Recombinant Human GM-CSF Protein

Recombinant Human GM-CSF (Catalog # 215-IL) stimulates cell proliferation of theTF-1 human erythroleukemic cell line. The ED50 for this effect is 6-30 pg/mL.

1 μg/lane of Recombinant Human GM-CSF was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa.

• Reactivity: Hu
• Applications: Bioactivity

Recombinant Human GM-CSF Protein Summary

• Additional Information: A New and Improved rh GM-CSF is Now Available! It has a lower endotoxin specification and is CHO expressed!
• Details of Functionality: Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED₅₀ for this effect is 6-30 pg/mL.
• Source: E. coli-derived human GM-CSF protein
  Ala18-Glu144
• Accession #: P04141.1
• N-terminal Sequence: Ala18
• Protein/Peptide Type: Recombinant Proteins
• Gene: CSF2
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Endotoxin Note: <1.0 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 14 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human GM-CSF Protein

• colony stimulating factor 2 (granulocyte-macrophage)
• Colony-stimulating factor
• CSF
• CSF2
• CSF-2
• GMCSF
• GM-CSF
• GMCSFgranulocyte-macrophage colony-stimulating factor
• granulocyte-macrophage colony stimulating factor
• MGC131935
• MGC138897
• Molgramostim
• molgramostin
• Sargramostim

Background

GM‑CSF was initially characterized as a factor that can support the in vitro colony formation of granulocyte‑macrophage progenitors. It is also a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. GM‑CSF is produced by a number of different cell types (including T cells, B cells, macrophages, mast cells, endothelial cells, fibroblasts, and adipocytes) in response to cytokine or inflammatory stimuli. On mature hematopoietic cells, GM‑CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages, and eosinophils (1, 2). GM‑CSF promotes a Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity (3‑5). It shows clinical effectiveness in ameliorating chemotherapy‑induced neutropenia, and GM‑CSF transfected tumor cells are utilized as cancer vaccines (6, 7). The 22 kDa glycosylated GM‑CSF, similar to IL‑3 and IL‑5, is a cytokine with a core of four bundled
alpha -helices (8‑12). Mature human GM‑CSF shares 63%‑70% amino acid sequence identity with canine, feline, porcine, and rat GM‑CSF and 54% with mouse GM‑CSF. GM‑CSF exerts its biological effects through a heterodimeric receptor complex composed of GM‑CSF R alpha /CD116 and the signal transducing common beta  chain (CD131) which is also a component of the high‑affinity receptors for IL‑3 and IL‑5 (13, 14). In addition, GM‑CSF binds a naturally occurring soluble form of GM‑CSF R alpha (15). Human GM‑CSF is active on canine and feline cells but not on murine cells (16‑18).

