PTGDR Antibody (1052528) [Alexa Fluor® 532]

• Reactivity: Hu
• Applications: IHC
• Clone: 1052528
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 532

PTGDR Antibody (1052528) [Alexa Fluor® 532] Summary

• Immunogen: Synthetic peptide within amino acids 50-150 of the Prostaglandin D2 receptor protein sequences
  Accession # Q13258
• Specificity: Detects Prostaglandin D2 receptor immunogen in Direct ELISA.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PTGDR Antibody (1052528) [Alexa Fluor® 532]

• AS1
• ASRT1
• DP
• DP1
• MGC49004
• PGD receptor
• PGD2 receptor
• prostaglandin D2 receptor (DP)
• prostaglandin D2 receptor
• Prostanoid DP receptor
• PTGDR
• PTGDR1

Background

PTGDR is a G protein-coupled receptor that has been shown to function as a prostanoid DP receptor. PTGDR is expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes. The activity of this receptor is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. Knockout studies in mice suggest that the ligand of PTGDR, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses. Genetic variations in PTGDR are associated with susceptibility to asthma-related traits type 1 (ASRT1). Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.