Recombinant Human Endoglin/CD105 Protein


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Product Details

Reactivity HuSpecies Glossary
Applications Bioactivity

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Recombinant Human Endoglin/CD105 Protein Summary

Additional Information
A New rh Endoglin is Available! It has ~100 fold better TGFbRI binding activity and has a Fc tag!
Details of Functionality
Measured by its ability to inhibit BMP-10-induced alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells. The ED50 for this effect is 0.06-0.36 μg/mL in the presence of 100 ng/mL of Recombinant Human BMP‑10 (Catalog # 2926-BP).
Mouse myeloma cell line, NS0-derived human Endoglin/CD105 protein
Accession #
N-terminal Sequence
Protein/Peptide Type
Recombinant Proteins
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<1.0 EU per 1 μg of the protein by the LAL method.


Theoretical MW
61 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
75-85 kDa, reducing conditions
Read Publications using
1097-EN in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 250 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human Endoglin/CD105 Protein

  • CD105 antigen
  • CD105
  • Endoglin
  • ENDOsler-Rendu-Weber syndrome 1
  • ENG
  • HHT1FLJ41744
  • ORW
  • ORW1


Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins (1‑3). Endoglin and betaglycan/T beta RIII are type III receptors for TGF beta superfamily ligands, sharing 71% aa identity in the transmembrane (TM) and cytoplasmic domains. Endoglin is highly expressed on proliferating vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta, with lower amounts on hematopoietic, mesenchymal and neural crest stem cells, activated monocytes, and lymphoid and myeloid leukemic cells (2 ‑ 5). Human endoglin cDNA encodes 658 amino acids (aa) including a 25 aa signal sequence, a 561 aa extracellular domain (ECD) with an orphan domain and a two‑part ZP domain, a TM domain and a 47 aa cytoplasmic domain (1‑3). An isoform with a 14 aa cytoplasmic domain (S‑endoglin) can oppose effects of long (L) endoglin (6, 7). The human endoglin ECD shares 65‑72% aa identity with mouse, rat, bovine, porcine and canine endoglin.  Endoglin homodimers interact with TGF‑ beta 1 and TGF‑ beta 3 (but not TGF‑ beta 2), but only after binding T beta RII (8). Similarly, they interact with activin‑A and BMP‑7 via activin type IIA or B receptors, and with BMP‑2 via BMPR‑1A/ALK‑3 or BMPR‑1B/ALK‑6 (9). BMP‑9, however, is reported to bind endoglin directly (10). Endoglin modifies ligand‑induced signaling in multiple ways. For example, expression of endoglin can inhibit TGF‑ beta 1 signals but enhance BMP7 signals in the same myoblast cell line (11). In endothelial cells, endoglin inhibits T beta RI/ALK5, but enhances ALK1‑mediated activation (12). Deletion of mouse endoglin causes lethal vascular and cardiovascular defects, and human endoglin haploinsufficiency can a cause the vascular disorder, hereditary hemorrhagic telangiectasia type I (13, 14). These abnormalities confirm the essential function of endoglin in differentiation of smooth muscle, angiogenesis, and neovascularization (2‑4, 12‑14).  In preeclampsia of pregnancy, high levels of proteolytically generated soluble endoglin and VEGF R1 (sFLT1), along with low placental growth factor (PlGF), are pathogenic due to antiangiogenic activity (15).

  1. Gougos, A. and Letarte, M. (1990) J. Biol. Chem. 265:8361.
  2. ten Dijke, P. et al. (2008) Angiogenesis 11:79.
  3. Bernabeu, C. et al. (2007) J. Cell. Biochem. 102:1375.
  4. Mancini, M.L. et al. (2007) Dev. Biol. 308:520.
  5. Moody, J.L. et al. (2007) Stem Cells 25:2809.
  6. Velasco, S. et al. (2008) J. Cell Sci. 121:913.
  7. Perez-Gomez, E. et al. (2005) Oncogene 24:4450.
  8. Cheifetz, S, et al. (1992) J. Biol. Chem. 267:19027.
  9. Barbara, N.P. et al. (1999) J. Biol. Chem. 274:584.
  10. Scharpfenecker, M. et al. (2007) J. Cell Sci. 120:964.
  11. Scherner, O. et al. (2007) J. Biol. Chem. 282:13934.
  12. Pece-Barbara, N. et al. (2005) J. Biol. Chem. 280:27800.
  13. Arthur, H.M. et al. (2000) Dev. Biol. 217:42.
  14. Lebrin, F. and C.L. Mummery (2008) Trends Cardiovasc. Med. 18:25.    
  15. Venkatesha, S. et al. (2006) Nat. Med. 12:642.

