Recombinant Human GM-CSF Protein

Recombinant Human GM-CSF Protein (Catalog # 215-GM) has a molecular weight (MW) of 14.1 kDa as analyzed by SEC-MALS, suggesting that this protein is a monomer.

Recombinant Human GM-CSF (Catalog # 215-IL) stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED50 for this effect is 6-30 pg/mL.

1 μg/lane of Recombinant Human GM-CSF was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa.

• Reactivity: Hu
• Applications: Bioactivity

Recombinant Human GM-CSF Protein Summary

• Additional Information: Analyzed by SEC-MALS
• Details of Functionality: Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED₅₀ for this effect is 6-30 pg/mL.
• Source: E. coli-derived human GM-CSF protein
  Ala18-Glu144
• Accession #: P04141.1
• N-terminal Sequence: Ala18
• Protein/Peptide Type: Recombinant Proteins
• Gene: CSF2
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <1.0 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 14 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human GM-CSF Protein

• colony stimulating factor 2 (granulocyte-macrophage)
• Colony-stimulating factor
• CSF
• CSF2
• CSF-2
• GMCSF
• GM-CSF
• GMCSFgranulocyte-macrophage colony-stimulating factor
• granulocyte-macrophage colony stimulating factor
• MGC131935
• MGC138897
• Molgramostim
• molgramostin
• Sargramostim

Background

GM‑CSF was initially characterized as a factor that can support the in vitro colony formation of granulocyte‑macrophage progenitors. It is also a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. GM‑CSF is produced by a number of different cell types (including T cells, B cells, macrophages, mast cells, endothelial cells, fibroblasts, and adipocytes) in response to cytokine or inflammatory stimuli. On mature hematopoietic cells, GM‑CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages, and eosinophils (1, 2). GM‑CSF promotes a Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity (3‑5). It shows clinical effectiveness in ameliorating chemotherapy‑induced neutropenia, and GM‑CSF transfected tumor cells are utilized as cancer vaccines (6, 7). The 22 kDa glycosylated GM‑CSF, similar to IL‑3 and IL‑5, is a cytokine with a core of four bundled
alpha -helices (8‑12). Mature human GM‑CSF shares 63%‑70% amino acid sequence identity with canine, feline, porcine, and rat GM‑CSF and 54% with mouse GM‑CSF. GM‑CSF exerts its biological effects through a heterodimeric receptor complex composed of GM‑CSF R alpha /CD116 and the signal transducing common beta  chain (CD131) which is also a component of the high‑affinity receptors for IL‑3 and IL‑5 (13, 14). In addition, GM‑CSF binds a naturally occurring soluble form of GM‑CSF R alpha (15). Human GM‑CSF is active on canine and feline cells but not on murine cells (16‑18).

1. Martinez-Moczygemba, M. and D.P. Huston (2003) J. Allergy Clin. Immunol. 112:653.
2. Barreda, D.R. et al. (2004) Dev. Comp. Immunol. 28:509.
3. Eksioglu, E.A. et al. (2007) Exp. Hematol. 35:1163.
4. Cao, Y. (2007) J. Clin. Invest. 117:2362.
5. Fleetwood, A.J. et al. (2005) Crit. Rev. Immunol. 25:405.
6. Heuser, M. et al. (2007) Semin. Hematol. 44:148.
7. Hege, K.M. et al. (2006) Int. Rev. Immunol. 25:321.
8. Kaushansky, K. et al. (1992) Biochemistry 31:1881.
9. Diederichs, K. et al. (1991) Science 254:1779. 
10. Cantrell, M.A. et al. (1985) Proc. Natl. Acad. Sci. 82:6250.
11. Lee, F. et al. (1985) Proc. Natl. Acad. Sci. 82:4360.
12. Wong, G.G. et al. (1985) Science 228:810.
13. Onetto-Pothier, N. et al. (1990) Blood 75:59.
14. Hayashida, K. et al. (1990) Proc. Natl. Acad. Sci. 87:9655.
15. Pelley, J.L. et al. (2007) Exp. Hematol. 35:1483.
16. Hogge, G.S. et al. (1990) Cancer Gene Ther. 6:26.
17. Sprague, W.S. et al. (2005) J. Comp. Pathol. 133:136.
18. Shanafelt, A.B. et al. (1991) J. Biol. Chem. 266:13804.

Publications for GM-CSF (215-GM)(280)

Publications using 215-GM

• Kent, GM;Atkins, MH;Lung, B;Nikitina, A;Fernandes, IM;Kwan, JJ;Andrews, TS;MacParland, SA;Keller, GM;Gage, BK; Human liver sinusoidal endothelial cells support the development of functional human pluripotent stem cell-derived Kupffer cells Cell reports 2024-08-14 [PMID: 39146183] (Bioassay, Human)
• Anderson, AE;Parashar, K;Jin, K;Clor, J;Stagnaro, CE;Vani, U;Singh, J;Chen, A;Guan, Y;Talukdar, P;Sathishkumar, P;Juat, DJ;Singh, H;Kushwaha, R;Zhao, X;Kaplan, A;Seitz, L;Walters, MJ;Fernandez-Salas, E;Walker, NPC;Bowman, CE; Characterization of AB598, a CD39 Enzymatic Inhibitory Antibody for the Treatment of Solid Tumors Molecular cancer therapeutics 2024-05-27 [PMID: 38797955] (Human)
• Yildirim-Balatan, C;Fenyi, A;Besnault, P;Gomez, L;Sepulveda-Diaz, JE;Michel, PP;Melki, R;Hunot, S; Parkinson's disease-derived ?-synuclein assemblies combined with chronic-type inflammatory cues promote a neurotoxic microglial phenotype Journal of neuroinflammation 2024-02-21 [PMID: 38383421] (Bioassay, Human)
• Múnera, JO;Kechele, DO;Bouffi, C;Qu, N;Jing, R;Maity, P;Enriquez, JR;Han, L;Campbell, I;Mahe, MM;McCauley, HA;Zhang, X;Sundaram, N;Hudson, JR;Zarsozo-Lacoste, A;Pradhan, S;Tominaga, K;Sanchez, JG;Weiss, AA;Chatuvedi, P;Spence, JR;Hachimi, M;North, T;Daley, GQ;Mayhew, CN;Hu, YC;Takebe, T;Helmrath, MA;Wells, JM; Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon Cell stem cell 2023-11-02 [PMID: 37922878] (Differentiation)
• Cortés-López, M;Chamely, P;Hawkins, AG;Stanley, RF;Swett, AD;Ganesan, S;Mouhieddine, TH;Dai, X;Kluegel, L;Chen, C;Batta, K;Furer, N;Vedula, RS;Beaulaurier, J;Drong, AW;Hickey, S;Dusaj, N;Mullokandov, G;Stasiw, AM;Su, J;Chaligné, R;Juul, S;Harrington, E;Knowles, DA;Potenski, CJ;Wiseman, DH;Tanay, A;Shlush, L;Lindsley, RC;Ghobrial, IM;Taylor, J;Abdel-Wahab, O;Gaiti, F;Landau, DA; Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths Cell stem cell 2023-08-09 [PMID: 37582363] (Bioassay, Human)
• Y Yu, M Wang, XW Li, J Mao, YJ Zhu, N Wang, LH Yin, ZL Guo, H Cai, T Li, TT Liang, J Cui, T Zhou Meloxicam inhibits STING phosphorylation and alleviates intracellular DNA-mediated autoimmune responses Cell & bioscience, 2023-04-29;13(1):76. 2023-04-29 [PMID: 37120570] (Bioassay, Human)
• JY Li, Y Zhao, S Gong, MM Wang, X Liu, QM He, YQ Li, SY Huang, H Qiao, XR Tan, ML Ye, XH Zhu, SW He, Q Li, YL Liang, KL Chen, SW Huang, QJ Li, J Ma, N Liu TRIM21 inhibits irradiation-induced mitochondrial DNA release and impairs antitumour immunity in nasopharyngeal carcinoma tumour models Nature Communications, 2023-02-16;14(1):865. 2023-02-16 [PMID: 36797289] (Bioassay, Human)
