GDNF Products

Antibodies
GDNF Antibody
GDNF Antibody
AF-212-NA
Species: Hu, Rt
Applications: WB, IHC, Neut
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
GDNF Antibody (27106) [Unconj ...
GDNF Antibody (27106) [Unconjugated]
MAB212
Species: Hu
Applications: WB, ELISA(Cap), Neut
Host: Mouse Monoclonal
GDNF Antibody
GDNF Antibody
AB-212-NA
Species: Hu, Rt
Applications: WB, Neut
Host: Goat Polyclonal
ELISA Kits
GDNF ELISA Kit [Biotin]
GDNF ELISA Kit [Biotin]
KA0341
Species: Rt
GDNF ELISA Kit [Biotin]
GDNF ELISA Kit [Biotin]
KA0984
Species: Hu
Lysates
GDNF Overexpression Lysate (N ...
GDNF Overexpression Lysate (Native)
NBL1-11032
Applications: WB
GDNF Overexpression Lysate (N ...
GDNF Overexpression Lysate (Native)
NBL1-11031
Applications: WB
GDNF Overexpression Lysate (N ...
GDNF Overexpression Lysate (Native)
NBP2-09015
Applications: WB
Proteins
Human GDNF Protein
Human GDNF Protein
NBP2-34888
Species: Hu
Applications: Func, PAGE
Rat GDNF Protein
Rat GDNF Protein
NBP2-35204
Species: Rt
Applications: Func, PAGE
GDNF Recombinant Protein
GDNF Recombinant Protein
P4394
Species: Hu
Applications: Func, PAGE
RNAi
GDNF RNAi
GDNF RNAi
H00002668-R02
Species: Hu
GDNF RNAi
GDNF RNAi
H00002668-R03
Species: Hu
GDNF RNAi
GDNF RNAi
H00002668-R01
Species: Hu

Description

GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. ; FUNCTION: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. SUBUNIT: Homodimer; disulfide-linked. SUBCELLULAR LOCATION: Secreted protein. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. ; DISEASE: Defects in GDNF may be a cause of Hirschsprung disease (HSCR). In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. DISEASE: Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Mouse
Product By Gene ID 2668
Alternate Names
  • hGDNF
  • glial cell line-derived neurotrophic factor
  • ATF
  • glial cell line derived neurotrophic factor
  • Astrocyte-derived trophic factor
  • HFB1-GDNF
  • ATF2
  • ATF1
  • HSCR3
  • glial cell derived neurotrophic factor

Research Areas for GDNF

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer

Bioinformatics Tool for GDNF

Discover related pathways, diseases and genes to GDNF. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related GDNF Blog Posts

Check out the latest blog posts on GDNF.
The identification of dopaminergic neurons using Tyrosine Hydroxylase in Parkinson's research and LRRK2
Tyrosine hydroxylase (TH) is a crucial enzyme involved in the biosynthesis of dopamine, norepinephrine and epinephrine in the brain.  Specifically, TH catalyzes the conversion of l-tyrosine to l-dihydroxyphenylalanine (l-dopa).  The importance of t...    Read more.
Read more GDNF related blogs.