, RQ Griswold, L Labarta-Ba, S Kannan, JA Greenbaum, N Bahia El I, MJ Pont, M Croft, SP Schoenberg TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg Cell Rep, 2020-04-07;31(1):107249. 2020-04-07 [PMID: 32268093] (Bioassay, Mouse)
• D Kazadi, J Lim, G Rothschild, V Grinstein, B Laffleur, O Becherel, MJ Lavin, U Basu Effects of senataxin and RNA exosome on B-cell chromosomal integrity Heliyon, 2020-03-12;6(3):e03442. 2020-03-12 [PMID: 32195383] (Cell Culture, Mouse)
• JH Koo, DH Kim, D Cha, MJ Kang, JM Choi LRR domain of NLRX1 protein delivery by dNP2 inhibits T cell functions and alleviates autoimmune encephalomyelitis Theranostics, 2020-02-10;10(7):3138-3150. 2020-02-10 [PMID: 32194859] (Cell Culture, Mouse)
• AE Morelli, TL Sumpter, DM Rojas-Cana, M Bandyopadh, Z Chen, O Tkacheva, WJ Shufesky, CT Wallace, SC Watkins, A Berger, CJ Paige, LD Falo, AT Larregina Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells Cell Rep, 2020-03-10;30(10):3448-3465.e8. 2020-03-10 [PMID: 32160549] (Bioassay, Mouse)
• W Qian, X Cai, Q Qian Sirt1 antisense long non-coding RNA attenuates pulmonary fibrosis through sirt1-mediated epithelial-mesenchymal transition Aging (Albany NY), 2020-03-06;12(5):4322-4336. 2020-03-06 [PMID: 32139663] (Cell Culture, Mouse)
• K Ford, CJ Hanley, M Mellone, C Szyndralew, F Heitz, P Wiesel, O Wood, M Machado, MA Lopez, AP Ganesan, C Wang, A Chakravart, TR Fenton, EV King, P Vijayanand, CH Ottensmeie, A Al-Shamkha, N Savelyeva, GJ Thomas NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors Cancer Res., 2020-03-02;0(0):. 2020-03-02 [PMID: 32122909] (In Vivo, Mouse)
• FC Simões, TJ Cahill, A Kenyon, D Gavriouchk, JM Vieira, X Sun, D Pezzolla, C Ravaud, E Masmanian, M Weinberger, S Mayes, ME Lemieux, DN Barnette, M Gunadasa-R, RM Williams, DR Greaves, LA Trinh, SE Fraser, SL Dallas, RP Choudhury, T Sauka-Spen, PR Riley Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair Nat Commun, 2020-01-30;11(1):600. 2020-01-30 [PMID: 32001677] (Bioassay, Mouse)
• TJ Broekelman, NK Bodmer, RP Mecham Identification of the growth factor binding sequence in the extracellular matrix protein MAGP-1 J. Biol. Chem., 2020-01-27;0(0):. 2020-01-27 [PMID: 31988245] (Bioassay, Surface Plasmon Resonance, N/A, Rat)
• H Yan, M Fernandez, J Wang, S Wu, R Wang, Z Lou, JB Moroney, CE Rivera, JR Taylor, H Gan, H Zan, D Kolvaskyy, D Liu, P Casali, Z Xu B Cell Endosomal RAB7 Promotes TRAF6 K63 Polyubiquitination and NF-kappaB Activation for Antibody Class-Switching J. Immunol., 2020-01-13;204(5):1146-1157. 2020-01-13 [PMID: 31932498] (Bioassay, Transgenic Mouse)
• LF Hu, J Feng, X Dai, Y Sun, M Xiong, L Lai, S Zhong, C Yi, G Chen, H Li, Q Yang, Q Kuang, T Long, J Zhan, T Tang, C Ge, J Tan, M Xu Oral flavonoid fisetin treatment protects against prolonged high-fat-diet-induced cardiac dysfunction by regulation of multicombined signaling J. Nutr. Biochem., 2019-11-25;77(0):108253. 2019-11-25 [PMID: 31835147] (Bioassay, Mouse, Rat)
• MG Kim, J Yang, YS Ko, HY Lee, SW Oh, WY Cho, SK Jo Impact of aging on transition of acute kidney injury to chronic kidney disease Sci Rep, 2019-12-05;9(1):18445. 2019-12-05 [PMID: 31804508] (Bioassay, Mouse)
• HG Lee, LK Kim, JM Choi NFAT-Specific Inhibition by dNP2-VIVITAmeliorates Autoimmune Encephalomyelitisby Regulation of Th1 and Th17 Mol Ther Methods Clin Dev, 2019-10-23;16(0):32-41. 2019-10-23 [PMID: 31737742] (Cell Culture, Mouse)
• M Li, Y Zhao, D Qi, J He, D Wang Tangeretin attenuates lipopolysaccharide-induced acute lung injury through Notch signaling pathway via suppressing Th17?cell response in mice Microb. Pathog., 2019-10-29;138(0):103826. 2019-10-29 [PMID: 31676364] (Cell Culture, Mouse)
• P Kadam, E Ntemou, J Onofre, D Van Saen, E Goossens Does co-transplantation of mesenchymal and spermatogonial stem cells improve reproductive efficiency and safety in mice? Stem Cell Res Ther, 2019-10-22;10(1):310. 2019-10-22 [PMID: 31640769] (Bioassay, Mouse)
• W Zhou, Y Yang, C Mei, P Dong, S Mu, H Wu, Y Zhou, Y Zheng, F Guo, JQ Yang Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection Cells, 2019-10-16;8(10):. 2019-10-16 [PMID: 31623153] (Cell Culture, Mouse)
• AA Lombardi, AA Gibb, E Arif, DW Kolmetzky, D Tomar, TS Luongo, P Jadiya, EK Murray, PK Lorkiewicz, G Hajnóczky, E Murphy, ZP Arany, DP Kelly, KB Margulies, BG Hill, JW Elrod Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation Nat Commun, 2019-10-04;10(1):4509. 2019-10-04 [PMID: 31586055] (Cell Culture, Mouse)
• G Liu, MA Cooley, AG Jarnicki, T Borghuis, PM Nair, G Tjin, AC Hsu, TJ Haw, M Fricker, CL Harrison, B Jones, NG Hansbro, PA Wark, JC Horvat, WS Argraves, BG Oliver, DA Knight, JK Burgess, PM Hansbro Fibulin-1c regulates transforming growth factor-beta activation in pulmonary tissue fibrosis JCI Insight, 2019-07-25;5(0):. 2019-07-25 [PMID: 31343988] (Bioassay, Mouse)
• C Lao, X Zhou, H Chen, F Wei, Z Huang, C Bai 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives as inhibitors of full-length RORγt Bioorg. Chem., 2019-06-21;90(0):103077. 2019-06-21 [PMID: 31323598] (Cell Culture, Mouse)
• S Saraswati, SMW Marrow, LA Watch, PP Young Identification of a pro-angiogenic functional role for FSP1-positive fibroblast subtype in wound healing Nat Commun, 2019-07-09;10(1):3027. 2019-07-09 [PMID: 31289275] (Bioassay, Mouse)
• W Chen, H Yuan, W Cao, T Wang, W Chen, H Yu, Y Fu, B Jiang, H Zhou, H Guo, X Zhao Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activation Theranostics, 2019-05-31;9(14):3980-3991. 2019-05-31 [PMID: 31281526] (Bioassay, Rat)
• J Yang, B Wang, N Li, Q Zhou, W Zhou, Z Zhan Salvia miltiorrhiza and Carthamus tinctorius Extract Prevents Cardiac Fibrosis and Dysfunction after Myocardial Infarction by Epigenetically Inhibiting Smad3 Expression Evid Based Complement Alternat Med, 2019-05-30;2019(0):6479136. 2019-05-30 [PMID: 31275414] (Bioassay, Mouse)
• JQ Yang, KW Kalim, Y Li, Y Zheng, F Guo Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation J. Leukoc. Biol., 2019-07-01;0(0):. 2019-07-01 [PMID: 31260596] (Bioassay, Mouse)
• J Tan, Y Wang, S Wang, S Wu, Z Yuan, X Zhu Label-free quantitative proteomics identifies transforming growth factorβ1 (TGF-?1) as an inhibitor of adipogenic transformation in OP9-DL1 cells and primary thymic stromal cells Cell Biosci, 2019-06-14;9(0):48. 2019-06-14 [PMID: 31249661] (Bioassay, Mouse)
• J Jung, YJ Lee, YH Choi, EM Park, HS Kim, JL Kang Gas6 Prevents Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells via Production of PGE2, PGD2 and Their Receptors Cells, 2019-06-26;8(7):. 2019-06-26 [PMID: 31247991] (Bioassay, Mouse)
