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355-BM) was serially diluted and captured by Mouse Anti-Human BMP‑2 Monoclonal Antibody (Catalog # MAB3551) coated on a Clear Polystyrene Microplate (Catalog # DY990). Mouse Anti-Human BMP‑2/BMP‑4 Monoclonal Antibody (Catalog # MAB3552) was biotinylated and incubated with the protein captured on the plate. Detection of the standard curve was achieved by incubating Streptavidin-HRP (Catalog # DY998)" class="big_lightbox" target="_blank">
355-BM) induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The ED50 for this effect is 40-200 ng/mL." class="big_lightbox" target="_blank">
Bone morphogenic proteins (BMPs) are members of the TGFbeta superfamily. BMPs are involved in the induction of cartilage and bone formation. In vivo studies have shown that BMP-2 (also designated BMP-2A) and BMP-3 can independently induce cartilage formation. Smad3 association with the TGFbeta receptor complex and Smad1 translocation to the nucleus are observed after the addition of BMP-4 (also designated BMP-2B), suggesting that BMP-4 may play a role in activation of the Smad pathway. BMP-5, BMP-6 and BMP-7 all share high sequence homology with BMP-2, indicating that they each may be able to induce cartilage formation. BMP-8 (also designated OP-2) is thought to be involved in early development, as detectable expression has not been found in adult organs.
![ELISA BMP-2 Antibody (100221) [Unconjugated]](http://images.novusbio.com/images/mab3551_human-bmp-2-mab-clone-100221-elisa-639201778069418752.jpg)
![Sandwich ELISA BMP-2 Antibody Pair [HRP]](http://images.novusbio.com/fullsize/BMP-2-Antibody-Pair-[HRP]-Sandwich-ELISA-NBP2-79572-img0001.jpg)
![N/A BMP-2 [HRP]](http://images.novusbio.com/fullsize/elisa/DATA_BMP2_DBP200_ELISA_593.jpg)
![N/A BMP-2 [Biotin]](http://images.novusbio.com/fullsize/elisa/DATA_BMP2_DY355_ELISA_1957.jpg)
![Bioactivity BMP-2 [Unconjugated]](http://images.novusbio.com/images/protein/355-bm_recombinant-human-mouse-rat-bmp-2-protein-bioactivity-181120209742.jpg)
![Bioactivity BMP-2 [Unconjugated]](http://images.novusbio.com/fullsize/protein/BMP2_355BEC_861.jpg)
![N/A BMP-2 [HRP]](http://images.novusbio.com/fullsize/elisa/BMP-2_DBP200_ELISA_39.jpg)
![SDS-Page BMP-2 [Unconjugated]](http://images.novusbio.com/fullsize/protein/BMP-2_355-BEC_583.jpg)
