Recombinant Human IL-33 Protein

Recombinant Human IL-33 (Catalog #3625‑IL) stimulates cell proliferation of the D10.G4.1 mouse helper T cell line. The ED50 for this effect is 0.06-0.24 ng/mL.

1 μg/lane of Recombinant Human IL-33 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 19 kDa.

• Reactivity: Hu
• Applications: Bioactivity

Recombinant Human IL-33 Protein Summary

• Details of Functionality: Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED₅₀ for this effect is 0.06-0.24 ng/mL.
  Optimal dilutions should be determined by each laboratory for each application.
• Source: E. coli-derived human IL-33 protein
  Ser112-Thr270
• Accession #: O95760.1
• N-terminal Sequence: Ser112
• Protein/Peptide Type: Recombinant Proteins
• Gene: IL33
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Endotoxin Note: <0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 18-21 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and DTT with BSA as a carrier protein.
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Reconstitution Instructions: Reconstitute at 10 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IL-33 Protein

• C9orf26
• C9orf26chromosome 9 open reading frame 26 (NF-HEV)
• DKFZp586H0523
• DVS27
• DVS27-related protein
• IL1F11
• IL-1F11
• IL33
• IL-33
• interleukin 33
• Interleukin-1 family member 11
• interleukin-33
• NFHEV
• NF-HEV
• NF-HEVNFEHEV
• Nuclear factor from high endothelial venules
• RP11-575C20.2

Background

IL-33, also known as NF-HEV and DVS 27, is a 30 kDa proinflammatory protein that may also regulate gene transcription (1‑3). DVS 27 was identifed as a gene that is upregulated in vasospastic cerebral arteries (1). NF‑HEV was described as a nuclear factor that is preferentially expressed in the endothelial cells of high endothelial venules relative to endothelial cells from other tissues (2). IL‑33 was identified based on sequence and structural homology with IL‑1 family cytokines (3). DVS 27, NF‑HEV, and IL‑33 share 100% amino acid sequence identity. IL‑33 is constitutively expressed in smooth muscle and airway epithelia. It is up-regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL‑1 alpha or IL‑1 beta stimulation (1, 3). Similar to IL‑1, IL‑33 can be cleaved in vitro by caspase‑1, generating an N‑terminal fragment that is slightly shorter than the C‑terminal fragment (3, 4). The N‑terminal portion of full length IL‑33 contains a predicted bipartite nuclear localization sequence and a homeodomain‑like helix‑turn‑helix DNA binding domain. By immunofluorescence, full length IL‑33 localizes to the nucleus in HUVECs and transfectants (2). The C‑terminal fragment, corresponding to mature IL‑33, binds and triggers signaling through mast cell IL‑1 R4/ST2L, a longtime orphan receptor involved in the augmentation of Th2 cell responses (3, 5‑7). A ternary signaling complex is formed by the subsequent association of IL‑33 and ST2L with IL‑1R AcP (8). Stimulation of Th2 polarized lymphocytes with mature IL‑33 in vitro induces IL‑5 and IL‑13 secretion (3). In vivo administration of mature IL‑33 promotes increased production of IL‑5, IL‑13, IgE, and IgA, as well as splenomegaly and inflammatory infiltration of mucosal tissues (3). Full length and mature human IL‑33 share
52‑58% aa sequence identity with mouse and rat IL‑33. Human IL‑33 shares less than 20% aa sequence identity with other IL‑1 family proteins.

1. Onda, H. et al. (1999) J. Cereb. Blood Flow Metab. 19:1279.
2. Baekkevold, E.S. et al. (2003) Am. J. Pathol. 163:69.
3. Schmitz, J. et al. (2005) Immunity 23:479.
4. Black, R.A. et al. (1989) J. Biol. Chem. 264:5323.
5. Xu, D. et al. (1998) J. Exp. Med. 187:787.
6. Lohning, M. et al. (1998) Proc. Natl. Acad. Sci. 95:6930.
7. Dinarello, C.A. (2005) Immunity 23:461.
8. Chackerian, A.A. et al. (2007) J. Immunol. 179:2551.