1. Martinez-Moczygemba, M. and D.P. Huston (2003) J. Allergy Clin. Immunol. 112:653.
2. Barreda, D.R. et al. (2004) Dev. Comp. Immunol. 28:509.
3. Eksioglu, E.A. et al. (2007) Exp. Hematol. 35:1163.
4. Cao, Y. (2007) J. Clin. Invest. 117:2362.
5. Fleetwood, A.J. et al. (2005) Crit. Rev. Immunol. 25:405.
6. Heuser, M. et al. (2007) Semin. Hematol. 44:148.
7. Hege, K.M. et al. (2006) Int. Rev. Immunol. 25:321.
8. Kaushansky, K. et al. (1992) Biochemistry 31:1881.
9. Diederichs, K. et al. (1991) Science 254:1779. 
10. Cantrell, M.A. et al. (1985) Proc. Natl. Acad. Sci. 82:6250.
11. Lee, F. et al. (1985) Proc. Natl. Acad. Sci. 82:4360.
12. Wong, G.G. et al. (1985) Science 228:810.
13. Onetto-Pothier, N. et al. (1990) Blood 75:59.
14. Hayashida, K. et al. (1990) Proc. Natl. Acad. Sci. 87:9655.
15. Pelley, J.L. et al. (2007) Exp. Hematol. 35:1483.
16. Hogge, G.S. et al. (1990) Cancer Gene Ther. 6:26.
17. Sprague, W.S. et al. (2005) J. Comp. Pathol. 133:136.
18. Shanafelt, A.B. et al. (1991) J. Biol. Chem. 266:13804.

Publications for GM-CSF (215-GM)(267)

Publications using 215-GM

• D Kwart, J He, S Srivatsan, C Lett, J Golubov, EM Oswald, P Poon, X Ye, J Waite, AG Zaretsky, S Haxhinasto, E Au-Yeung, NT Gupta, J Chiu, C Adler, S Cherravuru, E Malahias, N Negron, K Lanza, A Coppola, M Ni, H Song, Y Wei, GS Atwal, L Macdonald, NS Oristian, W Poueymirou, V Jankovic, M Fury, I Lowy, AJ Murphy, MA Sleeman, B Wang, D Skokos Cancer cell-derived type I interferons instruct tumor monocyte polarization Cell Reports, 2022;41(10):111769. 2022 [PMID: 36476866] (Bioassay, Human)
• H Salvator, A Cheng, LB Rosen, PR Williamson, JE Bennett, A Kashyap, L Ding, KJ Kwon-Chung, H Namkoong, CS Zerbe, SM Holland Neutralizing GM-CSF autoantibodies in pulmonary alveolar proteinosis, cryptococcal meningitis and severe nocardiosis Respiratory Research, 2022;23(1):280. 2022 [PMID: 36221098] (ELISA Development, Human)
• SP John, A Singh, J Sun, MJ Pierre, L Alsalih, C Lipsey, Z Traore, S Balcom-Luk, CJ Bradfield, J Song, TE Markowitz, M Smelkinson, M Ferrer, IDC Fraser Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infection Cell Reports, 2022;0(0):111441. 2022 [PMID: 36179680] (Bioassay, Human)
• YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells Science Advances, 2022;8(34):eabn5522. 2022 [PMID: 36001668] (Bioassay, Human)
• F Zeng, S Liao, Z Kuang, Q Zhu, H Wei, J Shi, E Zheng, Z Xu, S Huang, L Hong, T Gu, J Yang, H Yang, G Cai, S Moisyadi, J Urschitz, Z Li, Z Wu Genetically Engineered Pigs as Efficient Salivary Gland Bioreactors for Production of Therapeutically Valuable Human Nerve Growth Factor Cells, 2022;11(15):. 2022 [PMID: 35954224] (Bioassay, Human)
• SD van Haren, GK Pedersen, A Kumar, TJ Ruckwardt, S Moin, IN Moore, M Minai, M Liu, J Pak, F Borriello, S Doss-Golli, EMS Beijnen, S Ahmed, M Helmel, P Andersen, BS Graham, H Steen, D Christense, O Levy CAF08 adjuvant enables single dose protection against respiratory syncytial virus infection in murine newborns Nature Communications, 2022;13(1):4234. 2022 [PMID: 35918315] (Bioassay, Human)
• S Chen, RS Vedula, A Cuevas-Nav, B Lu, SJ Hogg, E Wang, S Benbarche, K Knorr, WJ Kim, RF Stanley, H Cho, C Erickson, M Singer, D Cui, S Tittley, BH Durham, TS Pavletich, E Fiala, MF Walsh, D Inoue, S Monette, J Taylor, N Rosen, F McCormick, RC Lindsley, P Castel, O Abdel-Waha Impaired proteolysis of non-canonical RAS proteins drives clonal hematopoietic transformation Cancer Discovery, 2022;0(0):. 2022 [PMID: 35904492] (Cell Culture, Human)
• IY Quiroga, AE Cruikshank, ML Bond, KSM Reed, BA Evangelist, JH Tseng, JV Ragusa, RB Meeker, H Won, S Cohen, TJ Cohen, DH Phanstiel Synthetic amyloid beta does not induce a robust transcriptional response in innate immune cell culture systems Journal of Neuroinflammation, 2022;19(1):99. 2022 [PMID: 35459147] (Bioassay, Human)
• P Sekhri, DK Ledezma, A Shukla, EE Sweeney, R Fernandes The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells Cancers, 2022;14(6):. 2022 [PMID: 35326601] (Cell Culture, Human)
• H Farese, Farese H, Noack M, M Noack, P Miossec Synoviocytes from pigmented villonodular synovitis are less sensitive to cadmium-induced cell death than synoviocytes from rheumatoid arthritis. Sci Rep, 0;12(1):3832. 0 [PMID: 35264617] (Bioassay, Human)
• Y Li, Y Zhu, S Feng, Y Ishida, TP Chiu, T Saito, S Wang, DK Ann, JJ Ou Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1beta to downregulate PPARalpha and FOXO3 Cell Reports, 2022;38(4):110284. 2022 [PMID: 35081341] (Bioassay, Human)
