Recombinant Human IL-21R Fc Chimera Protein, CF


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Product Details

Reactivity HuSpecies Glossary
Applications Bioactivity

Order Details

Recombinant Human IL-21R Fc Chimera Protein, CF Summary

Additional Information
A New rh IL-21 R is Available! It is HEK293 expressed, exhibits enhanced activity, and has a His-tag.
Details of Functionality
Measured by its ability to inhibit IL-21-dependent enhancement of IFN-gamma secretion in NK-92 human natural killer lymphoma cells. The ED50 for this effect is 40-400 ng/mL.
Mouse myeloma cell line, NS0-derived human IL-21R protein
Human IL-21 R Subunit
Accession # Q9HBE5
N-terminus C-terminus
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


Theoretical MW
51.7 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
80-85 kDa, reducing conditions
Read Publications using
991-R2 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS.
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions
Reconstitute at 500 μg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IL-21R Fc Chimera Protein, CF

  • CD360 antigen
  • CD360
  • IL-21 R
  • IL-21 receptor
  • IL21R
  • IL-21R
  • interleukin 21 receptor
  • interleukin-21 receptor
  • MGC10967
  • NILR
  • Novel interleukin receptor


Interleukin-21 Receptor (IL-21 R) is a type I transmembrane glycoprotein within the class I cytokine receptor family (1). IL-21 R associates with the common  gamma  chain ( gamma c) which is also a component of the receptors for IL-2, IL-4, IL-7, IL-9, IL-13, and IL-15 (2, 3). Mature human IL-21 R consists of a 213 amino acid (aa) extracellular domain (ECD) with 4 conserved cysteine residues, a fibronectin type III domain, and a WSxWS motif, followed by a 21 aa transmembrane domain and a 253 aa cytoplasmic domain with a Box 1 motif, a kinase domain, and several sites for tyrosine phosphorylation (4, 5). Within the ECD, human IL-21 R shares 69% aa identity with mouse and rat IL-21 R, respectively. IL-21 R is expressed mainly on B cells (highest on mature, activated, follicular and germinal center B cells), NK cells, and activated T cells, but is also found on dendritic cells, alternatively activated macrophages, intestinal lamina propria fibroblasts and epithelial cells, and keratinocytes (1, 4, 5). Both IL-21 and IL-4 are necessary for efficient B cell IgG1 production and normal germinal center architecture (6). B cell IL-21 R engagement induces Blimp-1 (which mediates plasma cell differentiation) and is important for memory responses (7, 8). IL-21 R engagement enhances NK cell mediated cytotoxic activity and IFN-gamma production (4, 9), control of viral infection and tumor growth by CD8+ T cells (10), development of regulatory T cells (11), IL-23 responsiveness of encephalitogenic Th17 cells (12), but suppresses the accumulation of IL-17 secreting gamma δ T cells in the airway (13). IL-21 R expression is often upregulated in allergic skin inflammation, systemic lupus erythematosus and diffuse large B cell lymphoma (DLBCL) (14, 15).
  1. Tangye, S.G. (2015) Curr. Opin. Immunol. 34:107.
  2. Asao, H. et al. (2001) J. Immunol. 167:1.
  3. Habib, T. et al. (2002) Biochemistry 41:8725.
  4. Parrish-Novak, et al. (2000) Nature 408:57.
  5. Ozaki, K. et al. (2000) Proc. Natl. Acad. Sci. USA 97:11439.
  6. Ozaki, K. et al. (2002) Science 298:1630.
  7. Rankin, A.L. et al. (2011) J. Immunol. 186:667.
  8. King, I.L. et al. (2010) J. Immunol. 185:6138.
  9. Kasaian, M.T. et al. (2002) Immunity 16:559.
  10. Frohlich, A. et al. (2009 Science 324:1576.
  11. Tortola, L. et al. (2010) Blood 116:5200.
  12. Lee, Y. et al. (2015) J. Clin. Invest. 125:4011.
  13. Moser, E.K. et al. (2015) PLoS One 10:e0120169.
  14. Jin, H. et al. (2009) J. Clin. Invest. 119:47.
  15. Sarosiek, K.A. et al. (2010) Blood 115:570.

