Recombinant Human VE-Cadherin Fc Chimera His-tag Protein, CF


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Product Details

Reactivity HuSpecies Glossary
Applications Bioactivity

Order Details

Recombinant Human VE-Cadherin Fc Chimera His-tag Protein, CF Summary

Details of Functionality
Measured by the ability of the immobilized protein to support the adhesion of BCE C/D‑1b bovine corneal endothelial cells. The ED50 for this effect is 40-160 ng/mL.
Optimal dilutions should be determined by each laboratory for each application.
Mouse myeloma cell line, NS0-derived human VE-Cadherin protein
Human VE-Cadherin
Accession # P33151
6-His tag
N-terminus C-terminus
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


Theoretical MW
89 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
116 kDa, reducing conditions
Read Publications using
938-VC in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS.
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human VE-Cadherin Fc Chimera His-tag Protein, CF

  • 7B4 antigen
  • 7B4
  • cadherin 5, type 2 (vascular endothelium)
  • cadherin 5, type 2, VE-cadherin (vascular epithelium)
  • Cadherin-5
  • CD144 antigen
  • CD144
  • CDH5
  • endothelial-specific cadherin
  • FLJ17376
  • Vascular endothelial cadherin
  • VECadherin
  • VE-Cadherin


VE-Cadherin, also known as Cadherin-5 and CD144, is a member of the atypical/type II subgroup of Cadherin homophilic adhesion proteins (1). Mature human VE-Cadherin is a 125-135 kDa transmembrane glycoprotein that consistis of a 552 amino acid (aa) extracellular domain (ECD) with five Ca++-binding Cadherin domains, a 21 aa transmembrane segment, and a 164 aa cytoplasmic domain (2, 3). Within the ECD, human VE-Cadherin shares approximately 75% aa sequence identity with mouse and rat VE-Cadherin. A 90 kDa portion of the VE-Cadherin ECD can be shed in a metalloproteinase-dependent mechanism and may function as a VE-Cadherin antagonist (4, 5). VE-Cadherin is expressed on the surface of vascular endothelial cells (EC) from early in embryogenesis through adulthood as well as in the placenta, on hematopoietic cell progenitors, and on a subpopulation of hematopoietic stem cells (6-8). It is a major protein component of adherens junctions between cells of the endothelium (9). VE-Cadherin supports the extension and stabilization of existing vascular sprouts (10). VE-Cadherin also regulates or is regulated by VEGF R2, type I and type II TGF-beta receptors, and other endothelial junction proteins such as JAM-C, Claudin-5, and N-Cadherin (11-15). Elevated levels of soluble VE-Cadherin are found in the serum of myocardial infarction, angina pectoris, rheumatoid arthritis, and colorectal cancer patients (16-18).
  1. Giannotta, M. et al. (2013) Dev. Cell 26:441.
  2. Breviario, F. et al. (1995) Arterioscler. Throm. Vasc. Biol. 15:1229.
  3. Geyer, H. et al. (1999) Glycobiology 9:915.
  4. Herren, B. et al. (1998) Mol. Biol. Cell 9:1589.
  5. Li, H. et al. (2010) Cancer Gene Ther. 17:700.
  6. Breier, G. et al. (1996) Blood 87:630.
  7. Ema, M. et al. (2006) Blood 108:4018.
  8. Oberlin, E. et al. (2010) Blood 116:4444.
  9. Lampugnani, M.G. et al. (1992) J. Cell Biol. 118:1511.
  10. Perryn, E.D. et al. (2008) Dev. Biol. 313:545.
  11. Gavard, J. and J.S. Gutkind (2006) Nat. Cell Biol. 8:1223.
  12. Orlova, V.V. et al. (2006) J. Exp. Med. 203:2703.
  13. Taddei, A. et al. (2008) Nat. Cell Biol. 10:923.
  14. Luo, Y. and G.L. Radice (2005) J. Cell Biol. 169:29.
  15. Rudini, N. et al. (2008) EMBO J. 27:993.
  16. Soeki, T. et al. (2004) Circ. J. 68:1.
  17. Sulkowska, M. et al. (2006) Tumori 92:67.
  18. Sidibe, A. et al. (2012) Arthritis Rheum. 64:77.

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Gene Symbol CDH5