• H Zheng, X Yu, ML Ibrahim, D Foresman, M Xie, JO Johnson, TA Boyle, B Ruffell, BA Perez, SJ Antonia, N Ready, AN Saltos, MJ Cantwell, AA Beg Combination IFNbeta and membrane-stable CD40L maximize tumor dendritic cell activation and lymph node trafficking to elicit systemic T-cell immunity Cancer Immunology Research, 2023-04-03;0(0):. 2023-04-03 [PMID: 36757308] (Bioassay, Human)
• D Kwart, J He, S Srivatsan, C Lett, J Golubov, EM Oswald, P Poon, X Ye, J Waite, AG Zaretsky, S Haxhinasto, E Au-Yeung, NT Gupta, J Chiu, C Adler, S Cherravuru, E Malahias, N Negron, K Lanza, A Coppola, M Ni, H Song, Y Wei, GS Atwal, L Macdonald, NS Oristian, W Poueymirou, V Jankovic, M Fury, I Lowy, AJ Murphy, MA Sleeman, B Wang, D Skokos Cancer cell-derived type I interferons instruct tumor monocyte polarization Cell Reports, 2022-12-06;41(10):111769. 2022-12-06 [PMID: 36476866] (Bioassay, Human)
• H Salvator, A Cheng, LB Rosen, PR Williamson, JE Bennett, A Kashyap, L Ding, KJ Kwon-Chung, H Namkoong, CS Zerbe, SM Holland Neutralizing GM-CSF autoantibodies in pulmonary alveolar proteinosis, cryptococcal meningitis and severe nocardiosis Respiratory Research, 2022-10-11;23(1):280. 2022-10-11 [PMID: 36221098] (ELISA Development, Human)
• SP John, A Singh, J Sun, MJ Pierre, L Alsalih, C Lipsey, Z Traore, S Balcom-Luk, CJ Bradfield, J Song, TE Markowitz, M Smelkinson, M Ferrer, IDC Fraser Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infection Cell Reports, 2022-09-15;0(0):111441. 2022-09-15 [PMID: 36179680] (Bioassay, Human)
• YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells Science Advances, 2022-08-24;8(34):eabn5522. 2022-08-24 [PMID: 36001668] (Bioassay, Human)
• F Zeng, S Liao, Z Kuang, Q Zhu, H Wei, J Shi, E Zheng, Z Xu, S Huang, L Hong, T Gu, J Yang, H Yang, G Cai, S Moisyadi, J Urschitz, Z Li, Z Wu Genetically Engineered Pigs as Efficient Salivary Gland Bioreactors for Production of Therapeutically Valuable Human Nerve Growth Factor Cells, 2022-08-02;11(15):. 2022-08-02 [PMID: 35954224] (Bioassay, Human)
• SD van Haren, GK Pedersen, A Kumar, TJ Ruckwardt, S Moin, IN Moore, M Minai, M Liu, J Pak, F Borriello, S Doss-Golli, EMS Beijnen, S Ahmed, M Helmel, P Andersen, BS Graham, H Steen, D Christense, O Levy CAF08 adjuvant enables single dose protection against respiratory syncytial virus infection in murine newborns Nature Communications, 2022-08-02;13(1):4234. 2022-08-02 [PMID: 35918315] (Bioassay, Human)
• S Chen, RS Vedula, A Cuevas-Nav, B Lu, SJ Hogg, E Wang, S Benbarche, K Knorr, WJ Kim, RF Stanley, H Cho, C Erickson, M Singer, D Cui, S Tittley, BH Durham, TS Pavletich, E Fiala, MF Walsh, D Inoue, S Monette, J Taylor, N Rosen, F McCormick, RC Lindsley, P Castel, O Abdel-Waha Impaired proteolysis of non-canonical RAS proteins drives clonal hematopoietic transformation Cancer Discovery, 2022-10-05;0(0):. 2022-10-05 [PMID: 35904492] (Cell Culture, Human)
• IY Quiroga, AE Cruikshank, ML Bond, KSM Reed, BA Evangelist, JH Tseng, JV Ragusa, RB Meeker, H Won, S Cohen, TJ Cohen, DH Phanstiel Synthetic amyloid beta does not induce a robust transcriptional response in innate immune cell culture systems Journal of Neuroinflammation, 2022-04-23;19(1):99. 2022-04-23 [PMID: 35459147] (Bioassay, Human)
• P Sekhri, DK Ledezma, A Shukla, EE Sweeney, R Fernandes The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells Cancers, 2022-03-11;14(6):. 2022-03-11 [PMID: 35326601] (Cell Culture, Human)
• H Farese, Farese H, M Noack, Noack M, P Miossec Synoviocytes from pigmented villonodular synovitis are less sensitive to cadmium-induced cell death than synoviocytes from rheumatoid arthritis. Sci Rep, 2022-03-09;12(1):3832. 2022-03-09 [PMID: 35264617] (Bioassay, Human)
• Y Li, Y Zhu, S Feng, Y Ishida, TP Chiu, T Saito, S Wang, DK Ann, JJ Ou Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1beta to downregulate PPARalpha and FOXO3 Cell Reports, 2022-01-25;38(4):110284. 2022-01-25 [PMID: 35081341] (Bioassay, Human)
• R Sagawa, S Sakata, B Gong, Y Seto, A Takemoto, S Takagi, H Ninomiya, N Yanagitani, M Nakao, M Mun, K Uchibori, M Nishio, Y Miyazaki, Y Shiraishi, S Ogawa, K Kataoka, N Fujita, K Takeuchi, R Katayama Soluble PD-L1 through alternative polyadenylation works as a decoy in lung cancer immunotherapy JCI Insight, 2022-01-11;0(0):. 2022-01-11 [PMID: 34874919] (Bioassay, Human)
• Y Qiao, Y Qiu, J Ding, N Luo, H Wang, X Ling, J Sun, Z Wu, Y Wang, Y Liu, F Guo, T Sun, W Shen, M Zhang, D Wu, B Chen, W Xu, X Wang Cancer immune therapy with PD-1-dependent CD137 co-stimulation provides localized tumour killing without systemic toxicity Nature Communications, 2021-11-04;12(1):6360. 2021-11-04 [PMID: 34737267] (Bioassay, Human)
• MD Cherne, B Sidar, TA Sebrell, HS Sanchez, K Heaton, FJ Kassama, MM Roe, AB Gentry, CB Chang, ST Walk, M Jutila, JN Wilking, D Bimczok A Synthetic Hydrogel, VitroGel� ORGANOID-3, Improves Immune Cell-Epithelial Interactions in a Tissue Chip Co-Culture Model of Human Gastric Organoids and Dendritic Cells Frontiers in Pharmacology, 2021-09-06;12(0):707891. 2021-09-06 [PMID: 34552484] (Bioassay, Human)
• A Banerjee, Y Lu, K Do, T Mize, X Wu, X Chen, J Chen Validation of Induced Microglia-Like Cells (iMG Cells) for Future Studies of Brain Diseases Frontiers in Cellular Neuroscience, 2021-04-09;15(0):629279. 2021-04-09 [PMID: 33897370] (Bioassay, Human)
• D Inoue, JT Polaski, J Taylor, P Castel, S Chen, S Kobayashi, SJ Hogg, Y Hayashi, JMB Pineda, E El Marabti, C Erickson, K Knorr, M Fukumoto, H Yamazaki, A Tanaka, C Fukui, SX Lu, BH Durham, B Liu, E Wang, S Mehta, D Zakheim, R Garippa, A Penson, GL Chew, F McCormick, RK Bradley, O Abdel-Waha Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition Nature Genetics, 2021-04-12;0(0):. 2021-04-12 [PMID: 33846634] (Bioassay, Human)
• R Song, Y Gao, I Dozmorov, V Malladi, I Saha, MM McDaniel, S Parameswar, C Liang, C Arana, B Zhang, B Wakeland, J Zhou, MT Weirauch, LC Kottyan, EK Wakeland, C Pasare IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility Cell Reports, 2021-03-23;34(12):108891. 2021-03-23 [PMID: 33761354] (Bioassay, Human)
• Bsat M, Mehta H, Rubio M, Sarfati M The Conversion of Human Tissue-Like Inflammatory Monocytes Into Macrophages. Curr Protoc, 2021-03-01;1(3):e74. 2021-03-01 [PMID: 33705607] (Bioassay, Human)
• J Li, A Wuethrich, AAI Sina, HH Cheng, Y Wang, A Behren, PN Mainwaring, M Trau A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy Nature Communications, 2021-02-17;12(1):1087. 2021-02-17 [PMID: 33597530] (Human)
• M Drill, KL Powell, LK Kan, NC Jones, TJ O'Brien, JA Hamilton, M Monif Inhibition of purinergic P2X receptor 7 (P2X7R) decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in U251 glioblastoma cells Sci Rep, 2020-09-09;10(1):14844. 2020-09-09 [PMID: 32908225] (Cell Culture, Human)
