TGF beta-1

TAZ Antibody: The Devil is in the Details

WW domain-containing transcription regulator protein 1 also known as WWTR1 and TAZ, is a 44KDa protein that acts as a downstream regulatory target in the Hippo signaling pathway. This protein undergoes post-translational modification and becomes phosphorylated by LATS2 and STK3/MST2. TAZ in its phosphorylated state is functionally inactive and is retained in the cytoplasm. When TAZ is not phosphorylated it can be retained in the nucleus by a protein called MED15.

A Role for HIF-1 alpha Antibody in Renal Research

The Hypoxia Inducible Factors (HIFs) are a family of mammalian transcription factors which are expressed in response to low cellular oxygen concentrations (hypoxia). Three human hypoxia inducible factors have been identified, HIF-1, HIF-2 and HIF-3, each having an alpha and a beta subunit.

SEPT4 is Targeted to Prevent Stem Cell Cancers

The antibodies in our stem cell antibody catalog are used in many areas of research, from developing therapies to investigating cancer. These research areas are related, because although pluripotent stem cells have the potential to replace organ transplants and heal paralysis, they also have the potential to develop into cancerous cells.