Publications for IL-33 (3625-IL)(58)

Publications using 3625-IL

• Pereira, NL;Schaible, N;Desai, A;Chan, EC;Ablooglu, AJ;Capuano, J;Lin, E;An, Z;Gebski, E;Jester, W;Ganesan, S;Balenga, N;Koziol-White, C;Panettieri, RA;Choudhury, S;Krishnan, R;Druey, KM; N-cadherin antagonism is bronchoprotective in severe asthma models Science advances 2024-11-29 [PMID: 39612338] (Bioassay, Human)
• Bao, K;Gu, X;Song, Y;Zhou, Y;Chen, Y;Yu, X;Yuan, W;Shi, L;Zheng, J;Hong, M; TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma Nature communications 2024-09-08 [PMID: 39245681] (Bioassay, Mouse)
• Tilsed, CM;Sadiq, BA;Papp, TE;Areesawangkit, P;Kimura, K;Noguera-Ortega, E;Scholler, J;Cerda, N;Aghajanian, H;Bot, A;Mui, B;Tam, Y;Weissman, D;June, CH;Albelda, SM;Parhiz, H; IL7 increases targeted lipid nanoparticle-mediated mRNA expression in T cells in vitro and in vivo by enhancing T cell protein translation Proceedings of the National Academy of Sciences of the United States of America 2024-03-26 [PMID: 38513098] (Bioassay, Human)
• Noguchi, S;Yamasaki, R;Nagai-Yoshioka, Y;Sato, T;Kuroishi, K;Gunjigake, K;Ariyoshi, W;Kawamoto, T; The Mechanism of Interleukin 33-Induced Stimulation of Interleukin 6 in MLO-Y4 Cells International journal of molecular sciences 2023-10-02 [PMID: 37834290] (Bioassay, Mouse)
• Huang, Y;Zhu, L;Cheng, S;Dai, R;Huang, C;Song, Y;Peng, B;Li, X;Wen, J;Gong, Y;Hu, Y;Qian, L;Zhu, L;Zhang, F;Yu, L;Yi, C;Gu, W;Ling, Z;Ma, L;Tang, W;Peng, L;Shi, G;Zhang, Y;Sun, B; Solar ultraviolet B radiation promotes ?-MSH secretion to attenuate the function of ILC2s via the pituitary-lung axis Nature communications 2023-09-12 [PMID: 37699899] (Bioassay, Human, Mouse)
• Liu, J;Liu, S;Zeng, L;Tsilioni, I; Amyloid Beta Peptides Lead to Mast Cell Activation in a Novel 3D Hydrogel Model International journal of molecular sciences 2023-07-26 [PMID: 37569378] (Bioassay, Human)
• Tsilioni, I;Theoharides, TC; Recombinant SARS-CoV-2 Spike Protein Stimulates Secretion of Chymase, Tryptase, and IL-1? from Human Mast Cells, Augmented by IL-33 International journal of molecular sciences 2023-05-30 [PMID: 37298438] (Bioassay, Human)
• X Wang, Y Shen, S Hong, H Kang, X Ke Changes in type 2 innate lymphoid cells and serum cytokines in sublingual immunotherapy in pediatric patients with allergic rhinitis BMC pediatrics, 2023-01-09;23(1):13. 2023-01-09 [PMID: 36624390] (Bioassay, Human)
• C Akoto, A Willis, CF Banas, JA Bell, D Bryant, C Blume, DE Davies, EJ Swindle IL-33 Induces an Antiviral Signature in Mast Cells but Enhances Their Permissiveness for Human Rhinovirus Infection Viruses, 2022-11-01;14(11):. 2022-11-01 [PMID: 36366528] (Bioassay, Human)
• K Rasheed, U Moens, B Policastro, JI Johnsen, V Koljonen, H Sihto, WO Lui, B Sveinbjørn The Merkel Cell Polyomavirus T-Antigens and IL-33/ST2-IL1RAcP Axis: Possible Role in Merkel Cell Carcinoma International Journal of Molecular Sciences, 2022-03-28;23(7):. 2022-03-28 [PMID: 35409061] (Bioassay, Human)
• DAB Rex, Y Subbannayy, PK Modi, A Palollathi, L Gopalakris, YP Bhandary, TSK Prasad, SM Pinto Temporal Quantitative Phosphoproteomics Profiling of Interleukin-33 Signaling Network Reveals Unique Modulators of Monocyte Activation Cells, 2022-01-01;11(1):. 2022-01-01 [PMID: 35011700] (Bioassay, Human)