• B Cioni, A Zaalberg, JR van Beijnu, MHM Melis, J van Burgst, MJ Muraro, E Hooijberg, D Peters, I Hofland, Y Lubeck, J de Jong, J Sanders, J Vivié, HG van der Po, JP de Boer, AW Griffioen, W Zwart, AM Bergman Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion Nat Commun, 2020-09-09;11(1):4498. 2020-09-09 [PMID: 32908142] (Bioassay, Human)
• S Vakili, TM Ahooyi, SS Yarandi, M Donadoni, J Rappaport, IK Sariyer Molecular and Cellular Impact of Inflammatory Extracellular Vesicles (EVs) Derived from M1 and M2 Macrophages on Neural Action Potentials Brain Sci, 2020-07-03;10(7):. 2020-07-03 [PMID: 32635207] (Bioassay, Human)
• X Guo, Y Pan, M Xiong, S Sanapala, C Anastasaki, O Cobb, S Dahiya, DH Gutmann Midkine activation of CD8+ T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth Nat Commun, 2020-05-01;11(1):2177. 2020-05-01 [PMID: 32358581] (Cell Culture, Human)
• J Lubow, MC Virgilio, M Merlino, DR Collins, M Mashiba, BG Peterson, Z Lukic, MM Painter, F Gomez-Rive, V Terry, G Zimmerman, KL Collins Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages Elife, 2020-03-02;9(0):. 2020-03-02 [PMID: 32119644] (Bioassay, Human)
• B ?y?y?ska-G, B Trzaskowsk, M Dutkiewicz, O Zegrocka-S, M Machci?ska, K Bocian, M Kowalewska, K Koziak The anti-inflammatory potential of cefazolin as common gamma chain cytokine inhibitor Sci Rep, 2020-02-19;10(1):2886. 2020-02-19 [PMID: 32076052] (Cell Culture, Human)
• H Xiang, CP Ramil, J Hai, C Zhang, H Wang, AA Watkins, R Afshar, P Georgiev, MA Sze, XS Song, PJ Curran, M Cheng, JR Miller, D Sun, A Loboda, Y Jia, LY Moy, A Chi, PE Brandish Cancer-associated fibroblasts promote immunosuppression by inducing ROS-generating monocytic MDSCs in lung squamous cell carcinoma Cancer Immunol Res, 2020-02-19;0(0):. 2020-02-19 [PMID: 32075803] (Bioassay, Human)
• JS Brunner, L Vulliard, M Hofmann, M Kieler, A Lercher, A Vogel, M Russier, JB Brüggenthi, M Kerndl, V Saferding, B Niederreit, A Junza, A Frauenstei, C Scholtysek, Y Mikami, K Klavins, G Krönke, A Bergthaler, JJ O'Shea, T Weichhart, F Meissner, JS Smolen, P Cheng, O Yanes, J Menche, PJ Murray, O Sharif, S Blüml, G Schabbauer Environmental arginine controls multinuclear giant cell metabolism and formation Nat Commun, 2020-01-22;11(1):431. 2020-01-22 [PMID: 31969567] (Differentiation, Differentiation, Human)
• JJ Montoya, MA Turnidge, DH Wai, AR Patel, DW Lee, V Gokhale, LH Hurley, RJ Arceci, C Wetmore, DO Azorsa In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells BMC Cancer, 2019-12-27;19(1):1251. 2019-12-27 [PMID: 31881855] (Bioassay, Human)
• R Chen, G Ji, H Ren, Z Liu, S Feng, T Zhang, L Xi, X Li Activation of autophagy and IL-10 production are regulated by Jun N-terminal kinase 1 and 2 and p38 mitogen activated protein kinase signaling pathways during Talaromyces marneffei infection within dendritic cells Microb. Pathog., 2019-11-26;139(0):103891. 2019-11-26 [PMID: 31783123] (Cell Culture, Human)
• S Patel, R Hanajiri, M Grant, D Saunders, S Van Pelt, M Keller, PJ Hanley, G Simon, DF Nixon, D Hardy, RB Jones, CM Bollard HIV-Specific T Cells Can Be Generated against Non-escaped T Cell Epitopes with a GMP-Compliant Manufacturing Platform Mol Ther Methods Clin Dev, 2019-10-11;16(0):11-20. 2019-10-11 [PMID: 31720305] (Cell Culture, Human)
• N Chiang, S Libreros, PC Norris, X de la Rosa, CN Serhan Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions J. Clin. Invest., 2019-12-02;0(0):. 2019-12-02 [PMID: 31657786] (Cell Culture, Human)
• A Yoshimi, KT Lin, DH Wiseman, MA Rahman, A Pastore, B Wang, SC Lee, JB Micol, XJ Zhang, S de Botton, V Penard-Lac, EM Stein, H Cho, RE Miles, D Inoue, TR Albrecht, TCP Somervaill, K Batta, F Amaral, F Simeoni, DP Wilks, C Cargo, AM Intlekofer, RL Levine, H Dvinge, RK Bradley, EJ Wagner, AR Krainer, O Abdel-Waha Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis Nature, 2019-10-02;0(0):. 2019-10-02 [PMID: 31578525] (Cell Culture, Human)
• SR Levan, KA Stamnes, DL Lin, AR Panzer, E Fukui, K McCauley, KE Fujimura, M McKean, DR Ownby, EM Zoratti, HA Boushey, MD Cabana, CC Johnson, SV Lynch Elevated faecal 12,13-diHOME concentration in neonates at high risk for asthma is produced by gut bacteria and impedes immune tolerance Nat Microbiol, 2019-07-22;4(11):1851-1861. 2019-07-22 [PMID: 31332384] (Cell Culture, Human)
• A Crotti, HR Sait, KM McAvoy, K Estrada, A Ergun, S Szak, G Marsh, L Jandreski, M Peterson, TL Reynolds, I Dalkilic-L, A Cameron, E Cahir-McFa, RM Ransohoff BIN1 favors the spreading of Tau via extracellular vesicles Sci Rep, 2019-07-01;9(1):9477. 2019-07-01 [PMID: 31263146] (Cell Culture, Human)
• AI Chiramel, NR Meyerson, KL McNally, RM Broeckel, VR Montoya, O Méndez-Sol, SJ Robertson, GL Sturdevant, KJ Lubick, V Nair, BH Youseff, RM Ireland, CM Bosio, K Kim, J Luban, VM Hirsch, RT Taylor, F Bouamr, SL Sawyer, SM Best TRIM5? Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation Cell Rep, 2019-06-11;27(11):3269-3283.e6. 2019-06-11 [PMID: 31189110] (Bioassay, Human)
• BD Bryson, TR Rosebrock, FG Tafesse, CY Itoh, A Nibasumba, GH Babunovic, B Corleis, C Martin, C Keegan, P Andrade, S Realegeno, D Kwon, RL Modlin, SM Fortune Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis Nat Commun, 2019-05-27;10(1):2329. 2019-05-27 [PMID: 31133636] (Bioassay, Human)
• VA Jennings, GB Scott, AMS Rose, KJ Scott, G Migneco, B Keller, K Reilly, O Donnelly, H Peach, D Dewar, KJ Harrington, H Pandha, A Samson, RG Vile, AA Melcher, F Errington- Potentiating Oncolytic Virus-Induced Immune-Mediated Tumor Cell Killing Using Histone Deacetylase Inhibition Mol. Ther., 2019-04-14;0(0):. 2019-04-14 [PMID: 31053413] (Bioassay, Human)
• S De Alessan, GJ Ferguson, AJ Dodd, JK Juss, A Devaprasad, S Piper, O Wyatt, H Killick, DJ Corkill, ES Cohen, A Pandit, TRDJ Radstake, R Simmonds, AM Condliffe, MA Sleeman, AS Cowburn, DK Finch, ER Chilvers Neutrophil GM-CSF receptor dynamics in acute lung injury J. Leukoc. Biol., 2019-04-03;0(0):. 2019-04-03 [PMID: 30942918] (Bioassay, Human)
• R Gramlich, E Aliahmadi, M Peiser In Vitro Induction of T Helper 17 Cells by Synergistic Activation of Human Monocyte-Derived Langerhans Cell-Like Cells with Bacterial Agonists Int J Mol Sci, 2019-03-19;20(6):. 2019-03-19 [PMID: 30893757] (Bioassay, Human)
• JC de Quaglia, AM Della Cole, TP Gardizani, GG Romagnoli, R Kaneno, LA Dias-Melic Involvement of the Dectin-1 Receptor upon the Effector Mechanisms of Human Phagocytic Cells against Paracoccidioides brasiliensis J Immunol Res, 2019-02-06;2019(0):1529189. 2019-02-06 [PMID: 30882002] (Bioassay, Human)