• R Sagawa, S Sakata, B Gong, Y Seto, A Takemoto, S Takagi, H Ninomiya, N Yanagitani, M Nakao, M Mun, K Uchibori, M Nishio, Y Miyazaki, Y Shiraishi, S Ogawa, K Kataoka, N Fujita, K Takeuchi, R Katayama Soluble PD-L1 through alternative polyadenylation works as a decoy in lung cancer immunotherapy JCI Insight, 2021;0(0):. 2021 [PMID: 34874919] (Bioassay, Human)
• Y Qiao, Y Qiu, J Ding, N Luo, H Wang, X Ling, J Sun, Z Wu, Y Wang, Y Liu, F Guo, T Sun, W Shen, M Zhang, D Wu, B Chen, W Xu, X Wang Cancer immune therapy with PD-1-dependent CD137 co-stimulation provides localized tumour killing without systemic toxicity Nature Communications, 2021;12(1):6360. 2021 [PMID: 34737267] (Bioassay, Human)
• MD Cherne, B Sidar, TA Sebrell, HS Sanchez, K Heaton, FJ Kassama, MM Roe, AB Gentry, CB Chang, ST Walk, M Jutila, JN Wilking, D Bimczok A Synthetic Hydrogel, VitroGel� ORGANOID-3, Improves Immune Cell-Epithelial Interactions in a Tissue Chip Co-Culture Model of Human Gastric Organoids and Dendritic Cells Frontiers in Pharmacology, 2021;12(0):707891. 2021 [PMID: 34552484] (Bioassay, Human)
• A Banerjee, Y Lu, K Do, T Mize, X Wu, X Chen, J Chen Validation of Induced Microglia-Like Cells (iMG Cells) for Future Studies of Brain Diseases Frontiers in Cellular Neuroscience, 2021;15(0):629279. 2021 [PMID: 33897370] (Bioassay, Human)
• D Inoue, JT Polaski, J Taylor, P Castel, S Chen, S Kobayashi, SJ Hogg, Y Hayashi, JMB Pineda, E El Marabti, C Erickson, K Knorr, M Fukumoto, H Yamazaki, A Tanaka, C Fukui, SX Lu, BH Durham, B Liu, E Wang, S Mehta, D Zakheim, R Garippa, A Penson, GL Chew, F McCormick, RK Bradley, O Abdel-Waha Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition Nature Genetics, 2021;0(0):. 2021 [PMID: 33846634] (Bioassay, Human)
• R Song, Y Gao, I Dozmorov, V Malladi, I Saha, MM McDaniel, S Parameswar, C Liang, C Arana, B Zhang, B Wakeland, J Zhou, MT Weirauch, LC Kottyan, EK Wakeland, C Pasare IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility Cell Reports, 2021;34(12):108891. 2021 [PMID: 33761354] (Bioassay, Human)
• Bsat M, Mehta H, Rubio M, Sarfati M The Conversion of Human Tissue-Like Inflammatory Monocytes Into Macrophages. Curr Protoc, 0;1(3):e74. 0 [PMID: 33705607] (Bioassay, Human)
• J Li, A Wuethrich, AAI Sina, HH Cheng, Y Wang, A Behren, PN Mainwaring, M Trau A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy Nature Communications, 2021;12(1):1087. 2021 [PMID: 33597530] (Human)
• M Drill, KL Powell, LK Kan, NC Jones, TJ O'Brien, JA Hamilton, M Monif Inhibition of purinergic P2X receptor 7 (P2X7R) decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in U251 glioblastoma cells Sci Rep, 2020;10(1):14844. 2020 [PMID: 32908225] (Cell Culture, Human)
• B Cioni, A Zaalberg, JR van Beijnu, MHM Melis, J van Burgst, MJ Muraro, E Hooijberg, D Peters, I Hofland, Y Lubeck, J de Jong, J Sanders, J Vivié, HG van der Po, JP de Boer, AW Griffioen, W Zwart, AM Bergman Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion Nat Commun, 2020;11(1):4498. 2020 [PMID: 32908142] (Bioassay, Human)
• S Vakili, TM Ahooyi, SS Yarandi, M Donadoni, J Rappaport, IK Sariyer Molecular and Cellular Impact of Inflammatory Extracellular Vesicles (EVs) Derived from M1 and M2 Macrophages on Neural Action Potentials Brain Sci, 2020;10(7):. 2020 [PMID: 32635207] (Bioassay, Human)
• X Guo, Y Pan, M Xiong, S Sanapala, C Anastasaki, O Cobb, S Dahiya, DH Gutmann Midkine activation of CD8+ T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth Nat Commun, 2020;11(1):2177. 2020 [PMID: 32358581] (Cell Culture, Human)
• J Lubow, MC Virgilio, M Merlino, DR Collins, M Mashiba, BG Peterson, Z Lukic, MM Painter, F Gomez-Rive, V Terry, G Zimmerman, KL Collins Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages Elife, 2020;9(0):. 2020 [PMID: 32119644] (Bioassay, Human)
• B ?y?y?ska-G, B Trzaskowsk, M Dutkiewicz, O Zegrocka-S, M Machci?ska, K Bocian, M Kowalewska, K Koziak The anti-inflammatory potential of cefazolin as common gamma chain cytokine inhibitor Sci Rep, 2020;10(1):2886. 2020 [PMID: 32076052] (Cell Culture, Human)
• H Xiang, CP Ramil, J Hai, C Zhang, H Wang, AA Watkins, R Afshar, P Georgiev, MA Sze, XS Song, PJ Curran, M Cheng, JR Miller, D Sun, A Loboda, Y Jia, LY Moy, A Chi, PE Brandish Cancer-associated fibroblasts promote immunosuppression by inducing ROS-generating monocytic MDSCs in lung squamous cell carcinoma Cancer Immunol Res, 2020;0(0):. 2020 [PMID: 32075803] (Bioassay, Human)