• J Li, A Ayoub, Y Xiu, X Yin, JO Sanders, A Mesfin, L Xing, Z Yao, BF Boyce TGFbeta-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis Nat Commun, 2019-06-26;10(1):2795. 2019-06-26 [PMID: 31243287] (Bioassay, Mouse)
• J Ren, L Han, J Tang, Y Liu, X Deng, Q Liu, P Hao, X Feng, B Li, H Hu, H Wang Foxp1 is critical for the maintenance of regulatory T-cell homeostasis and suppressive function PLoS Biol., 2019-05-24;17(5):e3000270. 2019-05-24 [PMID: 31125332] (Bioassay, Mouse)
• DK Kaushik, A Bhattachar, R Mirzaei, KS Rawji, Y Ahn, JM Rho, VW Yong Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis J. Clin. Invest., 2019-05-21;130(0):. 2019-05-21 [PMID: 31112527] (Cell Culture, Mouse)
• M Feng, JQ Jin, L Xia, T Xiao, S Mei, X Wang, X Huang, J Chen, M Liu, C Chen, S Rafi, AX Zhu, YX Feng, D Zhu Pharmacological inhibition of ?-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating Treg cells Sci Adv, 2019-05-08;5(5):eaau5240. 2019-05-08 [PMID: 31086813] (Bioassay, Human, Mouse)
• L Nicolas, M Cols, R Smolkin, KC Fernandez, WT Yewdell, WF Yen, S Zha, BQ Vuong, J Chaudhuri Cutting Edge: ATM Influences Germinal Center Integrity J. Immunol., 2019-04-26;0(0):. 2019-04-26 [PMID: 31028119] (Bioassay, Mouse)
• A Abdullah, M Maged, I Hairul-Isl, A Osama I, H Maha, A Manal, H Hamza Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis PLoS ONE, 2019-04-26;14(4):e0215981. 2019-04-26 [PMID: 31026283] (Bioassay, Mouse)
• G Chen, Y Ni, N Nagata, L Xu, F Zhuge, M Nagashimad, S Kaneko, T Ota Pirfenidone prevents and reverses hepatic insulin resistance and steatohepatitis by polarizing M2 macrophages Lab. Invest., 2019-04-24;0(0):. 2019-04-24 [PMID: 31019294] (Bioassay, Rat)
• DH Kim, HJ Park, HS Park, JU Lee, C Ko, MC Gye, JM Choi Estrogen receptor ? in T cells suppresses follicular helper T cell responses and prevents autoimmunity Exp. Mol. Med., 2019-04-15;51(4):41. 2019-04-15 [PMID: 30988419] (Bioassay, Mouse)
• J Kaiser, M Maibach, I Salpeter, N Hagenbuch, VBC de Souza, MD Robinson, ME Schwab The Spinal Transcriptome after Cortical Stroke: In Search of Molecular Factors Regulating Spontaneous Recovery in the Spinal Cord J. Neurosci., 2019-04-08;39(24):4714-4726. 2019-04-08 [PMID: 30962276] (Bioassay, Rat)
• J Yang, M Wang, F Zhu, J Sun, H Xu, OL Chong Lee, Z Zhao, G Pei, H Zhu, C Cao, X He, Y Huang, Z Ma, L Liu, L Wang, Y Ning, W Liu, G Xu, X Wang, R Zeng, Y Yao Putative endothelial progenitor cells do not promote vascular repair but attenuate pericyte-myofibroblast transition in UUO-induced renal fibrosis Stem Cell Res Ther, 2019-03-21;10(1):104. 2019-03-21 [PMID: 30898157] (Bioassay, Mouse)
• H Sonoda, BR Lee, KH Park, D Nihalani, JH Yoon, M Ikeda, SH Kwon miRNA profiling of urinary exosomes to assess the progression of acute kidney injury Sci Rep, 2019-03-18;9(1):4692. 2019-03-18 [PMID: 30886169] (Bioassay, Mouse, Rat)
• JS Park, Y Oh, YJ Park, O Park, H Yang, S Slania, LK Hummers, AA Shah, HT An, J Jang, MR Horton, J Shin, HC Dietz, E Song, DH Na, EJ Park, K Kim, KC Lee, VV Roschke, J Hanes, MG Pomper, S Lee Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma Nat Commun, 2019-03-08;10(1):1128. 2019-03-08 [PMID: 30850660] (Bioassay, Mouse)
• HS Cho, A Reboldi, JA Hall, LJ Berg The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine Nat Commun, 2019-02-15;10(1):784. 2019-02-15 [PMID: 30770814] (Bioassay, Mouse)
• HG Lee, JU Lee, DH Kim, S Lim, I Kang, JM Choi Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis Nat Commun, 2019-02-12;10(1):709. 2019-02-12 [PMID: 30755603] (Bioassay, Mouse)
• KL Graham, BJ Werner, KM Moyer, AK Patton, CR Krois, HS Yoo, M Tverskoy, M LaJevic, JL Napoli, RA Sobel, BA Zabel, EC Butcher DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis Proc. Natl. Acad. Sci. U.S.A., 2019-02-04;0(0):. 2019-02-04 [PMID: 30718413] (Bioassay, Mouse)
• V Bellver-La, F Bretheau, B Mailhot, N Vallières, M Lessard, ME Janelle, N Vernoux, MÈ Tremblay, T Fuehrmann, MS Shoichet, S Lacroix Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury Nat Commun, 2019-01-31;10(1):518. 2019-01-31 [PMID: 30705270] (Bioassay, Mouse)
• G Di Dalmazi, P Chalan, P Caturegli MYMD-1, a Novel Immunometabolic Regulator, Ameliorates Autoimmune Thyroiditis via Suppression of Th1 Responses and TNF-? Release J. Immunol., 2019-01-23;0(0):. 2019-01-23 [PMID: 30674573] (Bioassay, Mouse)
• K Paduch, A Debus, B Rai, U Schleicher, C Bogdan Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1 J. Immunol., 2019-01-21;0(0):. 2019-01-21 [PMID: 30665936] (Bioassay, Mouse)
• M de la Fuen, R Olguín-Alo, S Ortega-Fra, LC Bonifaz, G Soldevila Inhibins regulate peripheral regulatory T cell induction through modulation of dendritic cell function FEBS Open Bio, 2018-12-11;9(1):137-147. 2018-12-11 [PMID: 30652081] (Bioassay, Mouse)
• J Gilleron, G Bouget, S Ivanov, C Meziat, F Ceppo, B Vergoni, M Djedaini, A Soprani, K Dumas, A Jacquel, L Yvan-Charv, N Venteclef, JF Tanti, M Cormont Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance Cell Rep, 2018-12-18;25(12):3329-3341.e5. 2018-12-18 [PMID: 30566860] (Bioassay, Mouse)
• L Qian, H Zhang, Y Gu, D Li, S He, H Wang, Y Cheng, W Yang, H Yu, X Zhao, W Cai, L Meng, M Jin, Y Wang, Y Zhang Reduced production of laminin by hepatic stellate cells contributes to impairment in oval cell response to liver injury in aged mice Aging (Albany NY), 2018-12-04;0(0):. 2018-12-04 [PMID: 30513510] (Bioassay, Mouse)
• A Calcinotto, A Brevi, M Chesi, R Ferrarese, L Garcia Per, M Grioni, S Kumar, VM Garbitt, ME Sharik, KJ Henderson, G Tonon, M Tomura, Y Miwa, E Esplugues, RA Flavell, S Huber, F Canducci, VS Rajkumar, PL Bergsagel, M Bellone Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression Nat Commun, 2018-12-03;9(1):4832. 2018-12-03 [PMID: 30510245] (Bioassay, Mouse)
• W Liu, Y Cui, J Sun, L Cai, J Xie, X Zhou Transforming growth factor-?1 up-regulates connexin43 expression in osteocytes via canonical Smad-dependent signaling pathway Biosci. Rep., 2018-12-14;0(0):. 2018-12-14 [PMID: 30482881] (Bioassay, Mouse)
• P Kadam, E Ntemou, Y Baert, S Van Laere, D Van Saen, E Goossens Co-transplantation of mesenchymal stem cells improves spermatogonial stem cell transplantation efficiency in mice Stem Cell Res Ther, 2018-11-21;9(1):317. 2018-11-21 [PMID: 30463610] (Bioassay, Mouse)
• S Sharma, R Goswami, DX Zhang, SO Rahaman TRPV4 regulates matrix stiffness and TGF?1-induced epithelial-mesenchymal transition J. Cell. Mol. Med., 2018-11-18;0(0):. 2018-11-18 [PMID: 30450767] (Bioassay, Mouse)
