Recombinant Human C-Reactive Protein/CRP Protein


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Recombinant Human C-Reactive Protein/CRP Protein Summary

Details of Functionality
Measured by its binding ability in a functional ELISA. Immobilized recombinant human (rh) Fc gamma RIIA at 2 µg/mL (100 µL/well) can bind rhCRP with a linear range of 0.15-10 µg/mL.
Mouse myeloma cell line, NS0-derived human C-Reactive Protein/CRP protein
Accession #
N-terminal Sequence
Structure / Form
Protein/Peptide Type
Recombinant Proteins
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.


  • Binding Activity
Theoretical MW
23 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
26 kDa, reducing conditions
Read Publications using
1707-CR in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in Tris-HCl, NaCl and CaCl2 with BSA as a carrier protein.
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 200 μg/mL in sterile 20 mM Tris-HCl, pH 8.0 containing at least 0.1% human or bovine serum albumin.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human C-Reactive Protein/CRP Protein

  • C-Reactive Protein
  • C-reactive protein, pentraxin-related
  • CRP
  • MGC88244
  • pentraxin 1
  • PTX1MGC149895


CRP is a member of the pentraxin family of proteins that are characterized by a cyclic pentameric structure. Human CRP gene encodes a 224 amino acids precursor. The mature human CRP protein has 206 amino acids that are non-covalently linked to form the pentameter. Human CRP shares 71% and 64% amino acid sequence homology with mouse and rat respectively.

CRP, synthesized by hepatocytes, is a major acute phase serum protein in human. IL-6, IL-1 and glucocorticoids are the major inducer of the CRP gene. In response to infection, inflammation or tissue damage, the level of CRP in human serum can increase 1,000-fold within 24-48 hours. It will come back to base level of less than 1 μg/mL very fast. Human CRP is an acute-phase serum protein that plays a role in the first line in host innate host defense. Like other pentraxins, CRP exhibits Ca++‑dependent binding to ligands. Phosphocholine (PCh), a constituent of many bacterial and fungal walls, is a principal ligand of CRP. CRP also binds to the membrane of injured cells, membrane and nuclear components of necrotic and apoptotic cells. Upon binding with the ligands, CRP is recognized by C1q and initiates the activation of complement cascade. Ligand bound CRP also binds to Fc gamma RI and Fc gamma RIIa on phagocytes and activates phogocytotic responses. In addition to phogocytosis, CRP also can induce production of hydrogen peroxide and inflammatory cytokines, such as IL-1, IL-6 and TNF‑ alpha  by monocytes. With these functions, human CRP is an important serum protein for anti-bacterial pathogen and clearance of damaged and apoptotic cells. However, in mouse, CRP is expressed at very low level and is not an acute phase reactant. Serum amyloid P component (SAP), another pentraxin, is the major acute phase serum protein in mice. It has been shown that high levels of CRP in humans is associated with an increased risk of cardiovascular diseases.

  1. Gotschlich, E.C. and G.M. Edelman (1965) Proc. Natl. Acad. Sci. USA 54:558.
  2. Volanakis, J.E. (2001) Molecular Immunology 38:189.
  3. Bharadwaj, D. et al. (1999) J. Experimental Medicine 190:585.
  4. Ballou S.P. and G. Lozanski (1992) Cytokine 4:361.
  5. Danesh, J. et al. (2004) N. Engl. J. Med. 350:1387.

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Publications for C-Reactive Protein/CRP (1707-CR)(9)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Bioassay, Sample Preparation.

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Showing Publications 1 - 9 of 9.
Publications using 1707-CR Applications Species
D Zong, B Huang, Y Li, Y Lu, N Xiang, C Guo, Q Liu, Q Sha, P Du, Q Yu, W Zhang, P Cai, Y Sun, J Tao, X Li, S Cai, K Qu Chromatin accessibility landscapes of immune cells in rheumatoid arthritis nominate monocytes in disease pathogenesis Bmc Biology, 2021;19(1):79. 2021 [PMID: 33863328] (Bioassay, Human) Bioassay Human
M Björmsjö, O Hernell, B Lönnerdal, SK Berglund Reducing Iron Content in Infant Formula from 8 to 2 mg/L Does Not Increase the Risk of Iron Deficiency at 4 or 6 Months of Age: A Randomized Controlled Trial Nutrients, 2020;13(1):. 2020 [PMID: 33374970] (Sample Preparation, Human) Sample Preparation Human
D Rho, S Kim Demonstration of a Label-Free and Low-Cost Optical Cavity-Based Biosensor Using Streptavidin and C-Reactive Protein Biosensors, 2020;11(1):. 2020 [PMID: 33374119] (Bioassay, Human) Bioassay Human
LA Henze, TTD Luong, B Boehme, J Masyout, MP Schneider, S Brachs, F Lang, B Pieske, A Pasch, KU Eckardt, J Voelkl, I Alesutan Impact of C-reactive protein on osteo-/chondrogenic transdifferentiation and calcification of vascular smooth muscle cells Aging (Albany NY), 2019;11(15):5445-5462. 2019 [PMID: 31377747] (Bioassay, Human) Bioassay Human
C-Reactive Protein Promotes Diabetic Kidney Disease in db/db Mice via the CD32b-Smad3-mTOR signaling Pathway Sci Rep, 2016;6(0):26740. 2016 [PMID: 27221338] (Bioassay, Human) Bioassay Human
Liu F, Chen HY, Huang XR, Chung AC, Zhou L, Fu P, Szalai AJ, Lan HY C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes. Diabetologia, 2011;54(10):2713-23. 2011 [PMID: 21744073] (Bioassay, Human) Bioassay Human
Zhao XQ, Zhang MW, Wang F, Zhao YX, Li JJ, Wang XP, Bu PL, Yang JM, Liu XL, Zhang MX, Gao F, Zhang C, Zhang Y CRP enhances soluble LOX-1 release from macrophages by activating TNF-alpha converting enzyme. J. Lipid Res., 2011;52(5):923-33. 2011 [PMID: 21364202] (Bioassay, Human) Bioassay Human
Montecucco F, Steffens S, Burger F, Pelli G, Monaco C, Mach F C-reactive protein (CRP) induces chemokine secretion via CD11b/ICAM-1 interaction in human adherent monocytes. J. Leukoc. Biol., 2008;84(4):1109-19. 2008 [PMID: 18591415] (Bioassay, Human) Bioassay Human
Zhang R, Becnel L, Li M, Chen C, Yao Q C-reactive protein impairs human CD14+ monocyte-derived dendritic cell differentiation, maturation and function. Eur. J. Immunol., 2006;36(11):2993-3006. 2006 [PMID: 17051617] (Bioassay, Human) Bioassay Human

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Gene Symbol CRP