Rat TIM-1/KIM-1/HAVCR Quantikine ELISA Kit

• Reactivity: Rt
• Applications: ELISA
• Conjugate: HRP

Rat TIM-1/KIM-1/HAVCR Quantikine ELISA Kit Summary

• Background: The Quantikine Rat TIM-1 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure rat TIM-1 in cell culture supernates, tissue homogenates, serum, plasma, and urine. It contains NS0-expressed recombinant rat TIM-1 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained using natural rat TIM...-1 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring rat TIM-1.
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• Specificity: Natural and recombinant rat TIM-1
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Havcr1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Rat TIM-1/KIM-1/HAVCR Quantikine ELISA Kit

• CD365
• HAVCR1
• HAVCR-1
• HAVCRT cell immunoglobin domain and mucin domain protein 1
• hepatitis A virus cellular receptor 1
• Kidney injury molecule 1
• KIM1
• KIM-1
• T-cell immunoglobulin and mucin domain-containing protein 1
• TIM1
• TIM-1
• TIM-1TIM
• TIM1TIMD-1
• TIMD1T-cell membrane protein 1

Background

TIM-1 (T cell immunoglobulin and mucin domain 1), also known as KIM-1 and HAVcr1, is expressed on many immune cell types and epithelial cells. It binds to phosphatidylserine (PS), LMIR5/CD300b, TIM-1 (homophilic), TIM-4, IgA, and the glycoproteins of a number of enveloped viruses. Its interaction with PS enables TIM-1 to mediate the phagocytosis and clearance of apoptotic cells. TIM-1 signaling costimulates T cell activation and enhances Th2 cytokine production. TIM-1 serves as a cellular entry receptor for hepatitis A virus, Ebolavirus and Marburgvirus. Polymorphisms are associated with susceptibility to atopy, autoimmunity, and severe hepatitis A virus infection in humans. A soluble form of TIM-1 is elevated in the urine during nephropathy.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for TIM-1/KIM-1/HAVCR (RKM100)(15)

Publications using RKM100

• Ho, FJM;Siow, CJR;Aljaibeji, H;Ding, M;Mitchell, RN;Medicherla, S;Reddy, G;Gupta, S;Williams, GH;Romero, JR; UNI-494 treatment improves measures of renal dysfunction and cardiac pathology in male rats receiving L-NAME and angiotensin II Physiological reports 2025-11-01 [PMID: 41162192] (Rat)
• Sun, J;Niu, L;Wang, Y;Zhao, G;Tang, L;Jiang, J;Pan, S;Ge, X; MicroRNA?17?5p alleviates sepsis?related acute kidney injury in mice by modulating inflammation and apoptosis Molecular medicine reports 2024-08-01 [PMID: 38904199] (Mouse)
• Stojanovi?, NM;Miti?, KV;Neši?, M;Stankovi?, M;Petrovi?, V;Barali?, M;Randjelovi?, PJ;Sokolovi?, D;Radulovi?, N; Oregano (Origanum vulgare) Essential Oil and Its Constituents Prevent Rat Kidney Tissue Injury and Inflammation Induced by a High Dose of L-Arginine International journal of molecular sciences 2024-01-11 [PMID: 38256015] (Rat)
• Z Xing, K Gong, N Hu, Y Chen The Reduction of Uromodulin, Complement Factor H, and Their Interaction Is Associated with Acute Kidney Injury to Chronic Kidney Disease Transition in a Four-Time Cisplatin-Injected Rat Model International Journal of Molecular Sciences, 2023-04-02;24(7):. 2023-04-02 [PMID: 37047611] (Rat)
• J Huang, E Caliskan G, SK Gholami, KL Gawelek, RN Mitchell, LH Pojoga, JR Romero, GH Williams, GK Adler Effects of Mineralocorticoid Receptor Blockade and Statins on Kidney Injury Marker 1 (KIM-1) in Female Rats Receiving L-NAME and Angiotensin II International Journal of Molecular Sciences, 2023-03-30;24(7):. 2023-03-30 [PMID: 37047470] (Rat)
• K Pyrshev, A Stavniichu, VN Tomilin, NH Khayyat, G Ren, M Kordysh, O Zaika, M Mamenko, O Pochynyuk TRPV4 functional status in cystic cells regulates cystogenesis in autosomal recessive polycystic kidney disease during variations in dietary potassium Physiological Reports, 2023-03-01;11(6):e15641. 2023-03-01 [PMID: 36946001] (Rat)
• I Vildmyren, Å Oterhals, S Leh, TA Samuelsen, A Halstensen, HP Marti, OA Gudbrandse Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats Food & nutrition research, 2022-10-11;66(0):. 2022-10-11 [PMID: 36340918] (Rat)
• MJ Coyne, AE Schultze, DJ McCrann, RE Murphy, J Cross, M Strong-Tow, C Drake, R Mack Evaluation of renal injury and function biomarkers, including symmetric dimethylarginine (SDMA), in the rat passive Heymann nephritis (PHN) model PLoS ONE, 2022-05-27;17(5):e0269085. 2022-05-27 [PMID: 35622875] (Rat)
• Z Sang, S Dong, P Zhang, Y Wei miR?214 ameliorates sepsis?induced acute kidney injury via PTEN/AKT/mTOR?regulated autophagy Molecular Medicine Reports, 2021-07-30;24(4):. 2021-07-30 [PMID: 34328194] (Mouse)
• AK Medipally, M Xiao, BH Rovin, AA Satoskar, I Ivanov, S Qaisar, SV Brodsky Role of glomerular filtration rate-modifying drugs in the development of anticoagulant-related nephropathy Physiological Reports, 2021-01-01;9(1):e14697. 2021-01-01 [PMID: 33427414] (Rat)
• HR Turbeville, AC Johnson, MR Garrett, EL Dent, JM Sasser Nitric oxide and oxidative stress pathways do not contribute to sex differences in renal injury and function in Dahl SS/Jr rats Physiol Rep, 2020-07-01;8(13):e14440. 2020-07-01 [PMID: 32652814] (Rat)
• S Kovacevic, M Ivanov, Z Miloradovi, P Brkic, UJ Vajic, M Zivotic, N Mihailovic, D Jovovic, D Karanovic, R Jeremic, J Nesovic-Os Hyperbaric oxygen preconditioning and the role of NADPH oxidase inhibition in postischemic acute kidney injury induced in spontaneously hypertensive rats PLoS ONE, 2020-01-08;15(1):e0226974. 2020-01-08 [PMID: 31914135] (Rat)
• CN Patil, LC Racusen, JF Reckelhoff Consequences of advanced aging on renal function in chronic hyperandrogenemic female rat model: implications for aging women with polycystic ovary syndrome Physiol Rep, 2017-11-01;5(20):. 2017-11-01 [PMID: 29051304] (Rat)
• Alice Maria Costa Martins Nephroprotective effects of (-)-?-bisabolol against ischemic-reperfusion acute kidney injury Phytomedicine, 2016-11-11;23(14):1843-1852. 2016-11-11 [PMID: 27912887] (Rat)
• Martines M, Mendes M, Shimizu M, Melo Rodrigues V, de Castro I, Filho S, Malheiros D, Yu L, Burdmann E Effects of Schizolobium parahyba extract on experimental Bothrops venom-induced acute kidney injury. PLoS ONE, 2014-02-14;9(2):e86828. 2014-02-14 [PMID: 24551041] (Rat)

FAQs for TIM-1/KIM-1/HAVCR (RKM100). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Havcr1