Mouse Pentraxin 2/SAP Quantikine ELISA Kit

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse Pentraxin 2/SAP Quantikine ELISA Kit Summary

• Background: The Quantikine Mouse PTX2/SAP Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse PTX2/SAP in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant mouse PTX2/SAP and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant factor accurately. Results obtained using natural mouse PTX2/SAP show...ed dose-response curves that were parallel to the standard curves obtained using the recombinant kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse PTX2/SAP.
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• Specificity: Natural and recombinant mouse PTX2/SAP
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Apcs

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Pentraxin 2/SAP Quantikine ELISA Kit

• 9.5S alpha-1-glycoprotein
• amyloid P component, serum
• APCS
• MGC88159
• Pentraxin 2
• PTX2
• PTX2serum amyloid P-component
• SAP
• SAPpentaxin-related
• Serum Amyloid P component

Background

Pentraxin or Pentraxin 2 (PTX2), also known as Serum Amyloid P component (SAP), is a secreted serum glycoprotein belonging to the pentraxin superfamily. Pentraxins have a characteristic pentagonal discoid arrangement of five non-covalently bound subunits and bind a variety of molecules in a calcium- dependent lectin-like manner through a pattern-recognition-binding site. PTX2 is a major acute-phase protein and may function as an opsonin for a variety of ligands. PTX2 also associates ubiquitously with all amyloid deposits implicated in diseases including Alzheimer's and prion diseases, type 2 diabetes and various systemic amyloidoses.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Pentraxin 2/SAP (MPTX20)(5)

Publications using MPTX20

• Schwab, AD;Wyatt, TA;Schanze, OW;Nelson, AJ;Gleason, AM;Duryee, MJ;Mosley, DD;Thiele, GM;Mikuls, TR;Poole, JA; Lung-delivered IL-10 mitigates Lung inflammation induced by repeated endotoxin exposures in male mice Physiological reports 2025-02-01 [PMID: 39980189] (Mouse)
• JA Poole, TR Mikuls, GM Thiele, R Gaurav, AJ Nelson, MJ Duryee, A Mitra, C Hunter, TA Wyatt, BR England, DP Ascherman Increased susceptibility to organic dust exposure-induced inflammatory lung disease with enhanced rheumatoid arthritis-associated autoantigen expression in HLA-DR4 transgenic mice Respiratory Research, 2022-06-18;23(1):160. 2022-06-18 [PMID: 35717175] (Mouse)
• TR Mikuls, R Gaurav, GM Thiele, BR England, MG Wolfe, BP Shaw, KL Bailey, TA Wyatt, AJ Nelson, MJ Duryee, CD Hunter, D Wang, DJ Romberger, DP Ascherman, JA Poole The impact of airborne endotoxin exposure on rheumatoid arthritis-related joint damage, autoantigen expression, autoimmunity, and lung disease International immunopharmacology, 2021-08-27;100(0):108069. 2021-08-27 [PMID: 34461491] (Mouse)
• JR Burgos, BM Iresjö, L Olsson, U Smedh LPS immune challenge reduces arcuate nucleus TSHR and CART mRNA and elevates plasma CART peptides BMC Neurosci, 2019-12-11;20(1):59. 2019-12-11 [PMID: 31829131] (Mouse)
• H Kida, T Takahashi, Y Nakamura, T Kinoshita, M Hara, M Okamoto, S Okayama, K Nakamura, KI Kosai, T Taniwaki, Y Yamashita, T Matsuishi Pathogenesis of Lethal Aspiration Pneumonia in Mecp2-null Mouse Model for Rett Syndrome Sci Rep, 2017-09-20;7(1):12032. 2017-09-20 [PMID: 28931890] (Mouse)

FAQs for Pentraxin 2/SAP (MPTX20). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Apcs