Recombinant Human TrkB Fc Chimera Protein, CF


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Product Details

Reactivity HuSpecies Glossary
Applications Bioactivity

Order Details

Recombinant Human TrkB Fc Chimera Protein, CF Summary

Details of Functionality
Measured by its ability to inhibit BDNF-induced proliferation of BaF‑TrkB‑BD mouse pro‑B cells transfected with TrkB. The ED50 for this effect is 0.1‑0.4 µg/mL in the presence of 16 ng/mL of recombinant human BDNF.
Mouse myeloma cell line, NS0-derived human TrkB protein
Accession # Q16620.1
6-His tag
N-terminus C-terminus
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


Theoretical MW
71.7 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
120 kDa-130 kDa, reducing conditions
Read Publications using
688-TK in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS.
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human TrkB Fc Chimera Protein, CF

  • BDNF/NT-3 growth factors receptor
  • EC 2.7.10
  • EC
  • GP145-TrkB
  • Neurotrophic tyrosine kinase receptor type 2
  • neurotrophic tyrosine kinase, receptor, type 2
  • NTRK2
  • TrkB tyrosine kinase
  • TrkB
  • trk-B
  • TRKBBDNF-tropomyosine receptor kinase B
  • tyrosine kinase receptor B


The neurotrophins, including NGF, BDNF, NT-3, and NT-4/5 constitute a group of structurally related, secreted proteins that play an important role in the development and function of the nervous system. The biological activities of the neurotrophins are mediated by binding to the different members of the Trk family tyrosine kinase receptors. Three Trk family proteins, TrkA, TrkB, and TrkC, exhibiting different ligand specificities, have been identified. TrkA binds NGF, TrkB binds BDNF and NT‑4/5 and TrkC binds NT-3. All Trk family proteins share a conserved complex subdomain organization consisting of a signal peptide, two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain. Natural splice variants of the different Trks, including TrkB variants lacking the first cysteine-rich domain, the first and second or all three of the leucine-rich motifs, or the tyrosine kinase domain, have been described. The role of the different extracellular subdomains of TrkB in mediating neurotrophin binding and discrimination is currently being investigated. At the protein sequence level, human and rat TrkB are greater than 90% identical and the proteins exhibit cross-species activity. TrkB is primarily expressed in the nervous system. However, low levels of TrkB expression have also been observed in a wide variety of tissues (pancreas, kidneys, ovary) outside the nervous system.

  1. Ninkina, N. et al. (1997) J. Biol. Chem. 272:13019.
  2. Middlemas, D.S. et al. (1991) Mol. Cell Biol. 11:143.
  3. Soppet, D. et al. (1991) Cell 65:895.

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Publications for TrkB (688-TK)(44)

We have publications tested in 6 confirmed species: Human, Mouse, Rat, Bacteria, Chicken, N/A.

We have publications tested in 6 applications: Bioassay, Cell Culture, In Vivo, In vivo, PcIP, Surface Plasmon Resonance.

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Showing Publications 1 - 10 of 44. Show All 44 Publications.
Publications using 688-TK Applications Species
X Li, Q Wang, J Ding, S Wang, C Dong, Q Wu Exercise training modulates glutamic acid decarboxylase-65/67 expression through TrkB signaling to ameliorate neuropathic pain in rats with spinal cord injury Mol Pain, 2020;16(0):1744806920924. 2020 [PMID: 32418502] (In Vivo, Rat) In Vivo Rat
A Patnaik, E Spiombi, A Frasca, N Landsberge, M Zagrebelsk, M Korte Fingolimod Modulates Dendritic Architecture in a BDNF-Dependent Manner Int J Mol Sci, 2020;21(9):. 2020 [PMID: 32349283] (Cell Culture, Mouse) Cell Culture Mouse
G Fulgenzi, Z Hong, F Tomassoni-, LF Barella, J Becker, C Barrick, D Swing, S Yanpallewa, BS Croix, J Wess, O Gavrilova, L Tessarollo Novel metabolic role for BDNF in pancreatic &amp;beta-cell insulin secretion Nat Commun, 2020;11(1):1950. 2020 [PMID: 32327658] (Bioassay, Mouse) Bioassay Mouse
LE Montroull, V Danelon, AB Cragnolini, DH Mascó Loss of TrkB Signaling Due to Status Epilepticus Induces a proBDNF-Dependent Cell Death Front Cell Neurosci, 2019;13(0):4. 2019 [PMID: 30800056] (In Vivo, Rat) In Vivo Rat
JM Hall, F Gomez-Pini, LM Savage Nerve Growth Factor Is Responsible for Exercise-Induced Recovery of Septohippocampal Cholinergic Structure and Function Front Neurosci, 2018;12(0):773. 2018 [PMID: 30443202] (In vivo, Rat) In vivo Rat
H Zhang, C Zhang, J Vincent, D Zala, C Benstaali, M Sainlos, D Grillo-Bos, S Daburon, F Coussen, Y Cho, DJ David, F Saudou, Y Humeau, D Choquet Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington&#039;s disease models Nat Commun, 2018;9(1):4272. 2018 [PMID: 30323233] (Bioassay, Rat) Bioassay Rat
Q Wu, Q Wang, Z Li, X Li, J Zang, Z Wang, C Xu, Y Gong, J Cheng, H Li, G Shen, C Dong Human menstrual blood-derived stem cells promote functional recovery in a rat spinal cord hemisection model Cell Death Dis, 2018;9(9):882. 2018 [PMID: 30158539] (In Vivo, Rat) In Vivo Rat
X Li, Q Wu, C Xie, C Wang, Q Wang, C Dong, L Fang, J Ding, T Wang Blocking of BDNF-TrkB signaling inhibits the promotion effect of neurological function recovery after treadmill training in rats with spinal cord injury Spinal Cord, 2018;0(0):. 2018 [PMID: 30002472] (In Vivo, Rat) In Vivo Rat
CRAF Diniz, PC Casarotto, SM Fred, C Biojone, E Castrén, SRL Joca Antidepressant-like effect of losartan involves TRKB transactivation from angiotensin receptor type 2 (AGTR2) and recruitment of FYN Neuropharmacology, 2018;135(0):163-171. 2018 [PMID: 29550391] (Bioassay, Rat) Bioassay Rat
A Suzuki, D Matsuura, H Kanatani, S Yano, M Tsunakawa, S Matsuyama, H Shigemori Inhibitory Effects of Polyacetylene Compounds from Panax ginseng on Neurotrophin Receptor-Mediated Hair Growth Biol. Pharm. Bull., 2017;40(10):1784-1788. 2017 [PMID: 28966252] (Bioassay, Human) Bioassay Human
Show All 44 Publications.

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Blogs on TrkB.

TrkB: Bridging Ontogenesis and Oncogenesis
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its...  Read full blog post.

TrkB and Nervous System Function
Neutrophins and their receptors play an important role in regulating the development of both the central and peripheral nervous systems. Neurotrophin ligand binding to each of their respective Trk cellular receptors is essential for the growth and sur...  Read full blog post.

TrkB: Docking for Neurotrophins and Beyond.
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro...  Read full blog post.

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Gene Symbol NTRK2