• C Zheng, Z Lu, H Wu, L Cui, J Bi, X Wan Exogenous oxidative stress suppresses IL-33 -driven proliferation programming in group 2 innate lymphoid cells International immunopharmacology, 2021-03-20;95(0):107541. 2021-03-20 [PMID: 33756232] (Bioassay, Human)
• L Cristinzia, R Poto, G Criscuolo, AL Ferrara, MR Galdiero, L Modestino, S Loffredo, A de Paulis, G Marone, G Spadaro, G Varricchi IL-33 and Superantigenic Activation of Human Lung Mast Cells Induce the Release of Angiogenic and Lymphangiogenic Factors Cells, 2021-01-12;10(1):. 2021-01-12 [PMID: 33445787] (Bioassay, Human)
• Y Imoto, T Takabayash, M Sakashita, Y Kato, K Yoshida, M Kidoguchi, K Koyama, N Adachi, Y Kimura, K Ogi, Y Ito, M Kanno, M Okamoto, N Narita, S Fujieda Enhanced 15-Lipoxygenase 1 Production is Related to Periostin Expression and Eosinophil Recruitment in Eosinophilic Chronic Rhinosinusitis Biomolecules, 2020-11-18;10(11):. 2020-11-18 [PMID: 33218117] (Cell Culture, Human)
• Rui Zheng, Yang Chen, Jianbo Shi, Kai Wang, Xuekun Huang, Yueqi Sun et al. Combinatorial IL-17RB, ST2, and TSLPR Signaling in Dendritic Cells of Patients With Allergic Rhinitis Frontiers in Cell and Developmental Biology 2020-04-03 [PMID: 32309281] (Bioassay, Human)
• HH Park, S Lee, Y Yu, SM Yoo, SY Baek, N Jung, KW Seo, KS Kang TGF-&amp;beta secreted by human umbilical cord blood-derived mesenchymal stem cells ameliorates atopic dermatitis by inhibiting secretion of TNF-&amp;alpha and IgE Stem Cells, 2020-04-14;0(0):. 2020-04-14 [PMID: 32277785] (Bioassay, Human)
• T Petrova, J Pesic, K Pardali, M Gaestel, JSC Arthur p38 MAPK signalling regulates cytokine production in IL-33 stimulated Type 2 Innate Lymphoid cells Sci Rep, 2020-02-26;10(1):3479. 2020-02-26 [PMID: 32103032] (Cell Culture, Human)
• JF Zhang, T Tao, K Wang, GX Zhang, Y Yan, HR Lin, Y Li, MW Guan, JJ Yu, XD Wang IL-33/ST2 axis promotes glioblastoma cell invasion by accumulating tenascin-C Sci Rep, 2019-12-30;9(1):20276. 2019-12-30 [PMID: 31889095] (Whole Cells, Human)
• Y Mishima, H Sonoyama, S Ishihara, N Oshima, I Moriyama, K Kawashima, Y Kinoshita Interleukin-33 delays recovery of mucosal inflammation via downregulation of homeostatic ABCG5/8 in the colon Lab. Invest., 2019-10-22;0(0):. 2019-10-22 [PMID: 31641224] (Bioassay, Human)
• S Sugihara, S Sugimoto, K Tachibana, M Kobashi, H Nomura, T Miyake, Y Hirai, O Yamasaki, S Morizane TNF-α and IL-17A induce the expression of lympho-epithelial Kazal-type inhibitor in epidermal keratinocytes J. Dermatol. Sci., 2019-08-21;0(0):. 2019-08-21 [PMID: 31501002] (Cell Culture, Human)
• JH Bernink, Y Ohne, MBM Teunissen, J Wang, J Wu, L Krabbendam, C Guntermann, R Volckmann, J Koster, S van Tol, I Ramirez, Y Shrestha, MA de Rie, H Spits, X Romero Ros, AA Humbles c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies Nat. Immunol., 2019-07-01;0(0):. 2019-07-01 [PMID: 31263279] (Cell Culture, Human)
• T Hochdörfer, C Winkler, K Pardali, J Mjösberg Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells Eur. J. Immunol., 2019-03-28;0(0):. 2019-03-28 [PMID: 30892687] (Bioassay, Human)