• JS Brunner, L Vulliard, M Hofmann, M Kieler, A Lercher, A Vogel, M Russier, JB Brüggenthi, M Kerndl, V Saferding, B Niederreit, A Junza, A Frauenstei, C Scholtysek, Y Mikami, K Klavins, G Krönke, A Bergthaler, JJ O'Shea, T Weichhart, F Meissner, JS Smolen, P Cheng, O Yanes, J Menche, PJ Murray, O Sharif, S Blüml, G Schabbauer Environmental arginine controls multinuclear giant cell metabolism and formation Nat Commun, 2020;11(1):431. 2020 [PMID: 31969567] (Differentiation, Human)
• JJ Montoya, MA Turnidge, DH Wai, AR Patel, DW Lee, V Gokhale, LH Hurley, RJ Arceci, C Wetmore, DO Azorsa In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells BMC Cancer, 2019;19(1):1251. 2019 [PMID: 31881855] (Bioassay, Human)
• R Chen, G Ji, H Ren, Z Liu, S Feng, T Zhang, L Xi, X Li Activation of autophagy and IL-10 production are regulated by Jun N-terminal kinase 1 and 2 and p38 mitogen activated protein kinase signaling pathways during Talaromyces marneffei infection within dendritic cells Microb. Pathog., 2019;139(0):103891. 2019 [PMID: 31783123] (Cell Culture, Human)
• S Patel, R Hanajiri, M Grant, D Saunders, S Van Pelt, M Keller, PJ Hanley, G Simon, DF Nixon, D Hardy, RB Jones, CM Bollard HIV-Specific T Cells Can Be Generated against Non-escaped T Cell Epitopes with a GMP-Compliant Manufacturing Platform Mol Ther Methods Clin Dev, 2020;16(0):11-20. 2020 [PMID: 31720305] (Cell Culture, Human)
• N Chiang, S Libreros, PC Norris, X de la Rosa, CN Serhan Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions J. Clin. Invest., 2019;0(0):. 2019 [PMID: 31657786] (Cell Culture, Human)
• A Yoshimi, KT Lin, DH Wiseman, MA Rahman, A Pastore, B Wang, SC Lee, JB Micol, XJ Zhang, S de Botton, V Penard-Lac, EM Stein, H Cho, RE Miles, D Inoue, TR Albrecht, TCP Somervaill, K Batta, F Amaral, F Simeoni, DP Wilks, C Cargo, AM Intlekofer, RL Levine, H Dvinge, RK Bradley, EJ Wagner, AR Krainer, O Abdel-Waha Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis Nature, 2019;0(0):. 2019 [PMID: 31578525] (Cell Culture, Human)
• SR Levan, KA Stamnes, DL Lin, AR Panzer, E Fukui, K McCauley, KE Fujimura, M McKean, DR Ownby, EM Zoratti, HA Boushey, MD Cabana, CC Johnson, SV Lynch Elevated faecal 12,13-diHOME concentration in neonates at high risk for asthma is produced by gut bacteria and impedes immune tolerance Nat Microbiol, 2019;4(11):1851-1861. 2019 [PMID: 31332384] (Cell Culture, Human)
• A Crotti, HR Sait, KM McAvoy, K Estrada, A Ergun, S Szak, G Marsh, L Jandreski, M Peterson, TL Reynolds, I Dalkilic-L, A Cameron, E Cahir-McFa, RM Ransohoff BIN1 favors the spreading of Tau via extracellular vesicles Sci Rep, 2019;9(1):9477. 2019 [PMID: 31263146] (Cell Culture, Human)
• AI Chiramel, NR Meyerson, KL McNally, RM Broeckel, VR Montoya, O Méndez-Sol, SJ Robertson, GL Sturdevant, KJ Lubick, V Nair, BH Youseff, RM Ireland, CM Bosio, K Kim, J Luban, VM Hirsch, RT Taylor, F Bouamr, SL Sawyer, SM Best TRIM5? Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation Cell Rep, 2019;27(11):3269-3283.e6. 2019 [PMID: 31189110] (Bioassay, Human)
• BD Bryson, TR Rosebrock, FG Tafesse, CY Itoh, A Nibasumba, GH Babunovic, B Corleis, C Martin, C Keegan, P Andrade, S Realegeno, D Kwon, RL Modlin, SM Fortune Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis Nat Commun, 2019;10(1):2329. 2019 [PMID: 31133636] (Bioassay, Human)
• VA Jennings, GB Scott, AMS Rose, KJ Scott, G Migneco, B Keller, K Reilly, O Donnelly, H Peach, D Dewar, KJ Harrington, H Pandha, A Samson, RG Vile, AA Melcher, F Errington- Potentiating Oncolytic Virus-Induced Immune-Mediated Tumor Cell Killing Using Histone Deacetylase Inhibition Mol. Ther., 2019;0(0):. 2019 [PMID: 31053413] (Bioassay, Human)
• S De Alessan, GJ Ferguson, AJ Dodd, JK Juss, A Devaprasad, S Piper, O Wyatt, H Killick, DJ Corkill, ES Cohen, A Pandit, TRDJ Radstake, R Simmonds, AM Condliffe, MA Sleeman, AS Cowburn, DK Finch, ER Chilvers Neutrophil GM-CSF receptor dynamics in acute lung injury J. Leukoc. Biol., 2019;0(0):. 2019 [PMID: 30942918] (Bioassay, Human)
• R Gramlich, E Aliahmadi, M Peiser In Vitro Induction of T Helper 17 Cells by Synergistic Activation of Human Monocyte-Derived Langerhans Cell-Like Cells with Bacterial Agonists Int J Mol Sci, 2019;20(6):. 2019 [PMID: 30893757] (Bioassay, Human)
• JC de Quaglia, AM Della Cole, TP Gardizani, GG Romagnoli, R Kaneno, LA Dias-Melic Involvement of the Dectin-1 Receptor upon the Effector Mechanisms of Human Phagocytic Cells against Paracoccidioides brasiliensis J Immunol Res, 2019;2019(0):1529189. 2019 [PMID: 30882002] (Bioassay, Human)