• H Terashima, M Aonuma, H Tsuchida, K Sugimoto, M Yokoyama, M Kato Attenuation of pulmonary fibrosis in type I collagen-targeted reporter mice with ALK-5 inhibitors Pulm Pharmacol Ther, 2018-11-15;0(0):. 2018-11-15 [PMID: 30448291] (Bioassay, Mouse)
• K Souma, S Shichino, S Hashimoto, S Ueha, T Tsukui, T Nakajima, HI Suzuki, FHW Shand, Y Inagaki, T Nagase, K Matsushima Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-?-associated fibroblast activation in murine pulmonary fibrosis Sci Rep, 2018-11-09;8(1):16642. 2018-11-09 [PMID: 30413725] (Bioassay, Mouse)
• MN Lee, HS Hwang, SH Oh, A Roshanzade, JW Kim, JH Song, ES Kim, JT Koh Elevated extracellular calcium ions promote proliferation and migration of mesenchymal stem cells via increasing osteopontin expression Exp. Mol. Med., 2018-11-05;50(11):142. 2018-11-05 [PMID: 30393382] (Bioassay, Mouse)
• F Sasaki, T Koga, M Ohba, K Saeki, T Okuno, K Ishikawa, T Nakama, S Nakao, S Yoshida, T Ishibashi, H Ahmadieh, MR Kanavi, A Hafezi-Mog, JM Penninger, KH Sonoda, T Yokomizo Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models JCI Insight, 2018-09-20;3(18):. 2018-09-20 [PMID: 30232269] (Bioassay, Mouse)
• HC Chuang, CY Tsai, CH Hsueh, TH Tan GLK-IKK? signaling induces dimerization and translocation of the AhR-ROR?t complex in IL-17A induction and autoimmune disease Sci Adv, 2018-09-12;4(9):eaat5401. 2018-09-12 [PMID: 30214937] (Bioassay, Mouse)
• HA Ting, D de Almeida, AJ Rasky, CA Malinczak, IP Maillard, MA Schaller, NW Lukacs Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infection Mucosal Immunol, 2018-07-23;0(0):. 2018-07-23 [PMID: 30038214] (Bioassay, Mouse)
• SM Noordermee, S Adam, D Setiaputra, M Barazas, SJ Pettitt, AK Ling, M Olivieri, A Álvarez-Qu, N Moatti, M Zimmermann, S Annunziato, DB Krastev, F Song, I Brandsma, J Frankum, R Brough, A Sherker, S Landry, RK Szilard, MM Munro, A McEwan, T Goullet de, ZY Lin, T Hart, J Moffat, AC Gingras, A Martin, H van Attiku, J Jonkers, CJ Lord, S Rottenberg, D Durocher The shieldin complex mediates 53BP1-dependent DNA repair Nature, 2018-07-18;560(7716):117-121. 2018-07-18 [PMID: 30022168] (Bioassay, Mouse)
• X Zhang, X Xiao, P Lan, J Li, Y Dou, W Chen, N Ishii, S Chen, B Xia, K Chen, E Taparowsky, XC Li OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms Cell Rep, 2018-07-17;24(3):607-618. 2018-07-17 [PMID: 30021159] (Bioassay, Mouse)
• Y Nam, SM Jung, YA Rim, H Jung, K Lee, N Park, J Kim, Y Jang, YB Park, SH Park, JH Ju Intraperitoneal infusion of mesenchymal stem cell attenuates severity of collagen antibody induced arthritis PLoS ONE, 2018-06-07;13(6):e0198740. 2018-06-07 [PMID: 29879214] (Bioassay, Mouse)
• S Lively, D Lam, R Wong, LC Schlichter Comparing Effects of Transforming Growth Factor ?1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels Front Cell Neurosci, 2018-05-03;12(0):115. 2018-05-03 [PMID: 29780305] (Bioassay, Mouse)
• R Seitz, G Weber, S Albrecht, R Fuchshofer, ER Tamm, A Ohlmann Cross-Inhibition of Norrin and TGF-? Signaling Modulates Development of Retinal and Choroidal Vasculature Invest. Ophthalmol. Vis. Sci., 2018-05-01;59(6):2240-2251. 2018-05-01 [PMID: 29715368] (Bioassay, Mouse)
• XP Zhao, SY Chang, MC Liao, CS Lo, I Chenier, H Luo, JL Chiasson, JR Ingelfinge, JSD Chan, SL Zhang Hedgehog Interacting Protein Promotes Fibrosis and Apoptosis in Glomerular Endothelial Cells in Murine Diabetes Sci Rep, 2018-04-13;8(1):5958. 2018-04-13 [PMID: 29654303] (Bioassay, Mouse)
• AR Jensen, BV Kelley, GM Mosich, A Ariniello, CD Eliasberg, B Vu, P Shah, SK Devana, IR Murray, B Péault, A Dar, FA Petriglian Neer Award 2018: Platelet-derived growth factor receptor α co-expression typifies a subset of platelet-derived growth factor receptor β-positive progenitor cells that contribute to fatty degeneration and fibrosis of the murine rotator cuff J Shoulder Elbow Surg, 2018-04-10;0(0):. 2018-04-10 [PMID: 29653843] (Bioassay, Mouse)
• Y Han, Q Liu, J Hou, Y Gu, Y Zhang, Z Chen, J Fan, W Zhou, S Qiu, Y Zhang, T Dong, N Li, Z Jiang, H Zhu, Q Zhang, Y Ma, L Zhang, Q Wang, Y Yu, N Li, X Cao Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression Cell, 2018-03-29;0(0):. 2018-03-29 [PMID: 29606356] (Bioassay, Mouse)
• DJ Sharkey, DJ Glynn, JE Schjenken, KP Tremellen, SA Robertson Interferon-gamma inhibits seminal plasma induction of colony stimulating factor 2 in mouse and human reproductive tract epithelial cells Biol. Reprod., 2018-09-01;0(0):. 2018-09-01 [PMID: 29596569] (Bioassay, Mouse)
• G Meyer Zu H, D Przybylski, MA Schramm, C Wang, A Schnell, Y Lee, R Sobel, A Regev, VK Kuchroo Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1 Immunity, 2018-03-20;48(3):556-569.e7. 2018-03-20 [PMID: 29562202] (Bioassay, Mouse)
• S Rangaraju, SA Raza, NX Li, R Betarbet, EB Dammer, D Duong, JJ Lah, NT Seyfried, AI Levey Differential Phagocytic Properties of CD45lowMicroglia and CD45highBrain Mononuclear Phagocytes-Activation and Age-Related Effects Front Immunol, 2018-03-02;9(0):405. 2018-03-02 [PMID: 29552013] (Bioassay, Mouse)
• C Li, T Irrazabal, CC So, M Berru, L Du, E Lam, AK Ling, JL Gommerman, Q Pan-Hammar, A Martin The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining Nat Commun, 2018-03-08;9(1):1006. 2018-03-08 [PMID: 29520062] (Bioassay, Mouse)
• J Youm, H Lee, Y Choi, J Yoon DW2008S and its major constituents from Justicia procumbens exert anti-asthmatic effect via multitargeting activity J. Cell. Mol. Med., 2018-03-07;0(0):. 2018-03-07 [PMID: 29512870] (Bioassay, Mouse)
• T Sakabe, K Sakai, T Maeda, A Sunaga, N Furuta, R Schweitzer, T Sasaki, T Sakai Transcription factor scleraxis vitally contributes to progenitor lineage direction in wound healing of adult tendon in mice J. Biol. Chem., 2018-03-05;0(0):. 2018-03-05 [PMID: 29507095] (Bioassay, Mouse)
• B Sun, L Zhu, Y Tao, HX Sun, Y Li, P Wang, Y Hou, Y Zhao, X Zhang, L Zhang, N Na, Y Zhao Characterization and allergic role of IL-33-induced neutrophil polarization Cell. Mol. Immunol., 2018-03-05;0(0):. 2018-03-05 [PMID: 29503441] (Bioassay, Mouse)
• K Lee, N Park, H Jung, YA Rim, Y Nam, J Lee, SH Park, JH Ju Mesenchymal stem cells ameliorate experimental arthritis via expression of interleukin-1 receptor antagonist PLoS ONE, 2018-02-26;13(2):e0193086. 2018-02-26 [PMID: 29481574] (Bioassay, Mouse)
• J Zhang, J Shan, X Chen, S Li, D Long, Y Li Celastrol mediates Th17 and Treg cell generation via metabolic signaling Biochem. Biophys. Res. Commun., 2018-02-21;0(0):. 2018-02-21 [PMID: 29476742] (Bioassay, Mouse)
