PSAP Antibody (1D1-C12)

Images

 
Western Blot: PSAP Antibody (1D1-C12) [H00005660-M01] - Analysis of PSAP expression in transfected 293T cell line by PSAP monoclonal antibody (M01), clone 1D1-C12.Lane 1: PSAP transfected lysate(58.1 KDa).Lane 2: ...read more
Immunohistochemistry-Paraffin: PSAP Antibody (1D1-C12) [H00005660-M01] - Analysis of monoclonal antibody to PSAP on formalin-fixed paraffin-embedded human spleen tissue. Antibody concentration 5 ug/ml.
Immunoprecipitation: PSAP Antibody (1D1-C12) [H00005660-M01] - Analysis of PSAP transfected lysate using anti-PSAP monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with PSAP MaxPab rabbit polyclonal ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, IHC, IHC-P, IP
Clone
1D1-C12
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

PSAP Antibody (1D1-C12) Summary

Immunogen
PSAP (AAH01503, 18 a.a. ~ 524 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. PVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN
Specificity
PSAP - prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy)
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
PSAP
Purity
IgG purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Western Blot 1:500
Application Notes
Antibody reactivity against recombinant protein for WB. It has been used for IHC-P and ELISA.
Publications
Read Publications using H00005660-M01.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
In 1x PBS, pH 7.4
Preservative
No Preservative
Purity
IgG purified

Notes

Quality control test: Antibody Reactive Against Recombinant Protein.

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for PSAP Antibody (1D1-C12)

  • FLJ00245
  • GLBA
  • proactivator polypeptide
  • prosaposin
  • PSAP
  • SAP1
  • SAP1MGC110993
  • sphingolipid activator protein-1

Background

This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for PSAP Antibody (H00005660-M01)(2)


Showing Publications 1 - 2 of 2.
Publications using H00005660-M01 Applications Species
Koochekpour S, Hu S, Vellasco-Gonzalez C et al. Serum prosaposin levels are increased in patients with advanced prostate cancer. Prostate. 2011 May 31 [PMID: 21630292]
Halbert D, Domenyuk V, Spetzler D et al. Aptamers and uses thereof United States Patent Application US 9958448 B2 2018

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PSAP
Entrez
OMIM
Uniprot