• X Qin, M Liu, S Zhang, C Wang, T Zhang The role of IL-36? and its regulation in eosinophilic inflammation in allergic rhinitis Cytokine, 2019-03-01;117(0):84-90. 2019-03-01 [PMID: 30831444] (Bioassay, Human)
• K Matsumoto, H Kouzaki, H Kikuoka, T Kato, I Tojima, S Shimizu, T Shimizu Soluble ST2 suppresses IL-5 production by human basophilic KU812 cells, induced by epithelial cell-derived IL-33 Allergol Int, 2018-06-22;0(0):. 2018-06-22 [PMID: 29941231] (Bioassay, Human)
• J Liu, W Wang, L Wang, S Chen, B Tian, K Huang, CJ Corrigan, S Ying, W Wang, C Wang IL-33 Initiates Vascular Remodelling in Hypoxic Pulmonary Hypertension by up-Regulating HIF-1? and VEGF Expression in Vascular Endothelial Cells EBioMedicine, 2018-06-18;0(0):. 2018-06-18 [PMID: 29921553] (Bioassay, Human)
• WI Ryu, H Lee, HC Bae, J Jeon, HJ Ryu, J Kim, JH Kim, JW Son, J Kim, Y Imai, K Yamanishi, SH Jeong, SW Son IL-33 down-regulates CLDN1 expression through the ERK/STAT3 pathway in keratinocytes J. Dermatol. Sci., 2018-03-02;0(0):. 2018-03-02 [PMID: 29534857] (Cell Culture, Human)
• Q Miao, Y Wang, YG Liu, YX Ren, H Guan, Z Li, W Xu, L Xiang Seasonal variation in circulating group 2 innate lymphoid cells in mugwort-allergic asthmatics during and outside pollen season Allergy Asthma Clin Immunol, 2018-02-09;14(0):6. 2018-02-09 [PMID: 29449864] (Bioassay, Human)
• S Lopez-Last, G Masse-Rans, O Fiquet, S Darche, N Serafini, Y Li, M Dusséaux, H Strick-Mar, JP Di Santo A functional DC cross talk promotes human ILC homeostasis in humanized mice Blood Adv, 2017-04-06;1(10):601-614. 2017-04-06 [PMID: 29296702] (Human)
• JE Miller, SP Monsanto, SH Ahn, K Khalaj, AT Fazleabas, SL Young, BA Lessey, M Koti, C Tayade Interleukin-33 modulates inflammation in endometriosis Sci Rep, 2017-12-20;7(1):17903. 2017-12-20 [PMID: 29263351] (Bioassay, Human)
• K Wang, S Shan, Z Yang, X Gu, Y Wang, C Wang, T Ren IL-33 blockade suppresses tumor growth of human lung cancer through direct and indirect pathways in a preclinical model Oncotarget, 2017-08-02;8(40):68571-68582. 2017-08-02 [PMID: 28978138] (Bioassay, Human)
• D Díaz-Jimén, L Núñez, M De la Fuen, K Dubois-Cam, H Sepúlveda, M Montecino, A Torres-Riq, P García-Gon, J Chnaiderma, A Vossenkamp, TT MacDonald, D Simian, MJ González, JA Cidlowski, R Quera, MA Hermoso A functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis Sci Rep, 2017-08-31;7(1):10180. 2017-08-31 [PMID: 28860510] (Bioassay, Human)
• JF Zhang, P Wang, YJ Yan, Y Li, MW Guan, JJ Yu, XD Wang IL?33 enhances glioma cell migration and invasion by upregulation of MMP2 and MMP9 via the ST2-NF-?B pathway Oncol. Rep., 2017-08-25;38(4):2033-2042. 2017-08-25 [PMID: 28849217] (Bioassay, Human)
• XH Wang, W Liu, DX Fan, WT Hu, MQ Li, XY Zhu, LP Jin IL?33 restricts invasion and adhesion of trophoblast cell line JEG3 by downregulation of integrin ?4?1 and CD62L Mol Med Rep, 2017-07-26;0(0):. 2017-07-26 [PMID: 28765940] (Bioassay, Human)
• V Lombardi, S Luce, H Moussu, L Morizur, C Gueguen, C Neukirch, S Chollet-Ma, L Mascarell, M Aubier, V Baron-Bodo, P Moingeon Effector and regulatory dendritic cells display distinct patterns of miRNA expression Immun Inflamm Dis, 2017-05-12;0(0):. 2017-05-12 [PMID: 28497578] (Bioassay, Human)
