Recombinant Human Neurturin Protein, CF


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Reactivity HuSpecies Glossary
Applications Binding Activity, Bioactivity

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Recombinant Human Neurturin Protein, CF Summary

Details of Functionality
Measured in a cell proliferation assay using SH‑SY5Y human neuroblastoma cells. The ED50 for this effect is typically 20-80 ng/mL in the presence of Recombinant Human GFR alpha ‑2/GDNF R alpha ‑2 Fc Chimera (Catalog # 613‑FR). Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human GFR alpha ‑2/GDNF R alpha ‑2 Fc Chimera (Catalog # 613-FR) at 1 μg/mL can bind Recombinant Human Neurturin with an apparent KD <3.0 nM.
E. coli-derived human Neurturin protein
Ala96-Val197, with an N-terminal Met
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.


  • Binding Activity
  • Bioactivity
Theoretical MW
11.8 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Read Publications using
1297-NE/CF in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile 4 mM HCl.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human Neurturin Protein, CF

  • Neurturin
  • NRTN
  • NTN


Neurturin is a member of the GDNF family of ligands, which include glial cell-derived neurotrophic factor (GDNF), Neurturin, Persephin, and Artemin. GDNF family proteins are distant members of the Transforming Growth Factor beta (TGF-beta ) superfamily (1-4). Similarly to other TGF-beta family proteins, Neurturin is synthesized as a precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxy-terminal domain. The carboxy-terminal domain of Neurturin contains the characteristic seven conserved cysteine residues necessary for the formation of the cysteine-knot and the single interchain disulfide bond. Biologically active human Neurturin is a disulfide-linked homodimer of the carboxy-terminal 102 amino acid residues. Mature human Neurturin shares approximately 92% amino acid sequence identity with mouse Neurturin. Mature Neurturin also shares about 40% similarities with the other three members of the GDNF family ligands (2-5). Unlike other members of TGF-beta family, bioactivities of all GDNF family ligands are mediated through a unique multicomponent receptor complex composed of high affinity ligand binding component (GFR alpha -1-GFR alpha -4) and a common signaling component (cRET receptor tyrosine kinase). Each member of the GDNF family ligands has its preferred binding protein. Neurturin preferentially binds to GFR alpha -2 but can also bind GFR alpha -1 at higher concentrations (5‑8). Neurturin had been shown to promote the survival of a variety of neurons including sympathetic, sensory, and central nervous system neurons. Neurturin is expressed in both neuronal and non-neuronal tissues. It may play a role in regulating the development and maintenance of the central and peripheral nervous systems and as well as non-neuronal systems (9).

  1. Lin, L-F.H. et al. (1993) Science 260:1130.
  2. Kotzbauer, P.T. et al. (1996) Nature 384:467.
  3. Milbrandt, J. et al. (1998) Neuron 20:245.
  4. Baloh, R.H. et al. (1998) Neuron 21:1291.
  5. Takahashi, M. (2001) Cytokine and Growth Factor Reviews 12:361.
  6. Baloh, R.H. et al. (1997) Neuron 18:793.
  7. Jing, S. et al. (1996) Cell 85:1113.
  8. Jing, S. et al. (1997) J. Biol. Chem. 272:33111.
  9. Airaksinen. M. and M. Saarma (2002) Nature Review Neuroscience 3:383.

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Publications for Neurturin (1297-NE/CF)(9)

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Bacteria, Guinea Pig.

We have publications tested in 6 applications: Adsorption, Bioassay, Cell Culture, ELISA (Capture), In Vivo, Surface Plasmon Resonance.

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ELISA (Capture)
In Vivo
Surface Plasmon Resonance
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Showing Publications 1 - 9 of 9.
Publications using 1297-NE/CF Applications Species
B Sun, X Yang, F Hou, X Yu, Q Wang, HS Oh, P Raja, JM Pesola, EAH Vanni, S McCarron, J Morris-Lov, AHM Ng, GM Church, DM Knipe, DM Coen, D Pan Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency Nature Microbiology, 2021;0(0):. 2021 [PMID: 33558653] (Bioassay, Mouse) Bioassay Mouse
Chu Y, Bartus R, Manfredsson F, Olanow C, Kordower J Long-term post-mortem studies following neurturin gene therapy in patients with advanced Parkinson&#039;s disease. Brain, 0;143(3):960-975. 0 [PMID: 32203581] (Adsorption, Mouse) Adsorption Mouse
M Chenlo, IA Rodriguez-, R Serramito, AR Garcia-Ren, R Villar-Tai, E Fernandez-, S Perez-Rome, M Suarez-Far, A Garcia-All, JM Cabezas-Ag, J Rodriguez-, PV Lear, RM Alvarez-Sa, C Alvarez-Es, I Bernabeu, CV Alvarez Unmasking a new prognostic marker and therapeutic target from the GDNF-RET/PIT1/p14ARF/p53 pathway in acromegaly EBioMedicine, 2019;0(0):. 2019 [PMID: 30975543] (Cell Culture, Human) Cell Culture Human
JNA Ferreira, C Zheng, IMA Lombaert, CM Goldsmith, AP Cotrim, JM Symonds, VN Patel, MP Hoffman Neurturin Gene Therapy Protects Parasympathetic Function to Prevent Irradiation-Induced Murine Salivary Gland Hypofunction Mol Ther Methods Clin Dev, 2018;9(0):172-180. 2018 [PMID: 29560384] (Bioassay, Human) Bioassay Human
Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth. J. Biol. Chem., 2011;286(34):30034-46. 2011 [PMID: 21737454] (Surface Plasmon Resonance, Human) Surface Plasmon Resonance Human
Hadaczek P, Johnston L, Forsayeth J, Bankiewicz KS Pharmacokinetics and bioactivity of glial cell line-derived factor (GDNF) and neurturin (NTN) infused into the rat brain. Neuropharmacology, 2010;58(7):1114-21. 2010 [PMID: 20153340] (In Vivo, Rat) In Vivo Rat
Lu B, PereiraPerrin M A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruzi. Infect. Immun., 2008;76(8):3530-8. 2008 [PMID: 18541656] (ELISA (Capture), Bacteria) ELISA (Capture) Bacteria
Girard BM, Young BA, Buttolph TR, White SL, Parsons RL Regulation of neuronal pituitary adenylate cyclase-activating polypeptide expression during culture of guinea-pig cardiac ganglia. Neuroscience, 2007;146(2):584-93. 2007 [PMID: 17367946] (Bioassay, Guinea Pig) Bioassay Guinea Pig
Girard BM, Young BA, Buttolph TR, Locknar SA, White SL, Parsons RL Trophic factor modulation of cocaine- and amphetamine-regulated transcript peptide expression in explant cultured guinea-pig cardiac neurons. Neuroscience, 2006;139(4):1329-41. 2006 [PMID: 16516394] (Bioassay, Guinea Pig) Bioassay Guinea Pig

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Gene Symbol NRTN