• MY Jung, JH Kang, DM Hernandez, X Yin, M Andrianifa, Y Wang, A Gonzalez-G, AH Limper, R Lupu, EB Leof Fatty acid synthase is required for profibrotic TGF-? signaling FASEB J., 2018-02-16;0(0):fj201701187R. 2018-02-16 [PMID: 29475397] (Bioassay, Mouse)
• CC Liang, CS Li, IC Weng, HY Chen, HH Lu, CC Huang, FT Liu Galectin-9 is Critical for Mucosal Adaptive Immunity through the TH17-IgA Axis Am. J. Pathol., 2018-02-17;0(0):. 2018-02-17 [PMID: 29458010] (Bioassay, Mouse)
• S Hagiwara, K Sourris, M Ziemann, W Tieqiao, M Mohan, AD McClelland, E Brennan, J Forbes, M Coughlan, B Harcourt, S Penfold, B Wang, G Higgins, R Pickering, A El-Osta, MC Thomas, ME Cooper, P Kantharidi RAGE Deletion Confers Renoprotection by Reducing Responsiveness to Transforming Growth Factor-? and Increasing Resistance to Apoptosis Diabetes, 2018-02-15;0(0):. 2018-02-15 [PMID: 29449307] (Bioassay, Mouse)
• H Zhong, Y Liu, Z Xu, P Liang, H Yang, X Zhang, J Zhao, J Chen, S Fu, Y Tang, J Lv, J Wang, N Olsen, A Xu, SG Zheng TGF-?-Induced CD8CD103Regulatory T Cells Show Potent Therapeutic Effect on Chronic Graft-versus-Host Disease Lupus by Suppressing B Cells Front Immunol, 2018-01-30;9(0):35. 2018-01-30 [PMID: 29441062] (Cell Culture, Mouse)
• JR Podojil, I Hecht, MY Chiang, I Vaknin, I Barbiro, A Novik, E Neria, G Rotman, SD Miller ILDR2-Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance J. Immunol., 2018-02-05;0(0):. 2018-02-05 [PMID: 29431690] (Bioassay, Mouse)
• A Nishikimi, YI Koyama, S Ishihara, S Kobayashi, C Tometsuka, M Kusubata, K Kuwaba, O Hayashida, S Hattori, K Katagiri Collagen-derived peptides modulate CD4T-cell differentiation and suppress allergic responses in mice Immun Inflamm Dis, 2018-02-01;0(0):. 2018-02-01 [PMID: 29388365] (Bioassay, Mouse)
• SK Varanasi, U Jaggi, N Hay, BT Rouse Hexokinase II may be dispensable for CD4 T cell responses against a virus infection PLoS ONE, 2018-01-19;13(1):e0191533. 2018-01-19 [PMID: 29352298] (Bioassay, Mouse)
• RA Panchaksha, X Zhang, V Kumar, Z Du, PC Wei, J Kao, J Dong, FW Alt DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions Proc. Natl. Acad. Sci. U.S.A., 2018-01-08;0(0):. 2018-01-08 [PMID: 29311308] (Bioassay, Mouse)
• T He, Y Huang, C Zhang, D Liu, C Cheng, W Xu, X Zhang Interleukin-17A-promoted MSC2 polarization related with new bone formation of ankylosing spondylitis Oncotarget, 2017-09-11;8(57):96993-97008. 2017-09-11 [PMID: 29228588] (Bioassay, Mouse)
• T Rivera Var, Z Cai, Y Shen, M Dosset, I Benoit-Liz, T Martin, A Roussey, RA Flavell, F Ghiringhel, L Apetoh Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells Nat Commun, 2017-09-15;8(1):559. 2017-09-15 [PMID: 28916785] (Bioassay, Mouse)
• SMP Vadevoo, JE Kim, GR Gunassekar, HK Jung, L Chi, DE Kim, SH Lee, SH Im, B Lee Interleukin 4 receptor-targeted pro-apoptotic peptide blocks tumor growth and metastasis by enhancing anti-tumor immunity Mol. Cancer Ther., 2017-09-06;0(0):. 2017-09-06 [PMID: 28878029] (Bioassay, Mouse)
• SH Lee, JY Kwon, SY Kim, K Jung, ML Cho Interferon-gamma regulates inflammatory cell death by targeting necroptosis in experimental autoimmune arthritis Sci Rep, 2017-08-31;7(1):10133. 2017-08-31 [PMID: 28860618] (Bioassay, Mouse)
• M Turcotte, D Allard, D Mittal, Y Bareche, L Buisseret, V Jose, S Pommey, V Delisle, S Loi, H Joensuu, PL Kellokumpu, C Sotiriou, MJ Smyth, J Stagg CD73 promotes resistance to HER2/ErbB2 antibody therapy Cancer Res., 2017-08-30;0(0):. 2017-08-30 [PMID: 28855210] (Bioassay, Mouse)
• MH Ross, AK Esser, GC Fox, AH Schmieder, X Yang, G Hu, D Pan, X Su, Y Xu, DV Novack, T Walsh, GA Colditz, GH Lukaszewic, E Cordell, JS Novack, JAJ Fitzpatric, DL Waning, KS Mohammad, TA Guise, GM Lanza, KN Weilbaeche Bone-induced expression of integrin ?3 enables targeted nanotherapy of breast cancer metastases Cancer Res., 2017-08-30;0(0):. 2017-08-30 [PMID: 28855208] (Bioassay, Mouse)
• TS Zaman, H Arimochi, S Maruyama, C Ishifune, SI Tsukumo, A Kitamura, K Yasutomo Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 Expression J. Immunol., 2017-08-04;0(0):. 2017-08-04 [PMID: 28779023] (Bioassay, Mouse)
• SK Varanasi, D Donohoe, U Jaggi, BT Rouse Manipulating Glucose Metabolism during Different Stages of Viral Pathogenesis Can Have either Detrimental or Beneficial Effects J. Immunol., 2017-08-02;0(0):. 2017-08-02 [PMID: 28768727] (Bioassay, Mouse)
• T Hosokawa, T Kimura, S Nada, T Okuno, D Ito, S Kang, S Nojima, K Yamashita, T Nakatani, Y Hayama, Y Kato, Y Kinehara, M Nishide, N Mikami, S Koyama, H Takamatsu, D Okuzaki, N Ohkura, S Sakaguchi, M Okada, A Kumanogoh Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function J. Immunol., 2017-08-02;0(0):. 2017-08-02 [PMID: 28768723] (Bioassay, Mouse)
• M Fernández, EM Monsalve, S López-Lópe, A Ruiz-Garcí, S Mellado, E Caminos, JJ García-Ram, J Laborda, P Tranque, MJM Díaz-Guerr Absence of Notch1 in murine myeloid cells attenuates the development of experimental autoimmune encephalomyelitis by affecting Th1 and Th17 priming Eur. J. Immunol., 2017-08-31;0(0):. 2017-08-31 [PMID: 28762472] (Bioassay, Mouse)
• W Pan, WT Hao, YJ Shen, XY Li, YJ Wang, FF Sun, JH Yin, J Zhang, RX Tang, JP Cao, KY Zheng The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells Parasit Vectors, 2017-07-21;10(1):348. 2017-07-21 [PMID: 28732522] (Bioassay, Mouse)
• X Li, AR Cannon, AM Hammer, NL Morris, MA Choudhry IL-23 restoration of Th17 effector function is independent of IL-6 and TGF-? in a mouse model of alcohol and burn injury J. Leukoc. Biol., 2017-07-06;0(0):. 2017-07-06 [PMID: 28684599] (Bioassay, Mouse)
• Z You, M Timilshina, BS Jeong, JH Chang BJ-2266 ameliorates experimental autoimmune encephalomyelitis through down-regulation of the JAK/STAT signaling pathway Eur. J. Immunol., 2017-07-26;0(0):. 2017-07-26 [PMID: 28681958] (Bioassay, Mouse)
• M Billing, E Rörby, M Dahl, U Blank, S Andradottí, MM Matzuk, M Ehinger, S Karlsson Signaling via Smad2 and Smad3 is dispensable for adult murine hematopoietic stem cell function in vivo Exp. Hematol., 2017-06-27;0(0):. 2017-06-27 [PMID: 28666967] (Bioassay, Mouse)
• R Tang, G Zhang, YC Wang, X Mei, SY Chen The long non-coding RNA GAS5 regulates TGF-?-induced smooth muscle cell differentiation via RNA-Smad binding element J. Biol. Chem., 2017-06-28;0(0):. 2017-06-28 [PMID: 28659340] (Bioassay, Mouse)
• J Ye, Y Wang, X Liu, L Li, A Opejin, EC Hsueh, H Luo, T Wang, D Hawiger, G Peng TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy J. Immunol., 2017-06-26;0(0):. 2017-06-26 [PMID: 28652396] (Bioassay, Mouse)