• A Taracanova, M Alevizos, A Karagkouni, Z Weng, E Norwitz, P Conti, SE Leeman, TC Theoharide SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors Proc. Natl. Acad. Sci. U.S.A., 2017-05-01;0(0):. 2017-05-01 [PMID: 28461492] (Human)
• M Fang, Y Li, K Huang, S Qi, J Zhang, W Zgodzinski, M Majewski, G Wallner, S Gozdz, P Macek, A Kowalik, M Pasiarski, E Grywalska, L Vatan, N Nagarsheth, W Li, L Zhao, I Kryczek, G Wang, Z Wang, W Zou, L Wang IL-33 promotes colon cancer cell stemness via JNK activation and macrophage recruitment Cancer Res, 2017-03-01;0(0):. 2017-03-01 [PMID: 28249897] (Bioassay, Human)
• Soluble IL-33 receptor sST2 inhibits colorectal cancer malignant growth by modifying the tumour microenvironment Nat Commun, 2016-11-24;7(0):13589. 2016-11-24 [PMID: 27882929] (Bioassay, Human)
• PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells Sci Rep, 2016-11-09;6(0):36795. 2016-11-09 [PMID: 27827428] (Bioassay, Human)
• Functional IL-33 receptors are expressed in early progenitor stages of allergy-related granulocytes Immunology, 2016-09-30;0(0):. 2016-09-30 [PMID: 27568595] (Bioassay, Human)
• Tissue factor is induced by interleukin-33 in human endothelial cells: a new link between coagulation and inflammation Sci Rep, 2016-05-04;6(0):25171. 2016-05-04 [PMID: 27142573] (Bioassay, Human)
• SM Bal, JH Bernink, M Nagasawa, J Groot, MM Shikhagaie, K Golebski, CM van Drunen, R Lutter, RE Jonkers, P Hombrink, M Bruchard, J Villaudy, JM Munneke, W Fokkens, JS Erjefält, H Spits, XR Ros IL-1?, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs Nat Immunol, 2016-04-25;0(0):. 2016-04-25 [PMID: 27111145] (Bioassay, Human)
• Bu X, Zhang T, Wang C, Ren T, Wen Z IL-33 reflects dynamics of disease activity in patients with autoimmune hemolytic anemia by regulating autoantibody production. J Transl Med, 2015-12-16;13(0):381. 2015-12-16 [PMID: 26675669] (Bioassay, Human)
• Kempuraj D, Thangavel R, Yang E, Pattani S, Zaheer S, Santillan D, Santillan M, Zaheer A Dopaminergic Toxin 1-Methyl-4-Phenylpyridinium, Proteins alpha-Synuclein and Glia Maturation Factor Activate Mast Cells and Release Inflammatory Mediators. PLoS ONE, 2015-08-14;10(8):e0135776. 2015-08-14 [PMID: 26275153] (Bioassay, Human)
• Maywald R, Doerner S, Pastorelli L, De Salvo C, Benton S, Dawson E, Lanza D, Berger N, Markowitz S, Lenz H, Nadeau J, Pizarro T, Heaney J IL-33 activates tumor stroma to promote intestinal polyposis. Proc Natl Acad Sci U S A, 2015-04-27;112(19):E2487-96. 2015-04-27 [PMID: 25918379] (Bioassay, Human)
• Zhang Y, Zhang C, Zhuang R, Ma Y, Zhang Y, Yi J, Yang A, Jin B IL-33/ST2 correlates with severity of haemorrhagic fever with renal syndrome and regulates the inflammatory response in Hantaan virus-infected endothelial cells. PLoS Negl Trop Dis, 2015-02-06;9(2):e0003514. 2015-02-06 [PMID: 25658420] (Bioassay, Human)
• Kim J, Lim S, Kim G, Yun H, Ahn S, Choi H Interleukin-33/ST2 axis promotes epithelial cell transformation and breast tumorigenesis via upregulation of COT activity. Oncogene, 2014-12-22;34(38):4928-38. 2014-12-22 [PMID: 25531326] (In Vivo, Mouse)