• TA Sebrell, M Hashimi, B Sidar, R Wilkinson, L Kirpotina, MT Quinn, Z Malkoç, PJ Taylor, JN Wilking, D Bimczok A Novel Gastric Spheroid Co-Culture Model Reveals Chemokine-Dependent Recruitment of Human Dendritic Cells to the Gastric Epithelium Cell Mol Gastroenterol Hepatol, 2019-03-13;0(0):. 2019-03-13 [PMID: 30878664] (Bioassay, Human)
• M Kita, Y Ano, A Inoue, J Aoki Identification of P2Y receptors involved in oleamide-suppressing inflammatory responses in murine microglia and human dendritic cells Sci Rep, 2019-02-28;9(1):3135. 2019-02-28 [PMID: 30816271] (Bioassay, Human)
• E Tenland, A Pochert, N Krishnan, K Umashankar, S Kalsum, K Braun, I Glegola-Ma, M Lerm, BD Robertson, M Lindén, G Godaly Effective delivery of the anti-mycobacterial peptide NZX in mesoporous silica nanoparticles PLoS ONE, 2019-02-26;14(2):e0212858. 2019-02-26 [PMID: 30807612] (Bioassay, Human)
• CM Sellgren, J Gracias, B Watmuff, JD Biag, JM Thanos, PB Whittredge, T Fu, K Worringer, HE Brown, J Wang, A Kaykas, R Karmachary, CP Goold, SD Sheridan, RH Perlis Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning Nat. Neurosci., 2019-02-04;0(0):. 2019-02-04 [PMID: 30718903] (Bioassay, Human)
• M Pujol, C Borie, M Montoya, A Ferreira, R Vernal Brucella canis induces canine CD4+ T cells multi-cytokine Th1/Th17 production via dendritic cell activation Comp. Immunol. Microbiol. Infect. Dis., 2018-11-30;62(0):68-75. 2018-11-30 [PMID: 30711049] (Bioassay, Canine, Human)
• C Kim, B Hu, RR Jadhav, J Jin, H Zhang, MM Cavanagh, RS Akondy, R Ahmed, CM Weyand, JJ Goronzy Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells Cell Rep, 2018-11-20;25(8):2148-2162.e5. 2018-11-20 [PMID: 30463012] (Bioassay, Human)
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• AS Hansen, M Biltoft, B Bundgaard, AB Bohn, BK Møller, P Höllsberg CD46 activation induces distinct CXCL-10 response in monocytes and monocyte-derived dendritic cells Cytokine, 2018-07-04;0(0):. 2018-07-04 [PMID: 29980471] (Bioassay, Human)
• J Zhang, Z Xiang, PA Malaviarac, Y Yan, NJ Baltz, PD Emanuel, YL Liu PTEN is indispensable for cells to respond to MAPK inhibitors in myeloid leukemia Cell. Signal., 2018-06-28;50(0):72-79. 2018-06-28 [PMID: 29964149] (Bioassay, Human)
• ME Kirkling, U Cytlak, CM Lau, KL Lewis, A Resteu, A Khodadadi-, CW Siebel, H Salmon, M Merad, A Tsirigos, M Collin, V Bigley, B Reizis Notch Signaling Facilitates In�Vitro Generation of Cross-Presenting Classical Dendritic Cells Cell Rep, 2018-06-19;23(12):3658-3672.e6. 2018-06-19 [PMID: 29925006] (Bioassay, Human)
• H Nakano, Y Kirino, M Takeno, K Higashitan, H Nagai, R Yoshimi, Y Yamaguchi, I Kato, I Aoki, H Nakajima GWAS-identified CCR1 and IL10 loci contribute to M1 macrophage-predominant inflammation in Beh�et&#039;s disease Arthritis Res. Ther., 2018-06-12;20(1):124. 2018-06-12 [PMID: 29895319] (Bioassay, Human)
• H Chu, CM Chan, X Zhang, Y Wang, S Yuan, J Zhou, RK Au-Yeung, KH Sze, D Yang, H Shuai, Y Hou, C Li, X Zhao, VK Poon, SP Leung, ML Yeung, J Yan, G Lu, DY Jin, GF Gao, JF Chan, KY Yuen Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells J. Biol. Chem., 2018-06-10;0(0):. 2018-06-10 [PMID: 29887526] (Bioassay, Human)
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• A Alflen, N Stadler, P Aranda Lop, D Teschner, M Theobald, G He beta , MP Radsak Idelalisib impairs TREM-1 mediated neutrophil inflammatory responses Sci Rep, 2018-04-03;8(1):5558. 2018-04-03 [PMID: 29615799] (Bioassay, Human)
• X de la Rosa, PC Norris, N Chiang, AR Rodriguez, BW Spur, CN Serhan Identification and Complete Stereochemical Assignments of the New Resolvin Conjugates in Tissue Regeneration in Human Tissues that Stimulate Proresolving Phagocyte Functions and Tissue Regeneration Am. J. Pathol., 2018-04-01;188(4):950-966. 2018-04-01 [PMID: 29571326] (Bioassay, Human)
• X Chen, S Hao, Z Zhao, J Liu, Q Shao, F Wang, D Sun, Y He, W Gao, H Mao Interleukin 35: Inhibitory regulator in monocyte-derived dendritic cell maturation and activation Cytokine, 2018-03-20;108(0):43-52. 2018-03-20 [PMID: 29571039] (Bioassay, Human)
• C Napoletano, S Mattiucci, A Colantoni, F Battisti, IG Zizzari, H Rahimi, M Nuti, A Rughetti Anisakis pegreffii impacts differentiation and function of human dendritic cells Parasite Immunol., 2018-05-01;0(0):e12527. 2018-05-01 [PMID: 29569735] (Bioassay, Human)
• S Zheng, E Papalexi, A Butler, W Stephenson, R Satija Molecular transitions in early progenitors during human cord blood hematopoiesis Mol. Syst. Biol., 2018-03-15;14(3):e8041. 2018-03-15 [PMID: 29545397] (Bioassay, Human)
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• HD Chae, N Cox, GV Dahl, NJ Lacayo, KL Davis, S Capolicchi, M Smith, KM Sakamoto Niclosamide suppresses acute myeloid leukemia cell proliferation through inhibition of CREB-dependent signaling pathways Oncotarget, 2017-12-31;9(4):4301-4317. 2017-12-31 [PMID: 29435104] (Bioassay, Human)
• N Ilic, A Gruden-Mov, J Cvetkovic, S Tomic, DB Vucevic, C Aranzamend, M Colic, E Pinelli, L Sofronic-M Trichinella spiralis Excretory-Secretory Products Induce Tolerogenic Properties in Human Dendritic CellsviaToll-Like Receptors 2 and 4 Front Immunol, 2018-01-24;9(0):11. 2018-01-24 [PMID: 29416536] (Bioassay, Human)
• D Wang, XF Huang, B Hong, XT Song, L Hu, M Jiang, B Zhang, H Ning, Y Li, C Xu, X Lou, B Li, Z Yu, J Hu, J Chen, F Yang, H Gao, G Ding, L Liao, L Rollins, L Jones, SY Chen, H Chen Efficacy of intracellular immune checkpoint-silenced DC vaccine JCI Insight, 2018-02-08;3(3):. 2018-02-08 [PMID: 29415891] (Bioassay, Human)
• H Sic, M Speletas, V Cornacchio, M Seidl, M Beibel, B Linghu, F Yang, E Sevdali, AE Germenis, EJ Oakeley, E Vangreveli, AW Sailer, E Traggiai, H Gram, H Eibel An Activating Janus Kinase-3 Mutation Is Associated with Cytotoxic T Lymphocyte Antigen-4-Dependent Immune Dysregulation Syndrome Front Immunol, 2017-12-15;8(0):1824. 2017-12-15 [PMID: 29375547] (Bioassay, Human)
• MS Gresnigt, M Jaeger, RK Subbarao M, O Rasid, G Jouvion, C Fitting, WJG Melchers, TD Kanneganti, A Carvalho, O Ibrahim-Gr, FL van de Vee The Absence of NOD1 Enhances Killing of Aspergillus fumigatus Through Modulation of Dectin-1 Expression Front Immunol, 2017-12-13;8(0):1777. 2017-12-13 [PMID: 29326692] (Bioassay, Human)
• YJ Choi, SJ Park, YS Park, HS Park, KM Yang, K Heo EpCAM peptide-primed dendritic cell vaccination confers significant anti-tumor immunity in hepatocellular carcinoma cells PLoS ONE, 2018-01-03;13(1):e0190638. 2018-01-03 [PMID: 29298343] (Bioassay, Human)