• HP Thu Le, Y Nakamura, K Oh-Oka, K Ishimaru, S Nakajima, A Nakao The frequency of Th17�cells in the small intestine exhibits a day-night variation dependent on circadian clock activity Biochem. Biophys. Res. Commun., 2017-06-12;0(0):. 2017-06-12 [PMID: 28619514] (Bioassay, Mouse)
• IA Mufazalov, J Kuschmann, D Andruszews, J Masri, LA Gabriel, P Adams, S Reissig, N Hövelmeyer, A Waisman Balanced Bcl-3 expression in murine CD4(+) T cells is required for generation of encephalitogenic Th17 cells Eur. J. Immunol., 2017-06-29;0(0):. 2017-06-29 [PMID: 28598502] (Bioassay, Mouse)
• X Liu, Y Liu, X Li, J Zhao, Y Geng, W Ning Follistatin like-1 (Fstl1) is required for the normal formation of lung airway and vascular smooth muscle at birth PLoS ONE, 2017-06-02;12(6):e0177899. 2017-06-02 [PMID: 28574994] (Bioassay, Mouse)
• E Campos-San, N Deleyto-Se, V Dominguez, E Carrillo-d, K Ura, PP Rocha, J Kim, A Aljoufi, A Esteve-Cod, M Dabad, M Gut, H Heyn, Y Kaneda, K Nimura, JA Skok, ML Martinez-F, C Cobaleda Wolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development Cell Rep, 2017-05-23;19(8):1586-1601. 2017-05-23 [PMID: 28538178] (Bioassay, Mouse)
• E Oh, JY Kim, D Sung, Y Cho, N Lee, H An, YJ Kim, TM Cho, JH Seo Inhibition of ubiquitin-specific protease 34 (USP34) induces epithelial-mesenchymal transition and promotes stemness in mammary epithelial cells Cell. Signal., 2017-05-10;36(0):230-239. 2017-05-10 [PMID: 28499884] (Bioassay, Mouse)
• XW Chen, TJ Yu, J Zhang, Y Li, HL Chen, GF Yang, W Yu, YZ Liu, XX Liu, CF Duan, HL Tang, M Qiu, CL Wang, H Zheng, J Yue, AM Guo, J Yang CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis Oncogene, 2017-05-08;0(0):. 2017-05-08 [PMID: 28481877] (Bioassay, Mouse)
• D Daley, VR Mani, N Mohan, N Akkad, GSDB Pandian, S Savadkar, KB Lee, A Torres-Her, B Aykut, B Diskin, W Wang, MS Farooq, AI Mahmud, G Werba, EJ Morales, S Lall, BJ Wadowski, AG Rubin, ME Berman, R Narayanan, M Hundeyin, G Miller NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma J. Exp. Med., 2017-04-25;0(0):. 2017-04-25 [PMID: 28442553] (Bioassay, Mouse)
• J Lim, PK Giri, D Kazadi, B Laffleur, W Zhang, V Grinstein, E Pefanis, LM Brown, E Ladewig, O Martin, Y Chen, R Rabadan, F Boyer, G Rothschild, M Cogné, E Pinaud, H Deng, U Basu Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry Cell, 2017-04-20;169(3):523-537.e15. 2017-04-20 [PMID: 28431250] (Bioassay, Mouse)
• A Soofi, KI Wolf, MP Emont, N Qi, G Martinez-S, E Grimley, W Ostwani, GR Dressler The Kielin/chordin-like Protein (KCP) Attenuates High Fat Diet Induced Obesity and Metabolic Syndrome in Mice J. Biol. Chem., 2017-04-19;0(0):. 2017-04-19 [PMID: 28424263] (Bioassay, Mouse)
• Y Liu, F Lu, L Kang, Z Wang, Y Wang Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium BMC Pulm Med, 2017-04-18;17(1):63. 2017-04-18 [PMID: 28420366] (Bioassay, Mouse)
• G Fu, Q Xu, Y Qiu, X Jin, T Xu, S Dong, J Wang, Y Ke, H Hu, X Cao, D Wang, H Cantor, X Gao, L Lu Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1 J. Exp. Med., 2017-04-11;0(0):. 2017-04-11 [PMID: 28400474] (Bioassay, Mouse)
• Q Bian, L Ma, A Jain, JL Crane, K Kebaish, M Wan, Z Zhang, X Edward Guo, PD Sponseller, CA Séguin, LH Riley, Y Wang, X Cao Mechanosignaling activation of TGF? maintains intervertebral disc homeostasis Bone Res, 2017-03-21;5(0):17008. 2017-03-21 [PMID: 28392965] (Bioassay, Mouse)
• L Chen, W Zeng, B Yang, X Cui, C Feng, L Wang, H Wang, X Zhou, P Li, F Lv, T Li Expression of antisense of microRNA-26a-5p in mesenchymal stem cells increases their therapeutic effects against cirrhosis Am J Transl Res, 2017-03-15;9(3):1500-1508. 2017-03-15 [PMID: 28386375] (Bioassay, Mouse)
• T Bergsbaken, MJ Bevan, PJ Fink Local Inflammatory Cues Regulate Differentiation and Persistence of CD8(+) Tissue-Resident Memory T Cells Cell Rep, 2017-04-04;19(1):114-124. 2017-04-04 [PMID: 28380351] (Bioassay, Mouse)
• S Downs-Cann, S Berkey, GM Delgoffe, RP Edwards, T Curiel, K Odunsi, DL Bartlett, N Obermajer Suppressive IL-17A(+)Foxp3(+) and ex-Th17 IL-17A(neg)Foxp3(+) Treg cells are a source of tumour-associated Treg cells Nat Commun, 2017-03-14;8(0):14649. 2017-03-14 [PMID: 28290453] (Bioassay, Mouse)
• HJ Wu, JW Oh, DF Spandau, S Tholpady, J Diaz, LJ Schroeder, CD Offutt, AB Glick, MV Plikus, S Koyama, J Foley Estrogen modulates mesenchymal-epidermal interactions in the adult nipple Development, 2017-03-13;0(0):. 2017-03-13 [PMID: 28289136] (In Vivo, Mouse)
• H Chen, L Zhang, P Wang, H Su, W Wang, Z Chu, L Zhang, X Zhang, Y Zhao mTORC2 controls Th9 polarization and allergic airway inflammation Allergy, 2017-03-29;0(0):. 2017-03-29 [PMID: 28273354] (Bioassay, Mouse)
• L Franchi, I Monteleone, LY Hao, MA Spahr, W Zhao, X Liu, K Demock, A Kulkarni, CA Lesch, B Sanchez, L Carter, I Marafini, X Hu, O Mashadova, M Yuan, JM Asara, H Singh, CA Lyssiotis, G Monteleone, AW Opipari, GD Glick Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis J. Immunol, 2017-02-27;0(0):. 2017-02-27 [PMID: 28242647] (Bioassay, Mouse)
• Y Kang, M Timilshina, TG Nam, BS Jeong, JH Chang BJ-1108, a 6-Amino-2,4,5-trimethylpyridin-3-ol analogue, regulates differentiation of Th1 and Th17 cells to ameliorate experimental autoimmune encephalomyelitis Biol. Res, 2017-02-28;50(1):8. 2017-02-28 [PMID: 28241881] (Bioassay, Mouse)
• H Zan, C Tat, Z Qiu, JR Taylor, JA Guerrero, T Shen, P Casali Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination Nat Commun, 2017-02-08;8(0):14244. 2017-02-08 [PMID: 28176781] (Bioassay, Mouse)
• Longze Sha Pharmacologic inhibition of Hsp90 to prevent GLT-1 degradation as an effective therapy for epilepsy J. Exp. Med, 2016-12-27;0(0):. 2016-12-27 [PMID: 28028152] (Bioassay, Mouse)
• Atakan Tevlek Bi-layered constructs of poly(glycerol-sebacate)-?-tricalcium phosphate for bone-soft tissue interface applications Mater Sci Eng C Mater Biol Appl, 2016-11-27;72(0):316-324. 2016-11-27 [PMID: 28024592] (Bioassay, Mouse)
• Anna Daria Young microglia restore amyloid plaque clearance of aged microglia EMBO J, 2016-12-21;0(0):. 2016-12-21 [PMID: 28007893] (Bioassay, Mouse)
• Soo Jung Cho GLUT-1-Dependent Glycolysis is Increased During Aging-related Lung Fibrosis and Phloretin Inhibits Lung Fibrosis Am. J. Respir. Cell Mol. Biol, 2017-04-01;0(0):. 2017-04-01 [PMID: 27997810] (Bioassay, Mouse)
• All Trans Retinoic Acid, Transforming Growth Factor ? and Prostaglandin E2 in Mouse Plasma Synergize with Basophil-Secreted Interleukin-4 to M2 Polarize Murine Macrophages PLoS ONE, 2016-12-15;11(12):e0168072. 2016-12-15 [PMID: 27977740] (Bioassay, Mouse)