• TA Sebrell, M Hashimi, B Sidar, R Wilkinson, L Kirpotina, MT Quinn, Z Malkoç, PJ Taylor, JN Wilking, D Bimczok A Novel Gastric Spheroid Co-Culture Model Reveals Chemokine-Dependent Recruitment of Human Dendritic Cells to the Gastric Epithelium Cell Mol Gastroenterol Hepatol, 2019;0(0):. 2019 [PMID: 30878664] (Bioassay, Human)
• M Kita, Y Ano, A Inoue, J Aoki Identification of P2Y receptors involved in oleamide-suppressing inflammatory responses in murine microglia and human dendritic cells Sci Rep, 2019;9(1):3135. 2019 [PMID: 30816271] (Bioassay, Human)
• E Tenland, A Pochert, N Krishnan, K Umashankar, S Kalsum, K Braun, I Glegola-Ma, M Lerm, BD Robertson, M Lindén, G Godaly Effective delivery of the anti-mycobacterial peptide NZX in mesoporous silica nanoparticles PLoS ONE, 2019;14(2):e0212858. 2019 [PMID: 30807612] (Bioassay, Human)
• CM Sellgren, J Gracias, B Watmuff, JD Biag, JM Thanos, PB Whittredge, T Fu, K Worringer, HE Brown, J Wang, A Kaykas, R Karmachary, CP Goold, SD Sheridan, RH Perlis Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning Nat. Neurosci., 2019;0(0):. 2019 [PMID: 30718903] (Bioassay, Human)
• M Pujol, C Borie, M Montoya, A Ferreira, R Vernal Brucella canis induces canine CD4+ T cells multi-cytokine Th1/Th17 production via dendritic cell activation Comp. Immunol. Microbiol. Infect. Dis., 2019;62(0):68-75. 2019 [PMID: 30711049] (Bioassay, Canine)
• C Kim, B Hu, RR Jadhav, J Jin, H Zhang, MM Cavanagh, RS Akondy, R Ahmed, CM Weyand, JJ Goronzy Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells Cell Rep, 2018;25(8):2148-2162.e5. 2018 [PMID: 30463012] (Bioassay, Human)
• K Vaeteewoot, R Kariya, P Pothipan, S Fujikawa, C Pairojkul, S Waraasawap, K Kuwahara, C Wongkham, S Wongkham, S Okada Attenuation of CD47-SIRP? Signal in Cholangiocarcinoma Potentiates Tumor-Associated Macrophage-Mediated Phagocytosis and Suppresses Intrahepatic Metastasis Transl Oncol, 2018;12(2):217-225. 2018 [PMID: 30415063] (Bioassay, Human)
• AS Hansen, M Biltoft, B Bundgaard, AB Bohn, BK Møller, P Höllsberg CD46 activation induces distinct CXCL-10 response in monocytes and monocyte-derived dendritic cells Cytokine, 2018;0(0):. 2018 [PMID: 29980471] (Bioassay, Human)
• J Zhang, Z Xiang, PA Malaviarac, Y Yan, NJ Baltz, PD Emanuel, YL Liu PTEN is indispensable for cells to respond to MAPK inhibitors in myeloid leukemia Cell. Signal., 2018;50(0):72-79. 2018 [PMID: 29964149] (Bioassay, Human)
• ME Kirkling, U Cytlak, CM Lau, KL Lewis, A Resteu, A Khodadadi-, CW Siebel, H Salmon, M Merad, A Tsirigos, M Collin, V Bigley, B Reizis Notch Signaling Facilitates In�Vitro Generation of Cross-Presenting Classical Dendritic Cells Cell Rep, 2018;23(12):3658-3672.e6. 2018 [PMID: 29925006] (Bioassay, Human)
• H Nakano, Y Kirino, M Takeno, K Higashitan, H Nagai, R Yoshimi, Y Yamaguchi, I Kato, I Aoki, H Nakajima GWAS-identified CCR1 and IL10 loci contribute to M1 macrophage-predominant inflammation in Beh�et&#039;s disease Arthritis Res. Ther., 2018;20(1):124. 2018 [PMID: 29895319] (Bioassay, Human)
• H Chu, CM Chan, X Zhang, Y Wang, S Yuan, J Zhou, RK Au-Yeung, KH Sze, D Yang, H Shuai, Y Hou, C Li, X Zhao, VK Poon, SP Leung, ML Yeung, J Yan, G Lu, DY Jin, GF Gao, JF Chan, KY Yuen Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells J. Biol. Chem., 2018;0(0):. 2018 [PMID: 29887526] (Bioassay, Human)
• JA Marwick, R Mills, O Kay, K Michail, J Stephen, AG Rossi, I Dransfield, N Hirani Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-?B activation Cell Death Dis, 2018;9(6):665. 2018 [PMID: 29867198] (Bioassay, Human)
• L Ladislau, DM Portilho, T Courau, A Solares-Pé, E Negroni, J Lainé, D Klatzmann, A Bonomo, Y Allenbach, O Benveniste, I Riederer, W Savino, V Mouly, G Butler-Bro, CF Benjamim Activated dendritic cells modulate proliferation and differentiation of human myoblasts Cell Death Dis, 2018;9(5):551. 2018 [PMID: 29748534] (Bioassay, Human)
• LB Crawford, JH Kim, D Collins-Mc, BJ Lee, I Landais, C Held, JA Nelson, AD Yurochko, P Caposio Human Cytomegalovirus Encodes a Novel FLT3 Receptor Ligand Necessary for Hematopoietic Cell Differentiation and Viral Reactivation MBio, 2018;9(2):. 2018 [PMID: 29691342] (Bioassay, Human)
• JAT de Albuque, PP Banerjee, A Castoldi, R Ma, NB Zurro, LH Ynoue, C Arslanian, MUW Barbosa-Ca, JEM Correia-De, FG Weiler, MR Dias-da-Si, M Lazaretti-, LA Pedroza, NOS Câmara, E Mace, JS Orange, A Condino-Ne The Role of AIRE in the Immunity Against Candida Albicans in a Model of Human Macrophages Front Immunol, 2018;9(0):567. 2018 [PMID: 29666621] (Cell Culture, Human)
