Recombinant Human Adiponectin/Acrp30 Protein, CF


There are currently no images for Adiponectin/Acrp30 (1065-AP).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Reactivity HuSpecies Glossary
Applications Binding Activity, Bioactivity

Order Details

Recombinant Human Adiponectin/Acrp30 Protein, CF Summary

Details of Functionality
Measured by its ability to inhibit glucose production by rat hepatocytes. Zhou, H. et al. (2005) Biochem. Biophys. Res. Commun. 338:793.

The ED50 for this effect is 4‑20 µg/mL. Measured by its ability to induce TIMP-1 secretion by mouse macrophages. Kumada, M. et al. (2004) Circulation 109:2046. The ED50 for this effect is 1-5 µg/mL.

Mouse myeloma cell line, NS0-derived human Adiponectin/Acrp30 protein
Glu19-Asn244, with a C-terminal 6-His tag
Accession #
N-terminal Sequence
Structure / Form
Protein/Peptide Type
Recombinant Proteins
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<1.0 EU per 1 μg of the protein by the LAL method.


Theoretical MW
25.4 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
36 kDa, reducing conditions
Read Publications using
1065-AP in the following applications:

Packaging, Storage & Formulations

Do not freeze.
  • 6 months from date of receipt, 2 to 8 °C as supplied.
Supplied as a 0.2 μm filtered solution in PBS.
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human Adiponectin/Acrp30 Protein, CF

  • ACDC
  • Acrp30
  • adipocyte, C1Q and collagen domain containing
  • Adiponectin
  • adiponectin, C1Q and collagen domain containing
  • AdipoQ
  • ApM1
  • apM-1
  • APM1APM-1
  • C1q and collagen domain-containing protein
  • GBP28
  • GBP28apM1
  • Gelatin-binding protein


Adiponectin, also known as Acrp30, is an adipocyte-derived protein with wide ranging paracrine and endocrine effects on metabolism and inflammation. It is induced during adipocyte differentiation, and its secretion is stimulated by insulin. It promotes adipocyte differentiation, fatty acid catabolism, and insulin sensitivity and is negatively correlated with obesity, type 2 diabetes, and atherogenesis. In this context, Adiponectin is an anti-inflammatory agent, but it exerts pro-inflammatory effects in nonmetabolic disorders such as rheumatoid arthritis and inflammatory bowel disease (1 - 3). Adiponectin interacts with the receptors AdipoR1 and AdipoR2, calreticulin, and Cadherin-13/T-Cadherin, as well as with several growth factors (4 - 7). Mature human Adiponectin consists of a 60 amino acid (aa) N‑terminal collagenous region and a 137 aa C‑terminal C1q-like globular domain which can be cleaved by a leukocyte-derived elastase (8 - 9). Mature human Adiponectin shares 83% and 85% amino acid (aa) sequence identity with mouse and rat Adiponectin, respectively. Adiponectin associates into trimers that may assemble into medium molecular weight (MMW) hexamers and then into > 300 kDa high molecular weight (HMW) oligomers (10 - 12). The glycosylation of four hydroxylated lysine residues in the collagenous domain is required for the intracellular formation of HMW complexes (13). The various multimeric forms of Adiponectin exhibit distinct tissue specific and gender specific profiles and activities (12, 14).

  1. Lara-Castro, C. et al. (2007) Curr. Opin. Lipidol. 18:263.
  2. Tilg, H. and A.R. Moschen (2006) Nat. Rev. Immunol. 6:772.
  3. Fantuzzi, G. (2008) J. Allergy Clin. Immunol. 121:326.
  4. Yamauchi, T. et al. (2007) Nat. Med. 13:332.
  5. Takemura, Y. et al. (2007) J. Clin. Invest. 117:375.
  6. Hug, C. et al. (2004) Proc. Natl. Acad. Sci. 101:10308.
  7. Wang, Y. et al. (2005) J. Biol. Chem. 280:18341.
  8. Maeda, K. et al. (1996) Biochem. Biophys. Res. Commun. 221:286.
  9. Waki, H. et al. (2005) Endocrinology 146:790.
  10. Waki, H. et al. (2003) J. Biol. Chem. 278:40352.
  11. Tsao, T.S. et al. (2003) J. Biol. Chem. 278:50810.
  12. Wang, Y. et al. (2008) Biochem. J. 409:623.
  13. Wang, H. et al. (2006) J. Biol. Chem. 281:16391.
  14. Pajvani, U.B. et al. (2003) J. Biol. Chem. 278:9073.

Customers Who Viewed This Item Also Viewed...

Species: Hu, Mu, Po, Bv, Rb
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P, IP
Species: Hu, Mu
Applications: Flow, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt
Applications: WB
Species: Hu, Mu, Rt, Pm
Applications: WB, IHC, IHC-P
Species: Hu, Rt
Applications: WB
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-Fr, IHC-P
Species: Hu, Mu, Rt, Pm
Applications: WB, Simple Western, ELISA, Flow, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, ICC
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, S-ELISA
Species: Hu, Mu
Applications: IHC
Species: Hu, Mu, Rt, Bv, Rb
Applications: WB, ChIP, Flow, GS, ICC/IF, IHC, IHC-P, IP
Species: Hu, Mu, Rt
Applications: WB, Flow, IHC, IHC-P

Publications for Adiponectin/Acrp30 (1065-AP)(18)

We have publications tested in 5 confirmed species: Human, Mouse, Rat, N/A, Porcine.