• C Ge, R Li, H Song, T Geng, J Yang, Q Tan, L Song, Y Wang, Y Xue, Z Li, S Dong, Z Zhang, N Zhang, J Guo, L Hua, S Chen, X Song Phase I clinical trial of a novel autologous modified-DC vaccine in patients with resected NSCLC BMC Cancer, 2017-12-21;17(1):884. 2017-12-21 [PMID: 29268708] (Bioassay, Human)
• M Ohgidani, TA Kato, M Hosoi, M Tsuda, K Hayakawa, C Hayaki, R Iwaki, N Sagata, R Hashimoto, K Inoue, N Sudo, S Kanba Fibromyalgia and microglial TNF-?: Translational research using human blood induced microglia-like cells Sci Rep, 2017-09-19;7(1):11882. 2017-09-19 [PMID: 28928366] (Bioassay, Human)
• M Yoshida, Y Ishioka, T Ozawa, H Okuyama, M Iguchi, T Ota, T Ito, M Nagira, A Morita, H Tanaka, H Naito, H Kidoya, N Takakura Soluble HLA-associated peptide from PSF1 has a cancer vaccine potency Sci Rep, 2017-09-11;7(1):11137. 2017-09-11 [PMID: 28894200] (Bioassay, Human)
• H Nishi, K Furuhashi, X Cullere, G Saggu, MJ Miller, Y Chen, F Rosetti, SL Hamilton, L Yang, SP Pittman, J Liao, JM Herter, JC Berry, DJ DeAngelo, C Zhu, GC Tsokos, TN Mayadas Neutrophil Fc?RIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases J. Clin. Invest., 2017-09-11;0(0):. 2017-09-11 [PMID: 28891817] (Bioassay, Human)
• M Matsushita, K Ozawa, T Suzuki, M Nakamura, N Nakano, S Kanchi, D Ichikawa, E Matsuki, M Sakurai, D Karigane, H Kasahara, N Tsukamoto, T Shimizu, T Mori, H Nakajima, S Okamoto, Y Kawakami, Y Hattori CXorf48 is a potential therapeutic target for achieving treatment-free remission in CML patients Blood Cancer J, 2017-09-01;7(9):e601. 2017-09-01 [PMID: 28862699] (Bioassay, Human)
• P Thornton, J Sevalle, MJ Deery, G Fraser, Y Zhou, S Ståhl, EH Franssen, RB Dodd, S Qamar, B Gomez Pere, LS Nicol, S Eketjäll, J Revell, C Jones, A Billinton, PH St George-, I Chessell, DC Crowther TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer&#039;s disease-associated H157Y variant EMBO Mol Med, 2017-10-01;0(0):. 2017-10-01 [PMID: 28855301] (Bioassay, Human)
• L Butcher, M Ahluwalia, T Örd, J Johnston, RH Morris, E Kiss-Toth, T Örd, JD Erusalimsk Evidence for a role of TRIB3 in the regulation of megakaryocytopoiesis Sci Rep, 2017-07-27;7(1):6684. 2017-07-27 [PMID: 28751721] (Bioassay, Human)
• J Helft, F Anjos-Afon, AG van der Ve, P Chakravart, D Bonnet, C Reis E Sou Dendritic Cell Lineage Potential in Human Early Hematopoietic Progenitors Cell Rep, 2017-07-18;20(3):529-537. 2017-07-18 [PMID: 28723558] (Bioassay, Human)
• JH von Steman, AS Rigas, LW Thørner, DGK Rasmussen, OB Pedersen, K Rostgaard, C Erikstrup, H Ullum, MB Hansen Prevalence and correlation of cytokine-specific autoantibodies with epidemiological factors and C-reactive protein in 8,972 healthy individuals: Results from the Danish Blood Donor Study PLoS ONE, 2017-06-30;12(6):e0179981. 2017-06-30 [PMID: 28665954] (Control, Human)
• JT Schroeder, AP Bieneman Activation of Human Basophils by A549 Lung Epithelial Cells Reveals a Novel IgE-Dependent Response Independent of Allergen J. Immunol., 2017-06-26;0(0):. 2017-06-26 [PMID: 28652400] (Bioassay, Human)
• S Scholz, F Baharom, G Rankin, KT Maleki, S Gupta, S Vangeti, J Pourazar, A Discacciat, J Höijer, M Bottai, NK Björkström, J Rasmuson, M Evander, A Blomberg, HG Ljunggren, J Klingström, C Ahlm, A Smed-Sören Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways PLoS Pathog., 2017-06-22;13(6):e1006462. 2017-06-22 [PMID: 28640917] (Bioassay, Human)
• AA Panackal, LB Rosen, G Uzel, MJ Davis, G Hu, A Adeyemo, F Tekola-Aye, A Lisco, C Diachok, JD Kim, D Shaw, I Sereti, J Stoddard, J Niemela, SD Rosenzweig, JE Bennett, PR Williamson Susceptibility to Cryptococcal Meningoencephalitis Associated With Idiopathic CD4(+) Lymphopenia and Secondary Germline or Acquired Defects Open Forum Infect Dis, 2017-06-07;4(2):ofx082. 2017-06-07 [PMID: 28638843] (Bioassay, Human)
• T Liu, P Jia, H Ma, SA Reed, X Luo, HB Larman, PG Schultz Construction and Screening of a Lentiviral Secretome Library Cell Chem Biol, 2017-06-09;0(0):. 2017-06-09 [PMID: 28602759] (Bioassay, Human)
• AM Clemente, G Castronovo, A Antonelli, MM D'Andrea, M Tanturli, E Perissi, S Paccosi, A Parenti, F Cozzolino, GM Rossolini, MG Torcia Differential Th17 response induced by the two clades of the pandemic ST258 Klebsiella pneumoniae clonal lineages producing KPC-type carbapenemase PLoS ONE, 2017-06-06;12(6):e0178847. 2017-06-06 [PMID: 28586386] (Bioassay, Human)
• CSB Viegas, RM Costa, L Santos, PA Videira, Z Silva, N Araújo, AL Macedo, AP Matos, C Vermeer, DC Simes Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: Implications for calcification-related chronic inflammatory diseases PLoS ONE, 2017-05-18;12(5):e0177829. 2017-05-18 [PMID: 28542410] (Bioassay, Human)
• J Wang, H Ye, D Zhang, K Cheng, Y Hu, X Yu, L Lu, J Hu, C Zuo, B Qian, Y Yu, S Liu, G Liu, C Mao, S Liu Cancer-derived Circulating MicroRNAs Promote Tumor Angiogenesis by Entering Dendritic Cells to Degrade Highly Complementary MicroRNAs Theranostics, 2017-03-24;7(6):1407-1421. 2017-03-24 [PMID: 28529626] (Bioassay, Human)
• H Zhao, S Gulesseria, MC Malinao, S Kumar-Gane, J Song, MS Chang, MM Williams, Z Zeng, M Mattie, BA Mendelsohn, DR Stover, F Doñate A Potential Mechanism for ADC-Induced Neutropenia: Role of Neutrophils in Their Own Demise Mol. Cancer Ther., 2017-05-18;0(0):. 2017-05-18 [PMID: 28522588] (Bioassay, Human)
• SC Silva-Card, AJ Affandi, L Spel, M Cossu, JAG van Roon, M Boes, TRDJ Radstake CXCL4 Exposure Potentiates TLR-Driven Polarization of Human Monocyte-Derived Dendritic Cells and Increases Stimulation of T Cells J. Immunol., 2017-05-17;0(0):. 2017-05-17 [PMID: 28515281] (Bioassay, Human)
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• A Dyer, Y Di, H Calderon, S Illingwort, G Kueberuwa, A Tedcastle, P Jakeman, SL Chia, A Brown, MA Silva, D Barlow, J Beadle, T Hermiston, DJ Ferguson, B Champion, KD Fisher, LW Seymour Oncolytic Group B Adenovirus Enadenotucirev Mediates Non-apoptotic Cell Death with Membrane Disruption and Release of Inflammatory Mediators Mol Ther Oncolytics, 2016-12-10;4(0):18-30. 2016-12-10 [PMID: 28345021] (Bioassay, Human)
• X Zhang, T Zhou, J Yang, Y Lin, J Shi, X Zhang, DA Frabutt, X Zeng, S Li, PJ Venta, YH Zheng Identification of SERINC5-001 as the Predominant Spliced Isoform for HIV-1 Restriction J. Virol, 2017-04-28;0(0):. 2017-04-28 [PMID: 28275190] (Bioassay, Human)
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• JE Hammonds, N Beeman, L Ding, S Takushi, AC Francis, JJ Wang, GB Melikyan, P Spearman Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1 PLoS Pathog, 2017-01-27;13(1):e1006181. 2017-01-27 [PMID: 28129379] (Bioassay, Human)