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Publications for IL-21R (991-R2)(13)

We have publications tested in 3 confirmed species: Human, Mouse, N/A.

We have publications tested in 3 applications: Bioassay, Flow Cytometry, IHC.

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Showing Publications 1 - 10 of 13. Show All 13 Publications.
Publications using 991-R2 Applications Species
A Aljurayyan, S Puksuriwon, M Ahmed, R Sharma, M Krishnan, S Sood, K Davies, D Rajashekar, S Leong, PS McNamara, S Gordon, Q Zhang Activation and induction of antigen-specific T follicular helper cells (TFH) play a critical role in LAIV-induced human mucosal anti-influenza antibody response J. Virol., 2018;0(0):. 2018 [PMID: 29563292] (Bioassay, Human) Bioassay Human
O Désy, S Béland, P Vallin, J Riopel, E Latulippe, E Wagner, SA De Serres Allogeneic dendritic cells stimulated with antibodies against HLA class II polarize naive T cells in a follicular helper phenotype Sci Rep, 2018;8(1):4025. 2018 [PMID: 29507364] (Bioassay, Human) Bioassay Human
YM Kooy-Winke, D Bouwer, GM Janssen, A Thompson, MH Brugman, F Schmitz, AH de Ru, T van Gils, G Bouma, JJ van Rood, PA van Veelen, ML Mearin, CJ Mulder, F Koning, J van Bergen CD4 T-cell cytokines synergize to induce proliferation of malignant and nonmalignant innate intraepithelial lymphocytes Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):. 2017 [PMID: 28049849] (Bioassay, N/A) Bioassay N/A
Augmentation of Circulating Follicular Helper T Cells and Their Impact on Autoreactive B Cells in Myasthenia Gravis J Immunol, 2016;0(0):. 2016 [PMID: 27543617] (Bioassay, Human) Bioassay Human
Xing R, Yang L, Jin Y, Sun L, Li C, Li Z, Zhao J, Liu X Interleukin-21 Induces Proliferation and Proinflammatory Cytokine Profile of Fibroblast-like Synoviocytes of Patients with Rheumatoid Arthritis. Scand J Immunol, 2015;83(1):64-71. 2015 [PMID: 26482544] (Bioassay, Human) Bioassay Human
Harker J, Wong K, Dolgoter A, Zuniga E Cell-Intrinsic gp130 Signaling on CD4+ T Cells Shapes Long-Lasting Antiviral Immunity. J Immunol, 2016;195(3):1071-81. 2016 [PMID: 26085685] (IHC, Mouse) IHC Mouse
Kaltenmeier C, Gawanbacht A, Beyer T, Lindner S, Trzaska T, van der Merwe J, Harter G, Gruner B, Fabricius D, Lotfi R, Schwarz K, Schutz C, Honig M, Schulz A, Kern P, Bommer M, Schrezenmeier H, Kirchhoff F, Jahrsdorfer B CD4+ T cell-derived IL-21 and deprivation of CD40 signaling favor the in vivo development of granzyme B-expressing regulatory B cells in HIV patients. J Immunol, 2015;194(8):3768-77. 2015 [PMID: 25780036] (Bioassay, Human) Bioassay Human
Parmigiani A, Alcaide M, Freguja R, Pallikkuth S, Frasca D, Fischl M, Pahwa S Impaired antibody response to influenza vaccine in HIV-infected and uninfected aging women is associated with immune activation and inflammation. PLoS ONE, 2013;8(11):e79816. 2013 [PMID: 24236161] (Bioassay, Human) Bioassay Human
Mazerolles F, Picard C, Kracker S, Fischer A, Durandy A Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency. J Allergy Clin Immunol, 2013;131(4):1146-56, 1156. 2013 [PMID: 23403044] (Bioassay, Human) Bioassay Human
Kasagi S, Kawano S, Okazaki T, Honjo T, Morinobu A, Hatachi S, Shimatani K, Tanaka Y, Minato N, Kumagai S Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice. J. Immunol., 2010;184(5):2337-47. 2010 [PMID: 20139271] (Flow Cytometry, Human) Flow Cytometry Human
Show All 13 Publications.

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Gene Symbol IL21R