Rat TIM-1/KIM-1/HAVCR DuoSet ELISA, 15 Plate

• Reactivity: Rt
• Applications: ELISA
• Conjugate: Biotin

Rat TIM-1/KIM-1/HAVCR DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Havcr1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Rat TIM-1/KIM-1/HAVCR DuoSet ELISA, 15 Plate

• CD365
• HAVCR1
• HAVCR-1
• HAVCRT cell immunoglobin domain and mucin domain protein 1
• hepatitis A virus cellular receptor 1
• Kidney injury molecule 1
• KIM1
• KIM-1
• T-cell immunoglobulin and mucin domain-containing protein 1
• TIM1
• TIM-1
• TIM-1TIM
• TIM1TIMD-1
• TIMD1T-cell membrane protein 1

Background

TIM-1 (T cell immunoglobulin and mucin domain 1), also known as KIM-1 and HAVcr1, is expressed on many immune cell types and epithelial cells. It binds to phosphatidylserine (PS), LMIR5/CD300b, TIM-1 (homophilic), TIM-4, IgA, and the glycoproteins of a number of enveloped viruses. Its interaction with PS enables TIM-1 to mediate the phagocytosis and clearance of apoptotic cells. TIM-1 signaling costimulates T cell activation and enhances Th2 cytokine production. TIM-1 serves as a cellular entry receptor for hepatitis A virus, Ebolavirus and Marburgvirus. Polymorphisms are associated with susceptibility to atopy, autoimmunity, and severe hepatitis A virus infection in humans. A soluble form of TIM-1 is elevated in the urine during nephropathy.

Publications for TIM-1/KIM-1/HAVCR (DY3689)(5)

Publications using DY3689

• T Pelé, S Giraud, S Joffrion, V Ameteau, A Delwail, JM Goujon, L Macchi, T Hauet, F Dkhissi, O Benzakour Study of the Role of the Tyrosine Kinase Receptor MerTK in the Development of Kidney Ischemia-Reperfusion Injury in RCS Rats International Journal of Molecular Sciences, 2021-11-09;22(22):. 2021-11-09 [PMID: 34829984] (Rat)
• J Edwards, M Kowal, A VanDreel, P Lamar, W Prozialeck A Method for the Evaluation of Site-Specific Nephrotoxic Injury in the Intact Rat Kidney Toxics, 2020-01-20;8(1):. 2020-01-20 [PMID: 31968633] (Rat)
• J Cops, W Mullens, FH Verbrugge, Q Swennen, B De Moor, C Reynders, J Penders, R Achten, A Driessen, A Dendooven, JM Rigo, D Hansen Selective abdominal venous congestion induces adverse renal and hepatic morphological and functional alterations despite a preserved cardiac function Sci Rep, 2018-12-10;8(1):17757. 2018-12-10 [PMID: 30532057] (Rat)
• J Cops, W Mullens, FH Verbrugge, Q Swennen, C Reynders, J Penders, JM Rigo, D Hansen Selective abdominal venous congestion to investigate cardiorenal interactions in a rat model PLoS ONE, 2018-05-29;13(5):e0197687. 2018-05-29 [PMID: 29813081] (Rat)
• F Mohamed, NA Buckley, JW Pickering, K Wunnapuk, S Dissanayak, U Chathurang, I Gawaramman, S Jayamanne, ZH Endre Nephrotoxicity-induced proteinuria increases biomarker diagnostic thresholds in acute kidney injury BMC Nephrol, 2017-04-03;18(1):122. 2017-04-03 [PMID: 28372541] (Rat)

FAQs for TIM-1/KIM-1/HAVCR (DY3689). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Havcr1