• Nadine Leber SiRNA-mediated in vivo gene knockdown by acid-degradable cationic nanohydrogel particles J Control Release, 2016-12-09;0(0):. 2016-12-09 [PMID: 27940184] (Bioassay, Mouse)
• Katharina Hofmann Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosis Biochim. Biophys. Acta, 2016-12-06;1863(2):560-568. 2016-12-06 [PMID: 27932059] (Bioassay, Mouse)
• Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation Sci Rep, 2016-12-08;6(0):38387. 2016-12-08 [PMID: 27929069] (Bioassay, Mouse)
• Ha Won Lee Absence of miR-146a in podocytes increases risk of diabetic glomerulopathy via upregulation of erbb4 and notch-1 J. Biol. Chem, 2016-12-02;0(0):. 2016-12-02 [PMID: 27913625] (Bioassay, Mouse)
• Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis Sci Rep, 2016-12-01;6(0):37977. 2016-12-01 [PMID: 27905482] (Bioassay, Mouse)
• Beta 1-integrin ligation and TLR ligation enhance GM-CSF-induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties Sci Rep, 2016-11-29;6(0):37914. 2016-11-29 [PMID: 27897208] (Bioassay, Mouse)
• Cédric Blanpain Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition Cell Stem Cell, 2016-11-23;0(0):. 2016-11-23 [PMID: 27889319] (Bioassay, Mouse)
• Nikolaos G Frangogian The role of ?-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling Biochim. Biophys. Acta, 2016-11-04;0(0):. 2016-11-04 [PMID: 27825850] (Bioassay, Mouse)
• Annemieke Kavelaars CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain J. Neurosci., 2016-10-26;36(43):11074-11083. 2016-10-26 [PMID: 27798187] (In Vivo, Mouse)
• Sharad K Mittal, Masahiro Omoto, Afsaneh Amouzegar, Anuradha Sahu, Alexandra Rezazadeh, Kishore R Katikired, Dhvanit I Shah, Srikant K Sahu, Sunil K Chauhan Restoration of Corneal Transparency by Mesenchymal Stem Cells. Stem Cell Reports, 2016-09-29;0(0):2213-6711. 2016-09-29 [PMID: 27693426] (Bioassay, Mouse)
• Differential effects of Pax3 on expression of polysialyltransferases STX and PST in TGF-?-treated normal murine mammary gland cells Exp Biol Med (Maywood), 2016-10-04;0(0):. 2016-10-04 [PMID: 27651434] (Bioassay, Mouse)
• Affinity for self antigen selects Treg cells with distinct functional properties Nat Immunol, 2016-08-01;0(0):. 2016-08-01 [PMID: 27478940] (Bioassay, Mouse)
• Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-?-Slug signaling Proc Natl Acad Sci USA, 2016-07-08;113(30):E4320-7. 2016-07-08 [PMID: 27466403] (Bioassay, Mouse)
• Autonomous membrane IgE signaling prevents IgE-memory formation Nat Immunol, 2016-07-18;0(0):. 2016-07-18 [PMID: 27428827] (Bioassay, Mouse)
• Koji Ueno Treatment of refractory cutaneous ulcers with mixed sheets consisting of peripheral blood mononuclear cells and fibroblasts Sci Rep, 2016-06-22;6(0):28538. 2016-06-22 [PMID: 27329845] (Bioassay, Mouse)
• LN Guthrie, K Abiraman, ES Plyler, NT Sprenkle, SA Gibson, BC McFarland, R Rajbhandar, AL Rowse, EN Benveniste, GP Meares Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses J. Biol. Chem., 2016-05-23;291(30):15830-40. 2016-05-23 [PMID: 27226638] (Bioassay, Mouse)
• Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity Eur J Immunol, 2016-06-13;0(0):. 2016-06-13 [PMID: 27222115] (Bioassay, Mouse)
• Reduced TCR-dependent activation through citrullination of a T-cell epitope enhances Th17 development by disruption of the STAT3/5 balance Eur J Immunol, 2016-07-01;0(0):. 2016-07-01 [PMID: 27173727] (Bioassay, Mouse)
• I Meininger, RA Griesbach, D Hu, T Gehring, T Seeholzer, A Bertossi, J Kranich, A Oeckinghau, AC Eitelhuber, U Greczmiel, A Gewies, M Schmidt-Su, J Ruland, T Brocker, V Heissmeyer, F Heyd, D Krappmann Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells Nat Commun, 2016-04-12;7(0):11292. 2016-04-12 [PMID: 27068814] (Bioassay, Mouse)
• BW Li, MJ de Bruijn, I Tindemans, M Lukkes, A KleinJan, HC Hoogsteden, RW Hendriks T cells are necessary for ILC2 activation in house dust mite-induced allergic airway inflammation in mice Eur J Immunol, 2016-05-12;0(0):. 2016-05-12 [PMID: 27062360] (Bioassay, Mouse)
• O'Brien C, Bonanno L, Zhang H, Wyss-Coray T Beclin 1 regulates neuronal transforming growth factor-beta signaling by mediating recycling of the type I receptor ALK5. Mol Neurodegener, 2015-12-21;10(1):69. 2015-12-21 [PMID: 26692002] (Bioassay, Mouse)
• Labedz-Maslowska A, Lipert B, Berdecka D, Kedracka-Krok S, Jankowska U, Kamycka E, Sekula M, Madeja Z, Dawn B, Jura J, Zuba-Surma E Monocyte Chemoattractant Protein-Induced Protein 1 (MCPIP1) Enhances Angiogenic and Cardiomyogenic Potential of Murine Bone Marrow-Derived Mesenchymal Stem Cells. PLoS ONE, 2015-07-27;10(7):e0133746. 2015-07-27 [PMID: 26214508] (Bioassay, Mouse)
• Hadland B, Varnum-Finney B, Poulos M, Moon R, Butler J, Rafii S, Bernstein I Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells. J Clin Invest, 2015-04-13;125(5):2032-45. 2015-04-13 [PMID: 25866967] (Bioassay, Mouse)
• Nguyen , Vivien, Pearson , Kandyce, Kim , Jee-Hyun, Kamdar , Karishma, DePaolo , R Willia Retinoic acid can exacerbate T cell intrinsic TLR2 activation to promote tolerance. PLoS ONE, 2015-03-31;10(3):e0118875. 2015-03-31 [PMID: 25826367] (Bioassay, Mouse)
• Quan S, Kim H, Dukala D, Sheng J, Soliven B Impaired dendritic cell function in a spontaneous autoimmune polyneuropathy. J Immunol, 2015-03-30;194(9):4175-84. 2015-03-30 [PMID: 25825437] (Bioassay, Mouse)
• Lee H, Ko J, Jeong H, Ko A, Kim M, Wee W, Yoon S, Oh J Mesenchymal stem/stromal cells protect against autoimmunity via CCL2-dependent recruitment of myeloid-derived suppressor cells. J Immunol, 2015-03-13;194(8):3634-45. 2015-03-13 [PMID: 25769927] (Bioassay, Mouse)
• Noval Rivas M, Burton O, Wise P, Charbonnier L, Georgiev P, Oettgen H, Rachid R, Chatila T Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy. Immunity, 2015-03-10;42(3):512-23. 2015-03-10 [PMID: 25769611] (Bioassay, Mouse)
• Liu G, Bi Y, Xue L, Zhang Y, Yang H, Chen X, Lu Y, Zhang Z, Liu H, Wang X, Wang R, Chu Y, Yang R Dendritic cell SIRT1-HIF1alpha axis programs the differentiation of CD4+ T cells through IL-12 and TGF-beta1. Proc Natl Acad Sci U S A, 2015-02-17;112(9):E957-65. 2015-02-17 [PMID: 25730867] (Bioassay, Mouse)
• Schwinge D, Carambia A, Quaas A, Krech T, Wegscheid C, Tiegs G, Prinz I, Lohse A, Herkel J, Schramm C Testosterone suppresses hepatic inflammation by the downregulation of IL-17, CXCL-9, and CXCL-10 in a mouse model of experimental acute cholangitis. J Immunol, 2015-02-11;194(6):2522-30. 2015-02-11 [PMID: 25672751] (Bioassay, Mouse)
• Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance. Nat Immunol, 2015-02-02;16(3):286-95. 2015-02-02 [PMID: 25642823] (Bioassay, Mouse)