• MJ Bae, S Ryu, HJ Kim, SI Cha, CH Kim, J Lee Mycobacterium tuberculosis ESAT6 and CPF10 Induce Adenosine Deaminase 2 mRNA Expression in Monocyte-Derived Macrophages Tuberc Respir Dis (Seoul), 2016-12-30;80(1):77-82. 2016-12-30 [PMID: 28119750] (Bioassay, Human)
• Stephane Esnault IL-3 Up-regulates and Activates Human Eosinophil CD32 and ?M�2 Integrin Causing Degranulation Clin. Exp. Allergy, 2017-01-23;0(0):. 2017-01-23 [PMID: 28000949] (Bioassay, Human)
• Yusuke Tomita The interplay of epigenetic therapy and immunity in locally recurrent or metastatic estrogen receptor-positive breast cancer: Correlative analysis of ENCORE 301, a randomized, placebo-controlled phase II trial of exemestane with or without entinostat Oncoimmunology, 2016-08-31;5(11):e1219008. 2016-08-31 [PMID: 27999738] (Bioassay, Human)
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• Jiang Zheng 1400W ameliorates acute hypobaric hypoxia/reoxygenation-induced cognitive deficits by suppressing the induction of inducible nitric oxide synthase in rat cerebral cortex microglia Behav. Brain Res., 2016-11-22;319(0):188-199. 2016-11-22 [PMID: 27888018] (Bioassay, Rat)
• Xiang-Ming Lao Peritumoral stromal neutrophils are essential for c-Met-elicited metastasis in human hepatocellular carcinoma Oncoimmunology, 2016-09-27;5(10):e1219828. 2016-09-27 [PMID: 27853643] (Bioassay, Human)
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• CD11c/CD18 Dominates Adhesion of Human Monocytes, Macrophages and Dendritic Cells over CD11b/CD18 PLoS ONE, 2016-09-22;11(9):e0163120. 2016-09-22 [PMID: 27658051] (Bioassay, Human)
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• Lajos V Kemény Melanoma Cells Can Adopt the Phenotype of Stromal Fibroblasts and Macrophages by Spontaneous Cell Fusion in Vitro Int J Mol Sci, 2016-06-02;17(6):. 2016-06-02 [PMID: 27271591] (Bioassay, Human)
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• Decitabine enhances anti-CD33 monoclonal antibody BI 836858-mediated natural killer ADCC against AML blasts Blood, 2016-03-24;127(23):2879-89. 2016-03-24 [PMID: 27013443] (Bioassay, Human)
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• Brusic , Ana, Hainz , Ursula, Wadleigh , Martha, Neuberg , Donna, Su , Mei, Canning , Christin, Deangelo , Daniel J, Stone , Richard, Lee , Jeng-Shi, Mulligan , Richard, Ritz , Jerome, Dranoff , Glenn, Sasada , Tetsuro, Wu , Catherin Detecting T-cell reactivity to whole cell vaccines: Proof of concept analysis of T-cell response to K562 cell antigens in CML patients. Oncoimmunology, 2012-10-01;1(7):1095-1103. 2012-10-01 [PMID: 23170257] (Bioassay, Human)
• Selleri S, Dieng M, Nicoletti S, Louis I, Beausejour C, Le Deist F, Haddad E Cord-blood-derived mesenchymal stromal cells downmodulate CD4+ T-cell activation by inducing IL-10-producing Th1 cells. Stem Cells Dev, 2013-01-04;22(7):1063-75. 2013-01-04 [PMID: 23167734] (Bioassay, Human)
• Nitric oxide-producing myeloid-derived suppressor cells inhibit vascular E-selectin expression in human squamous cell carcinomas. J. Invest. Dermatol., 2012-06-21;132(11):2642-51. 2012-06-21 [PMID: 22718118] (Bioassay, Human)
• Graham LM, Gupta V, Schafer G, Reid DM, Kimberg M, Dennehy KM, Hornsell WG, Guler R, Campanero-Rhodes MA, Palma AS, Feizi T, Kim SK, Sobieszczuk P, Willment JA, Brown GD The C-type Lectin Receptor CLECSF8 (CLEC4D) Is Expressed by Myeloid Cells and Triggers Cellular Activation through Syk Kinase. J. Biol. Chem., 2012-06-11;287(31):25964-74. 2012-06-11 [PMID: 22689578] (Bioassay, Human)
• CD34-derived dendritic cells transfected ex vivo with HIV-Gag mRNA induce polyfunctional T-cell responses in nonhuman primates. Eur. J. Immunol., 2012-07-04;42(8):2019-30. 2012-07-04 [PMID: 22585548] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• Napoletano C, Zizzari IG, Rughetti A, Rahimi H, Irimura T, Clausen H, Wandall HH, Belleudi F, Bellati F, Pierelli L, Frati L, Nuti M Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation. Eur. J. Immunol., 2012-04-01;42(4):936-45. 2012-04-01 [PMID: 22531918] (Bioassay, Human)
• Figueiredo AB, Serafim TD, Marques-da-Silva EA, Meyer-Fernandes JR, Afonso LC Leishmania amazonensis impairs DC function by inhibiting CD40 expression via A2B adenosine receptor activation. Eur. J. Immunol., 2012-05-01;42(5):1203-15. 2012-05-01 [PMID: 22311598] (Bioassay, Mouse)
• Kawamura T, Ogawa Y, Nakamura Y Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency. J. Clin. Invest., 2012-01-03;122(2):722-32. 2012-01-03 [PMID: 22214844] (Bioassay, Human)
• Emara M, Royer PJ, Mahdavi J Retagging identifies dendritic cell-specific intercellular adhesion molecule-3 (ICAM3)-grabbing non-integrin (DC-SIGN) protein as a novel receptor for a major allergen from house dust mite. J. Biol. Chem., 2011-12-28;287(8):5756-63. 2011-12-28 [PMID: 22205703] (Bioassay, Human)
• Kessler C, Greindl A, Breuer B, Haberl U, Rybka A, Emgenbroich M, Frank HG, Potgens AJ Erythropoietin mimetic compound AGEM400(HES) binds to the same receptor as erythropoietin but displays a different spectrum of activities. Cytokine, 2011-12-03;57(2):226-37. 2011-12-03 [PMID: 22142701] (Bioassay, Human)
• Song W, Tai YT, Tian Z, Hideshima T, Chauhan D, Nanjappa P, Exley MA, Anderson KC, Munshi NC HDAC inhibition by LBH589 affects the phenotype and function of human myeloid dendritic cells. Leukemia, 2010-11-19;25(1):161-8. 2010-11-19 [PMID: 21102427] (Bioassay, Human)
• Peressin M, Holl V, Schmidt S, Decoville T, Mirisky D, Lederle A, Delaporte M, Xu K, Aubertin AM, Moog C HIV-1 replication in Langerhans and interstitial dendritic cells is inhibited by neutralizing and Fc-mediated inhibitory antibodies. J. Virol., 2010-11-17;85(2):1077-85. 2010-11-17 [PMID: 21084491] (Bioassay, Human)
• Xu H, Wang X, Pahar B Increased B7-H1 expression on dendritic cells correlates with programmed death 1 expression on T cells in simian immunodeficiency virus-infected macaques and may contribute to T cell dysfunction and disease progression. J. Immunol., 2010-11-08;185(12):7340-8. 2010-11-08 [PMID: 21059890] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))
• Zhang HH, Song K, Rabin RL, Hill BJ, Perfetto SP, Roederer M, Douek DC, Siegel RM, Farber JM CCR2 identifies a stable population of human effector memory CD4+ T cells equipped for rapid recall response. J. Immunol., 2010-10-27;185(11):6646-63. 2010-10-27 [PMID: 20980630] (Bioassay, Human)
• Kirouac DC, Ito C, Csaszar E, Roch A, Yu M, Sykes EA, Bader GD, Zandstra PW Dynamic interaction networks in a hierarchically organized tissue. Mol. Syst. Biol., 2010-10-05;6(0):417. 2010-10-05 [PMID: 20924352] (Bioassay, Human)