• D Kishimoto, Y Kirino, M Tamura, M Takeno, Y Kunishita, K Takase-Min, H Nakano, I Kato, K Nagahama, R Yoshimi, K Igarashi, I Aoki, H Nakajima Dysregulated heme oxygenase-1low M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons Arthritis Res. Ther., 2018;20(1):64. 2018 [PMID: 29636091] (Bioassay, Human)
• A Alflen, N Stadler, P Aranda Lop, D Teschner, M Theobald, G He beta , MP Radsak Idelalisib impairs TREM-1 mediated neutrophil inflammatory responses Sci Rep, 2018;8(1):5558. 2018 [PMID: 29615799] (Bioassay, Human)
• X de la Rosa, PC Norris, N Chiang, AR Rodriguez, BW Spur, CN Serhan Identification and Complete Stereochemical Assignments of the New Resolvin Conjugates in Tissue Regeneration in Human Tissues that Stimulate Proresolving Phagocyte Functions and Tissue Regeneration Am. J. Pathol., 2018;188(4):950-966. 2018 [PMID: 29571326] (Bioassay, Human)
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• C Napoletano, S Mattiucci, A Colantoni, F Battisti, IG Zizzari, H Rahimi, M Nuti, A Rughetti Anisakis pegreffii impacts differentiation and function of human dendritic cells Parasite Immunol., 2018;0(0):e12527. 2018 [PMID: 29569735] (Bioassay, Human)
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• T Kato, T Matsuda, Y Ikeda, JH Park, M Leisegang, S Yoshimura, T Hikichi, M Harada, M Zewde, S Sato, K Hasegawa, K Kiyotani, Y Nakamura Effective screening of T cells recognizing neoantigens and construction of T-cell receptor-engineered T cells Oncotarget, 2018;9(13):11009-11019. 2018 [PMID: 29541393] (Bioassay, Human)
• HD Chae, N Cox, GV Dahl, NJ Lacayo, KL Davis, S Capolicchi, M Smith, KM Sakamoto Niclosamide suppresses acute myeloid leukemia cell proliferation through inhibition of CREB-dependent signaling pathways Oncotarget, 2018;9(4):4301-4317. 2018 [PMID: 29435104] (Bioassay, Human)
• N Ilic, A Gruden-Mov, J Cvetkovic, S Tomic, DB Vucevic, C Aranzamend, M Colic, E Pinelli, L Sofronic-M Trichinella spiralis Excretory-Secretory Products Induce Tolerogenic Properties in Human Dendritic CellsviaToll-Like Receptors 2 and 4 Front Immunol, 2018;9(0):11. 2018 [PMID: 29416536] (Bioassay, Human)
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• H Sic, M Speletas, V Cornacchio, M Seidl, M Beibel, B Linghu, F Yang, E Sevdali, AE Germenis, EJ Oakeley, E Vangreveli, AW Sailer, E Traggiai, H Gram, H Eibel An Activating Janus Kinase-3 Mutation Is Associated with Cytotoxic T Lymphocyte Antigen-4-Dependent Immune Dysregulation Syndrome Front Immunol, 2017;8(0):1824. 2017 [PMID: 29375547] (Bioassay, Human)
• MS Gresnigt, M Jaeger, RK Subbarao M, O Rasid, G Jouvion, C Fitting, WJG Melchers, TD Kanneganti, A Carvalho, O Ibrahim-Gr, FL van de Vee The Absence of NOD1 Enhances Killing of Aspergillus fumigatus Through Modulation of Dectin-1 Expression Front Immunol, 2017;8(0):1777. 2017 [PMID: 29326692] (Bioassay, Human)
• YJ Choi, SJ Park, YS Park, HS Park, KM Yang, K Heo EpCAM peptide-primed dendritic cell vaccination confers significant anti-tumor immunity in hepatocellular carcinoma cells PLoS ONE, 2018;13(1):e0190638. 2018 [PMID: 29298343] (Bioassay, Human)
• C Ge, R Li, H Song, T Geng, J Yang, Q Tan, L Song, Y Wang, Y Xue, Z Li, S Dong, Z Zhang, N Zhang, J Guo, L Hua, S Chen, X Song Phase I clinical trial of a novel autologous modified-DC vaccine in patients with resected NSCLC BMC Cancer, 2017;17(1):884. 2017 [PMID: 29268708] (Bioassay, Human)
• M Ohgidani, TA Kato, M Hosoi, M Tsuda, K Hayakawa, C Hayaki, R Iwaki, N Sagata, R Hashimoto, K Inoue, N Sudo, S Kanba Fibromyalgia and microglial TNF-?: Translational research using human blood induced microglia-like cells Sci Rep, 2017;7(1):11882. 2017 [PMID: 28928366] (Bioassay, Human)
• M Yoshida, Y Ishioka, T Ozawa, H Okuyama, M Iguchi, T Ota, T Ito, M Nagira, A Morita, H Tanaka, H Naito, H Kidoya, N Takakura Soluble HLA-associated peptide from PSF1 has a cancer vaccine potency Sci Rep, 2017;7(1):11137. 2017 [PMID: 28894200] (Bioassay, Human)
• H Nishi, K Furuhashi, X Cullere, G Saggu, MJ Miller, Y Chen, F Rosetti, SL Hamilton, L Yang, SP Pittman, J Liao, JM Herter, JC Berry, DJ DeAngelo, C Zhu, GC Tsokos, TN Mayadas Neutrophil Fc?RIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases J. Clin. Invest., 2017;0(0):. 2017 [PMID: 28891817] (Bioassay, Human)
• M Matsushita, K Ozawa, T Suzuki, M Nakamura, N Nakano, S Kanchi, D Ichikawa, E Matsuki, M Sakurai, D Karigane, H Kasahara, N Tsukamoto, T Shimizu, T Mori, H Nakajima, S Okamoto, Y Kawakami, Y Hattori CXorf48 is a potential therapeutic target for achieving treatment-free remission in CML patients Blood Cancer J, 2017;7(9):e601. 2017 [PMID: 28862699] (Bioassay, Human)
