Human Haptoglobin Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human Haptoglobin Quantikine ELISA Kit Summary

• Background: The Quantikine Human Haptoglobin Immunoassay is a 4.5 hour solid phase ELISA designed to measure haptoglobin in serum-free cell culture supernates, serum, plasma, saliva, and urine
  
• Specificity: Natural human haptoglobin
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: HP

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Haptoglobin Quantikine ELISA Kit

• binding peptide
• BP
• haptoglobin alpha(1S)-beta
• haptoglobin alpha(2FS)-beta
• Haptoglobin
• haptoglobin, alpha polypeptide
• haptoglobin, beta polypeptide
• HP
• HP-1
• hp2-alpha
• HP2ALPHA2
• HPA1S
• MGC111141
• zonulin

Background

Haptoglobin is an acute phase glycoprotein that is an inactive member of the peptidase S1 family of serine proteases. It is secreted by multiple cell types and binds with high affinity to circulating Hemoglobin. Association of Haptoglobin with free Hemoglobin protects tissues from Hemoglobin-mediated oxidative damage and facilitates Hemoglobin clearance. In addition, Haptoglobin has anti-inflammatory properties that are independent of Hemoglobin binding. It inhibits prostaglandin synthesis, scavenges nitric oxide, dampens the inflammatory response to endotoxins, and inhibits T cell proliferation and neutrophil respiratory bursts. Deletion of Haptoglobin in mice facilitates the development of autoimmune inflammation.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Haptoglobin (DHAPG0)(7)

Publications using DHAPG0

• Pandur, E;Pap, R;Jánosa, G;Horváth, A;Sipos, K; The Role of Fractalkine in the Regulation of Endometrial Iron Metabolism in Iron Deficiency International journal of molecular sciences 2023-06-08 [PMID: 37373063] (Human)
• A Olsson, S Gustavsen, IC Hasselbalc, AR Langkilde, F Sellebjerg, AB Oturai, HB Søndergaar Biomarkers of inflammation and epithelial barrier function in multiple sclerosis Mult Scler Relat Disord, 2020-09-19;46(0):102520. 2020-09-19 [PMID: 32980645] (Human)
• A Wiedemann, E Foucat, H Hocini, C Lefebvre, BP Hejblum, M Durand, M Krüger, AK Keita, A Ayouba, S Mély, JC Fernandez, A Touré, S Fourati, C Lévy-March, H Raoul, E Delaporte, L Koivogui, R Thiébaut, C Lacabaratz, Y Lévy Long-lasting severe immune dysfunction in Ebola virus disease survivors Nat Commun, 2020-07-24;11(1):3730. 2020-07-24 [PMID: 32709840] (Human)
• NK Sharma, BL Ferreira, AK Tashima, MKC Brunialti, RJS Torquato, A Bafi, M Assuncao, LCP Azevedo, R Salomao Lipid metabolism impairment in patients with sepsis secondary to hospital acquired pneumonia, a proteomic analysis Clin Proteomics, 2019-07-16;16(0):29. 2019-07-16 [PMID: 31341447] (Human)
• S Wang, J Wang, R Zhang, A Zhao, X Zheng, D Yan, F Jiang, W Jia, C Hu, W Jia Association between serum haptoglobin and carotid arterial functions: usefulness of a targeted metabolomics approach Cardiovasc Diabetol, 2019-01-11;18(1):8. 2019-01-11 [PMID: 30634984] (Human)
• RL Gurung, R Dorajoo, S Liu, Y M, JJ Liu, L Wang, L Guo, X Yu, JJ Liu, SC Lim Genetic markers for urine haptoglobin is associated with decline in renal function in type 2 diabetes in East Asians Sci Rep, 2018-03-23;8(1):5109. 2018-03-23 [PMID: 29572449] (Human)
• S Wang, J Wang, R Zhang, T Wang, D Yan, Z He, F Jiang, C Hu, W Jia Mendelian randomization analysis to assess a causal effect of haptoglobin on macroangiopathy in Chinese type 2 diabetes patients Cardiovasc Diabetol, 2018-01-16;17(1):14. 2018-01-16 [PMID: 29338727] (Human)

FAQs for Haptoglobin (DHAPG0). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: HP