Recombinant Mouse Adiponectin/Acrp30 Protein, CF

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Bioactivity
Format
Carrier-Free

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Recombinant Mouse Adiponectin/Acrp30 Protein, CF Summary

Details of Functionality
Measured by its ability to induce TIMP-1 secretion by mouse macrophages. Kumada, M. et al. (2004) Circulation 109:2046. The ED50 for this effect is 5-20 μg/mL.
Source
Mouse myeloma cell line, NS0-derived mouse Adiponectin/Acrp30 protein
Glu18-Asn247, with a C-terminal 6-His tag
Accession #
N-terminal Sequence
Glu18
Structure / Form
Oligomer
Protein/Peptide Type
Recombinant Proteins
Gene
Adipoq
Purity
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<1.0 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Theoretical MW
25.8 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
28-38 kDa, under reducing conditions
Publications
Read Publications using
5095-AC in the following applications:

Packaging, Storage & Formulations

Storage
Do not freeze.
  • 6 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied as a 0.2 μm filtered solution in PBS.
Purity
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse Adiponectin/Acrp30 Protein, CF

  • ACDC
  • Acrp30
  • ACRP30ADPN
  • adipocyte, C1Q and collagen domain containing
  • Adiponectin
  • adiponectin, C1Q and collagen domain containing
  • AdipoQ
  • ADIPQTL1
  • ApM1
  • apM-1
  • APM1APM-1
  • C1q and collagen domain-containing protein
  • GBP28
  • GBP28apM1
  • Gelatin-binding protein

Background

Adiponectin, also known as Acrp30, is an adipocyte-derived protein with wide ranging paracrine and endocrine effects on metabolism and inflammation. It promotes adipocyte differentiation, fatty acid catabolism, and insulin sensitivity, and is negatively correlated with obesity, type 2 diabetes, and atherogenesis. In this context, adiponectin is an anti-inflammatory agent, but it exerts pro-inflammatory effects in nonmetabolic disorders such as rheumatoid arthritis and inflammatory bowel disease (1-3). Adiponectin interacts with the receptors AdipoR1 and AdipoR2, calreticulin, and Cadherin-13/T-Cadherin, as well as with several growth factors (4-7). Mature mouse adiponectin consists of a 66 amino acid (aa) N-terminal collagenous region and a 137 aa C-terminal C1q-like globular domain which can be cleaved by a leukocyte-derived elastase (8-10). Mature mouse adiponectin shares 83% and 91% amino acid (aa) sequence identity with human and rat adiponectin, respectively. Adiponectin associates into trimers that may assemble into medium molecular weight (MMW) hexamers and then into >300 kDa high molecular weight (HMW) oligomers (11-13). The glycosylation of four hydroxylated lysine residues in the collagenous domain is required for the intracellular formation of HMW complexes (14). The various multimeric forms of adiponectin exhibit distinct tissue specific and gender specific profiles and activities (13, 15).

  1. Lara-Castro, C. et al. (2007) Curr. Opin. Lipidol. 18:263.
  2. Tilg, H. and A.R. Moschen (2006) Nat. Rev. Immunol. 6:772.
  3. Fantuzzi, G. (2008) J. Allergy Clin. Immunol. 121:326.
  4. Yamauchi, T. et al. (2007) Nat. Med. 13:332.
  5. Takemura, Y. et al. (2007) J. Clin. Invest. 117:375.
  6. Hug, C. et al. (2004) Proc. Natl. Acad. Sci. 101:10308.
  7. Wang, Y. et al. (2005) J. Biol. Chem. 280:18341.
  8. Scherer, P.E. et al. (1995) J. Biol. Chem. 270:26746.
  9. Hu, E. et al. (1996) J. Biol. Chem. 271:10697.
  10. Waki, H. et al. (2005) Endocrinology 146:790.
  11. Waki, H. et al. (2003) J. Biol. Chem. 278:40352.
  12. Tsao, T.S. et al. (2003) J. Biol. Chem. 278:50810.
  13. Wang, Y. et al. (2008) Biochem. J. 409:623.
  14. Wang, H. et al. (2006) J. Biol. Chem. 281:16391.
  15. Pajvani, U.B. et al. (2003) J. Biol. Chem. 278:9073.

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Publications for Adiponectin/Acrp30 (5095-AC)(6)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Bioassay, In Vivo.


Filter By Application
Bioassay
(5)
In Vivo
(1)
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Mouse
(6)
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Showing Publications 1 - 6 of 6.
Publications using 5095-AC Applications Species
J Choi, H Kobayashi, H Okuda, KH Harada, M Takeda, H Fujimoto, S Yamane, D Tanaka, S Youssefian, N Inagaki, A Koizumi ?-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice PLoS ONE, 2018;13(1):e0190863. 2018 [PMID: 29304075] (Bioassay, Mouse) Bioassay Mouse
S Fu, H Xu, M Gu, C Liu, Q Wang, X Wan, Y Chen, Q Chen, Y Peng, Z Cai, J Zhou, Z Wang Adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity Sci Rep, 2017;7(0):43771. 2017 [PMID: 28256562] (In Vivo, Mouse) In Vivo Mouse
Aiko Inoue Exercise restores muscle stem cell mobilization, regenerative capacity and muscle metabolic alterations via adiponectin/AdipoR1 activation in SAMP10 mice J Cachexia Sarcopenia Muscle, 2016;0(0):. 2016 [PMID: 27897419] (Bioassay, Mouse) Bioassay Mouse
Abbott M, Roth T, Ho L, Wang L, O'Carroll D, Nissenson R Negative Skeletal Effects of Locally Produced Adiponectin. PLoS ONE, 2015;10(7):e0134290. 2015 [PMID: 26230337] (Bioassay, Mouse) Bioassay Mouse
Mori T, Koyama Y, Maeda N, Nakamura Y, Fujishima Y, Matsuda K, Funahashi T, Shimada S, Shimomura I Ultrastructural localization of adiponectin protein in vasculature of normal and atherosclerotic mice. Sci Rep, 2014;4(0):4895. 2014 [PMID: 24809933] (Bioassay, Mouse) Bioassay Mouse
Fujii, Yasuhiro, Okada, Atsushi, Yasui, Takahiro, Niimi, Kazuhiro, Hamamoto, Shuzo, Hirose, Masahito, Kubota, Yasue, Tozawa, Keiichi, Hayashi, Yutaro, Kohri, Kenjiro Effect of adiponectin on kidney crystal formation in metabolic syndrome model mice via inhibition of inflammation and apoptosis. PLoS ONE, 2013;8(4):e61343. 2013 [PMID: 23630583] (Bioassay, Mouse) Bioassay Mouse

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Bioinformatics

Gene Symbol Adipoq
Uniprot