• P Thornton, J Sevalle, MJ Deery, G Fraser, Y Zhou, S Ståhl, EH Franssen, RB Dodd, S Qamar, B Gomez Pere, LS Nicol, S Eketjäll, J Revell, C Jones, A Billinton, PH St George-, I Chessell, DC Crowther TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer&#039;s disease-associated H157Y variant EMBO Mol Med, 2017;0(0):. 2017 [PMID: 28855301] (Bioassay, Human)
• L Butcher, M Ahluwalia, T Örd, J Johnston, RH Morris, E Kiss-Toth, T Örd, JD Erusalimsk Evidence for a role of TRIB3 in the regulation of megakaryocytopoiesis Sci Rep, 2017;7(1):6684. 2017 [PMID: 28751721] (Bioassay, Human)
• J Helft, F Anjos-Afon, AG van der Ve, P Chakravart, D Bonnet, C Reis E Sou Dendritic Cell Lineage Potential in Human Early Hematopoietic Progenitors Cell Rep, 2017;20(3):529-537. 2017 [PMID: 28723558] (Bioassay, Human)
• JH von Steman, AS Rigas, LW Thørner, DGK Rasmussen, OB Pedersen, K Rostgaard, C Erikstrup, H Ullum, MB Hansen Prevalence and correlation of cytokine-specific autoantibodies with epidemiological factors and C-reactive protein in 8,972 healthy individuals: Results from the Danish Blood Donor Study PLoS ONE, 2017;12(6):e0179981. 2017 [PMID: 28665954] (Control, Human)
• JT Schroeder, AP Bieneman Activation of Human Basophils by A549 Lung Epithelial Cells Reveals a Novel IgE-Dependent Response Independent of Allergen J. Immunol., 2017;0(0):. 2017 [PMID: 28652400] (Bioassay, Human)
• S Scholz, F Baharom, G Rankin, KT Maleki, S Gupta, S Vangeti, J Pourazar, A Discacciat, J Höijer, M Bottai, NK Björkström, J Rasmuson, M Evander, A Blomberg, HG Ljunggren, J Klingström, C Ahlm, A Smed-Sören Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways PLoS Pathog., 2017;13(6):e1006462. 2017 [PMID: 28640917] (Bioassay, Human)
• AA Panackal, LB Rosen, G Uzel, MJ Davis, G Hu, A Adeyemo, F Tekola-Aye, A Lisco, C Diachok, JD Kim, D Shaw, I Sereti, J Stoddard, J Niemela, SD Rosenzweig, JE Bennett, PR Williamson Susceptibility to Cryptococcal Meningoencephalitis Associated With Idiopathic CD4(+) Lymphopenia and Secondary Germline or Acquired Defects Open Forum Infect Dis, 2017;4(2):ofx082. 2017 [PMID: 28638843] (Bioassay, Human)
• T Liu, P Jia, H Ma, SA Reed, X Luo, HB Larman, PG Schultz Construction and Screening of a Lentiviral Secretome Library Cell Chem Biol, 2017;0(0):. 2017 [PMID: 28602759] (Bioassay, Human)
• AM Clemente, G Castronovo, A Antonelli, MM D'Andrea, M Tanturli, E Perissi, S Paccosi, A Parenti, F Cozzolino, GM Rossolini, MG Torcia Differential Th17 response induced by the two clades of the pandemic ST258 Klebsiella pneumoniae clonal lineages producing KPC-type carbapenemase PLoS ONE, 2017;12(6):e0178847. 2017 [PMID: 28586386] (Bioassay, Human)
• CSB Viegas, RM Costa, L Santos, PA Videira, Z Silva, N Araújo, AL Macedo, AP Matos, C Vermeer, DC Simes Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: Implications for calcification-related chronic inflammatory diseases PLoS ONE, 2017;12(5):e0177829. 2017 [PMID: 28542410] (Bioassay, Human)
• J Wang, H Ye, D Zhang, K Cheng, Y Hu, X Yu, L Lu, J Hu, C Zuo, B Qian, Y Yu, S Liu, G Liu, C Mao, S Liu Cancer-derived Circulating MicroRNAs Promote Tumor Angiogenesis by Entering Dendritic Cells to Degrade Highly Complementary MicroRNAs Theranostics, 2017;7(6):1407-1421. 2017 [PMID: 28529626] (Bioassay, Human)
• H Zhao, S Gulesseria, MC Malinao, S Kumar-Gane, J Song, MS Chang, MM Williams, Z Zeng, M Mattie, BA Mendelsohn, DR Stover, F Doñate A Potential Mechanism for ADC-Induced Neutropenia: Role of Neutrophils in Their Own Demise Mol. Cancer Ther., 2017;0(0):. 2017 [PMID: 28522588] (Bioassay, Human)
• SC Silva-Card, AJ Affandi, L Spel, M Cossu, JAG van Roon, M Boes, TRDJ Radstake CXCL4 Exposure Potentiates TLR-Driven Polarization of Human Monocyte-Derived Dendritic Cells and Increases Stimulation of T Cells J. Immunol., 2017;0(0):. 2017 [PMID: 28515281] (Bioassay, Human)
• G Izumi, K Koga, M Takamura, W Bo, M Nagai, M Miyashita, M Harada, T Hirata, Y Hirota, O Yoshino, T Fujii, Y Osuga Oil-Soluble Contrast Medium (OSCM) for Hysterosalpingography Modulates Dendritic Cell and Regulatory T Cell Profiles in the Peritoneal Cavity: A Possible Mechanism by Which OSCM Enhances Fertility J. Immunol., 2017;0(0):. 2017 [PMID: 28455434] (Bioassay, Human)