We have publications tested in 4 applications: Bioassay, ELISA (Standard), In Vivo, Western Blot.

Filter By Application
ELISA (Standard)
In Vivo
Western Blot
All Applications
Filter By Species
All Species
Showing Publications 1 - 10 of 18. Show All 18 Publications.
Publications using 1065-AP Applications Species
A Miranda-Ma, OF Mercado-Gó, V Arriaga-Áv, R Guevara-Gu Distribution of Adiponectin Receptors 1 and 2 in the Rat Olfactory Bulb and the Effect of Adiponectin Injection on Insulin Receptor Expression Int J Endocrinol, 2017;2017(0):4892609. 2017 [PMID: 29463982] (In Vivo, Rat) In Vivo Rat
A Rak, K Zajda, E? Gregoraszc Endocrine disrupting compounds modulates adiponectin secretion, expression of its receptors and action on steroidogenesis in ovarian follicle Reprod. Toxicol, 2017;0(0):. 2017 [PMID: 28284726] (Bioassay, Porcine) Bioassay Porcine
K Gasbarrino, H Zheng, A Hafiane, JP Veinot, C Lai, SS Daskalopou Decreased Adiponectin-Mediated Signaling Through the AdipoR2 Pathway Is Associated With Carotid Plaque Instability Stroke, 2017;0(0):. 2017 [PMID: 28258256] (Bioassay, Human) Bioassay Human
S Fu, H Xu, M Gu, C Liu, Q Wang, X Wan, Y Chen, Q Chen, Y Peng, Z Cai, J Zhou, Z Wang Adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity Sci Rep, 2017;7(0):43771. 2017 [PMID: 28256562] (Bioassay, Human) Bioassay Human
R Ito, S Narita, M Huang, T Nara, K Numakura, K Takayama, H Tsuruta, A Maeno, M Saito, T Inoue, N Tsuchiya, S Satoh, T Habuchi The impact of obesity and adiponectin signaling in patients with renal cell carcinoma: A potential mechanism for the obesity paradox PLoS ONE, 2017;12(2):e0171615. 2017 [PMID: 28178338] (Bioassay, Human) Bioassay Human
Nokhbehsaim M, Keser S, Nogueira A, Cirelli J, Jepsen S, Jager A, Eick S, Deschner J Beneficial effects of adiponectin on periodontal ligament cells under normal and regenerative conditions. J Diabetes Res, 2014;2014(0):796565. 2014 [PMID: 25121107] (Bioassay, Human) Bioassay Human
Chen H, Tsou H, Chen J, Shih J, Chen Y, Tang C Adiponectin enhances intercellular adhesion molecule-1 expression and promotes monocyte adhesion in human synovial fibroblasts. PLoS ONE, 2014;9(3):e92741. 2014 [PMID: 24667577] (Bioassay, Human) Bioassay Human
Lavoie V, Kernaleguen AE, Charron G, Farhat N, Cossette M, Mamarbachi AM, Allen BG, Rheaume E, Tardif JC Functional effects of adiponectin on endothelial progenitor cells. Obesity (Silver Spring), 2011;19(4):722-8. 2011 [PMID: 20814418] (Bioassay, Human) Bioassay Human
Schipper HS, De Jager W, van Dijk ME, Meerding J, Zelissen PM, Adan RA, Prakken BJ, Kalkhoven E A multiplex immunoassay for human adipokine profiling. Clin. Chem., 2010;56(0):1320. 2010 [PMID: 20530731]
von Eynatten M, Liu D, Hock C, Oikonomou D, Baumann M, Allolio B, Korosoglou G, Morcos M, Campean V, Amann K, Lutz J, Heemann U, Nawroth PP, Bierhaus A, Humpert PM Urinary adiponectin excretion: a novel marker for vascular damage in type 2 diabetes. Diabetes, 2009;58(9):2093-9. 2009 [PMID: 19509019] (Western Blot, N/A) Western Blot N/A
Show All 18 Publications.

Reviews for Adiponectin/Acrp30 (1065-AP) (0)

There are no reviews for Adiponectin/Acrp30 (1065-AP). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

FAQs for Adiponectin/Acrp30 (1065-AP) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Other Available Formats

Additional Adiponectin/Acrp30 Products

Bioinformatics Tool for Adiponectin/Acrp30 (1065-AP)

Discover related pathways, diseases and genes to Adiponectin/Acrp30 (1065-AP). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Adiponectin/Acrp30 (1065-AP)

Discover more about diseases related to Adiponectin/Acrp30 (1065-AP).

Pathways for Adiponectin/Acrp30 (1065-AP)

View related products by pathway.

PTMs for Adiponectin/Acrp30 (1065-AP)

Learn more about PTMs related to Adiponectin/Acrp30 (1065-AP).

Blogs on Adiponectin/Acrp30

There are no specific blogs for Adiponectin/Acrp30, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Contact Information

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our Recombinant Human Adiponectin/Acrp30 Protein, CF and receive a gift card or discount.


Gene Symbol ADIPOQ