• Johnson LA, Jackson DG Inflammation-induced secretion of CCL21 in lymphatic endothelium is a key regulator of integrin-mediated dendritic cell transmigration. Int. Immunol., 2010-08-25;22(10):839-49. 2010-08-25 [PMID: 20739459] (Bioassay, Human)
• Pietila TE, Latvala S, Osterlund P, Julkunen I Inhibition of dynamin-dependent endocytosis interferes with type III IFN expression in bacteria-infected human monocyte-derived DCs. J. Leukoc. Biol., 2010-07-07;88(4):665-74. 2010-07-07 [PMID: 20610797] (Bioassay, Human)
• Ghirelli C, Zollinger R, Soumelis V Systematic cytokine receptor profiling reveals GM-CSF as a novel TLR-independent activator of human plasmacytoid predendritic cells. Blood, 2010-04-09;115(24):5037-40. 2010-04-09 [PMID: 20382843] (Bioassay, Human)
• Ha CT, Wu JA, Irmak S, Lisboa FA, Dizon AM, Warren JW, Ergun S, Dveksler GS Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis. Biol. Reprod., 2010-03-24;83(1):27-35. 2010-03-24 [PMID: 20335639] (Bioassay, Human)
• Zheng X, Ma P, De Paiva CS, Cunningham MA, Hwang CS, Pflugfelder SC, Li DQ TSLP and downstream molecules in experimental mouse allergic conjunctivitis. Invest. Ophthalmol. Vis. Sci., 2010-01-27;51(6):3076-82. 2010-01-27 [PMID: 20107175] (Bioassay, Human)
• Kishuku M, Nishioka Y, Abe S, Kishi J, Ogino H, Aono Y, Azuma M, Kinoshita K, Batmunkh R, Rentsenhand B, Makino H, Ranjan P, Minakuchi K, Sone S Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property. J. Immunol., 2009-12-15;183(12):8176-85. 2009-12-15 [PMID: 20007583] (Cell Culture, Human)
• Correale J, Farez M Helminth antigens modulate immune responses in cells from multiple sclerosis patients through TLR2-dependent mechanisms. J. Immunol., 2009-10-07;183(9):5999-6012. 2009-10-07 [PMID: 19812189] (Bioassay, Human)
• Puxeddu I, Berkman N, Ribatti D Osteopontin is expressed and functional in human eosinophils. Allergy, 2009-10-05;65(2):168-74. 2009-10-05 [PMID: 19804447] (Bioassay, Human)
• Duraisingham SS, Hornig J, Gotch F, Patterson S TLR-stimulated CD34 stem cell-derived human skin-like and monocyte-derived dendritic cells fail to induce Th17 polarization of naive T cells but do stimulate Th1 and Th17 memory responses. J. Immunol., 2009-07-22;183(4):2242-51. 2009-07-22 [PMID: 19625644] (Bioassay, Human)
• Furukawa M, Takaishi H, Takito J, Yoda M, Sakai S, Hikata T, Hakozaki A, Uchikawa S, Matsumoto M, Chiba K, Kimura T, Okada Y, Matsuo K, Yoshida H, Toyama Y IL-27 abrogates receptor activator of NF-kappa B ligand-mediated osteoclastogenesis of human granulocyte-macrophage colony-forming unit cells through STAT1-dependent inhibition of c-Fos. J. Immunol., 2009-07-20;183(4):2397-406. 2009-07-20 [PMID: 19620301] (Bioassay, Human)
• Margulis A, Nocka KH, Brennan AM, Deng B, Fleming M, Goldman SJ, Kasaian MT Mast cell-dependent contraction of human airway smooth muscle cell-containing collagen gels: influence of cytokines, matrix metalloproteases, and serine proteases. J. Immunol., 2009-07-10;183(3):1739-50. 2009-07-10 [PMID: 19592653] (Bioassay, Human)
• Aliahmadi E, Gramlich R, Grutzkau A, Hitzler M, Kruger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23. Eur. J. Immunol., 2009-05-01;39(5):1221-30. 2009-05-01 [PMID: 19350551] (Bioassay, Human)
• Ogawa Y, Kawamura T, Kimura T, Ito M, Blauvelt A, Shimada S Gram-positive bacteria enhance HIV-1 susceptibility in Langerhans cells, but not in dendritic cells, via Toll-like receptor activation. Blood, 2009-03-11;113(21):5157-66. 2009-03-11 [PMID: 19279330] (Bioassay, Human)
• McAulay KA, Haque T, Urquhart G, Bellamy C, Guiretti D, Crawford DH Epitope specificity and clonality of EBV-specific CTLs used to treat posttransplant lymphoproliferative disease. J. Immunol., 2009-03-15;182(6):3892-901. 2009-03-15 [PMID: 19265169] (Bioassay, Human)
• Saulle E, Riccioni R, Coppola S, Parolini I, Diverio D, Riti V, Mariani G, Laufer S, Sargiacomo M, Testa U Colocalization of the VEGF-R2 and the common IL-3/GM-CSF receptor beta chain to lipid rafts leads to enhanced p38 activation. Br. J. Haematol., 2009-02-24;145(3):399-411. 2009-02-24 [PMID: 19245429] (Bioassay, Human)
• Margulis A, Nocka KH, Wood NL, Wolf SF, Goldman SJ, Kasaian MT MMP dependence of fibroblast contraction and collagen production induced by human mast cell activation in a three-dimensional collagen lattice. Am. J. Physiol. Lung Cell Mol. Physiol., 2008-12-05;296(2):L236-47. 2008-12-05 [PMID: 19060229] (Bioassay, Human)
• Schnickmann S, Camacho-Trullio D, Bissinger M, Eils R, Angel P, Schirmacher P, Szabowski A, Breuhahn K AP-1-controlled hepatocyte growth factor activation promotes keratinocyte migration via CEACAM1 and urokinase plasminogen activator/urokinase plasminogen receptor. J. Invest. Dermatol., 2008-11-20;129(5):1140-8. 2008-11-20 [PMID: 19020551] (Bioassay, Human)
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• Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM Adenosine receptors in regulation of dendritic cell differentiation and function. Blood, 2008-06-17;112(5):1822-31. 2008-06-17 [PMID: 18559975] (Bioassay, Human)
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• Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M Isolation and characterization of CD146+ multipotent mesenchymal stromal cells. Exp. Hematol., 2008-05-27;36(8):1035-46. 2008-05-27 [PMID: 18504067] (Bioassay, Human)
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• Chamoux E, Houde N, L'Eriger K, Roux S Osteoprotegerin decreases human osteoclast apoptosis by inhibiting the TRAIL pathway. J. Cell. Physiol., 2008-08-01;216(2):536-42. 2008-08-01 [PMID: 18338379] (Bioassay, Human)
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• Huang SJ, Chen CP, Schatz F, Rahman M, Abrahams VM, Lockwood CJ Pre-eclampsia is associated with dendritic cell recruitment into the uterine decidua. J. Pathol., 2008-02-01;214(3):328-36. 2008-02-01 [PMID: 18069648] (Bioassay, Human)
• Esnault S, Rosenthal LA, Shen ZJ, Sedgwick JB, Szakaly RJ, Sorkness RL, Malter JS A critical role for Pin1 in allergic pulmonary eosinophilia in rats. J. Allergy Clin. Immunol., 2007-08-27;120(5):1082-8. 2007-08-27 [PMID: 17720236] (Bioassay, Human)
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• Wang J, Zhang Y, Wei J, Zhang X, Zhang B, Zhu Z, Zou W, Wang Y, Mou Z, Ni B, Wu Y Lewis X oligosaccharides targeting to DC-SIGN enhanced antigen-specific immune response. Immunology, 2007-03-20;121(2):174-82. 2007-03-20 [PMID: 17371544] (Bioassay, Human)
• Rajesh</LastName><ForeNam D</Initial, Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells. Stem Cells, 2007-02-01;25(2):490-9. 2007-02-01 [PMID: 17284653] (Bioassay, Rat)