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Publications for Endoglin/CD105 (1097-EN)(7)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Bioassay, Cell Culture.

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Cell Culture
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All Species
Showing Publications 1 - 7 of 7.
Publications using 1097-EN Applications Species
E Gallardo-V, L Gamella-Po, L Perez-Roqu, JL Bartha, I Garcia-Pal, JI Casal, JM López-Novo, M Pericacho, C Bernabeu Potential Role of Circulating Endoglin in Hypertension via the Upregulated Expression of BMP4 Cells, 2020;9(4):. 2020 [PMID: 32316263] (Cell Culture, Human) Cell Culture Human
E Gallardo-V, L Ruiz-Llore, J Casado-Vel, MJ Ruiz-Rodrí, N López-Andr, AK Pattnaik, M Quintanill, C Bernabeu Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners Cells, 2019;8(9):. 2019 [PMID: 31540324] (Bioassay, Human) Bioassay Human
DG Walker, LF Lue, TG Beach, I Tooyama Microglial Phenotyping in Neurodegenerative Disease Brains: Identification of Reactive Microglia with an Antibody to Variant of CD105/Endoglin Cells, 2019;8(7):. 2019 [PMID: 31340569] (Bioassay, Human) Bioassay Human
L Ruiz-Remol, C Ollauri-Ib, L Pérez-Roqu, E Núñez-Góme, F Pérez-Barr, JM López-Novo, M Pericacho, A Rodríguez- Circulating soluble endoglin modifies the inflammatory response in mice PLoS ONE, 2017;12(11):e0188204. 2017 [PMID: 29145462] (Bioassay, Human) Bioassay Human
Olsen O, Wader K, Misund K, Vatsveen T, Ro T, Mylin A, Turesson I, Stordal B, Moen S, Standal T, Waage A, Sundan A, Holien T Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin. Blood Cancer J, 2014;4(0):e196. 2014 [PMID: 24658374] (Bioassay, Human) Bioassay Human
Rossi E, Sanz-Rodriguez F, Eleno N, Duwell A, Blanco F, Langa C, Botella L, Cabanas C, Lopez-Novoa J, Bernabeu C Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration. Blood, 2013;121(2):403-15. 2013 [PMID: 23074273] (Bioassay, Human) Bioassay Human
Hawinkels LJ, Kuiper P, Wiercinska E Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis. Cancer Res., 2010;70(10):4141-50. 2010 [PMID: 20424116] (Bioassay, Human) Bioassay Human

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FAQs for Endoglin/CD105 (1097-EN). (Showing 1 - 2 of 2 FAQs).

  1. I wonder if you have a CD105 or CD34 antibody suitable for IHC that is specific for human and do not bind mouse?
    • We do not have any anti-human CD34 or CD105 antibodies that are confirmed to NOT detect the mouse protein. When we have tested an antibody and confirmed that it will not react with mouse samples, we will add Mu(-) to the datasheet, and unfortunately all of our CD105 and CD34 antibodies will either detect the mouse protein, or they have not been used in mouse samples before.
  2. We are interested in CD105 antibodies that could react with dog, please let me know which products in your catalog you would recommend.
    • We do not currently carry any CD105 antibodies that have been validated for use in dog samples. However, if you are interested in testing any of our CD105 antibodies with dog samples you would be eligible for our Innovators Reward Program, in which you can get a discount voucher for the purchase price of the product. Please contact us at with any questions regarding this program.

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Gene Symbol ENG