RAGE Antibody

Images

 
Western Blot: RAGE Antibody [NBP2-03950] - analysis of RAGE in 1) human lung tissue lysate, mouse lung tissue lysate in the 2) absence and 3) presence of immunizing peptide, and 4) rat lung tissue lysate using this ...read more
Immunohistochemistry-Paraffin: RAGE Antibody [NBP2-03950] - analysis of RAGE in formalin-fixed, paraffin-embedded human brain tissue using this antibody at 5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit

Order Details

RAGE Antibody Summary

Immunogen
A portion of amino acids 1-60 of human RAGE was used as the immunogen.
Clonality
Polyclonal
Host
Rabbit
Gene
MOK
Purity
Protein A purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Conjugate
Unconjugated
Buffer
0.2 ml PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Applications/Dilutions

Dilutions
  • Western Blot 1-3 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 5 ug/ml

Reactivity Notes

Human, Mouse, Rat

Alternate Names for RAGE Antibody

  • AGER
  • EC 2.7.11.22
  • MOK protein kinase
  • MOKMAPK/MAK/MRK overlapping kinase
  • RAGE
  • RAGE-1
  • RAGE1renal cell carcinoma antigen (MOK protein kinase)
  • Renal tumor antigen 1
  • renal tumor antigen

Background

Advanced glycation end-products receptor (RAGE) is reported to be a multiligand receptor of the immunoglobulin superfamily expressed in myoblasts. It is developmentally regulated in skeletal muscle. It is reported that RAGE along with Amphoterin stimulates myoblast differentiation by the combined effect of stimulation of differentiation and inhibition of proliferation, and deregulation of RAGE expression in myoblasts might contribute to their neoplastic transformation. Various studies report that RAGE signaling in microglia contributes to the pathogenesis of an inflammatory response that ultimately impairs neuronal function and directly affects amyloid accumulation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Research Areas for RAGE Antibody (NBP2-03950)

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Blogs on RAGE.

Five Funny Protein Names: Infographic
Some proteins have the strangest names. Check out our list for some of the funniest ones and learn more about each protein including their function, gene symbol, molecular weight and family.Novus Biologicals offers reagents for each target:Merli...  Read full blog post.

For Inflammation Research, S100A12 is all the RAGE
S100A12 (Calgranulin C) belongs to the S100 family of calcium-binding proteins. The 20 members of this group share EF-hand domains which are involved in binding of calcium. S100A12 is expressed by granulocytes, whereas its expression by monocytes rema...  Read full blog post.

Contact Information

Product PDFs

Bioinformatics

Gene Symbol MOK
Entrez
Uniprot

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