TGF-beta 1 Products

Description

TGF-beta-1 is a multifunctional cytokine that belongs to a superfamily of structurally related regulatory proteins, which includes three mammalian TGF-beta isoforms (TGF-beta-1, -beta-2, and -beta-3), activin/inhibins and bone morphogenetic proteins. The most abundant isoform, TGF-beta-1, is a 25kDa homodimer composed of two 12.5kDa subunits joined by disulfide bonds. TGF-beta-1 is a highly conserved molecule - the amino acid sequence between human and mouse differ only by one residue. Although originally defined by its ability to cause anchorage independent cell growth and changes in cell morphology of rat fibroblasts, subsequent research has revealed that TGF-beta is actually a major growth inhibitor for most cell types. It is produced by a wide variety of cell and tissue types during all stages of cell differentiation. TGF-beta-1 sources include platelets, bone and soft tissues such as placenta and kidneys.

Bioinformatics

Entrez	21803 Mouse 59086 Rat 7040 Human 7042 Human
Uniprot	AAH01180.1 Human NM_000660 Human NM_000660.4 Human NP_000651 Human NP_000651.3 Human O95411 Human P01137 Human P61812 Human
Product By Gene ID	7040
Alternate Names	CEDLAP DPD1 latency-associated peptide TGF beta TGFB TGF-beta 1 protein TGFbeta TGF-beta-1 transforming growth factor beta-1 transforming growth factor, beta 1

Research Areas for TGF-beta 1

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Apoptosis
Asthma
Cancer
Immunology
Phospho-Specific

Related TGF-beta 1 Blog Posts

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TGF-beta 1 - a versatile signaling molecule with roles in development and disease The transforming growth factor-beta (TGF-beta) family consists of a wide variety of signaling proteins with roles in development. TGF-beta signaling controls growth, differentiation, and immune responses and is often misregulated in cancer. TGF-beta ...    Read more.

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