• Kurooka M, Kaneda Y Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells. Cancer Res., 2007-01-01;67(1):227-36. 2007-01-01 [PMID: 17210703] (Bioassay, Human)
• Zhang R, Becnel L, Li M, Chen C, Yao Q C-reactive protein impairs human CD14+ monocyte-derived dendritic cell differentiation, maturation and function. Eur. J. Immunol., 2006-11-01;36(11):2993-3006. 2006-11-01 [PMID: 17051617] (Bioassay, Human)
• Pontikoglou C, Liapakis G, Pyrovolaki K, Papadakis M, Bux J, Eliopoulos GD, Papadaki HA Evidence for downregulation of erythropoietin receptor in bone marrow erythroid cells of patients with chronic idiopathic neutropenia. Exp. Hematol., 2006-10-01;34(10):1312-22. 2006-10-01 [PMID: 16982324] (Bioassay, Human)
• Walker J, Tough DF Modification of TLR-induced activation of human dendritic cells by type I IFN: synergistic interaction with TLR4 but not TLR3 agonists. Eur. J. Immunol., 2006-07-01;36(7):1827-36. 2006-07-01 [PMID: 16783851] (Bioassay, Human)
• Vaknin-Dembinsky A, Balashov K, Weiner HL IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J. Immunol., 2006-06-15;176(12):7768-74. 2006-06-15 [PMID: 16751425] (Bioassay, Human)
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• Reed JA, Clegg DJ, Smith KB, Tolod-Richer EG, Matter EK, Picard LS, Seeley RJ GM-CSF action in the CNS decreases food intake and body weight. J. Clin. Invest., 2005-11-01;115(11):3035-44. 2005-11-01 [PMID: 16276414] (In Vivo, Rat)
• Hanley MB, Napolitano LA, McCune JM Growth hormone-induced stimulation of multilineage human hematopoiesis. Stem Cells, 2005-06-13;23(8):1170-9. 2005-06-13 [PMID: 15955828] (Bioassay, Human)
• Roux S, Lambert-Comeau P, Saint-Pierre C, Lepine M, Sawan B, Parent JL Death receptors, Fas and TRAIL receptors, are involved in human osteoclast apoptosis. Biochem. Biophys. Res. Commun., 2005-07-22;333(1):42-50. 2005-07-22 [PMID: 15936719] (Bioassay, Human)
• Takei M, Umeyama A, Arihara S, Matsumoto H Effect of piceatannol in human monocyte-derived dendritic cells in vitro. J Pharm Sci, 2005-05-01;94(5):974-82. 2005-05-01 [PMID: 15793803] (Bioassay, Human)
• Yamamoto H, Nagata M, Sakamoto Y CC chemokines and transmigration of eosinophils in the presence of vascular cell adhesion molecule 1. Ann. Allergy Asthma Immunol., 2005-02-01;94(2):292-300. 2005-02-01 [PMID: 15765748] (Bioassay, Human)
• Pound JD, Batth BK, Johannessen I, Wood K Enhanced apoptotic cell clearance capacity and B cell survival factor production by IL-10-activated macrophages: implications for Burkitt&#039;s lymphoma. J. Immunol., 2005-03-01;174(5):3015-23. 2005-03-01 [PMID: 15728515] (Bioassay, Human)
• Puxeddu I, Alian A, Piliponsky AM, Ribatti D, Panet A, Levi-Schaffer F Human peripheral blood eosinophils induce angiogenesis. Int. J. Biochem. Cell Biol., 2005-03-01;37(3):628-36. 2005-03-01 [PMID: 15618019] (Bioassay, Human)
• Eubank TD, Roberts R, Galloway M, Wang Y, Cohn DE, Marsh CB GM-CSF induces expression of soluble VEGF receptor-1 from human monocytes and inhibits angiogenesis in mice. Immunity, 2004-12-01;21(6):831-42. 2004-12-01 [PMID: 15589171] (Bioassay, Human)
• Godfrey WR, Spoden DJ, Ge YG, Baker SR, Liu B, Levine BL, June CH, Blazar BR, Porter SB Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood, 2004-09-16;105(2):750-8. 2004-09-16 [PMID: 15374887] (Bioassay, Human)
• Nagineni CN, Kutty V, Detrick B, Hooks JJ Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta. J. Cell. Physiol., 2005-04-01;203(1):35-43. 2005-04-01 [PMID: 15368539] (Bioassay, Human)
• Scapini P, Carletto A, Nardelli B, Calzetti F, Roschke V, Merigo F, Tamassia N, Pieropan S, Biasi D, Sbarbati A, Sozzani S, Bambara L, Cassatella MA Proinflammatory mediators elicit secretion of the intracellular B-lymphocyte stimulator pool (BLyS) that is stored in activated neutrophils: implications for inflammatory diseases. Blood, 2004-09-09;105(2):830-7. 2004-09-09 [PMID: 15358625] (Bioassay, Human)
• Saeki S, Matsuse H, Kondo Y, Machida I, Kawano T, Tomari S, Obase Y, Fukushima C, Kohno S Effects of antiasthmatic agents on the functions of peripheral blood monocyte-derived dendritic cells from atopic patients. J. Allergy Clin. Immunol., 2004-09-01;114(3):538-44. 2004-09-01 [PMID: 15356554] (Bioassay, Human)
• Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J. Immunol., 2004-09-01;173(5):3482-91. 2004-09-01 [PMID: 15322213] (Bioassay, Human)
• Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R IL-22 increases the innate immunity of tissues. Immunity, 2004-08-01;21(2):241-54. 2004-08-01 [PMID: 15308104] (Bioassay, Human)
• Johansson MW, Lye MH, Barthel SR, Duffy AK, Annis DS, Mosher DF Eosinophils adhere to vascular cell adhesion molecule-1 via podosomes. Am. J. Respir. Cell Mol. Biol., 2004-06-25;31(4):413-22. 2004-06-25 [PMID: 15220135] (Bioassay, Human)
• Sen Y, Chunsong H, Baojun H, Linjie Z, Qun L, San J, Qiuping Z, Junyan L, Zhang X, Jinquan T Aberration of CCR7 CD8 memory T cells from patients with systemic lupus erythematosus: an inducer of T helper type 2 bias of CD4 T cells. Immunology, 2004-06-01;112(2):274-89. 2004-06-01 [PMID: 15147571] (Bioassay, Human)
• Godfrey WR, Ge YG, Spoden DJ, Levine BL, June CH, Blazar BR, Porter SB In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood, 2004-03-18;104(2):453-61. 2004-03-18 [PMID: 15031211] (Bioassay, Human)
• Wang P, Zhang J, Bian H, Wu P, Kuvelkar R, Kung TT, Crawley Y, Egan RW, Billah MM Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor. Biochem. J., 2004-06-01;380(0):425-33. 2004-06-01 [PMID: 14992689] (Bioassay, Human)
• Uchida K, Nakata K, Trapnell BC, Terakawa T, Hamano E, Mikami A, Matsushita I, Seymour JF, Oh-Eda M, Ishige I, Eishi Y, Kitamura T, Yamada Y, Hanaoka K, Keicho N High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis. Blood, 2003-09-25;103(3):1089-98. 2003-09-25 [PMID: 14512323] (SDS-Page, Human)
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• Tailleux L, Schwartz O, Herrmann JL, Pivert E, Jackson M, Amara A, Legres L, Dreher D, Nicod LP, Gluckman JC, Lagrange PH, Gicquel B, Neyrolles O DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells. J. Exp. Med., 2003-01-06;197(1):121-7. 2003-01-06 [PMID: 12515819] (Bioassay, Human)
• Manz MG, 107325, Miyamoto T, Akashi K, Weissman IL Prospective isolation of human clonogenic common myeloid progenitors. Ultra-Sensitive and Semi-Quantitative Vertical Flow Assay for the Rapid Detection of Interleukin-6 in Inflammatory Diseases, 2002-08-22;99(18):11872-7. 2002-08-22 [PMID: 12193648] (Bioassay, Human)
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Bioinformatics

• Gene Symbol: CSF2
• Uniprot:
  • P04141.1()