• Richards E, Zhang G, Li Z, Permuth-Wey J, Challa S, Li Y, Kong W, Dan S, Bui M, Coppola D, Mao W, Sellers T, Cheng J Long non-coding RNAs (LncRNA) regulated by transforming growth factor (TGF) beta: LncRNA-hit-mediated TGFbeta-induced epithelial to mesenchymal transition in mammary epithelia. J Biol Chem, 2015-01-20;290(11):6857-67. 2015-01-20 [PMID: 25605728] (Bioassay, Mouse)
• Buckley M, Trampont P, Arandjelovic S, Fond A, Juncadella I, Ravichandran K ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers. J Immunol, 2015-01-16;194(4):1665-76. 2015-01-16 [PMID: 25595778] (Bioassay, Mouse)
• Dong Y, Geng Y, Li L, Li X, Yan X, Fang Y, Li X, Dong S, Liu X, Li X, Yang X, Zheng X, Xie T, Liang J, Dai H, Liu X, Yin Z, Noble P, Jiang D, Ning W Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice. J Exp Med, 2015-01-12;212(2):235-52. 2015-01-12 [PMID: 25584011] (Bioassay, Mouse)
• Kannan A, Kim D, August A, Bynoe M Itk signals promote neuroinflammation by regulating CD4+ T-cell activation and trafficking. J Neurosci, 2015-01-07;35(1):221-33. 2015-01-07 [PMID: 25568116] (Bioassay, Mouse)
• Trembley M, Velasquez L, de Mesy Bentley K, Small E Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels. Development, 2015-01-01;142(1):21-30. 2015-01-01 [PMID: 25516967] (Bioassay, Mouse)
• Sarmiento J, Wallis R, Ning T, Marandi L, Chao G, Veillette A, Lernmark A, Paterson A, Poussier P A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat. J Immunol, 2014-12-12;194(2):615-29. 2014-12-12 [PMID: 25505293] (Bioassay, Rat)
• Wang J, Cao Z, Zhang X, Nakamura M, Sun M, Hartman J, Harris R, Sun Y, Cao Y Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development. Cancer Res, 2014-12-09;75(2):306-15. 2014-12-09 [PMID: 25492861] (Bioassay, Mouse)
• Haftmann C, Stittrich A, Zimmermann J, Fang Z, Hradilkova K, Bardua M, Westendorf K, Heinz G, Riedel R, Siede J, Lehmann K, Weinberger E, Zimmel D, Lauer U, Haupl T, Sieper J, Backhaus M, Neumann C, Hoffmann U, Porstner M, Chen W, Grun J, Baumgrass R, Matz M, Lohning M, Scheffold A, Wittmann J, Chang H, Rajewsky N, Jack H, Radbruch A, Mashreghi M miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim. Eur J Immunol, 2015-01-22;45(4):1192-205. 2015-01-22 [PMID: 25486906] (Bioassay, Mouse)
• Alberton P, Dex S, Popov C, Shukunami C, Schieker M, Docheva D Loss of tenomodulin results in reduced self-renewal and augmented senescence of tendon stem/progenitor cells. Stem Cells Dev, 2014-12-10;24(5):597-609. 2014-12-10 [PMID: 25351164] (Bioassay, Mouse)
• Buckley M, Arandjelovic S, Trampont P, Kim T, Braciale T, Ravichandran K Unexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation. PLoS ONE, 2014-08-25;9(8):e105576. 2014-08-25 [PMID: 25153088] (Bioassay, Mouse)
• Ohm I, Alfsnes K, Belland Olsen M, Ranheim T, Sandanger O, Dahl T, Aukrust P, Finsen A, Yndestad A, Vinge L Toll-like receptor 9 mediated responses in cardiac fibroblasts. PLoS ONE, 2014-08-15;9(8):e104398. 2014-08-15 [PMID: 25126740] (Bioassay, Mouse)
• Choi Y, Kim H, Woo J, Hwang E, Cho K, Kim S, Moon W Real-time imaging of the epithelial-mesenchymal transition using microRNA-200a sequence-based molecular beacon-conjugated magnetic nanoparticles. PLoS ONE, 2014-07-21;9(7):e102164. 2014-07-21 [PMID: 25048580] (Bioassay, Canine, Mouse)
• Mahoney J, Mori M, Szymaniak A, Varelas X, Cardoso W The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors. Dev Cell, 2014-07-17;30(2):137-50. 2014-07-17 [PMID: 25043473] (Bioassay, Mouse)
• Schiering C, Krausgruber T, Chomka A, Frohlich A, Adelmann K, Wohlfert E, Pott J, Griseri T, Bollrath J, Hegazy A, Harrison O, Owens B, Lohning M, Belkaid Y, Fallon P, Powrie F The alarmin IL-33 promotes regulatory T-cell function in the intestine. Nature, 2014-07-16;513(7519):564-8. 2014-07-16 [PMID: 25043027] (Bioassay, Mouse)
• Bakdash G, Vogelpoel L, Van Capel T, Kapsenberg M, de Jong E Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells. Mucosal Immunol, 2014-07-16;8(2):265-78. 2014-07-16 [PMID: 25027601] (Bioassay, Mouse)
• Mori T, Iwasaki Y, Seki Y, Iseki M, Katayama H, Yamamoto K, Takatsu K, Takaki S Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN-gamma-producing T cells. J Immunol, 2014-07-14;193(4):1728-36. 2014-07-14 [PMID: 25024389] (Bioassay, Mouse)
• Chen X, Wang H, Liao H, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang Z, Vega-Montoto L, Vanacore R, Fassler R, Zent R, Pozzi A Integrin-mediated type II TGF-beta receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. J Clin Invest, 2014-07-01;124(8):3295-310. 2014-07-01 [PMID: 24983314] (Bioassay, Mouse)
• Burghardt S, Claass B, Erhardt A, Karimi K, Tiegs G Hepatocytes induce Foxp3(+) regulatory T cells by Notch signaling. J Leukoc Biol, 2014-06-26;96(4):571-7. 2014-06-26 [PMID: 24970859] (Bioassay, Mouse)
• Mycko M, Sliwinska B, Cichalewska M, Cwiklinska H, Raine C, Selmaj K Brain glycolipids suppress T helper cells and inhibit autoimmune demyelination. J Neurosci, 2014-06-18;34(25):8646-58. 2014-06-18 [PMID: 24948818] (Bioassay, Mouse)
• Wu Z, Rowe R, Lim K, Lin Y, Willis A, Tang Y, Li X, Nor J, Maillard I, Weiss S A Snail1/Notch1 signalling axis controls embryonic vascular development. Nat Commun, 2014-06-04;5(0):3998. 2014-06-04 [PMID: 24894949] (Bioassay, Mouse)
• Reynolds C, Chong D, Raynsford E, Quigley K, Kelly D, Llewellyn-Hughes J, Altmann D, Boyton R Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile. BMC Biol, 2014-05-09;12(0):32. 2014-05-09 [PMID: 24886643] (Bioassay, Mouse)
• Yeste A, Mascanfroni I, Nadeau M, Burns E, Tukpah A, Santiago A, Wu C, Patel B, Kumar D, Quintana F IL-21 induces IL-22 production in CD4+ T cells. Nat Commun, 2014-05-06;5(0):3753. 2014-05-06 [PMID: 24796415] (Bioassay, Mouse)
• Kim H, Lee A, Choi E, Kie J, Lim W, Lee H, Moon B, Seoh J Attenuation of experimental colitis in glutathione peroxidase 1 and catalase double knockout mice through enhancing regulatory T cell function. PLoS ONE, 2014-04-17;9(4):e95332. 2014-04-17 [PMID: 24743300] (Bioassay, Mouse)
• Ning L, Kurihara H, de Vega S, Ichikawa-Tomikawa N, Xu Z, Nonaka R, Kazuno S, Yamada Y, Miner J, Arikawa-Hirasawa E Laminin alpha1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGF-beta pathway. Am J Pathol, 2014-04-08;184(6):1683-94. 2014-04-08 [PMID: 24720953] (ELISA Developmet, Mouse)
• Lantero A, Tramullas M, Pilar-Cuellar F, Valdizan E, Santillan R, Roques B, Hurle M TGF-beta and opioid receptor signaling crosstalk results in improvement of endogenous and exogenous opioid analgesia under pathological pain conditions. J Neurosci, 2014-04-09;34(15):5385-95. 2014-04-09 [PMID: 24719115] (In Vivo, Mouse)