• Stojkovic S, Kaun C, Heinz M, Krychtiuk K, Rauscher S, Lemberger C, de Martin R, Groger M, Petzelbauer P, Huk I, Huber K, Wojta J, Demyanets S Interleukin-33 induces urokinase in human endothelial cells--possible impact on angiogenesis. J Thromb Haemost, 2014-06-01;12(6):948-57. 2014-06-01 [PMID: 24702774] (Bioassay, Human)
• Levescot A, Flamant S, Basbous S, Jacomet F, Feraud O, Anne Bourgeois E, Bonnet M, Giraud C, Roy L, Barra A, Chomel J, Turhan A, Guilhot F, Girard J, Gombert J, Herbelin A BCR-ABL-induced deregulation of the IL-33/ST2 pathway in CD34+ progenitors from chronic myeloid leukemia patients. Cancer Res, 2014-03-27;74(10):2669-76. 2014-03-27 [PMID: 24675360] (Bioassay, Human)
• Teunissen M, Munneke J, Bernink J, Spuls P, Res P, Te Velde A, Cheuk S, Brouwer M, Menting S, Eidsmo L, Spits H, Hazenberg M, Mjosberg J Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients. J Invest Dermatol, 2014-03-21;134(9):2351-60. 2014-03-21 [PMID: 24658504] (Bioassay, Human)
• Wong , Tina W, Doyle , Alfred D, Lee , James J, Jelinek , Diane F Eosinophils regulate peripheral B cell numbers in both mice and humans. J Immunol, 2014-03-10;192(8):3548-58. 2014-03-10 [PMID: 24616476] (Bioassay, Human)
• Thierry A, Giraud S, Robin A, Barra A, Bridoux F, Ameteau V, Hauet T, Girard J, Touchard G, Gombert J, Herbelin A The alarmin concept applied to human renal transplantation: evidence for a differential implication of HMGB1 and IL-33. PLoS ONE, 2014-02-20;9(2):e88742. 2014-02-20 [PMID: 24586382] (Bioassay, Human)
• Qiu H, Wong C, Chu I, Hu S, Lam C Muramyl dipeptide mediated activation of human bronchial epithelial cells interacting with basophils: a novel mechanism of airway inflammation. Clin Exp Immunol, 2013-04-01;172(1):81-94. 2013-04-01 [PMID: 23480188] (Bioassay, Human)
• Liu K, Hu S, Chan B, Wat E, Lau C, Hon K, Fung K, Leung P, Hui P, Lam C, Wong C Anti-inflammatory and anti-allergic activities of Pentaherb formula, Moutan Cortex (Danpi) and gallic acid. Molecules, 2013-02-25;18(3):2483-500. 2013-02-25 [PMID: 23439564] (Flow Cytometry, IHC, Human)
• Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J. Exp. Med., 2012-07-16;209(8):1505-17. 2012-07-16 [PMID: 22802353] (Bioassay, Human)
• Sahlander K, Larsson K, Palmberg L Daily exposure to dust alters innate immunity. PLoS ONE, 2012-02-15;7(2):e31646. 2012-02-15 [PMID: 22355383] (Bioassay, Human)
• Vasiadi M, Therianou A, Alysandratos KD, Katsarou-Katsari A, Petrakopoulou T, Theoharides A, Papadavid E, Stavrianeas N, Antoniou C, Kalogeromitros D, Theoharides TC Serum neurotensin (NT) is increased in psoriasis and NT induces vascular endothelial growth factor release from human mast cells. Br. J. Dermatol., 2012-05-14;166(6):1349-52. 2012-05-14 [PMID: 22283733] (Bioassay, Human)
• Hong YS, Moon SJ, Moon S, Joo YB, Joo Y, Jeon CH, Jeon C, Cho ML, Ju JH, Oh HJ, Heo YJ, Heo Y, Park SH, Kim HY, Min JK Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis. J Korean Med Sci, 2011-09-01;26(9):1132-9. 2011-09-01 [PMID: 21935266] (ELISA (Standard))
• Cherry WB, Yoon J, Bartemes KR, Iijima K, Kita H A novel IL-1 family cytokine, IL-33, potently activates human eosinophils. J. Allergy Clin. Immunol., 2008-06-01;121(6):1484-90. 2008-06-01 [PMID: 18539196] (Bioassay, Human)

Bioinformatics

• Gene Symbol: IL33
• Uniprot:
  • O95760.1()