• A Dyer, Y Di, H Calderon, S Illingwort, G Kueberuwa, A Tedcastle, P Jakeman, SL Chia, A Brown, MA Silva, D Barlow, J Beadle, T Hermiston, DJ Ferguson, B Champion, KD Fisher, LW Seymour Oncolytic Group B Adenovirus Enadenotucirev Mediates Non-apoptotic Cell Death with Membrane Disruption and Release of Inflammatory Mediators Mol Ther Oncolytics, 2017;4(0):18-30. 2017 [PMID: 28345021] (Bioassay, Human)
• X Zhang, T Zhou, J Yang, Y Lin, J Shi, X Zhang, DA Frabutt, X Zeng, S Li, PJ Venta, YH Zheng Identification of SERINC5-001 as the Predominant Spliced Isoform for HIV-1 Restriction J. Virol, 2017;0(0):. 2017 [PMID: 28275190] (Bioassay, Human)
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• JE Hammonds, N Beeman, L Ding, S Takushi, AC Francis, JJ Wang, GB Melikyan, P Spearman Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1 PLoS Pathog, 2017;13(1):e1006181. 2017 [PMID: 28129379] (Bioassay, Human)
• MJ Bae, S Ryu, HJ Kim, SI Cha, CH Kim, J Lee Mycobacterium tuberculosis ESAT6 and CPF10 Induce Adenosine Deaminase 2 mRNA Expression in Monocyte-Derived Macrophages Tuberc Respir Dis (Seoul), 2017;80(1):77-82. 2017 [PMID: 28119750] (Bioassay, Human)
• Stephane Esnault IL-3 Up-regulates and Activates Human Eosinophil CD32 and ?M�2 Integrin Causing Degranulation Clin. Exp. Allergy, 2016;0(0):. 2016 [PMID: 28000949] (Bioassay, Human)
• Yusuke Tomita The interplay of epigenetic therapy and immunity in locally recurrent or metastatic estrogen receptor-positive breast cancer: Correlative analysis of ENCORE 301, a randomized, placebo-controlled phase II trial of exemestane with or without entinostat Oncoimmunology, 2016;5(11):e1219008. 2016 [PMID: 27999738] (Bioassay, Human)
• Eóin N McNamee Targeting GM-CSF in epithelial and vascular remodeling in experimental Eosinophilic Esophagitis Allergy, 2016;0(0):. 2016 [PMID: 27926989] (Bioassay, Human)
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• Xiang-Ming Lao Peritumoral stromal neutrophils are essential for c-Met-elicited metastasis in human hepatocellular carcinoma Oncoimmunology, 2016;5(10):e1219828. 2016 [PMID: 27853643] (Bioassay, Human)
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• CD11c/CD18 Dominates Adhesion of Human Monocytes, Macrophages and Dendritic Cells over CD11b/CD18 PLoS ONE, 2016;11(9):e0163120. 2016 [PMID: 27658051] (Bioassay, Human)
• Functional IL-33 receptors are expressed in early progenitor stages of allergy-related granulocytes Immunology, 2016;0(0):. 2016 [PMID: 27568595] (Bioassay, Human)
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• Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation J Immunol, 2016;0(0):. 2016 [PMID: 27521339] (Bioassay, Human)
• Sarah E Clark Bacterial Manipulation of NK Cell Regulatory Activity Increases Susceptibility to Listeria monocytogenes Infection PLoS Pathog, 2016;12(6):e1005708. 2016 [PMID: 27295349] (Bioassay, Human)
• Lajos V Kemény Melanoma Cells Can Adopt the Phenotype of Stromal Fibroblasts and Macrophages by Spontaneous Cell Fusion in Vitro Int J Mol Sci, 2016;17(6):. 2016 [PMID: 27271591] (Bioassay, Human)
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• Human mesenchymal stromal cell-secreted lactate induces M2-macrophage differentiation by metabolic reprogramming Oncotarget, 2016;7(21):30193-210. 2016 [PMID: 27070086] (Bioassay, Human)
• Decitabine enhances anti-CD33 monoclonal antibody BI 836858-mediated natural killer ADCC against AML blasts Blood, 2016;127(23):2879-89. 2016 [PMID: 27013443] (Bioassay, Human)
• TM Garcia-Bat, E Kim, F Concha-Ben, S Trivedi, RB Mailliard, A Gambotto, RL Ferris Enhanced Cytotoxic CD8 T Cell Priming Using Dendritic Cell-Expressing Human Papillomavirus-16 E6/E7-p16INK4 Fusion Protein with Sequenced Anti-Programmed Death-1 J. Immunol, 2016;196(6):2870-8. 2016 [PMID: 26851223] (Bioassay, Human)
• Younis R, Han K, Webb T Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells. J Immunol, 2016;196(3):1419-29. 2016 [PMID: 26740106] (Bioassay, Human)
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• Dutta D, Potnis P, Rhodes K, Wood S Wear particles derived from metal hip implants induce the generation of multinucleated giant cells in a 3-dimensional peripheral tissue-equivalent model. PLoS ONE, 2015;10(4):e0124389. 2015 [PMID: 25894745] (Bioassay, Human)
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• Purushothaman P, Thakker S, Verma S Transcriptome analysis of Kaposi&#039;s sarcoma-associated herpesvirus during de novo primary infection of human B and endothelial cells. J Virol, 2015;89(6):3093-111. 2015 [PMID: 25552714] (Bioassay, Human)
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Bioinformatics

• Gene Symbol: CSF2
• Uniprot:
  • P04141.1()