• Li S, Huang P, Yang A, Tarng D, Yang W, Lin C, Chen J, Schmid-Schonbein G, Lin S Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulation of podocyte functions and dedifferentiation. Kidney Int, 2014-03-26;86(2):358-69. 2014-03-26 [PMID: 24670409] (Bioassay, Mouse)
• Rebhandl S, Huemer M, Zaborsky N, Gassner F, Catakovic K, Felder T, Greil R, Geisberger R Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia. Eur J Immunol, 2014-04-15;44(7):2175-87. 2014-04-15 [PMID: 24668151] (Bioassay, Mouse)
• Uslu K, Coleman A, Allman W, Katsenelson N, Bram R, Alugupalli K, Akkoyunlu M Impaired B cell receptor signaling is responsible for reduced TACI expression and function in X-linked immunodeficient mice. J Immunol, 2014-03-19;192(8):3582-95. 2014-03-19 [PMID: 24646744] (Bioassay, Mouse)
• McSorley H, Blair N, Smith K, McKenzie A, Maizels R Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy. Mucosal Immunol, 2014-02-05;7(5):1068-78. 2014-02-05 [PMID: 24496315] (In Vivo, Mouse)
• Yoshida Y, Yoshimi R, Yoshii H, Kim D, Dey A, Xiong H, Munasinghe J, Yazawa I, O'Donovan M, Maximova O, Sharma S, Zhu J, Wang H, Morse H, Ozato K The transcription factor IRF8 activates integrin-mediated TGF-beta signaling and promotes neuroinflammation. Immunity, 2014-01-30;40(2):187-98. 2014-01-30 [PMID: 24485804] (Bioassay, Mouse)
• Hagiwara , Kunie, Obayashi , Takeshi, Sakayori , Nobuyuki, Yamanishi , Emiko, Hayashi , Ryuhei, Osumi , Noriko, Nakazawa , Toru, Nishida , Kohji Molecular and cellular features of murine craniofacial and trunk neural crest cells as stem cell-like cells. PLoS ONE, 2014-01-20;9(1):e84072. 2014-01-20 [PMID: 24465393] (Bioassay, Mouse)
• Chrobak P, Afkhami S, Priceputu E, Poudrier J, Meunier C, Hanna Z, Sparwasser T, Jolicoeur P HIV Nef expression favors the relative preservation of CD4+ T regulatory cells that retain some important suppressive functions. J Immunol, 2014-01-24;192(4):1681-92. 2014-01-24 [PMID: 24465014] (Bioassay, Mouse)
• Seth A, Ye J, Yu N, Guez F, Bedford D, Neale G, Cordi S, Brindle P, Lemaigre F, Kaestner K, Sosa-Pineda B Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development, 2014-02-01;141(3):538-47. 2014-02-01 [PMID: 24449835] (Bioassay, Mouse)
• Suga H, Rennert R, Rodrigues M, Sorkin M, Glotzbach J, Januszyk M, Fujiwara T, Longaker M, Gurtner G Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing. Stem Cells, 2014-05-01;32(5):1347-60. 2014-05-01 [PMID: 24446236] (Bioassay, Mouse)
• Rodgers B, Wiedeback B, Hoversten K, Jackson M, Walker R, Thompson T Myostatin stimulates, not inihibits, C2C12 myoblast proliferation. Endocrinology, 2014-01-01;155(3):670-5. 2014-01-01 [PMID: 24424069] (Bioassay, Mouse)
• Sun Y, Qu X, Li X, Nikolic-Paterson D, Li J Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney. PLoS ONE, 2013-12-31;8(12):e84063. 2013-12-31 [PMID: 24391884] (Cell Culture, Rat)
• Veremeyko , Tatyana, Siddiqui , Shafiudd, Sotnikov , Ilya, Yung , Amanda, Ponomarev , Eugene D IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation. PLoS ONE, 2013-12-16;8(12):e81774. 2013-12-16 [PMID: 24358127] (Bioassay, Mouse)
• van Voorhis , Michael, Knopp , Samantha, Julliard , Walker, Fechner , John H, Zhang , Xiaoji, Schauer , James J, Mezrich , Joshua D Exposure to atmospheric particulate matter enhances Th17 polarization through the aryl hydrocarbon receptor. PLoS ONE, 2013-12-11;8(12):e82545. 2013-12-11 [PMID: 24349309] (Cell Culture, Mouse)
• Kowalczyk A, D'Souza C, Zhang L Cell-extrinsic CTLA4-mediated regulation of dendritic cell maturation depends on STAT3. Eur J Immunol, 2014-01-22;44(4):1143-55. 2014-01-22 [PMID: 24338929] (Bioassay, Mouse)
• Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song S, Hoshino T, Yagita H, Ohteki T, Iwata M Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells. Mucosal Immunol, 2013-11-13;7(4):786-801. 2013-11-13 [PMID: 24220301] (Bioassay, Mouse)
• Gonzalez-Quesada C, Cavalera M, Biernacka A, Kong P, Lee D, Saxena A, Frunza O, Dobaczewski M, Shinde A, Frangogiannis N Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation. Circ Res, 2013-09-30;113(12):1331-44. 2013-09-30 [PMID: 24081879] (Bioassay, Mouse)
• Gao Y, Nish S, Jiang R, Hou L, Licona-Limon P, Weinstein J, Zhao H, Medzhitov R Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity, 2013-09-26;39(4):722-32. 2013-09-26 [PMID: 24076050] (Bioassay, Mouse)
• Kim H, Claps G, Moller A, Bowtell D, Lu X, Ronai Z Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability. Oncogene, 2013-05-06;33(15):2004-10. 2013-05-06 [PMID: 23644657] (Bioassay, Mouse)
• Lee J, Lee J, Park M, Lim M, Park E, Kim E, Yang E, Lee S, Jhun J, Park S, Kim H, Cho M Interferon gamma suppresses collagen-induced arthritis by regulation of Th17 through the induction of indoleamine-2,3-deoxygenase. PLoS ONE, 2013-04-16;8(4):e60900. 2013-04-16 [PMID: 23613752] (Bioassay, Mouse)
• Szewczyk K, Fuller K, Chambers T Distinctive subdomains in the resorbing surface of osteoclasts. PLoS ONE, 2013-03-21;8(3):e60285. 2013-03-21 [PMID: 23555944] (Bioassay, Mouse)
• Gui T, Sun Y, Gai Z, Shimokado A, Muragaki Y, Zhou G The loss of Trps1 suppresses ureteric bud branching because of the activation of TGF-beta signaling. Dev Biol, 2013-03-26;377(2):415-27. 2013-03-26 [PMID: 23537899] (Bioassay, Mouse)
• Li S, Meyer N, Quarto N, Longaker M Integration of multiple signaling regulates through apoptosis the differential osteogenic potential of neural crest-derived and mesoderm-derived Osteoblasts. PLoS ONE, 2013-03-25;8(3):e58610. 2013-03-25 [PMID: 23536803] (Bioassay, Mouse)
• Ding Q, Cai G, Hu M, Yang Y, Zheng A, Tang Q, Gladson C, Hayasaka H, Wu H, You Z, Southern B, Grove L, Rahaman S, Fang H, Olman M FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis. Am J Pathol, 2013-03-14;182(5):1572-84. 2013-03-14 [PMID: 23499373] (Bioassay, Mouse)
• Tigges U, Boroujerdi A, Welser-Alves J, Milner R TNF-alpha promotes cerebral pericyte remodeling in vitro, via a switch from alpha1 to alpha2 integrins. J Neuroinflammation, 2013-03-01;10(0):33. 2013-03-01 [PMID: 23448258] (Bioassay, Mouse)
• Lien S, Wei S, Chang S, Chang M, Chang J, Chiu J Activation of PPAR-alpha induces cell cycle arrest and inhibits transforming growth factor-beta1 induction of smooth muscle cell phenotype in 10T1/2 mesenchymal cells. Cell Signal, 2013-02-04;25(5):1252-63. 2013-02-04 [PMID: 23385087] (Bioassay, Mouse)
• Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse)

Bioinformatics

• Gene Symbol: Tgfb1
• Uniprot:
  • P04202()